Abstract: The present invention provides engineered acid alpha-glucosidase (GAA) polypeptides and compositions thereof. In some embodiments, the engineered GAA polypeptides have been optimized to provide increased expression, stability at neutral pH, and activity in cell lysates. The invention also provides methods for utilization of the compositions comprising the engineered GAA polypeptides for therapeutic and other purposes.

Abstract: A generation identifier is employed with various systems and methods in order to identify situations where a workload has been reassigned to a new node and where a workload is still being processed by an old node during a failure between nodes. A master node may assign a workload to a worker node. The worker node sends a request to access target data. The request may be associated with a generation identifier and workload identifier that identifies the node and workload. At some point, a failure occurs between the master node and worker node. The master node reassigns the workload to another worker node. The new worker node accesses the target data with a different generation identifier, indicating to the storage system that the workload has been reassigned. The old worker node receives an indication from the storage system that the workload has been reassigned and stops processing the workload.

Abstract: The present disclosure relates to a carrier for sustained-release of a drug and use thereof. The carrier is used to carry a drug. The carrier is in a gel state, a semi-solid state, or a solid state. The carrier includes a polyol fatty acid ester as a main component and a hydrogenated vegetable oil dissolved in the polyol fatty acid ester. The state of the sustained-release carrier can be adjusted by adjusting the amount of the dissolved hydrogenated vegetable oil.

Abstract: The present disclosure provides compositions and methods useful for inducing an immune response and overcoming immune tolerance in a subject suffering from Hepatitis B. As described herein, the compositions of the disclosure comprise HBsAg having S, Pre-S1 and Pre-S2 proteins, an aluminum phosphate adjuvant and interferon-?.

Abstract: Compounds and pharmaceutical compositions that modulate kinase activity, including mutant EGFR and mutant HER2 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including mutant EGFR and mutant HER2 activity, are described herein.

Abstract: A control device for controlling a temperature of a laser device includes a pulse width modulation (PWM) signal generator, a temperature acquisition circuit, a voltage comparator, and a logic circuit. The a pulse width modulation (PWM) signal generator configured to generate a PWM signal; a temperature acquisition circuit configured to acquire a temperature of the laser device and convert the temperature into a measurement voltage; a voltage comparator configured to compare the acquired measurement voltage associated with the temperature of the laser device with a temperature threshold voltage and output a comparison result signal; and a logic circuit configured to generate a drive signal based on the PWM signal and the comparison result signal to drive the laser device.

Abstract: The disclosure is directed to compounds of formula (I), and pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprising compounds of formula (I), as well as methods of their use and preparation, are also described.

Abstract: Remote automated assistant component(s) generate client device notification(s) based on a received IoT state change notification that indicates a change in at least one state associated with at least one IoT device. The generated client device notification(s) can each indicate the change in state associated with the at least one IoT device, and can optionally indicate the at least one IoT device. Further, the remote automated assistant component(s) can identify candidate assistant client devices that are associated with the at least one IoT device, and determine whether each of the one or more of the candidate assistant client device(s) should render a corresponding client device notification.

Abstract: A composition, a gas diffusion electrode, and a method for fabricating the same is disclosed. In an example, the composition includes carbon supported carboxyl surface functionalized silver nanoparticles. The gas diffusion electrode can be fabricated with the carbon supported carboxyl surface functionalized silver nanoparticles and deployed in a membrane electrode assembly for various applications.

Abstract: A Method and System for coordinating help to an individual experiencing a medical emergency from their designated Emergency Care Team (ECT). The location of the Person in Distress (PID) and all of their emergency contacts is determined. A real time audio video conference is created which enables the PID and all members of the ECT to communicate. Real time vital signs from the PID's wearable health monitor is streamed to all participants. The PID's medical history is temporarily unlocked and provided on demand to the ECT members. The ECT members participate as available with no single person or call center coordinating this effort. Additional participants may be added to the conference at the discretion of the ECT members including, but not limited to the E911 operator for the PID's locale, the PID's medical providers, other individuals from the PID's contact list, or other individuals as may be deemed important to the response.

Abstract: The application provides anti-4-1BB monoclonal antibodies, antigen binding portions thereof, therapeutic compositions thereof and/or nucleic acid encoding the same, and their use to upregulate the function of T-cells to enhance cell-mediated immune responses in the treatment of cancer and other T-cell dysfunctional disorders.

Abstract: The present invention relates to inkjet ink compositions that take advantage of solvent mixtures containing an ester, a ketone, and optionally an alcohol, in order to provide ink compositions that have suitable qualities for inkjet printing. Preferred ink compositions include a C1-C3 alkyl ester of C1-C3 carboxylic acid, a C3-C7 ketone, and optionally a C2-C3 alkyl alcohol.

Abstract: A method and apparatus is provided for controlling the operation of an autonomous vehicle. According to one aspect, the autonomous vehicle may track the trajectories of other vehicles on a road. Based on the other vehicle's trajectories, the autonomous vehicle may generate a pool of combined trajectories. Subsequently, the autonomous vehicle may select one of the combined trajectories as a representative trajectory. The representative trajectory may be used to change at least one of the speed or direction of the autonomous vehicle.

Abstract: An autonomous vehicle that is equipped with image capture devices can use information gathered from the image capture devices to plan a future three-dimensional (3D) trajectory through a physical environment. To this end, a technique is described for image-space based motion planning. In an embodiment, a planned 3D trajectory is projected into an image-space of an image captured by the autonomous vehicle. The planned 3D trajectory is then optimized according to a cost function derived from information (e.g., depth estimates) in the captured image. The cost function associates higher cost values with identified regions of the captured image that are associated with areas of the physical environment into which travel is risky or otherwise undesirable. The autonomous vehicle is thereby encouraged to avoid these areas while satisfying other motion planning objectives.

Abstract: The application provides anti-4-1BB monoclonal antibodies, antigen binding portions thereof, therapeutic compositions thereof and/or nucleic acid encoding the same, and their use to upregulate the function of T-cells to enhance cell-mediated immune responses in the treatment of cancer and other T-cell dysfunctional disorders.

Abstract: Systems and methods deliver advertisements to electronic billboards, additionally deliver social media content relevant to the advertisements, control content of the electronic billboards, including through social media interactions, and deliver interactive applications to the electronic billboards and control the interactive applications. An advertisement is delivered to an electronic billboard for display, and social media content relevant to the advertisement is also delivered to the electronic billboard for display in real time. The social media content is used to update the display of the electronic billboard in temporal proximity to a time of posting of social media content. Content and applications are received at the electronic billboard by push, and may be removed from storage of electronic billboard after display to make storage room available for additional interactive applications and to ensure that updated content is always displayed.

Abstract: Methods for treating cancer with a stabilized BCL9 peptide are encompassed, wherein the stabilized peptide comprises a portion of the HD2 domain of the BCL9 protein containing a hydrocarbon crosslinker generated using ?,?-disubstituted amino acids.

Abstract: Disclosed here are polypeptides derived from the HD2 domain of human B-cell CLL/lymphoma 9 (BCL9) protein and variants thereof, as well as their use in the diagnosis, prevention, and/or treatment of a disease or disorder. Also disclosed are methods of generating such polypeptides and variants thereof.

Abstract: Methods for treating cancer with a stabilized BCL9 peptide are encompassed, wherein the stabilized peptide comprises a portion of the HD2 domain of the BCL9 protein containing a hydrocarbon crosslinker generated using ?, ?-disubstituted amino acids.

Abstract: Methods and systems establishing a telehealth session between a patient and a healthcare provider (HP) are disclosed herein. One of the systems includes: a HP-side application residing a HP-side device; a patient-side application residing on a patient's device; and a telehealth application residing on a server. During a telehealth session, the HP-side application is configured to: generate one or more graphical user interfaces (GUIs) that display patient-related data on the display of the HP-side device; enable the healthcare provider to edit, using the one or more GUIs, one or more portions of the patient-related data; and send the one or more edited portions of the patient-related data to the telehealth application on the server for storage.