Patents by Inventor Dean Falb

Dean Falb has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bacteria Engineered to Treat Diseases Associated with Hyperammonemia
    Publication number: 20160333326
    Abstract: Genetically engineered bacteria, pharmaceutical compositions thereof, and methods of modulating and treating disorders associated with hyperammonemia are disclosed.
    Type: Application
    Filed: May 25, 2016
    Publication date: November 17, 2016
    Inventors: Dean Falb, Vincent M. Isabella, Jonathan W. Kotula, Paul F. Miller, Suman Machinani
  • Bacteria engineered to treat diseases associated with hyperammonemia
    Patent number: 9487764
    Abstract: Genetically engineered bacteria, pharmaceutical compositions thereof, and methods of modulating and treating disorders associated with hyperammonemia are disclosed.
    Type: Grant
    Filed: December 4, 2015
    Date of Patent: November 8, 2016
    Assignee: Synlogic, Inc.
    Inventors: Dean Falb, Vincent M. Isabella, Jonathan W. Kotula, Paul F. Miller
  • Bacteria engineered to treat diseases that benefit from reduced gut inflammation and/or tighten gut mucosal barrier
    Publication number: 20160206666
    Abstract: Genetically engineered bacteria, pharmaceutical compositions thereof, and methods of treating or preventing autoimmune disorders, inhibiting inflammatory mechanisms in the gut, and/or tightening gut mucosal barrier function are disclosed.
    Type: Application
    Filed: December 22, 2015
    Publication date: July 21, 2016
    Applicant: Synlogic, Inc.
    Inventors: Dean Falb, Vincent M. Isabella, Jonathan W. Kotula, Paul F. Miller
  • Bacteria Engineered to Treat Diseases Associated with Hyperammonemia
    Publication number: 20160177274
    Abstract: Genetically engineered bacteria, pharmaceutical compositions thereof, and methods of modulating and treating disorders associated with hyperammonemia are disclosed.
    Type: Application
    Filed: December 4, 2015
    Publication date: June 23, 2016
    Inventors: Dean Falb, Vincent M. Isabella, Jonathan W. Kotula, Paul F. Miller
  • METHODS FOR TREATING PAIN INDUCED BY INJURIES AND DISEASES OF AN ARTICULAR JOINT
    Publication number: 20110224138
    Abstract: Described herein are methods for using bone morphogenetic proteins (BMPs), such as OP-1 (also known as BMP-7), to treat pain caused by osteoarthritis. The methods involve administering to a patient suffering from pain caused by osteoarthritis a BMP, for example, intraarticularly by injection directly into the joint afflicted with osteoarthritis. The methods of the invention provide long-term pain relief to sufferers of osteoarthritis and can improve the functionality of the joint to which the BMP is administered.
    Type: Application
    Filed: September 9, 2010
    Publication date: September 15, 2011
    Inventors: Julie Krop, Marilyn Pike, Dean Falb, Bret Shirley, Denis Schrier, Mary Elizabeth Goad
  • Compositions and methods for the treatment and diagnosis of cardiovascular disease using fehd545 as a target
    Patent number: 6759210
    Abstract: The present invention relates to methods and compositions for the treatment and diagnosis of cardiovascular disease, including, but not limited to, atherosclerosis, ischemia/reperfusion, hypertension, restenosis, and arterial inflammation. Specifically, the present invention identifies and describes genes which are differentially expressed in cardiovascular disease states, relative to their expression in normal, or non-cardiovascular disease states, and/or in response to manipulations relevant to cardiovascular disease. Further, the present invention identifies and describes genes via the ability of their gene products to interact with gene products involved in cardiovascular disease. Still further, the present invention provides methods for the identification and therapeutic use of compounds as treatments of cardiovascular disease.
    Type: Grant
    Filed: March 28, 1997
    Date of Patent: July 6, 2004
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Dean A. Falb, Michael A. Gimbrone, Jr.
  • Compositions and methods for the treatment and diagnosis of cardiovascular disease
    Publication number: 20040081992
    Abstract: The present invention relates to methods and compositions for the treatment and diagnosis of cardiovascular disease, including, but not limited to, atherosclerosis, ischemia/reperfusion, hypertension, restenosis, and arterial inflammation. Specifically, the present invention identifies and describes genes which are differentially expressed in cardiovascular disease states, relative to their expression in normal, or non-cardiovascular disease states, and/or in response to manipulations relevant to cardiovascular disease. Further, the present invention identifies and describes genes via the ability of their gene products to interact with gene products involved in cardiovascular disease. Still further, the present invention provides methods for the identification and therapeutic use of compounds as treatments of cardiovascular disease.
    Type: Application
    Filed: September 3, 2003
    Publication date: April 29, 2004
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Dean A. Falb, Michael A. Gimbrone
  • Compositions and methods for the treatment and diagnosis of cardiovascular disease
    Publication number: 20030188327
    Abstract: The present invention relates to methods and compositions for the treatment and diagnosis of cardiovascular disease, including, but not limited to, atherosclerosis, ischemia/reperfusion, hypertension, restenosis, and arterial inflammation. Specifically, the present invention identifies and describes genes which are differentially expressed in cardiovascular disease states, relative to their expression in normal, or non-cardiovascular disease states, and/or in response to manipulations relevant to cardiovascular disease. Further, the present invention identifies and describes genes via the ability of their gene products to interact with gene products involved in cardiovascular disease. Still further, the present invention provides methods for the identification and therapeutic use of compounds as treatments of cardiovascular disease.
    Type: Application
    Filed: July 2, 2002
    Publication date: October 2, 2003
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Dean A. Falb, Michael A. Gimbrone
  • Compositions and methods for the treatment and diagnosis of cardiovascular disease
    Publication number: 20030097668
    Abstract: The present invention relates to methods and compositions for the treatment and diagnosis of cardiovascular disease, including, but not limited to, atherosclerosis, advanced atherosclerosis/plaque rupture, ischemia/reperfusion, hypertension, restenosis, cardiac calcification, allo/xenograft valvular calcifications, and arterial inflammation. Specifically, the present invention identifies and describes genes which are differentially expressed in cardiovascular disease states, relative to their expression in normal, or non-cardiovascular disease states, and/or in response to manipulations relevant to cardiovascular disease. Further, the present invention identifies and describes genes via the ability of their gene products to interact with gene products involved in cardiovascular disease. Still further, the present invention provides methods for the identification and therapeutic use of compounds as treatments of cardiovascular disease.
    Type: Application
    Filed: February 8, 2002
    Publication date: May 22, 2003
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Katherine Galvin, Dean A. Falb, Michael J. Donovan, Dennis Huszar, Michael A. Gimbrone
  • Compositions and methods for the treatment and diagnosis of cardiovascular disease
    Publication number: 20030073076
    Abstract: The present invention relates to methods and compositions for the treatment and diagnosis of cardiovascular disease, including, but not limited to, atherosclerosis, ischemia/reperfusion, hypertension, restenosis, and arterial inflammation. Specifically, the present invention identifies and describes genes which are differentially expressed in cardiovascular disease states, relative to their expression in normal, or non-cardiovascular disease states, and/or in response to manipulations relevant to cardiovascular disease. Further, the present invention identifies and describes genes via the ability of their gene products to interact with gene products involved in cardiovascular disease. Still further, the present invention provides methods for the identification and therapeutic use of compounds as treatments of cardiovascular disease.
    Type: Application
    Filed: April 28, 2000
    Publication date: April 17, 2003
    Inventor: Dean A Falb
  • Compositions and methods for the treatment and diagnosis of cardiovascular disease
    Patent number: 6534641
    Abstract: The present invention relates to methods and compositions for the treatment and diagnosis of cardiovascular disease, including, but not limited to, atherosclerosis, ischemia/reperfusion, hypertension, restenosis, and arterial inflammation. Specifically, the present invention identifies and describes genes which are differentially expressed in cardiovascular disease states, relative to their expression in normal, or non-cardiovascular disease states, and/or in response to manipulations relevant to cardiovascular disease. Further, the present invention identifies and describes genes via the ability of their gene products to interact with gene products involved in cardiovascular disease. Still further, the present invention provides methods for the identification and therapeutic use of compounds as treatments of cardiovascular disease.
    Type: Grant
    Filed: March 28, 1997
    Date of Patent: March 18, 2003
    Assignees: Millennium Pharmaceuticals, Inc., Brigham and Women's Hospital
    Inventors: Dean A. Falb, Michael A. Gimbrone, Jr.
  • Compositions and methods for the treatment and diagnosis of cardiovascular disease
    Patent number: 6492126
    Abstract: The present invention relates to methods and compositions for the treatment and diagnosis of cardiovascular disease, including, but not limited to, atherosclerosis, ischemia/reperfusion, hypertension, restenosis, and arterial inflammation. Specifically, the present invention identifies and describes genes which are differentially expressed in cardiovascular disease states, relative to their expression in normal, or non-cardiovascular disease states, and/or in response to manipulations relevant to cardiovascular disease. Further, the present invention identifies and describes genes via the ability of their gene products to interact with gene products involved in cardiovascular disease. Still further, the present invention provides methods for the identification and therapeutic use of compounds as treatments of cardiovascular disease.
    Type: Grant
    Filed: August 11, 1999
    Date of Patent: December 10, 2002
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Dean A. Falb, Michael A. Gimbrone, Jr.
  • Compositions and methods for the treatment and diagnosis of cardiovascular disease using rchd534 as a target
    Publication number: 20020178458
    Abstract: The present invention relates to methods and compositions for the treatment and diagnosis of cardiovascular disease, including, but not limited to, atherosclerosis, ischemia/reperfusion, hypertension, restenosis, and arterial inflammation. Specifically, the present invention identifies and describes genes which are differentially expressed in cardiovascular disease states, relative to their expression in normal, or non-cardiovascular disease states, and/or in response to manipulations relevant to cardiovascular disease. Further, the present invention identifies and describes genes via the ability of their gene products to interact with gene products involved in cardiovascular disease. Still further, the present invention provides methods for the identification and therapeutic use of compounds as treatments of cardiovascular disease.
    Type: Application
    Filed: November 9, 2001
    Publication date: November 28, 2002
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Dean A. Falb, Michael A. Gimbrone
  • Compositions and methods for the treatment and diagnosis of cardiovascular disease
    Publication number: 20020170077
    Abstract: The present invention relates to methods and compositions for the treatment and diagnosis of cardiovascular disease, including, but not limited to, atherosclerosis, ischemia/reperfusion, hypertension, restenosis, and arterial inflammation. Specifically, the present invention identifies and describes genes which are differentially expressed in cardiovascular disease states, relative to their expression in normal, or non-cardiovascular disease states, and/or in response to manipulations relevant to cardiovascular disease. Further, the present invention identifies and describes genes via the ability of their gene products to interact with gene products involved in cardiovascular disease. Still further, the present invention provides methods for the identification and therapeutic use of compounds as treatments of cardiovascular disease.
    Type: Application
    Filed: October 5, 2001
    Publication date: November 14, 2002
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Dean A. Falb, Michael A. Gimbrone
  • Compositions and methods for the treatment and diagnosis of cardiovascular disease
    Publication number: 20020142441
    Abstract: The present invention relates to methods and compositions for the treatment and diagnosis of cardiovascular disease, including, but not limited to, atherosclerosis, ischemia/reperfusion, hypertension, restenosis, and arterial inflammation. Specifically, the present invention identifies and describes genes which are differentially expressed in cardiovascular disease states, relative to their expression in normal, or non-cardiovascular disease states, and/or in response to manipulations relevant to cardiovascular disease. Further, the present invention identifies and describes genes via the ability of their gene products to interact with gene products involved in cardiovascular disease. Still further, the present invention provides methods for the identification and therapeutic use of compounds as treatments of cardiovascular disease.
    Type: Application
    Filed: August 7, 2001
    Publication date: October 3, 2002
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Dean A. Falb, Michael A. Gimbrone
  • COMPOSITIONS AND METHODS FOR THE TREATMENT AND DIAGNOSIS OF CARDIOVASCULAR DISEASE
    Publication number: 20020137700
    Abstract: The present invention relates to methods and compositions for the treatment and diagnosis of cardiovascular disease, including, but not limited to, atherosclerosis, ischemia/reperfusion, hypertension, restenosis, and arterial inflammation. Specifically, the present invention identifies and describes genes which are differentially expressed in cardiovascular disease states, relative to their expression in normal, or non-cardiovascular disease states, and/or in response to manipulations relevant to cardiovascular disease. Further, the present invention identifies and describes genes via the ability of their gene products to interact with gene products involved in cardiovascular disease. Still further, the present invention provides methods for the identification and therapeutic use of compounds as treatments of cardiovascular disease.
    Type: Application
    Filed: August 11, 1999
    Publication date: September 26, 2002
    Inventors: DEAN A. FALB, MICHAEL A. GIMBRONE
  • COMPOSITIONS AND METHODS FOR THE TREATMENT AND DIAGNOSIS OF CARDIOVASCULAR DISEASE
    Publication number: 20020102603
    Abstract: The present invention relates to methods and compositions for the treatment and diagnosis of cardiovascular disease, including, but not limited to, atherosclerosis, ischemia/reperfusion, hypertension, restenosis, and arterial inflammation. Specifically, the present invention identifies and describes genes which are differentially expressed in cardiovascular disease states, relative to their expression in normal, or non-cardiovascular disease states, and/or in response to manipulations relevant to cardiovascular disease. Further, the present invention identifies and describes genes via the ability of their gene products to interact with gene products involved in cardiovascular disease. Still further, the present invention provides methods for the identification and therapeutic use of compounds as treatments of cardiovascular disease.
    Type: Application
    Filed: August 11, 1999
    Publication date: August 1, 2002
    Inventors: DEAN A. FALB, MICHAEL A. GIMBRONE
  • COMPOSITIONS AND METHODS FOR THE TREATMENT AND DIAGNOSIS OF CARDIOVASCULAR DISEASE
    Publication number: 20020034736
    Abstract: The present invention relates to methods and compositions for the treatment and diagnosis of cardiovascular disease, including, but not limited to, atherosclerosis, ischemia/reperfusion, hypertension, restenosis, and arterial inflammation. Specifically, the present invention identifies and describes genes which are differentially expressed in cardiovascular disease states, relative to their expression in normal, or non-cardiovascular disease states, and/or in response to manipulations relevant to cardiovascular disease. Further, the present invention identifies and describes genes via the ability of their gene products to interact with gene products involved in cardiovascular disease. Still further, the present invention provides methods for the identification and therapeutic use of compounds as treatments of cardiovascular disease.
    Type: Application
    Filed: June 6, 1997
    Publication date: March 21, 2002
    Inventors: DEAN A. FALB, Michael A. Gimbrone
  • Compositions and methods for the treatment and diagnosis of cardiovascular disease
    Patent number: 6359194
    Abstract: The present invention is based on the generation and phenotypic characterization of transgenic knockout homozygous rchd534 mutant mice which display characteristic cardiovascular disease symptoms. Such transgenic knockout homozygous rchd534 mutant mice are useful models for the analysis and characterization of rchd534 protein involvement in development and homeostasis of the cardiovascular system and tissue-specific regulation of the TGF-&bgr; signaling pathways. Such transgenic mice may be used for screening compounds that may potentially useful for treating or preventing cardiovascular disease.
    Type: Grant
    Filed: April 8, 1999
    Date of Patent: March 19, 2002
    Assignees: Millennium Pharmaceuticals, Inc., Brigham & Women's Hospital
    Inventors: Katherine Galvin, Dean A. Falb, Michael J. Donovan, Dennis Huszar, Michael A. Gimbrone, Jr.
  • COMPOSITIONS AND METHODS FOR THE TREATMENT AND DIAGNOSIS OF CARDIOVASCULAR DISEASE
    Publication number: 20020016303
    Abstract: The present invention relates to methods and compositions for the treatment and diagnosis of cardiovascular disease, including, but not limited to, atherosclerosis, ischemia/reperfusion, hypertension, restenosis, and arterial inflammation. Specifically, the present invention identifies and describes genes which are differentially expressed in cardiovascular disease states, relative to their expression in normal, or non-cardiovascular disease states, and/or in response to manipulations relevant to cardiovascular disease. Further, the present invention identifies and describes genes via the ability of their gene products to interact with gene products involved in cardiovascular disease. Still further, the present invention provides methods for the identification and therapeutic use of compounds as treatments of cardiovascular disease.
    Type: Application
    Filed: March 28, 1997
    Publication date: February 7, 2002
    Inventor: DEAN A. FALB