Patents by Inventor David Weiner

David Weiner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11596678
    Abstract: Nucleic acid molecules and compositions comprising one or more nucleic acid sequences that encode a consensus Marburgvirus filovirus glycoprotein immunogens. Immunomodulatory methods and methods of inducing an immune response against Marburgvirus are disclosed. Method of preventing infection by Marburgvirus and methods of treating individuals infected with Marburgvirus are disclosed. Consensus Marburgvirus filovirus glycoprotein immunogens are disclosed.
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: March 7, 2023
    Assignees: The Trustees of the University of Pennsylvania, The Wistar Institute of Anatomv and Biologv
    Inventors: David Weiner, Ami Patel, Sarah Elliott
  • Publication number: 20230063151
    Abstract: Disclosed herein are combinations of inhibitors of B cell maturation and recombinant nucleic acid molecules encoding synthethic antibodies, and their use for extending the duration of circulating synthetic antibodies and for treating diseases and disorders.
    Type: Application
    Filed: January 29, 2021
    Publication date: March 2, 2023
    Inventors: David Weiner, Ami Patel, Alfredo Perales-Puchalt, Megan C. Wise, Sarah T.C. Elliott
  • Publication number: 20220370598
    Abstract: Provided herein are methods of inducing an immune response against Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) in a subject in need thereof by administering an immunogenic composition to the subject, wherein the subject exhibits: an increase in antigen-specific cellular immune response as measured by Interferon-gamma (IFN-?) Enzyme-linked Immunospot (ELISpot) assay relative to baseline; and/or an increase in neutralizing antibody response as measured by a pseudovirus neutralizing assay relative to baseline.
    Type: Application
    Filed: May 5, 2022
    Publication date: November 24, 2022
    Inventors: Jian Yan, Kate Broderick, David Weiner, Kar Muthumani, Ami Patel
  • Publication number: 20220354945
    Abstract: Nucleic acid molecules and compositions comprising one or more nucleotide sequences that encode a consensus Epstein-Barr virus (EBV) antigen. Immunomodulatory methods and methods of inducing an immune response against EBV are disclosed. Method of treating infection by EBV and methods of treating or preventing a disease or disorder associated with EBV are disclosed. Modified consensus EBV antigens are disclosed.
    Type: Application
    Filed: June 22, 2022
    Publication date: November 10, 2022
    Inventors: David Weiner, Alfredo Perales Puchalt
  • Patent number: 11485971
    Abstract: An expression construct is disclosed which comprises: (i) a DNA sequence which encodes at least one guide RNA (gRNA) operatively linked to a transcriptional regulatory sequence so as to allow expression of the gRNA in a target cell; (ii) a barcode sequence for identification of the at least one gRNA operatively linked to a transcriptional regulatory sequence so as to allow expression of the barcode sequence in the target cell.
    Type: Grant
    Filed: September 14, 2017
    Date of Patent: November 1, 2022
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Ido Amit, Diego Jaitin, David Lara-Astiaso, Assaf Weiner, Ido Yofe
  • Publication number: 20220324948
    Abstract: Disclosed herein are compositions for generating a synthetic antibody or synthetic multivalent antibody in a subject. Also disclosed are methods for generating a synthetic antibody or synthetic multivalent antibody in a subject by administering a composition including one or more recombinant nucleic acid sequence that encodes a synthetic antibody or synthetic multivalent antibody to the subject. The disclosure also provides a compositions and methods of preventing and/or treating a Neisseria gonorrhoeae infection in a subject using said synthetic antibody or synthetic multivalent antibody.
    Type: Application
    Filed: July 31, 2020
    Publication date: October 13, 2022
    Inventors: David Weiner, Elizabeth Parzych, Ami Patel
  • Patent number: 11464841
    Abstract: Disclosed herein are compositions comprising optimized consensus TERT antigens and methods for treating cancer and in particular immunogenic compositions that treat and provide protection against tumor.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: October 11, 2022
    Assignees: The Trustees of the University of Pennsylvania, The Wistar Institute of Anatomy and Biology, Inovio Pharmaceuticals, Inc.
    Inventors: David Weiner, Jian Yan
  • Patent number: 11461505
    Abstract: A method for obfuscation of operations using minimal additional hardware is presented herein. The method can begin by executing a first iteration of a set of computations, the execution of the set of computations resulting in a first iteration output. The method can continue by executing a second iteration of the set of computations, wherein the second execution is distinct from the first iteration but should satisfy a matching condition. The distinction can be a rearrangement of sub-operations, insertion of dummy sub-operations, or a combination of the two. After the iterations are complete, the iteration outputs can be compared. If the comparison of the first iteration output and the second iteration output satisfy the matching condition, the process result can be output. If the matching condition is not satisfied, an error detected signal can be output.
    Type: Grant
    Filed: October 17, 2019
    Date of Patent: October 4, 2022
    Assignee: ARM LIMITED
    Inventors: Michael Weiner, Oded Golombek, David Yellin
  • Publication number: 20220275065
    Abstract: Disclosed herein are compositions for generating a synthetic antibody or synthetic multivalent antibody in a subject. Also disclosed are methods for generating a synthetic antibody or synthetic multivalent antibody in a subject by administering a composition including a recombinant nucleic acid sequence that encodes an antibody, a synthetic antibody, or a synthetic multivalent antibody to a subject. The disclosure also provides compositions and methods of preventing and/or treating a bacterial infection in a subject using said antibody, synthetic antibody, or synthetic multivalent antibody.
    Type: Application
    Filed: July 31, 2020
    Publication date: September 1, 2022
    Inventors: David Weiner, Ami Patel
  • Patent number: 11423726
    Abstract: Systems and methods for displaying a dynamic badge for accessing a facility are disclosed. The dynamic badge may include a display of one or more objects that change shape over time according to a predetermined pattern. The dynamic badge may visible at a specified distance (such as a social distancing limitation). The dynamic badge may be scanned or recognized by a scanning device at the specified distance to determine facility access for a user of the badge.
    Type: Grant
    Filed: April 22, 2021
    Date of Patent: August 23, 2022
    Assignee: Maximus, Inc.
    Inventors: David Cowles, Dan Biernacki, Abby Flock, Fran Casale, Michael Garbus, Michael Weiner, Bruce Perkins
  • Patent number: 11395851
    Abstract: Nucleic acid molecules and compositions comprising one or more nucleotide sequences that encode a consensus Epstein-Barr virus (EBV) antigen. Immunomodulatory methods and methods of inducing an immune response against EBV are disclosed. Method of treating infection by EBV and methods of treating or preventing a disease or disorder associated with EBV are disclosed. Modified consensus EBV antigens are disclosed.
    Type: Grant
    Filed: February 15, 2019
    Date of Patent: July 26, 2022
    Assignee: THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY
    Inventors: David Weiner, Alfredo Perales Puchalt
  • Publication number: 20220193230
    Abstract: Nucleic acid molecules and compositions comprising: a nucleic acid sequence that encodes IL-12 p35 subunit or a functional fragment thereof and/or a nucleic acid sequence that encodes IL12 p40 subunit or a functional fragment thereof, are disclosed. The nucleic acid molecules and compositions further comprising a nucleic acid sequence that encodes an immunogen are also disclosed. Method of modulating immune response and methods of inducing an immune response against an immunogen are disclosed. Therapeutic and prophylactic vaccination methods are also disclosed.
    Type: Application
    Filed: December 28, 2021
    Publication date: June 23, 2022
    Inventors: David Weiner, Matthew P. Morrow, Jian Yan
  • Publication number: 20220112273
    Abstract: Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating disease in a subject using said composition and method of generation.
    Type: Application
    Filed: December 17, 2021
    Publication date: April 14, 2022
    Inventors: David Weiner, Karuppiah Muthumani, Seleeke Flingai, Niranjan Sardesai
  • Publication number: 20220112271
    Abstract: Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody to a Middle East Respiratory Syncytial Coronavirus (MERS-CoV) viral antigen. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating an MERS-CoV virus infection in a subject using said composition and method of generation.
    Type: Application
    Filed: December 23, 2021
    Publication date: April 14, 2022
    Inventors: David WEINER, Trevor RF SMITH, Kar MUTHUMANI
  • Publication number: 20220098324
    Abstract: Disclosed herein are compositions comprising a recombinant nucleic acid sequence encoding a bispecific immune cell engaging antibody (DICE), a recombinant nucleic acid sequence encoding a bispecific T cell engaging (DBiTE) antibody, a fragment thereof, a variant thereof, or a combination thereof.
    Type: Application
    Filed: January 30, 2020
    Publication date: March 31, 2022
    Inventors: David Weiner, Alfredo Perales-Puchalt, Kar Muthumani, Elizabeth Duperret
  • Publication number: 20220054620
    Abstract: An aspect of the present invention is related to nucleic acid constructs capable of expressing at least one Powassan virus (POWV) antigen that elicits an immune response in a mammal against POWV virus, and methods of use thereof.
    Type: Application
    Filed: December 20, 2019
    Publication date: February 24, 2022
    Inventors: Kar Muthumani, David Weiner, Hyeree Choi, Sagar B. Kudchodkar
  • Patent number: 11241496
    Abstract: Nucleic acid molecules and compositions comprising: a nucleic acid sequence that encodes IL-12 p35 subunit or a functional fragment thereof and/or a nucleic acid sequence that encodes IL12 p40 subunit or a functional fragment thereof, are disclosed. The nucleic acid molecules and compositions further comprising a nucleic acid sequence that encodes an immunogen are also disclosed. Method of modulating immune response and methods of inducing an immune response against an immunogen are disclosed. Therapeutic and prophylactic vaccination methods are also disclosed.
    Type: Grant
    Filed: May 9, 2018
    Date of Patent: February 8, 2022
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: David Weiner, Matthew P. Morrow, Jian Yan
  • Patent number: 11230592
    Abstract: Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody to a Middle East Respiratory Syncytial Coronavirus (MERS-CoV) viral antigen. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating an MERS-CoV virus infection in a subject using said composition and method of generation.
    Type: Grant
    Filed: September 27, 2018
    Date of Patent: January 25, 2022
    Assignees: THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY, INOVIO PHARMACEUTICALS, INC.
    Inventors: David Weiner, Trevor R F Smith, Kar Muthumani
  • Publication number: 20220016228
    Abstract: Provided herein are consensus amino acid sequences of prostate antigens that are capable of breaking tolerance in a targeted species, including PSA, PSMA, STEAP and PSCA antigens. Also provided are nucleic acid sequences that encode one or more consensus amino acid sequences of prostate antigens PSA, PSMA, STEAP and PSCA, as well as genetic constructs/vectors and vaccines expressing the sequences. Also provided herein are methods for generating an autoimmune response against prostate cancer cells by administering one or more of the vaccines, proteins, and/or nucleic acid sequences that are provided.
    Type: Application
    Filed: June 28, 2021
    Publication date: January 20, 2022
    Inventors: David Weiner, Jian Yan, Bernadette Ferraro, Niranjan Y. Sardesai, Mathura P. Ramanathan
  • Publication number: 20210401978
    Abstract: Disclosed herein is a vaccine comprising an antigen and checkpoint inhibitor. Also disclosed herein is a method for enhancing an immune response in a subject. The method may comprise administering the vaccine to the subject in need thereof.
    Type: Application
    Filed: September 14, 2021
    Publication date: December 30, 2021
    Inventors: David Weiner, Karuppiah Muthumani, Niranjan Sardesai