Abstract: Described herein are devices and methods related to compositionally graded buffers (CGB) and methods and/or systems for producing CGBs. CGBs enable the growth of high quality materials that are lattice mismatched to a substrate. More specifically, the present disclosure relates to methods for making CGBs by hydride vapor phase epitaxy (HVPE). HVPE methods using a single chamber for producing a CGB may result in a transience in the CGB layers as the flows supplying the reactants are switched to produce the next subsequent layer in the CGB. In contrast to this static style of grading, the present disclosure describes a dynamic method for producing CGBs, in which multiple growth chambers are utilized.

Abstract: Devices, methods for analog-to-digital converters (ADCs) that perform high-dynamic range measurements based on optical techniques are disclosed. In one example aspect, an optical encoder includes a polarization rotator configured to receive a train of optical pulses, and an electro-optic (EO) modulator coupled to an output of the polarization rotator. The EO modulator is configured to receive a radio frequency (RF) signal and to produce a phase modulated signal in accordance with the RF signal. The optical encoder also includes a polarizing beam splitter coupled to the output of the EO modulator; and an optical hybrid configured to receive two optical signals from the polarizing beam splitter and to produce four optical outputs that are each phase shifted with respect to one another.

Abstract: The present invention relates to adjustable flow control valves, for example to an Adjustable Pressure Limiting (APL) valve. The adjustable valve (2) described comprises a valve body (4) comprising a valve seat (6), a valve member (10) movable relative to the valve seat (6), a first valve cap (20), a second valve cap (50) and a biasing element (30) to bias the valve member (10) away from the first valve cap (20). The first valve cap (20) is movable to increase the biasing force applied by the biasing element (30). The second valve cap (50) is engageable with the first valve cap (20) to prevent such movement of the first valve cap (20) beyond a selected position, but to allow movement of the first valve cap (20) in an opposite direction, way from said position.

Abstract: Face masks, including filter masks, and methods for their production. The disclosed masks include a face mask comprising a mask body that defines a cavity for accommodating the nose and mouth of a wearer and a sealing member depending from the mask body for engagement with the wearer's face, the mask body comprising a filter (91) and a gas inlet (142), the filter being located in a first region of the mask body and the gas inlet being located in a second region of the mask body; and a nasal portion for accommodating the nose of the wearer, a mouth portion for accommodating the mouth of the wearer, and cheek portions (134, 135) extending laterally across the wearer's cheeks.

Abstract: Face masks, including filter masks, having improved stability, including face masks having a sealing member (25) depending from the mask body for engagement with the wearer's face, the mask body comprising a nasal portion (27) for accommodating the nose of the wearer, a mouth portion (26) for accommodating the mouth of the wearer, and cheek portions (28) extending laterally across the wearer's cheeks.

Abstract: Face masks, including filter masks, and methods for their production. The disclosed methods include using an overmoulding step to both form a sealing member and to fix the sealing member to a support frame and a sheet of filtering material.

Abstract: The disclosed methods of manufacturing filter masks include using an overmoulding step to both form a sealing member and to fix the sealing member to a support frame and a sheet of filtering material.

Abstract: Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. In certain embodiments, the inventive systems and methods can be used to perform solid phase peptide synthesis quickly while maintaining high yields. Certain embodiments relate to processes and systems that may be used to heat, transport, and/or mix reagents in ways that reduce the amount of time required to perform solid phase peptide synthesis.

Abstract: The present invention relates to methods and compositions for the treatment of BAF-related disorders such as cancers and viral infections.

Abstract: Methods and systems for control of solid phase peptide synthesis are generally described. Control of solid phase peptide synthesis involves the use of feedback from one or more reactions and/or processes (e.g., reagent removal) taking place in the solid phase peptide synthesis system. In some embodiments, a detector may detect one or more fluids flowing across a detection zone of a solid phase peptide synthesis system and one or more signals may be generated corresponding to the fluid(s). For instance, an electromagnetic radiation detector positioned downstream of a reactor may detect a fluid exiting the reactor after a deprotection reactor and produce a signal(s). In some embodiments, based at least in part on information derived from the signal(s), a parameter of the system may be modulated prior to and/or during one or more subsequent reactions and/or processes taking place in the solid phase peptide synthesis system.

Abstract: Disclosed is a respiratory interface device (1) and components thereof. The respiratory interface device (1) comprises a body (2), a frame (3), and an inlet conduit (4). The frame has a front wall (10a), side walls (10b), and side arms (12), and a support platform (11) extending rearwardly from the front wall (10a). An inlet opening (13) is defined in the support platform (11). The body (2) forms a chamber with the support platform (11) and comprises at least one nasal outlet (5), a base opening (7), and at least one further opening (6), through which the support platform (11) extends. The inlet conduit (4) comprises a connector (18) that clamps the body (2) and the support platform (11) together.

Abstract: Disclosed are cartridge components, cartridges, systems, and methods for isolating analytes from biological samples. In various aspects, the cartridge components, cartridges, systems, and methods may allow for a rapid procedure that requires a minimal amount of material from complex fluids.

Abstract: Methods and system for solid phase peptide synthesis are provided. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. New amino acid residues are added via a coupling reaction between an activated amino acid and an amino acid residue of the immobilized peptide. Amino acids may be activated using, e.g., a base and an activating agent. Certain inventive concepts, described herein, relate to methods and systems for the activation of amino acids. These systems and methods may allow for fewer side reactions and a higher yield compared to conventional activation techniques as well as the customization of the coupling reaction on a residue-by-residue basis without the need for costly and/or complex processes.

Abstract: The present disclosure features compounds useful for the treatment of BAF complex-related disorders.

Abstract: The present disclosure features compounds useful for the treatment of BAF complex-related disorders.

Abstract: Devices, methods and systems for generating wideband, high-fidelity arbitrary radio frequency (RF) passband signals are described. A voltage tunable optical filter for arbitrary RF passband signal generation includes a first input configured to receive a broadband optical pulse train, a second input configured to receive a first control voltage representative of an amplitude signal, an electrooptic modulator to receive the broadband optical pulse train and the first control voltage, to modulate the broadband optical pulse train in accordance with the amplitude signal, and to produce two complementary optical outputs that form two arms of an interferometer, an optical delay component to impart an optical path difference into one of the complementary outputs of the electrooptic modulator, and a combiner or a splitter to receive two complementary optical outputs of the electrooptic modulator after impartation of the optical path difference and to produce an output interference pattern of fringes.

Abstract: The present disclosure features compounds useful for the treatment of BAF complex-related disorders.

Abstract: Disclosed herein is the controlled epitaxy of AlxGa1-xAs, AlxIn1-xP, and AlxGayIn1-x-yP by hydride vapor phase epitaxy (HVPE) through use of an external AlCl3 generator.

Abstract: A fuel supply circuit of an aircraft engine includes a centrifugal pump mechanically coupled with an engine shaft delivering mechanical power. The circuit further includes at least one electromagnetic pump including at least one stator delimiting an annular internal volume in which is present a rotor able to drive a fluid, a plurality of magnets annularly distributed on the rotor and at least a plurality of coils annularly distributed inside the stator face-to-face with the magnets. The rotor is connected to the engine shaft by a one-way clutching element.