Abstract: A meibomian gland manual device allows for a cost-effective device for use in the home by individuals who suffer from dry eye or for daily eye hygiene. The device allows for a safe self-administration to gently express the meibomian gland, the leading underlying cause of chronic dry eye. The semi-circular projection combined with the action of gently applying pressure to the eyelid while following the natural direction of the eyelid, increases the effectiveness of expressing the meibomian gland. The material of the device allows for ease of cleaning for repeated use. Combining the device with either a warm shower or applying a warm compress to the eyes increases the effectiveness of the device to induce a manual extraction of the gland contents.

Abstract: A damper includes a housing with at least one axially offset longitudinally extending guide channel for receiving a plunger of a piston assembly. The plunger is axially offset from a control rod extending through the housing and the piston assembly. A coil spring surrounds the housing and extends between a hemispherical cap of the housing and the piston. The plunger includes a friction pad which engages the guide channel of the housing to provide frictional inter-engagement for the damper. In one embodiment, the housing includes a pair of axially offset guide channels and the piston assembly includes a pair of axially offset plungers which extend within a pair of guides of the housing. One of the plungers includes a linear sensor which provides signal information for use by a washer control circuit.

Abstract: In one embodiment, a polymerase chain reaction (PCR) system includes a mixture chamber, a denature chamber, an annealing chamber, an extension chamber, and a product chamber, that are fluidically coupled to one another through a plurality of microfluidic channels. An inertial pump is associated with each microfluidic channel, and each inertial pump includes a fluid actuator integrated asymmetrically within its associated microfluidic channel. The fluid actuators are capable of selective activation to circulate fluid between the chambers in a controlled cycle.

Abstract: Methods and systems for autonomous generation of shortest lateral paths for unmanned aerial systems are described. An example system includes memory storing code and at least one processor to execute the code to cause the at least one processor to access an initial scenario including a source point, a target point, and a no flight zone, determine a computation time for identifying a lateral path for an aircraft to traverse that avoids the no flight zone, determine whether the determined computation time satisfies a threshold of a reference computation time, change the first number of vertices to a second number of vertices when the reference computation time is not satisfied, determine a buffer area surrounding the no flight zone, construct a visibility graph including lateral paths, and identify one of the lateral paths as being shorter than others of the lateral paths.

Abstract: An insulated composite fabric has an inner fabric layer, an outer fabric layer, and an insulating-filler layer enclosed there between. The insulating-filler layer is a textile fabric with at least one raised surface. One side of the insulating-filler layer comprises a first surface with relatively high pile, including regions of no pile or relatively low pile interspersed among regions of relatively high pile. The other side of the insulating-filler layer comprises a second surface with relatively high pile, including regions of no pile or relatively low pile interspersed among regions of relatively high pile. Interconnecting piles are formed with regions of the relatively high pile of the first pile surface and regions of the relatively high pile of the second pile surface.

Abstract: Processes and systems applying day cycle temperature changes in conjunction with cool storage are provided. A thermal energy storage material is placed in heat transfer communication with lower temperature nighttime air resulting in a cooled thermal energy storage material. The cooled thermal energy storage material is subsequently utilized to cool an item such as a supply of higher temperature air, such as daytime air, or a cooling medium.

Abstract: A diagnostic reagent or device comprises at least one ligand capable of specifically complexing with, binding to, or quantitatively detecting or identifying the biomarker chloride intracellular channel protein 4 (CLIC4) or an isoform, pro-form, modified molecular form including posttranslational modification, or unique peptide fragment or nucleic acid fragment thereof. An alternative diagnostic reagent or device comprises ligand or ligands capable of specifically complexing with, binding to, or quantitatively detecting or identifying multiple tropomyosin biomarkers. Optionally, such reagent or device includes a signaling molecule and/or a substrate on which the ligand is immobilized. Other reagents and methods of diagnosing ovarian cancer include use of CLIC4 ligands and/or multiple tropomyosin ligands with an additional ovarian cancer biomarker. For example, CLIC4 combined with one or more of CLIC1 and/or one or multiple members of the tropomyosin family, e.g.

Abstract: The present disclosure is directed to compositions comprising blended materials comprising a substantially crystalline HCV nucleotide polymerase inhibitor; a solid dispersion formulation, which comprises an HCV NS5a inhibitor or a pharmaceutically acceptable salt thereof, one or more pharmaceutically acceptable polymers or a mixture thereof, and optionally one or more pharmaceutically acceptable surfactants or a mixture thereof; and optionally one or more pharmaceutically acceptable surfactants or a mixture thereof; and optionally one or more excipients.

Abstract: An electrical connector includes a housing and both signal conductors and ground conductors held by the housing. The ground conductors are arranged in an array with the signal conductors and provide electrical shielding between the signal conductors. The ground conductors have an electrically conductive metal body extending a length between a terminating end and a mating distal end. The ground conductors are configured to engage corresponding mating ground conductors of a mating connector at a contact location of the respective ground conductor. The ground conductors further include a damping segment disposed between the contact location and the mating distal end. The damping segment is characterized by a lossy coating at least partially covering the metal body to dissipate electrical energy.

Abstract: A vehicle is disclosed having a motor and engine selectively coupled to the motor via a clutch. The vehicle includes a controller configured to, in response to a vehicle wheel torque reversal, open the clutch to disconnect the engine from the motor, command the engine to enter a speed control mode, and control a motor output torque through a region surrounding the vehicle wheel torque reversal to reduce torque disturbances in a vehicle driveline.

Abstract: An internet of things (IoT) edge appliance is configured to perform a method that includes receiving a configuration signal to configure the IoT edge appliance to communicate with at least one of a first device on the cloud network or a second device on the industrial process control and automation system network. The method also includes configuring a communication link with a cloud network and an industrial process control and automation system network. The method further includes communicating data with the at least one of the first device on the cloud network or the second device on the industrial process control and automation system network.

Abstract: A method for usage based rental (UBR) of an industrial or engineering application includes providing an application with instructions executable on a computer system comprising a processor; providing multiple usage based rental (UBR) options for the application, each usage based rental (UBR) option comprising an intermitted usage to fixed and continuous time duration ratio R between 0 (zero) and 1 (one); and selecting a usage based rental (UBR) option from the multiple usage based rental (UBR) options, wherein the application is operable according to the selected ratio R governing the usage based rental (UBR) option. Further, a usage based rental (UBR) management system is disclosed.

Abstract: The present invention is directed to golf balls consisting of a multi-layer core and a cover. The multi-layer core includes at least one layer formed from a relatively soft or low modulus HNP composition and at least one layer formed from a relatively hard or high modulus HNP composition.

Abstract: An elastic band for use in a resistance-type exerciser. The elastic band includes a continuous loop of elastic material having a pair of receiving portions and a pair of spanning portions extending between the pair of receiving portions. A cross-sectional area of each receiving portion is greater than a cross-sectional area of each spanning portion.

Abstract: A liquid formulation for addition to a polymeric material comprises a vehicle, an additive (e.g. a colourant) and carbonyl bis (1-caprolactan)). The liquid formulation may be used to colour melt spun fibre (e.g. PET or polyamide).

Abstract: A rotary electric machine stator (2) includes a stator body (20) and a stator winding (22) supported by the stator body (20), in which the stator body extends around an axis (X) while being delimited by an internal radial surface (3) and an external radial surface (4), said stator bodies having a plurality of teeth (6) formed respectively between two slots (5) arranged in said stator body from the internal radial surface and extending axially to receive at least one stator winding element (22). The stator has at least one deformed tooth (6) which comprises, at its loose end (7) helping to define the internal radial surface, at least one protrusion (10) extending across an adjacent slot, said protrusion (10) being obtained by material deformation of said deformed tooth (6).

Abstract: A tool apparatus and a method for actuating a tool apparatus are disclosed. The tool apparatus includes an actuator housing, and an elongate tool manipulator extending outwardly from the actuator housing and having a plurality of control links extending along a length of the tool manipulator. The control links are operable to cause movement of a distal end of the tool manipulator in response to movement of the control links in an actuating direction generally aligned with the length of the tool manipulator. The apparatus also includes a plurality of actuators, each actuator being associated with at least one of the control links and being mounted in the actuator housing to facilitate a range of travel in a transverse direction substantially orthogonal to the actuating direction, and a plurality of linkages. Each linkage is associated with one of the control links and extends between the control link and the respective actuator and is operable to transmit drive forces between the actuator and the control link.

Abstract: 7-Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of a 7-azaindazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.

Abstract: Topical formulations comprising soft glycopyrrolates are useful for treating excessive sweating conditions in subjects, such as humans suffering from hyperhidrosis. Preferably, at least one soft anticholinergic agent is provided in an effective amount or concentration in an anhydrous formulation that can inhibit excessive perspiration resulting from a condition such as hyperhidrosis.

Abstract: A motion simulation system includes actuators having a planetary gearbox engaged with and driven by a servomotor engaged with a crank. A connector rod is engaged with the crank of each actuator, and engaged with a platform configured to attach to a vehicle. A control system is operable with each electric servo motor of each actuator for delivering control for providing a simulated motion to the top plate. Control data is sent to the servomotors using a msec data send and receive rate, with internal processing within the nano-second range. Such update rates coupled with a real time, dynamically responsive motion controller results in a desirably smooth and accurate simulator motion. The control system includes a washout filter for transforming input forces and rotational movements. One to six degrees of freedom systems having smooth performance with high payload capability are provided.