Patents by Inventor Dean Artis

Dean Artis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds and methods for kinase modulation, and indications therefor
    Patent number: 8268858
    Abstract: Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
    Type: Grant
    Filed: December 20, 2007
    Date of Patent: September 18, 2012
    Assignee: Plexxikon Inc.
    Inventors: Guoxian Wu, Wayne Spevak, Songyuan Shi, Hanna Cho, Prabha N. Ibrahim, Chao Zhang, Shenghua Shi, Yong Zhou, Dean Artis, Jiazhong Zhang
  • COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
    Publication number: 20080188514
    Abstract: Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
    Type: Application
    Filed: December 20, 2007
    Publication date: August 7, 2008
    Inventors: Guoxian Wu, Wayne Spevak, Songyuan Shi, Hanna Cho, Prabha N. Ibrahim, Chao Zhang, Shenghua Shi, Yong Zhou, Dean Artis, Jiazhong Zhang
  • PPAR active compounds
    Publication number: 20080096913
    Abstract: Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.
    Type: Application
    Filed: December 7, 2007
    Publication date: April 24, 2008
    Inventors: James Arnold, Dean Artis, Clarence Hurt, Prabha Ibrahim, Heike Krupka, Jack Lin, Michael Milburn, Weiru Wang, Chao Zhang
  • PPAR ACTIVE COMPOUNDS
    Publication number: 20080045581
    Abstract: Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.
    Type: Application
    Filed: February 27, 2007
    Publication date: February 21, 2008
    Inventors: James Arnold, Dean Artis, Clarence Hurt, Prabha Ibrahim, Heike Krupka, Jack Lin, Michael Milburn, Weiru Wang, Chao Zhang
  • PPAR ACTIVE COMPOUNDS
    Publication number: 20070155818
    Abstract: Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.
    Type: Application
    Filed: February 27, 2007
    Publication date: July 5, 2007
    Inventors: Dean Artis, Prabha Ibrahim, Jack Lin, Chao Zhang
  • PPAR ACTIVE COMPOUNDS
    Publication number: 20070149603
    Abstract: Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.
    Type: Application
    Filed: February 27, 2007
    Publication date: June 28, 2007
    Inventors: James Arnold, Dean Artis, Clarence Hurt, Prabha Ibrahim, Heike Krupka, Jack Lin, Michael Milburn, Weiru Wang, Chao Zhang
  • PPAR active compounds
    Publication number: 20070072904
    Abstract: Compounds are described that are active on PPARs, including pan-active compounds and compounds selective for any one or any two of PPAR?, PPAR? and PPAR?. Also described are methods of use of the compounds in treating various diseases.
    Type: Application
    Filed: September 6, 2006
    Publication date: March 29, 2007
    Inventors: Jack Lin, Patrick Womack, Byunghun Lee, Shenghua Shi, Chao Zhang, Rebecca Zuckerman, Dean Artis, Prabha Ibrahim, Weiru Wang
  • Compounds and methods for development of RET modulators
    Publication number: 20070066641
    Abstract: Compounds active on Ret and/or FGFR are described, as well as methods of using such compounds. Also described are crystal structures of Ret surrogates that were determined using X-ray crystallography. The use of such Ret surrogate crystals and structural information can, for example, be used for identifying molecular scaffolds and for developing ligands that bind to and modulate Ret and for identifying improved ligands based on known ligands.
    Type: Application
    Filed: July 14, 2006
    Publication date: March 22, 2007
    Inventors: Prabha Ibrahim, Dean Artis, Gaston Habets, Rebecca Zuckerman
  • Compounds and methods for development of Ret modulators
    Publication number: 20070049615
    Abstract: Compounds active on Ret are described, as well as methods of using such compounds. Also described are crystal structures of Ret surrogates that were determined using X-ray crystallography. The use of such Ret surrogate crystals and strucural information can, for example, be used for identifying molecular scaffolds and for developing ligands that bind to and modulate Ret and for identifying improved ligands based on known ligands.
    Type: Application
    Filed: December 17, 2004
    Publication date: March 1, 2007
    Inventors: Prabha Ibrahim, Dean Artis, Ryan Bremer, Gaston Habets, Clarence Hurt, Shumeye Mamo, Marika Nespi, Chao Zhang, Jiazhong Zhang, Yong Zhu, Rebecca Zuckerman, Heike Krupka, Abhinav Kumar, Brian West
  • Serine Protease Inhibitors
    Publication number: 20070037813
    Abstract: Compounds having the structure shown below are useful to inhibit serine protease enzymes, such as TF/factor VIIa, factor Xa, thrombin and kallikrein. These compounds may be used in methods of preventing and/or treating clotting disorders.
    Type: Application
    Filed: September 29, 2006
    Publication date: February 15, 2007
    Applicant: Genentech, Inc.
    Inventors: Ignacio Aliagas-Martin, Dean Artis, Michael Dina, John Flygare, Richard Goldsmith, Regina Munroe, Alan Olivero, Richard Pastor, Thomas Rawson, Kirk Robarge, Daniel Sutherlin, Kenneth Weese, Aihe Zhou, Yan Zhu
  • Compounds modulating c-kit and c-fms activity and uses therefor
    Publication number: 20070032519
    Abstract: Compounds active on the receptor protein tyrosine kinases c-kit and c-fms are provided herewith. Also provided herewith are compositions useful for treatment of c-kit mediated diseases or condition and c-fms-mediated diseases or condition, and methods for the use thereof.
    Type: Application
    Filed: May 16, 2006
    Publication date: February 8, 2007
    Inventors: Chao Zhang, Jiazhong Zhang, Prabha Ibrahim, Clarence Hurt, Rebecca Zuckerman, Dean Artis, Ryan Bremer, Wayne Spevak, Guoxian Wu, Hongyao Zhu
  • Assay method
    Publication number: 20060234306
    Abstract: A new method for assaying the ability of a compound to block the binding of an ?4 integrin to a binding partner thereof provides a useful screening tool.
    Type: Application
    Filed: June 16, 2006
    Publication date: October 19, 2006
    Applicant: Genentech, Inc.
    Inventors: Dean Artis, David Jackson, Susan Keating, Maureen Beresini
  • PPAR active compounds
    Publication number: 20060135540
    Abstract: Compounds are described that are active on at least one of PPAR?, PPAR?, and PPAR?, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPAR?, PPAR?, and PPAR?.
    Type: Application
    Filed: November 29, 2005
    Publication date: June 22, 2006
    Inventors: Jack Lin, Prabha Ibrahim, Dean Artis, Chao Zhang, Weiru Wang, Shenghua Shi
  • PPAR active compounds
    Publication number: 20060116416
    Abstract: Compounds are described that are active on at least one of PPAR?, PPAR?, and PPAR?, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPAR?, PPAR?, and PPAR?.
    Type: Application
    Filed: November 29, 2005
    Publication date: June 1, 2006
    Inventors: Jack Lin, Dean Artis, Prabha Ibrahim, Chao Zhang, Rebecca Zuckerman, Ryan Bremer, Shenghua Shi, Byunghun Lee
  • PDE4B inhibitors
    Publication number: 20060100218
    Abstract: Compounds are described that are active on PDE4. Also described are crystal structures of PDE4B determined using X-ray crystallography, the use of PDE4B crystals and strucural information for identifying molecular scaffolds, for developing ligands that bind to and modulate PDE4B, and for identifying improved ligands based on known ligands.
    Type: Application
    Filed: September 2, 2005
    Publication date: May 11, 2006
    Inventors: Prabha Ibrahim, Ryan Bremer, Sam Gillette, Hanna Cho, Marika Nespi, Shumeye Mamo, Chao Zhang, Dean Artis, Byunghun Lee, Rebecca Zuckerman
  • PDE4B inhibitors and uses therefor
    Publication number: 20060041006
    Abstract: Compounds active on phosphodiesterase PDE4B are provided. Also provided herewith are compositions useful for treatment of PDE4B-mediated diseases or conditions, and methods for the use thereof.
    Type: Application
    Filed: May 6, 2005
    Publication date: February 23, 2006
    Inventors: Prabha Ibrahim, Hanna Cho, Bruce England, Sam Gillette, Dean Artis, Rebecca Zuckerman, Chao Zhang
  • PPAR active compounds
    Publication number: 20050288354
    Abstract: Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.
    Type: Application
    Filed: September 8, 2004
    Publication date: December 29, 2005
    Inventors: James Arnold, Dean Artis, Clarence Hurt, Prabha Ibrahim, Heike Krupka, Jack Lin, Michael Milburn, Weiru Wang, Chao Zhang
  • Assay method
    Publication number: 20050233387
    Abstract: A new method for assaying the ability of a compound to block the binding of an ?4 integrin to a binding partner thereof provides a useful screening tool.
    Type: Application
    Filed: June 3, 2005
    Publication date: October 20, 2005
    Applicant: Genentech, Inc.
    Inventors: Dean Artis, David Jackson, Susan Keating, Maureen Beresini
  • Serine protease inhibitors
    Publication number: 20050186198
    Abstract: Compounds having the structure shown below are useful to inhibit serine protease enzymes, such as TF/factor VIIa, factor Xa, thrombin and kallikrein. These compounds may be used in methods of preventing and/or treating clotting disorders.
    Type: Application
    Filed: March 24, 2005
    Publication date: August 25, 2005
    Inventors: Ignacio Aliagas-Martin, Dean Artis, Michael Dina, John Flygare, Richard Goldsmith, Regina Munroe, Alan Olivero, Richard Pastor, Thomas Rawson, Kirk Robarge, Daniel Sutherlin, Kenneth Weese, Aihe Zhou, Yan Zhu
  • Integrin receptor inhibitors
    Publication number: 20050187284
    Abstract: Provided are compounds of formula (I) wherein A, Q, W, X, Y, Z, R1 to R4, m and n are as defined herein. Compounds of the invention bind to ?4 integrin receptors and thereby inhibit binding of ligands for ?4 integrins which is useful for prophylactic and/or therapeutic treatment of diseases and conditions associated with ?4 integrins or their ligands.
    Type: Application
    Filed: April 20, 2005
    Publication date: August 25, 2005
    Applicant: Genentech, Inc.
    Inventors: Dean Artis, David Jackson, Thomas Rawson, Mark Reynolds, Daniel Sutherlin, Mark Stanley