Abstract: Methods and systems for control of solid phase peptide synthesis are generally described. Control of solid phase peptide synthesis involves the use of feedback from one or more reactions and/or processes (e.g., reagent removal) taking place in the solid phase peptide synthesis system. In some embodiments, a detector may detect one or more fluids flowing across a detection zone of a solid phase peptide synthesis system and one or more signals may be generated corresponding to the fluid(s). For instance, an electromagnetic radiation detector positioned downstream of a reactor may detect a fluid exiting the reactor after a deprotection reactor and produce a signal(s). In some embodiments, based at least in part on information derived from the signal(s), a parameter of the system may be modulated prior to and/or during one or more subsequent reactions and/or processes taking place in the solid phase peptide synthesis system.

Abstract: Devices, systems and methods for encoding information using optical components are described. Information associated with a first optical signal (e.g., an optical pump) is encoded onto the phase of a second optical signal (e.g., an optical probe) using cross phase modulation (XPM) in a non-linear optical medium. The optical signals are multiplexed together into the nonlinear optical medium. The probe experiences a modified index of refraction as it propagates through the medium and thus accumulates a phase change proportional to the intensity of the pump. The disclosed devices can be incorporated into larger components and systems for various applications such as scientific diagnostics, radar, remote sensing, wireless communications, and quantum computing that can benefit from encoding and generation of low noise, high resolution signals.

Abstract: Disclosed are implantable ocular drainage devices that include a reversible switch mechanism to control flow through the drainage device. The devices include a drainage tube and a reversible, bi-stable switch mechanism that includes first and second stationary magnets spaced apart from one another and a magnetic or ferromagnetic mobile element moveably disposed in a channel in the housing.

Abstract: Disclosed are cartridge components, cartridges, systems, and methods for isolating analytes from biological samples. In various aspects, the cartridge components, cartridges, systems, and methods may allow for a rapid procedure that requires a minimal amount of material from complex fluids.

Abstract: The invention provides a solid state reference electrode comprising a reference element embedded in an electrochemically active composite, the electrochemically active composite comprising a polymeric matrix loaded with a solid inorganic salt, wherein the polymeric matrix comprises a cross-linked vinyl polymer of a vinyl monomer containing a heteroatom.

Abstract: The invention provides a solid state reference electrode comprising: a reference element in ionic communication with a composite, the composite comprising a water-permeable polymeric matrix loaded with a solid inorganic salt comprising a reference anion; an electrode surface for contacting an analyte; and a solid ion-exchange material located between the electrode surface and the reference element, the solid ion-exchange material comprising one or more non-interfering ions, wherein in use the solid ionexchange material immobilises one or more interfering ions, when present in solution in the analyte, by exchange with the noninterfering ions.

Abstract: The present disclosure features compounds useful for the treatment of BAF complex-related disorders.

Abstract: Described in this disclosure are rare earth element (REE)-binding proteins (e.g., lanthanide-binding proteins), host cells expressing the REE-binding proteins, and methods of recovering REEs.

Abstract: Devices, methods for analog-to-digital converters (ADCs) that perform high-dynamic range measurements based on optical techniques are disclosed. In one example aspect, an optical encoder includes a polarization rotator configured to receive a train of optical pulses, and an electro-optic (EO) modulator coupled to an output of the polarization rotator. The EO modulator is configured to receive a radio frequency (RF) signal and to produce a phase modulated signal in accordance with the RF signal. The optical encoder also includes a polarizing beam splitter coupled to the output of the EO modulator; and an optical hybrid configured to receive two optical signals from the polarizing beam splitter and to produce four optical outputs that are each phase shifted with respect to one another.

Abstract: Methods, devices and systems for providing accurate measurements of timing errors using optical techniques are described. An example timing measurement device includes an optical hybrid that receives two optical pulse trains and produces two or more phase shifted optical outputs. The timing measurement device further includes two or more optical filters that receive the outputs of the optical hybrid to produce multiple pulse signals with distinctive frequency bands. The device also includes one or more photodetectors and analog-to-digital converters to receive to produce electrical signals in the digital domain corresponding to the optical outputs of the hybrid. A timing error associated with the optical pulse trains can be determined using the electrical signals in digital domain based on a computed phase difference between a first frequency band signal and a second frequency band signal and a computed frequency difference between the first frequency band signal and the second frequency band.

Abstract: Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. In certain embodiments, the inventive systems and methods can be used to perform solid phase peptide synthesis quickly while maintaining high yields. Certain embodiments relate to processes and systems that may be used to heat, transport, and/or mix reagents in ways that reduce the amount of time required to perform solid phase peptide synthesis.

Abstract: The present invention relates to adjustable flow control valves, for example to an Adjustable Pressure Limiting (APL) valve. The adjustable valve (2) described comprises a valve body (4) comprising a valve seat (6), a valve member (10) movable relative to the valve seat (6), a first valve cap (20), a second valve cap (50) and a biasing element (30) to bias the valve member (10) away from the first valve cap (20). The first valve cap (20) is movable to increase the biasing force applied by the biasing element (30). The second valve cap (50) is engageable with the first valve cap (20) to prevent such movement of the first valve cap (20) beyond a selected position, but to allow movement of the first valve cap (20) in an opposite direction, way from said position.

Abstract: Methods, devices and systems for providing accurate measurements of timing errors using optical techniques are described. An example timing measurement device includes an optical hybrid that receives two optical pulse trains and produces two or more phase shifted optical outputs. The timing measurement device further includes two or more optical filters that receive the outputs of the optical hybrid to produce multiple pulse signals with distinctive frequency bands. The device also includes one or more photodetectors and analog-to-digital converters to receive to produce electrical signals in the digital domain corresponding to the optical outputs of the hybrid. A timing error associated with the optical pulse trains can be determined using the electrical signals in digital domain based on a computed phase difference between a first frequency band signal and a second frequency band signal and a computed frequency difference between the first frequency band signal and the second frequency band.

Abstract: The present disclosure features compounds useful for the treatment of BAF complex-related disorders.

Abstract: Devices, methods and systems for generating wideband, high-fidelity arbitrary radio frequency (RF) passband signals are described. A voltage tunable optical filter for arbitrary RF passband signal generation includes a first input configured to receive a broadband optical pulse train, a second input configured to receive a first control voltage representative of an amplitude signal, an electrooptic modulator to receive the broadband optical pulse train and the first control voltage, to modulate the broadband optical pulse train in accordance with the amplitude signal, and to produce two complementary optical outputs that form two arms of an interferometer, an optical delay component to impart an optical path difference into one of the complementary outputs of the electrooptic modulator, and a combiner or a splitter to receive two complementary optical outputs of the electrooptic modulator after impartation of the optical path difference and to produce an output interference pattern of fringes.

Abstract: Devices, systems and methods for encoding information using optical components are described. Information associated with a first optical signal (e.g., an optical pump) is encoded onto the phase of a second optical signal (e.g., an optical probe) using cross phase modulation (XPM) in a non-linear optical medium. The optical signals are multiplexed together into the nonlinear optical medium. The probe experiences a modified index of refraction as it propagates through the medium and thus accumulates a phase change proportional to the intensity of the pump. The disclosed devices can be incorporated into larger components and systems for various applications such as scientific diagnostics, radar, remote sensing, wireless communications, and quantum computing that can benefit from encoding and generation of low noise, high resolution signals.

Abstract: An external rearview device for a motor vehicle includes a base assembly provided for arrangement on the motor vehicle; a head assembly configured to be attached to the base assembly; rearview means including at least one of a camera unit and a reflective element secured within the head assembly, the head assembly configured to be detachable and selected from a set comprising a first head assembly with a first rearview means including at least one reflective element and a second head assembly with a second rearview means including at least one reflective element, and a camera unit configured to obtain a rearview image through the reflective element, and a third head assembly with a third rearview means including the camera unit.

Abstract: A lap top work station featuring an adjustable side by side tilting of a main support platform for eliminating a side by side out of level condition caused by a structural deformation and also featuring a pair of accessory mounting sockets, both features are accomplished by a pair of clevis, one clevis assembly attached at the end of a cross arm to provide the out of level condition, and the other fixed to the back of the main support platform and the other clevis assembly supporting the accessory mounting sockets.

Abstract: Non-limiting examples of the present disclosure enable creation and management of representations of content through the execution of copy actions, paste actions or a combination thereof. An indication of a copy action is received that copies a content portion. The copy action is analyzed to generate a (live) representation of the content portion. Other examples of representations are also generatable including a static representation and/or a live non-editable representation. As an example, a live representation is an editable and synchronized representation of the content portion that is synchronized with original source content. The live representation comprises a selectable data link that links back to the original source content and an editable representation of the content portion. In response to receiving an indication of a paste action, the live representation of the content portion is automatically rendered inline within a graphical user interface of a host application/service endpoint.

Abstract: The present disclosure provides rapid, convenient and sensitive means to detect low abundance target Gram negative bacteria such as Salmonella contamination from a range of samples, including food samples and environmental samples, through a single-step culture method and downstream sensitive detection.