Abstract: The present disclosure generally relates to compounds of Formula (1) and pharmaceutical compositions that may be used in methods of treating cancer.

Abstract: A redundant power supply has a first power supply, which is disconnectedly connected to a busbar by means of a first tie switch and is connectable to a first load without a tie switch, and having a second power supply, which is disconnectedly connected to the busbar by means of a second tie switch and is connectable to the first load without a tie switch, and having a third power supply, which is disconnectedly connected to the busbar by means of a third tie switch and is connectable to a second load without a tie switch, and having a fourth power supply, which is disconnectedly connected to the busbar by means of a fourth tie switch and is connectable to the second load without a tie switch. All of the tie switches are closed during trouble-free operation.

Abstract: The invention relates to an acrylic copolymer composition, wherein said copolymer comprises one or more (meth)acrylic monomer units and hydrophilic 2-carboxyethyl acrylate (CEA) and/or (meth)acrylic acid (MAA or AA) hydrophilic monomer units. The copolymer may be an amphiphilic terpolymer further including hydrophobic monomer units, such as tert-butyl cyclohexyl (meth)acrylate, isobornyl methyl acrylate (IBOMA) and isobornyl acrylate (IBOA). The copolymers are designed to meet the requirements of high heat resistance, improved bonding adhesion, and exhibit excellent mechanical properties, along with excellent chemical resistance. The copolymers of the invention possess a high Tg along with sufficiently high molecular weight for applications in battery cathode binders, coatings, composites, glass-/carbon-fiber re-enforced composites, water filtration membranes, optical lenses, extruded films, laminates, and (co-)extruded sheets/profiles.

Abstract: Disclosed here are polypeptides derived from the HD2 domain of human B-cell CLL/lymphoma 9 (BCL9) protein and variants thereof, as well as their use in the diagnosis, prevention, and/or treatment of a disease or disorder. Also disclosed are methods of generating such polypeptides and variants thereof.

Abstract: Systems and methods deliver advertisements to electronic billboards, additionally deliver social media content relevant to the advertisements, control content of the electronic billboards, including through social media interactions, and deliver interactive applications to the electronic billboards and control the interactive applications. An advertisement is delivered to an electronic billboard for display, and social media content relevant to the advertisement is also delivered to the electronic billboard for display in real time. The social media content is used to update the display of the electronic billboard in temporal proximity to a time of posting of social media content. Content and applications are received at the electronic billboard by push, and may be removed from storage of electronic billboard after display to make storage room available for additional interactive applications and to ensure that updated content is always displayed.

Abstract: Methods for treating cancer with a stabilized BCL9 peptide are encompassed, wherein the stabilized peptide comprises a portion of the HD2 domain of the BCL9 protein containing a hydrocarbon crosslinker generated using ?,?-disubstituted amino acids.

Abstract: Disclosed here are polypeptides derived from the HD2 domain of human B-cell CLL/lymphoma 9 (BCL9) protein and variants thereof, as well as their use in the diagnosis, prevention, and/or treatment of a disease or disorder. Also disclosed are methods of generating such polypeptides and variants thereof.

Abstract: Methods for treating cancer with a stabilized BCL9 peptide are encompassed, wherein the stabilized peptide comprises a portion of the HD2 domain of the BCL9 protein containing a hydrocarbon crosslinker generated using ?, ?-disubstituted amino acids.

Abstract: Methods and systems establishing a telehealth session between a patient and a healthcare provider (HP) are disclosed herein. One of the systems includes: a HP-side application residing a HP-side device; a patient-side application residing on a patient's device; and a telehealth application residing on a server. During a telehealth session, the HP-side application is configured to: generate one or more graphical user interfaces (GUIs) that display patient-related data on the display of the HP-side device; enable the healthcare provider to edit, using the one or more GUIs, one or more portions of the patient-related data; and send the one or more edited portions of the patient-related data to the telehealth application on the server for storage.

Abstract: A Method and System for coordinating help to an individual experiencing a medical emergency from their designated Emergency Care Team (ECT). The location of the Person in Distress (PID) and all of their emergency contacts is determined. A real time audio video conference is created which enables the PID and all members of the ECT to communicate. Real time vital signs from the PID's wearable health monitor is streamed to all participants. The PID's medical history is temporarily unlocked and provided on demand to the ECT members. The ECT members participate as available with no single person or call center coordinating this effort. Additional participants may be added to the conference at the discretion of the ECT members including, but not limited to the E911 operator for the PID's locale, the PID's medical providers, other individuals from the PID's contact list, or other individuals as may be deemed important to the response.

Abstract: Methods for treating cancer with a stabilized BCL9 peptide are encompassed, wherein the stabilized peptide comprises a portion of the HD2 domain of the BCL9 protein containing a hydrocarbon crosslinker generated using ?, ?-disubstituted amino acids.

Abstract: Methods for treating cancer with a stabilized BCL9 peptide are encompassed, wherein the stabilized peptide comprises a portion of the HD2 domain of the BCL9 protein containing a hydrocarbon crosslinker generated using ?, ?-disubstituted amino acids.

Abstract: Disclosed here are polypeptides derived from the HD2 domain of human B-cell CLL/lymphoma 9 (BCL9) protein and variants thereof, as well as their use in the diagnosis, prevention, and/or treatment of a disease or disorder. Also disclosed are methods of generating such polypeptides and variants thereof.

Abstract: Methods for treating cancer with a stabilized BCL9 peptide are encompassed, wherein the stabilized peptide comprises a portion of the HD2 domain of the BCL9 protein containing a hydrocarbon crosslinker generated using ?, ?-disubstituted amino acids.

Abstract: Electronic logic gates that operate using N logic state levels, where N is greater than 2, and methods of operating such gates. The electronic logic gates operate according to truth tables. At least two input signals each having a logic state that can range over more than two logic states are provided to the logic gates. The logic gates each provide an output signal that can have one of N logic states. Examples of gates described include NAND/NAND gates having two inputs A and B and NAND/NAND gates having three inputs A, B, and C, where A, B and C can take any of four logic states. Systems using such gates are described, and their operation illustrated. Optical logic gates that operate using N logic state levels are also described.

Abstract: Systems and methods deliver advertisements to electronic billboards, additionally deliver social media content relevant to the advertisements, control content of the electronic billboards, including through social media interactions, and deliver interactive applications to the electronic billboards and control the interactive applications. An advertisement is delivered to an electronic billboard for display, and social media content relevant to the advertisement is also delivered to the electronic billboard for display in real time. The social media content is used to update the display of the electronic billboard in temporal proximity to a time of posting of social media content. Content and applications are received at the electronic billboard by push, and may be removed from storage of electronic billboard after display to make storage room available for additional interactive applications and to ensure that updated content is always displayed.

Abstract: Vibration of an electric submersible pump assembly is monitored to produce a vibration spectrum. The vibration spectrum is compared to a known vibration signature for a pump condition that precedes gas lock. The pump condition is at least one of an impeller rotating stall condition, a diffuser stall condition, a pre-surge condition, and percentage of free gas within the wellbore fluid. Operation of the pump is then adjusted in response to the similarity of the vibration spectrum to the vibration signature for the pump condition to prevent impending gas lock.

Abstract: Electronic logic gates that operate using N logic state levels, where N is greater than 2, and methods of operating such gates. The electronic logic gates operate according to truth tables. At least two input signals each having a logic state that can range over more than two logic states are provided to the logic gates. The logic gates each provide an output signal that can have one of N logic states. Examples of gates described include NAND/NAND gates having two inputs A and B and NAND/NAND gates having three inputs A, B, and C, where A, B and C can take any of four logic states. Systems using such gates are described, and their operation illustrated. Optical logic gates that operate using N logic state levels are also described.

Abstract: The present inventions relate to compositions and methods for imaging and treating atherosclerotic diseases, pathogen infections, and tumors by administering actively targeting magnetic nanoparticles. In particular, the present inventions provide new types of targeting ligands attached to magnetic nanoparticles for magnetic resonance imaging. The use of these targeted magnetic nanoparticles is contemplated as a means to treat atherosclerotic diseases, including but not limited to inhibiting and removing atherosclerotic plaques. Further, actively targeting magnetic nanoparticles are contemplated for use with multiple labels for use in nuclear medicine imaging, computed tomography (CT) techniques and other types of imaging for medical and research applications.

Abstract: The tray or tray assembly of this invention allows hobbyists and professionals working on a step ladder to have easy and stable access to their tools and equipment. The tray is attached directly or by way of a support backing to struts on the ladder such that it projects outwards from the front or back to which it is attached. The tray or tray assembly can be built with a bracket that opposed diverging channels that engage diverging struts on the ladder so as to support the tray and its contents. As a result, the tray is vertically positioned within the footprint of the ladder, providing a convenient, stable, and safe arrangement by which the user may attend to the task at hand.