Patents by Inventor David Y. Chien

David Y. Chien has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Protease regulator screening assay
    Publication number: 20030113825
    Abstract: A polypeptide containing an anchor region, a protease recognition site, and a detectable signal region can be produced recombinantly and directly attached to a solid support. The polypeptide is useful for screening protease regulators, especially protease inhibitors.
    Type: Application
    Filed: August 20, 2002
    Publication date: June 19, 2003
    Inventors: David Y. Chien, Mark J. Selby, Kevin Shoemaker, Robert L. Warne
  • Buffers for stabilizing antigens
    Patent number: 6537745
    Abstract: The present invention is directed to an antigen diluent or buffer for antigens, in particular HCV recombinant antigens, comprising a reducing agent. The antigen diluent or buffer serves as a stabilizing buffer for the antigens. The present invention is also directed to antigen diluents or buffers for use in an automated immunoassay.
    Type: Grant
    Filed: February 2, 2001
    Date of Patent: March 25, 2003
    Assignee: Chiron Corporation
    Inventors: David Y. Chien, Phillip Arcangel, Stephen Tirell, Wanda Zeigler
  • HCV antigen/antibody combination assay
    Publication number: 20020192639
    Abstract: An HCV core antigen and NS3/4a antibody combination assay that can detect both HCV antigens and antibodies present in a sample using a single solid matrix, is provided, as well as immunoassay solid supports for use in the assay.
    Type: Application
    Filed: June 14, 2001
    Publication date: December 19, 2002
    Inventors: David Y. Chien, Phillip Arcangel, Laura Tandeske, Carlos George-Nascimento, Doris Coit, Angelica Medina-Selby
  • Immunoassays for anti-HCV antibodies using antigens with conformational epitopes
    Publication number: 20020150883
    Abstract: Immunoassay methods utilizing HCV envelope antigens that contain conformational epitopes reactive with antibodies in serum from infected individuals are useful for screening and diagnosis. These antigens detect antibodies that are not detected by denatured HCV envelope antigens. In addition, these HCV envelope antigens comprised of conformational epitopes are more immunologically reactive than a number of other HCV antigens. This is the first evidence that conformational epitopes may be involved in the immunologic response to HCV antigens.
    Type: Application
    Filed: August 2, 2001
    Publication date: October 17, 2002
    Inventor: David Y. Chien
  • Immunoassays for anti-HCV antibodies
    Publication number: 20020146685
    Abstract: HCV immunoassays comprising an NS3/4a conformational epitope and a multiple epitope fusion antigen are provided, as well as immunoassay solid supports for use with the immunoassays.
    Type: Application
    Filed: June 14, 2001
    Publication date: October 10, 2002
    Inventors: David Y. Chien, Phillip Arcangel, Laura Tandeske, Carlos George-Nascimento, Doris Coit, Angelica Medina-Selby
  • Protease regulator screening assay
    Patent number: 6436666
    Abstract: A polypeptide containing an anchor region, a protease recognition site, and a detectable signal region can be produced recombinantly and directly attached to a solid support. The polypeptide is useful for screening protease regulators, especially protease inhibitors.
    Type: Grant
    Filed: October 17, 1997
    Date of Patent: August 20, 2002
    Assignee: Chiron Corporation
    Inventors: David Y. Chien, Mark J. Selby, Kevin Shoemaker, Robert L. Warne
  • Methods of typing hepatitis C virus and reagents for use therein
    Patent number: 6416944
    Abstract: The claimed invention provides methods of detecting and typing HCV using nucleic acid molecules encoding type specific and type-cluster specific epitopes. The nucleic acid molecules flanking regions encoding type specific or type cluster specific epitopes are useful in priming the polymerase chain reaction to determine the genotype an HCV isolate.
    Type: Grant
    Filed: May 11, 1995
    Date of Patent: July 9, 2002
    Assignee: Chiron Corporation
    Inventors: David Y. Chien, George Kuo
  • Methods of typing hepatitis C virus and reagents for use therein
    Patent number: 6416946
    Abstract: The present invention provides methods and compositions for use therein for typing hepatitis C viruses.
    Type: Grant
    Filed: November 9, 1999
    Date of Patent: July 9, 2002
    Assignee: Chiron Corporation
    Inventors: David Y. Chien, George Kuo
  • Method for detecting antibodies in a sample
    Patent number: 6391540
    Abstract: The present invention is directed to assays for detecting antibodies in a sample in a single incubation step. The assays employ universal solid phases and/or universal detectable markers, and facilitate the detection and differentiation of antigens from the same source or from different sources in a single test sample. The present invention includes test kits for performing the methods according to the invention.
    Type: Grant
    Filed: September 22, 1998
    Date of Patent: May 21, 2002
    Assignee: Chiron Corporation
    Inventors: David Y. Chien, Phillip Arcangel, Stephen Tirell, Wanda Zeigler
  • NANBV diagnostics and vaccines
    Patent number: 6346375
    Abstract: We have discovered epitopes of the HCV viral proteins which are immunoreactive with immune serum. The epitopes are useful in immunodiagnostic assays and as immunogens.
    Type: Grant
    Filed: March 14, 1995
    Date of Patent: February 12, 2002
    Assignee: Chiron Corporation
    Inventor: David Y. Chien
  • Buffers for stabilizing antigens
    Publication number: 20010039009
    Abstract: The present invention is directed to an antigen diluent or buffer for antigens, in particular HCV recombinant antigens, comprising a reducing agent. The antigen diluent or buffer serves as a stabilizing buffer for the antigens. The present invention is also directed to antigen diluents or buffers for use in an automated immunoassay.
    Type: Application
    Filed: February 2, 2001
    Publication date: November 8, 2001
    Applicant: Chiron Corporation
    Inventors: David Y. Chien, Phillip Arcangel, Stephen Tirell, Wanda Zeigler
  • Buffers for stabilizing antigens
    Patent number: 6261764
    Abstract: The present invention is directed to an antigen diluent or buffer for antigens, in particular HCV recombinant antigens, comprising a reducing agent. The antigen diluent or buffer serves as a stabilizing buffer for the antigens. The present invention is also directed to antigen diluents or buffers for use in an automated immunoassay.
    Type: Grant
    Filed: September 22, 1998
    Date of Patent: July 17, 2001
    Assignee: Chiron Corporation
    Inventors: David Y. Chien, Phillip Arcangel, Stephen Tirell, Wanda Zeigler
  • NANBV diagnostics and vaccines
    Patent number: 6150087
    Abstract: We have discovered epitopes of the HCV viral proteins which are immunoreactive with immune serum. The epitopes are useful in immunodiagnostic assays and as immunogens.
    Type: Grant
    Filed: May 18, 1995
    Date of Patent: November 21, 2000
    Assignee: Chiron Corporation
    Inventor: David Y. Chien
  • Methods of typing hepatitis C virus and reagents for use therein
    Patent number: 6054264
    Abstract: The claimed invention provides methods of detecting and typing HCV using type specific and type-cluster specific epitopes. The claimed invention also provides peptides having type specific and type-cluster specific epitopes.
    Type: Grant
    Filed: November 9, 1994
    Date of Patent: April 25, 2000
    Assignee: Chiron Corporation
    Inventors: David Y. Chien, George Kuo