Patents by Inventor David Weiner

David Weiner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • OPTIMIZED NUCLEIC ACID ANTIBODY CONSTRUCTS
    Publication number: 20210188947
    Abstract: Disclosed herein are compositions comprising structurally modified DNA encoded antibodies (DMAbs), methods of structurally modifying DMAbs, and methods of using structurally modified DMAbs.
    Type: Application
    Filed: May 10, 2018
    Publication date: June 24, 2021
    Inventors: David Weiner, Ghiabe Guibinga, Neil Cooch, Charles Reed
  • Extreme Polyvalency Induces Potent Cross-Clade Cellular and Humoral Responses in Rabbits and Non-human Primates
    Publication number: 20210138061
    Abstract: The present invention relates to compositions comprising two or more DNA plasmids encoding consensus and transmitted founder HIV envelope glycoproteins which expressed and induce a potent immune response.
    Type: Application
    Filed: November 10, 2020
    Publication date: May 13, 2021
    Inventors: David Weiner, Megan Wise
  • Vaccines For Human Papilloma Virus And Methods For Using The Same
    Publication number: 20210121560
    Abstract: Improved anti-HPV immunogens and nucleic acid molecules that encode them are disclosed. Immunogens disclosed include those having consensus HPV39 E6E7 and HPV45 E6E7. Pharmaceutical composition, recombinant vaccines comprising DNA plasmid and live attenuated vaccines are disclosed as well methods of inducing an immune response in an individual against HPV are disclosed.
    Type: Application
    Filed: January 5, 2021
    Publication date: April 29, 2021
    Inventors: David Weiner, Jian Yan
  • DNA ANTIBODY CONSTRUCTS FOR USE AGAINST HIV
    Publication number: 20210107970
    Abstract: Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody to an HIV antigen. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating an HIV infection in a subject using said composition and method of generation.
    Type: Application
    Filed: March 27, 2018
    Publication date: April 15, 2021
    Inventors: David Weiner, Megan Wise
  • Engineered Optimized Cytokine Compositions
    Publication number: 20210101952
    Abstract: The present invention relates to recombinant optimized polynucleotide encoding a cytokine or cytokine receptor and to methods of making a recombinant optimized polynucleotide encoding a cytokine or cytokine receptor.
    Type: Application
    Filed: April 9, 2019
    Publication date: April 8, 2021
    Inventors: Rajasekharan Somasundaram, Kar Muthumani, David Weiner
  • PD1 AND PDL1 ANTIBODIES AND VACCINE COMBINATIONS AND USE OF SAME FOR IMMUNOTHERAPY
    Publication number: 20210085779
    Abstract: Disclosed herein is a vaccine comprising an antigen and PD1 antibody and/or PDL1 antibody. Also disclosed herein is a method for enhancing an immune response in a subject. The method may comprise administering the vaccine to the subject in need thereof.
    Type: Application
    Filed: October 6, 2020
    Publication date: March 25, 2021
    Inventors: David WEINER, Karuppiah MUTHUMANI, Niranjan SARDESAI
  • Vaccines with interleukin-33 as an adjuvant
    Patent number: 10933130
    Abstract: Disclosed herein is a vaccine comprising an antigen and IL-33. Also disclosed herein is a method for increasing an immune response in a subject in need thereof. Further disclosed herein is a method for treating cancer in a subject in need thereof. The methods may comprise administering the vaccine to the subject.
    Type: Grant
    Filed: August 30, 2018
    Date of Patent: March 2, 2021
    Assignees: The Trustees of the University of Pennsylvania, Inovio Pharmaceuticals, Inc.
    Inventors: David Weiner, Daniel Villarreal, Matthew Morrow, Jian Yan
  • Vaccines with CD40 ligand as an adjuvant
    Patent number: 10925961
    Abstract: Disclosed herein is a vaccine comprising an antigen and CD40L. Also disclosed herein are methods for increasing an immune response in a subject. The methods may comprise administering the vaccine to the subject in need thereof.
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: February 23, 2021
    Assignees: The Trustees of the University of Pennsylvania, INOVIO PHARMACEUTICALS. INC.
    Inventors: David Weiner, Matthew Morrow, Megan Wise
  • NUCLEIC ACID ANTIBODY CONSTRUCTS FOR USE AGAINST RESPIRATORY SYNCYTIAL VIRUS
    Publication number: 20210047390
    Abstract: Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody to a Respiratory Syncytial Virus antigen. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating an Respiratory Syncytial virus infection in a subject using said composition and method of generation.
    Type: Application
    Filed: January 31, 2019
    Publication date: February 18, 2021
    Inventors: David Weiner, Kar Muthumani, Jing Chen, Trevor Smith, Katherine Schultheis
  • NUCLEIC ACID ANTIBODY CONSTRUCTS FOR USE AGAINST EBOLA VIRUS
    Publication number: 20210047388
    Abstract: Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody to an Ebola viral antigen. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating an Ebola virus infection in a subject using said composition and method of generation.
    Type: Application
    Filed: January 31, 2019
    Publication date: February 18, 2021
    Inventor: David Weiner
  • EPSTEIN-BARR VIRUS NUCLEIC ACID CONSTRUCTS AND VACCINES MADE THEREFROM, AND METHODS OF USING SAME
    Publication number: 20210038711
    Abstract: Nucleic acid molecules and compositions comprising one or more nucleotide sequences that encode a consensus Epstein-Barr virus (EBV) antigen. Immunomodulatory methods and methods of inducing an immune response against EBV are disclosed. Method of treating infection by EBV and methods of treating or preventing a disease or disorder associated with EBV are disclosed. Modified consensus EBV antigens are disclosed.
    Type: Application
    Filed: February 15, 2019
    Publication date: February 11, 2021
    Inventors: David Weiner, Alfredo Perales Puchalt
  • Vaccines for human papilloma virus and methods for using the same
    Patent number: 10905755
    Abstract: Improved anti-HPV immunogens and nucleic acid molecules that encode them are disclosed. Immunogens disclosed include those having consensus HPV39 E6E7 and HPV45 E6E7. Pharmaceutical composition, recombinant vaccines comprising DNA plasmid and live attenuated vaccines are disclosed as well methods of inducing an immune response in an individual against HPV are disclosed.
    Type: Grant
    Filed: March 11, 2019
    Date of Patent: February 2, 2021
    Assignees: The Trustees of the University of Pennsylvania, Inovio Pharmaceuticals, Inc.
    Inventors: David Weiner, Jian Yan
  • NUCLEIC ACID MONOCLONAL ANTIBODIES TARGETING PCSK9 AND METHODS OF USE
    Publication number: 20200362055
    Abstract: Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody or fragment thereof that targets PCSK9. The disclosure also provides a method of preventing and/or treating disease, such as cardiovascular disease or hypercholesterolemia, in a subject using the composition of the invention.
    Type: Application
    Filed: January 31, 2019
    Publication date: November 19, 2020
    Inventors: David Weiner, Makan Khoshnejad, Kar Muthumani, Ami Patel
  • PD1 and PDL1 antibodies and vaccine combinations and use of same for immunotherapy
    Patent number: 10835595
    Abstract: Disclosed herein is a vaccine comprising an antigen and PD1 antibody and/or PDL1 antibody. Also disclosed herein is a method for enhancing an immune response in a subject. The method may comprise administering the vaccine to the subject in need thereof.
    Type: Grant
    Filed: January 6, 2015
    Date of Patent: November 17, 2020
    Assignees: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, INOVIO PHARMACEUTICALS, INC.
    Inventors: David Weiner, Karuppiah Muthumani, Niranjan Sardesai
  • Extreme polyvalency induces potent cross-clade cellular and humoral responses in rabbits and non-human primates
    Patent number: 10828363
    Abstract: The present invention relates to compositions comprising two or more DNA plasmids encoding consensus and transmitted founder HIV envelope glycoproteins which expressed and induce a potent immune response.
    Type: Grant
    Filed: September 15, 2017
    Date of Patent: November 10, 2020
    Assignees: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY
    Inventors: David Weiner, Megan Wise
  • ISG15 and its use as an adjuvant
    Patent number: 10792358
    Abstract: Disclosed herein is a vaccine comprising an antigen and ISG15. Also disclosed herein is a method for increasing an immune response in a subject in need thereof. Further disclosed herein is a method for treating a subject in need thereof. The methods may comprise administering the vaccine to the subject.
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: October 6, 2020
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: David Weiner, Daniel Villarreal
  • DNA ANTIBODY CONSTRUCTS FOR USE AGAINST MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS
    Publication number: 20200299359
    Abstract: Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody to a Middle East Respiratory Syncytial Coronavirus (MERS-CoV) viral antigen. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating an MERS-CoV virus infection in a subject using said composition and method of generation.
    Type: Application
    Filed: September 27, 2018
    Publication date: September 24, 2020
    Inventors: David WEINER, Trevor RF SMITH
  • DNA MONOCLONAL ANTIBODIES TARGETING CTLA-4 FOR THE TREATMENT AND PREVENTION OF CANCER
    Publication number: 20200283525
    Abstract: Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody or fragment thereof that targets CTLA-4. The disclosure also provides a method of preventing and/or treating disease, such as cancer, in a subject using the composition of the invention.
    Type: Application
    Filed: October 3, 2018
    Publication date: September 10, 2020
    Inventors: David WEINER, Elizabeth DUPERRET
  • MERS-CoV Vaccine
    Publication number: 20200222527
    Abstract: Disclosed herein is a vaccine comprising a Middle East Respiratory Syndrome coronavirus (MERS-CoV) antigen. The antigen can be a consensus antigen. The consensus antigen can be a consensus spike antigen. Also disclosed herein is a method of treating a subject in need thereof, by administering the vaccine to the subject.
    Type: Application
    Filed: February 4, 2020
    Publication date: July 16, 2020
    Inventors: David Weiner, Karuppiah Muthumani, Niranjan Y. Sardesai
  • DNA ANTIBODY CONSTRUCTS FOR USE AGAINST EBOLA VIRUS
    Publication number: 20200216519
    Abstract: Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody to an Ebola viral antigen. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating an Ebola virus infection in a subject using said composition and method of generation.
    Type: Application
    Filed: September 17, 2018
    Publication date: July 9, 2020
    Inventors: David Weiner, Ami Patel