Abstract: The present invention relates to compounds of formula (I) The compounds act via antagonism of the CCR2b receptor and may be used to treat inflammatory disease and/or neuropathic pain.

Abstract: During polishing of a substrate at a first platen and prior to a first time, a first sequence of values is obtained for a first zone of the first substrate and a second sequence of values is obtained for a different second zone of the substrate with an in-situ monitoring system. A first function is fit to a portion of the first sequence of values obtained prior to the first time, and a second function is fit to a portion of the second sequence of values obtained prior to the second time. At least one polishing parameter is adjusted based on the first fitted function and the second fitted function so as to reduce an expected difference between the zones. A second substrate is polished on the first platen using an adjusted polishing parameter calculated based on the first fitted function and the second fitted function.

Abstract: A system includes a turbine. The turbine includes a rotor, a stator, and a cooling insert. The rotor includes multiple turbine blades. The stator surrounds the rotor and includes an inner wall surrounding the multiple turbine blades, an outer wall surrounding the inner wall, and a cooling chamber between the inner wall and the outer wall. The cooling insert extends through an opening in the outer wall into the cooling chamber. The insert includes a side wall extending around an axis, an end wall crosswise to the axis, a set of lateral ports extending through the side wall, and end ports extending through the end wall. The cooling insert is configured to direct a cooling fluid through the set of lateral ports and end ports into the cooling chamber.

Abstract: A drug delivery device (1) comprises a housing (2) and a cap (3) attachable onto the housing (2). The cap (3) comprises one or more snap features (33) to attach the cap (3) onto the housing (2) and one or more orientation features (34) to define the orientation of the cap (3) relative to the housing (2). At least one of the orientation features (34) is located at a rigid part of the cap (3) and at least one of the snap features (34) is located at a less rigid part of the cap (3).

Abstract: A transducer has a magnetic field concentrating member a first coil to couple with a first portion of the magnetic field concentrating member positioned adjacent the first coil and a second coil to couple with a second portion of the magnetic field concentrating member positioned adjacent the second coil, the second portion being spaced along the magnetic field concentrating member from the first portion. The transducer comprises a resonator having a coil wound around a portion of said magnetic field concentrating member which is located between said first and second portions. The transducer is arranged so that the electromagnetic coupling between the resonator and at least one of the first and second coils varies as a function of the relative position between the elongate field concentrating member and that coil. In this way, separate processing electronics can process the signals obtained from the transducer to determine the desired position information.

Abstract: The specification generally discloses systems and methods for mixing and delivering fluids in microfluidic systems. The fluids can contain, in some embodiments reagents that can participate in one or more chemical or biological reactions. Some embodiments relate to systems and methods employing one or more vent valves to controllably flow and/or mix portions of fluid within the microfluidic system. Advantageously, fluid control such as a sequence of fluid flow and/or a change in flow rate, can be achieved by opening and closing one or more vent valves and by applying a single source of fluid flow (e.g., a vacuum) operated at a substantially constant pressure. This can simplify the operation and use of the device by an intended user.

Abstract: An LED-based light can be installed in a conventional light fixture. The LED-based light can include a sensor operable to output a first signal indicative of whether an area of one or more of the rooms is in an occupied state or a non-occupied state, and the LED-based light can also include an LED controller operable to control at least one LED in the light in response to the first signal. Additionally, the LED-based light can include a transmitter operable to output a second signal indicative of whether the area is in the occupied state or the non-occupied state to a building environment regulator.

Abstract: A system and processes for aligning an antenna boresight from a position which is internal to a structure on which the antenna is mounted is described. The system includes a laser tracking system and a plurality of targets disposed on a surface of the antenna.

Abstract: A system and method for enabling spectators to participate in a sporting event in a way that may materially affect the course, and outcome, of the event. The players, or teams, participating in the sporting event agree to have certain decisions made by spectators who are supporters of the player or team. The decisions may range from the choice of the starting line up to actually calling plays during the game. The game influencing decisions are made by pre-registered spectators who vote by making a selection from a menu of possible choices related to a player's participation in the live sporting event. The spectators may be remote to the game and watching it on a television and voting using their remote control to make menu selections. Or the spectators may be in the stands watching the game, getting and responding to menus via their cell phones.

Abstract: Embodiments of the components and processes for recording selected Web site data described herein adhere to long-term stability guidelines so as to improve maintainability and viability over time. Additionally, the data recording components can be placed within a software architecture to minimize the number of redundant data recording components. Furthermore, the data recording components can be tailored to specific data recording purposes. Additionally, the data recording components can be designed to take into account system performance issues and minimally impact system performance. Furthermore, the data recording components can be tailored to gather specific data useful for various analytical processes. Additionally, embodiments of the data recording components are relatively easy to implement and able to handle idiosyncrasies and changes of various Web sites in which they are placed.

Abstract: An inflatable mattress-sling having an inflatable torso support pad, a first leg extending out from a first portion of the inflatable torso support pad, and a second leg spaced from the first leg and extending out from a second portion of the inflatable torso support pad. The legs include straps attached to their inner and outer seams so as to facilitate lifting of a patient.

Abstract: A vehicle body structure includes a roof ditch and an elongated molding member. The roof ditch is defined by a recessed support surface and first and second wall surfaces extending longitudinally along opposite sides of the recessed support surface. The molding member includes a plurality of roof attachment portions securing the molding member longitudinally along the roof ditch. The molding member includes a top portion, a first lateral side extending downward from the top portion along the first wall surface of the roof ditch and a second lateral side extending downward from the top portion along the second wall surface of the roof ditch. The first and second lateral sides include a plurality of longitudinally spaced apart stabilizing projections extending downward from bottom edges of the first and second lateral sides into contact with the recessed support surface of the roof ditch.

Abstract: An example gear arrangement includes a gearbox shaft and a journal shaft. The journal shaft establishes an opening that receives an end portion of the gearbox shaft. The gearbox shaft is configured to rotate the journal shaft. The journal shaft is configured to selectively rotatably couple with another shaft. The journal shaft is allowed to align to the bearing surface while the gearbox shaft allows for misalignment between the accessory and gearbox drive.

Abstract: This invention relates to novel compounds of the Formula I, Ik, Iq1-21, Ir1-21, Is1-21, It1-7, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11 ?-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of cortisol in a cell or the inhibition of the conversion of cortisone to cortisol in a cell.

Abstract: A fan blade anti-fretting insert is described whereby to reduce wear between the root portion of a fan blade and the root slot of the rotor fan hub of a turbo fan engine to which the fan blade are secured. The anti-fretting insert can be formed of a composite spring material having a memory and is dimensioned and shaped to be fitted between the fan blade platform and the outer surface portion of the rotor fan hub between adjacent fan blades, whereby to apply a pushing force against the platform and consequently to the fan blades secure thereto thereby applying a resulting pulling force on the root portion of the fan blades to prevent rocking of the root portion in their root slots formed in the rotor fan hub.

Abstract: A mobile ad-hoc network includes a plurality of N mobile nodes and wireless communication links connecting the mobile nodes, which each include a communications device for transmitting and routing data packets wirelessly to other mobile nodes via the wireless communication links in accordance with a time division multiple access (TDMA) data transmission protocol using a TDMA epoch that is divided into a beacon interval, digital voice interval and digital data interval. The mobile nodes monitor channel conditions using the beacon, digital voice and digital data intervals and provide a network conductivity performance as valid receptions occur within mobile nodes. A data rate is calculated and set for other N?1 mobile nodes using monitored channel conditions for the beacon, digital voice and digital data intervals.

Abstract: Methods and systems for controlling an imaging procedure are provided. A medical device is introduced within a patient, and a position (e.g., location and/or orientation) of the medical device is detected within the patient relative to a reference position (e.g., a previously detected position of the medical device or a position within a desired path). Imaging of the patient is automatically activated based on the detected relative position, such that the patient is imaged only during relevant times. In one method, instability/stability of the medical device is detected, in which case, the imaging is automatically activated when the medical device is unstable, and deactivated when the medical device is stable. For example, if tissue is to be ablated with the medical device, medical personnel can be made aware of inadvertent movement of the medical device via the image, and can correct any displacement of the medical device from the ablation site.

Abstract: Disclosed is a system for, and method of, calculating parameters used to determine whether records and entity representations should be linked. Such parameters may be set as negative to account for fields that do not match. The system and method apply iterative techniques such that parameters from each linking iteration are used in the next linking iteration. The system and method need no human interaction in order to calibrate and utilize record matching formulas used for the linking decisions.