Abstract: An acetabular cup assembly for use with liners is described. The acetabular cup assembly includes a cup and a liner. The cup has an outer surface, a generally concave inner surface and a top face. The inner surface includes a cylindrical band having a plurality of inward-facing recessed scallops, a tapered wall adjacent to the band, and an inner spherical surface adjacent the tapered wall. The inner spherical surface has a substantially uniform radius of curvature. A single groove interrupts the spherical surface. The liner has a substantially convex outer surface and includes a rim and a plurality of outward-projecting scallops adjacent the rim. The scallops of the liner are configured to engage the scallops of the cup when the liner is seated in the cup. Related methods of use are also provided.

Abstract: A method includes receiving, by a first computing system, a first package of electrocardiogram (ECG) data and metadata associated with the ECG data. The method further includes generating, by the first computing system, a report simulation page including strips of the ECG data and a summary of patient data based on the ECG data and the metadata. The method further includes displaying the report simulation page in a user interface (UI) and displaying a report build page in the UI. The report build page includes the ECG data and the metadata. The method further includes modifying the metadata in the report build page and automatically updating the report simulation page in response to the modifying the metadata.

Abstract: In one aspect, rotary cutting tools are described herein comprising sets of coolant channels having exit aperture in the flutes of the tools for efficient coolant delivery to multiple cutting surfaces. Briefly, a rotary cutting tool comprises a shank portion, and a cutting portion extending from the shank portion along a longitudinal axis, the cutting portion comprising flutes helically extending along the longitudinal axis and internal coolant channels comprising exit apertures in the flutes. A projection of an exit aperture of a first set of internal coolant channels intersects a rake face extending below a corner edge of the rotary cutting tool, and a projection of an exit aperture of a second set of internal coolant channels intersects a rake face below a radial cutting edge of the rotary cutting tool.

Abstract: In one aspect, rotary cutting tools are described herein comprising sets of coolant channels having exit aperture in the flutes of the tools for efficient coolant delivery to multiple cutting surfaces. Briefly, a rotary cutting tool comprises a shank portion, and a cutting portion extending from the shank portion along a longitudinal axis, the cutting portion comprising flutes helically extending along the longitudinal axis and internal coolant channels comprising exit apertures in the flutes. A projection of an exit aperture of a first set of internal coolant channels intersects a rake face extending below a corner edge of the rotary cutting tool, and a projection of an exit aperture of a second set of internal coolant channels intersects a rake face below a radial cutting edge of the rotary cutting tool.

Abstract: A door assembly for a vehicle. The door assembly includes a door frame, a door panel, a rotating strut, and a linear door guide. The door opens and closes through a combination of rotating and sliding motion, which minimizes the required operational footprint. The strut is mounted on the door panel such that the strut is hidden from view when the door is in an open position.

Abstract: A door assembly for a vehicle. The door assembly includes a door frame, a door panel, a rotating strut, and a linear door guide. The door opens and closes through a combination of rotating and sliding motion, which minimizes the required operational footprint. The strut is mounted on the door panel such that the strut is hidden from view when the door is in an open position.

Abstract: A double-sided tangential cutting insert, as well as a tool holder system that carries a plurality of the double-sided tangential cutting inserts, that has a peripheral side shape, as viewed from one of said cutting rake faces, that includes a pair of generally identical opposing main cutting edges wherein each of the main cutting edge comprises a substantially straight main cutting edge portion and an adjoining convex main cutting edge portion. The convex main cutting edge portion is truncated by an adjacent convex minor side face so as to define a generally sharp edge and a point of truncation. The peripheral side shape further includes a pair of opposing full nose cutting edges with a nose cutting radius; and a pair of opposing convex minor cutting edges with a minor cutting edge radius. The minor cutting edge radius is at least about four times greater than the nose cutting radius.

Abstract: A double-sided tangential cutting insert, as well as a tool holder system that carries a plurality of the double-sided tangential cutting inserts, that has a peripheral side shape, as viewed from one of said cutting rake faces, that includes a pair of generally identical opposing main cutting edges wherein each of the main cutting edge comprises a substantially straight main cutting edge portion and an adjoining convex main cutting edge portion. The convex main cutting edge portion is truncated by an adjacent convex minor side face so as to define a generally sharp edge and a point of truncation. The peripheral side shape further includes a pair of opposing full nose cutting edges with a nose cutting radius; and a pair of opposing convex minor cutting edges with a minor cutting edge radius. The minor cutting edge radius is at least about four times greater than the nose cutting radius.

Abstract: A method and circuit for dynamically changing the frequency of clock signals. The method including: detecting an edge of a first clock signal operating at a first frequency using a second clock signal operating at a second frequency; detecting an edge of the second clock signal using the first clock signal; detecting coincident edges of the first and the second clock signals; and changing the second frequency to a third frequency different from the second frequency upon detection of the coincident edges.

Abstract: An arrangement for fastening a body to a surface, the body having a bore defined there through, includes, but is not limited to, a fitting configured for attachment to the surface. The fitting has a first flange and a second flange spaced apart from the first flange. The first flange has a first opening and the second flange has a second opening substantially axially aligned with the first opening. The arrangement further includes a retaining pin configured to extend through the first opening, the bore, and the second opening when a portion of the body is positioned between the first flange and the second flange. The arrangement further includes a cover member configured to be fastened to the first flange and to obstruct outward movement of the retaining pin from the first opening, the bore, and the second opening when the cover member is fastened to the first flange.

Abstract: A method and circuit for dynamically changing the frequency of clock signals. The method including: detecting an edge of a first clock signal operating at a first frequency using a second clock signal operating at a second frequency; detecting an edge of the second clock signal using the first clock signal; detecting coincident edges of the first and the second clock signals; and changing the second frequency to a third frequency different from the second frequency upon detection of the coincident edges.

Abstract: In one general embodiment, a design structure is provided including a first delay line having at least one buffer, the first delay line being for shifting a clock, a second delay line having at least one buffer, the second delay line being for shifting data, and a logic block adapted to identify a predetermined section of a data window. Additionally, the logic block monitors a clock signal along predetermined portions of the delay line to identify the predetermined section of the data window. Once the predetermined section of the data window is identified the logic block forwards the data associated with the predetermined section to an output pin, with the proviso that no memory element is present, and with the proviso that no feedback line is present.

Abstract: A design structure embodied in a machine-readable medium is disclosed in one embodiment of the invention as including a flexible logic block to facilitate engineering changes at selected locations within an IC. The flexible logic block has a consistent and identifiable structure such that a simple automated process may be used to reconfigure the structure to perform different logical operations. In certain embodiments, the flexible logic block includes a circuit, such as a multiplexer, having multiple inputs and at least one output. A metal interconnect structure is coupled to the inputs and enables connection of each of the inputs to one of several electrical potentials using a focused-ion-beam (FIB) tool. In this way, the circuit may be configured to perform different logical operations after components in the IC exist in hardware.

Abstract: The present invention relates to PNA derivatives which carry, at the C terminus, or at both the C and N termini of the PNA backbone, one or more phosphoryl radicals. The phosphoryl radicals carry, where appropriate, one or more labeling groups, groups for crosslinking, groups which promote intracellular uptake, or groups which increase the binding affinity of the PNA derivative for nucleic acids. The invention furthermore relates to a process for preparing the above-mentioned PNA derivatives and to their use as pharmaceuticals or diagnostic agents.

Abstract: The present invention relates to ceramic cutting tools, such as, a aluminum oxide with zirconium oxide ceramic cutting tool with diffusion bonding enhanced layer and CVD coatings, particularly useful for machining modem metal materials. The method comprises a chemical reaction with a mixture including nitrogen and aluminum chloride introduced to form a diffusion bonding enhanced layer between the ceramic substrate and the CVD coatings. Thus formed diffusion bonding is highly adherent to the aluminum oxide with zirconium oxide ceramic substrate and significantly enhances the CVD coating properties, and thus improving the machining performance in terms of the tool life of zirconium-based aluminum oxide with zirconium oxide ceramic cutting tools.

Abstract: Disclosed are compounds according to the general formula (I), where the definitions of the substituents X, R1 and R2 are detailed in the description, as well as their physiologically acceptable salts and solvate, methods for producing these compounds and their use as pharmaceuticals. These compounds are kinase inhibitors, in particular inhibitors of the kinase CDK2 (cyclin-dependent kinase 2).

Abstract: The present invention relates to acylguanidino derivatives of formula (I), in which R1, R2, R3, A, B, X, Y and n have the meanings indicated in claim 1, their physiologically tolerable salts and their prodrugs. The compounds of the formula (I) are valuable pharmaceutically active compounds. They are vitronectin receptor antagonists and inhibitors of cell adhesion and bone resorption by osteoclasts. This renders them suitable, for example, for the therapy and prophylaxis of illness which are based on the interaction between vitronectin receptors and their ligands in cell-cell or cell-matrix interaction processes or which can be prevented, alleviated or cured by influencing such interactions. For example, they can be applied for treating and preventing osteoporosis, or for inhibiting undesired angiogenesis or proliferation of cells of the vascular smooth muscles.

Abstract: A cutting insert for milling operations, such as, face milling, slot milling, plunge milling, and ramping operations. The cutting insert exhibits a combination of favorable cutting edge strength, and unique cutting edge geometry, thus, allowing milling operations at relatively high feed rates. The cutting insert includes at least four cutting edges, wherein at least one of the cutting edges is a convex cutting edge. Certain embodiments of square cutting inserts will have four convex cutting edges which may be connected by nose corners. The convex cutting edge may comprise at least one of a circular arc, a portion of an ellipse, a portion of a parabola, a multi-segment spline curve, a straight line, or combinations of these. Wherein the convex cutting edge comprises a circular arc, the circular arc may have a radius greater than or equal to two times a radius of the largest circle that may be inscribed on the top surface.