Patents by Inventor Dean Falb

Dean Falb has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for the treatment and diagnosis of cardiovascular disease using rchd534 as a target
    Patent number: 6225084
    Abstract: The present invention relates to methods and compositions for the treatment and diagnosis of cardiovascular disease, including, but not limited to, atherosclerosis, ischemia/reperfusion, hypertension, restenosis, and arterial inflammation. Specifically, the present invention identifies and describes genes which are differentially expressed in cardiovascular disease states, relative to their expression in normal, or non-cardiovascular disease states, and/or in response to manipulations relevant to cardiovascular disease. Further, the present invention identifies and describes genes via the ability of their gene products to interact with gene products involved in cardiovascular disease. Still further, the present invention provides methods for the identification and therapeutic use of compounds as treatments of cardiovascular disease.
    Type: Grant
    Filed: September 9, 1997
    Date of Patent: May 1, 2001
    Assignees: Millennium Pharmaceuticals, Inc., Brigham and Women's Hospital
    Inventors: Dean A. Falb, Michael A. Gimbrone, Jr.
  • Compositions and methods for the treatment and diagnosis of cardiovascular disease using fchd540 as a target
    Patent number: 6221628
    Abstract: The present invention relates to methods and compositions for the treatment and diagnosis of cardiovascular disease, including, but not limited to, atherosclerosis, ischemia/reperfusion, hypertension, restenosis, and arterial inflammation. Specifically, the present invention identifies and describes genes which are differentially expressed in cardiovascular disease states, relative to their expression in normal, or non-cardiovascular disease states, and/or in response to manipulations relevant to cardiovascular disease. Further, the present invention identifies and describes genes via the ability of their gene products to interact with gene products involved in cardiovascular disease. Still further, the present invention provides methods for the identification and therapeutic use of compounds as treatments of cardiovascular disease.
    Type: Grant
    Filed: September 8, 1997
    Date of Patent: April 24, 2001
    Assignees: Brigham & Women's Hospital, Millennium Pharmaceuticals, Inc.
    Inventors: Dean A. Falb, Michael A. Gimbrone, Jr.
  • Methods for the treatment and diagnosis of cardiovascular disease
    Patent number: 6156500
    Abstract: The present invention relates to methods and compositions for the treatment and diagnosis of cardiovascular disease, including, but not limited to, atherosclerosis, ischemia/reperfusion, hypertension, restenosis, and arterial inflammation. Specifically, the present invention identifies and describes genes which are differentially expressed in cardiovascular disease states, relative to their expression in normal, or non-cardiovascular disease states, and/or in response to manipulations relevant to cardiovascular disease. Further, the present invention identifies and describes genes via the ability of their gene products to interact with gene products involved in cardiovascular disease. Still further, the present invention provides methods for the identification and therapeutic use of compounds as treatments of cardiovascular disease.
    Type: Grant
    Filed: February 10, 1995
    Date of Patent: December 5, 2000
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventor: Dean Falb
  • Compositions and methods for treatment and diagnosis of cardiovascular disease
    Patent number: 6124433
    Abstract: The present invention relates to methods and compositions for the treatment and diagnosis of cardiovascular disease, including, but not limited to, atherosclerosis, ischemia/reperfusion, hypertension, restenosis, and arterial inflammation. Specifically, the present invention identifies and describes genes which are differentially expressed in cardiovascular disease states, relative to their expression in normal, or non-cardiovascular disease states, and/or in response to manipulations relevant to cardiovascular disease. Further, the present invention identifies and describes genes via the ability of their gene products to interact with gene products involved in cardiovascular disease. Still further, the present invention provides methods for the identification and therapeutic use of compounds as treatments of cardiovascular disease.
    Type: Grant
    Filed: October 6, 1997
    Date of Patent: September 26, 2000
    Assignees: Millennium Pharmaceuticals, Inc., Brigham and Women's Hospital
    Inventors: Dean A. Falb, Michael A. Gimbrone, Jr.
  • Compositions and methods for the treatment and diagnosis of cardiovascular disease
    Patent number: 6099823
    Abstract: The present invention relates to methods and compositions for the treatment and diagnosis of cardiovascular disease, including, but not limited to, atherosclerosis, ischemia/reperfusion, hypertension, restenosis, and arterial inflammation. Specifically, the present invention identifies and describes genes which are differentially expressed in cardiovascular disease states, relative to their expression in normal, or non-cardiovascular disease states, and/or in response to manipulations relevant to cardiovascular disease. Further, the present invention identifies and describes genes via the ability of their gene products to interact with gene products involved in cardiovascular disease. Still further, the present invention provides methods for the identification and therapeutic use of compounds as treatments of cardiovascular disease.
    Type: Grant
    Filed: July 30, 1998
    Date of Patent: August 8, 2000
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventor: Dean A. Falb
  • Compositions and methods for the treatment and diagnosis of cardiovascular disease
    Patent number: 6087477
    Abstract: The present invention relates to methods and compositions for the treatment and diagnosis of cardiovascular disease, including, but not limited to, atherosclerosis, ischemia/reperfusion, hypertension, restenosis, and arterial inflammation. Specifically, the present invention identifies and describes genes which are differentially expressed in cardiovascular disease states, relative to their expression in normal, or non-cardiovascular disease states, and/or in response to manipulations relevant to cardiovascular disease. Further, the present invention identifies and describes genes via the ability of their gene products to interact with gene products involved in cardiovascular disease. Still further, the present invention provides methods for the identification and therapeutic use of compounds as treatments of cardiovascular disease.
    Type: Grant
    Filed: October 6, 1997
    Date of Patent: July 11, 2000
    Assignees: Millennium Pharmaceuticals, Inc., Brigham and Women's Hospital
    Inventors: Dean A. Falb, Michael A. Gimbrone, Jr.
  • Compositions and methods for the treatment and diagnosis of cardiovascular disease using rchd534 as a target
    Patent number: 6054558
    Abstract: The present invention relates to methods and compositions for the treatment and diagnosis of cardiovascular disease, including, but not limited to, atherosclerosis, ischemia/reperfusion, hypertension, restenosis, and arterial inflammation. Specifically, the present invention identifies and describes genes which are differentially expressed in cardiovascular disease states, relative to their expression in normal, or non-cardiovascular disease states, and/or in response to manipulations relevant to cardiovascular disease. Further, the present invention identifies and describes genes via the ability of their gene products to interact with gene products involved in cardiovascular disease. Still further, the present invention provides methods for the identification and therapeutic use of compounds as treatments of cardiovascular disease.
    Type: Grant
    Filed: September 9, 1997
    Date of Patent: April 25, 2000
    Assignees: Millennium Pharmaceuticals, Inc., Brigham and Womens's Hospital
    Inventors: Dean A. Falb, Michael A. Gimbrone, Jr.
  • Compositions and methods for the treatment and diagnosis of cardiovascular disease
    Patent number: 6048709
    Abstract: The present invention relates to methods and compositions for the treatment and diagnosis of cardiovascular disease, including, but not limited to, atherosclerosis, ischemia/reperfusion, hypertension, restenosis, and arterial inflammation. Specifically, the present invention identifies and describes genes which are differentially expressed in cardiovascular disease states, relative to their expression in normal, or non-cardiovascular disease states, and/or in response to manipulations relevant to cardiovascular disease. Further, the present invention identifies and describes genes via the ability of their gene products to interact with gene products involved in cardiovascular disease.
    Type: Grant
    Filed: March 28, 1997
    Date of Patent: April 11, 2000
    Assignee: Millennium Pharmaceuticals Inc.
    Inventor: Dean A. Falb
  • Conservin compositions
    Patent number: 6031076
    Abstract: The present invention relates to the discovery of novel conservin genes and polypeptides. Therapeutics, diagnostics and screening assays based on these molecules are also disclosed.
    Type: Grant
    Filed: January 5, 1998
    Date of Patent: February 29, 2000
    Assignee: Millenium Pharmaceuticals, Inc.
    Inventors: Dean A. Falb, Carlos J. Gimeno
  • Compositions and methods for the treatment and diagnosis of cardiovascular disease using rchd523 as a target
    Patent number: 6020463
    Abstract: The present invention relates to methods and compositions for the treatment and diagnosis of cardiovascular disease, including, but not limited to, atherosclerosis, ischemia/reperfusion, hypertension, restenosis, and arterial inflammation. Specifically, the present invention identifies and describes genes which are differentially expressed in cardiovascular disease states, relative to their expression in normal, or non-cardiovascular disease states, and/or in response to manipulations relevant to cardiovascular disease. Further, the present invention identifies and describes genes via the ability of their gene products to interact with gene products involved in cardiovascular disease. Still further, the present invention provides methods for the identification and therapeutic use of compounds as treatments of cardiovascular disease.
    Type: Grant
    Filed: October 6, 1997
    Date of Patent: February 1, 2000
    Assignees: Millennium Pharmaceuticals, Inc., Brigham and Women's Hospital
    Inventors: Dean A. Falb, Michael A. Gimbrone, Jr.
  • Compositions and methods for the treatment and diagnosis of cardiovascular disease using rchd528 as a target
    Patent number: 6018025
    Abstract: The present invention relates to methods and compositions for the treatment and diagnosis of cardiovascular disease, including, but not limited to, atherosclerosis, ischemia/reperfusion, hypertension, restenosis, and arterial inflammation. Specifically, the present invention identifies and describes genes which are differentially expressed in cardiovascular disease states, relative to their expression in normal, or non-cardiovascular disease states, and/or in response to manipulations relevant to cardiovascular disease. Further, the present invention identifies and describes genes via the ability of their gene products to interact with gene products involved in cardiovascular disease. Still further, the present invention provides methods for the identification and therapeutic use of compounds as treatments of cardiovascular disease.
    Type: Grant
    Filed: October 6, 1997
    Date of Patent: January 25, 2000
    Assignees: Millenium Pharmaceuticals, Inc., Brigham and Women's Hospital
    Inventors: Dean A. Falb, Michael A. Gimbrone, Jr.
  • Compositions and methods for the treatment and diagnosis of cardiovascular disease using rchd523 as a target
    Patent number: 5968770
    Abstract: The present invention relates to methods and compositions for the treatment and diagnosis of cardiovascular disease, including, but not limited to, atherosclerosis, ischemia/reperfusion, hypertension, restenosis, and arterial inflammation. Specifically, the present invention identifies and describes genes which are differentially expressed in cardiovascular disease states, relative to their expression in normal, or non-cardiovascular disease states, and/or in response to manipulations relevant to cardiovascular disease. Further, the present invention identifies and describes genes via the ability of their gene products to interact with gene products involved in cardiovascular disease. Still further, the present invention provides methods for the identification and therapeutic use of compounds as treatments of cardiovascular disease.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 19, 1999
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Dean A. Falb, Michael A. Gimbrone, Jr.
  • TGF-.beta. pathway genes
    Patent number: 5948639
    Abstract: The invention provides isolated nucleic acids molecules, designated EMI1 nucleic acid molecules, which encode proteins involved in growth factor, e.g., TGF-.beta., cell signaling. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing EMI1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an EMI1 gene has been introduced or disrupted. The invention still further provides isolated EMI1 proteins, fusion proteins, antigenic peptides and anti-EMI1 antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.
    Type: Grant
    Filed: April 10, 1997
    Date of Patent: September 7, 1999
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Carlos J. Gimeno, Dean A. Falb
  • Compositions and method for the treatment and diagnosis of cardiovascular disease using rchd502 as a target
    Patent number: 5882925
    Abstract: The present invention relates to methods and compositions for the treatment and diagnosis of cardiovascular disease, including, but not limited to, atherosclerosis, ischemia/reperfusion, hypertension, restenosis, and arterial inflammation. Specifically, the present invention identifies and describes genes which are differentially expressed in cardiovascular disease states, relative to their expression in normal, or non-cardiovascular disease states, and/or in response to manipulations relevant to cardiovascular disease. Further, the present invention identifies and describes genes via the ability of their gene products to interact with gene products involved in cardiovascular disease. Still further, the present invention provides methods for the identification and therapeutic use of compounds as treatments of cardiovascular disease.
    Type: Grant
    Filed: February 9, 1996
    Date of Patent: March 16, 1999
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventor: Dean A. Falb
  • Compositions and methods for the treatment and diagnosis of cardiovascular using RCHD528 as a target
    Patent number: 5849578
    Abstract: The present invention relates to methods and compositions for the treatment and diagnosis of cardiovascular disease, including, but not limited to, atherosclerosis, ischemia/reperfusion, hypertension, restenosis, and arterial inflammation. Specifically, the present invention identifies and describes genes which are differentially expressed in cardiovascular disease states, relative to their expression in normal, or non-cardiovascular disease states, and/or in response to manipulations relevant to cardiovascular disease. Further, the present invention identifies and describes genes via the ability of their gene products to interact with gene products involved in cardiovascular disease. Still further, the present invention provides methods for the identification and therapeutic use of compounds as treatments of cardiovascular disease.
    Type: Grant
    Filed: March 15, 1996
    Date of Patent: December 15, 1998
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventor: Dean A. Falb
  • Compositions and methods using rchd534, a gene uregulated by shear stress
    Patent number: 5834248
    Abstract: The present invention relates to methods and compositions for the treatment and diagnosis of cardiovascular disease, including, but not limited to, atherosclerosis, ischemia/reperfusion, hypertension, restenosis, and arterial inflammation. Specifically, the present invention identifies and describes genes which are differentially expressed in cardiovascular disease states, relative to their expression in normal, or non-cardiovascular disease states, and/or in response to manipulations relevant to cardiovascular disease. Further, the present invention identifies and describes genes via the ability of their gene products to interact with gene products involved in cardiovascular disease. Still further, the present invention provides methods for the identification and therapeutic use of compounds as treatments of cardiovascular disease.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 10, 1998
    Assignee: Millennium Pharmaceuticals Inc.
    Inventor: Dean Falb
  • Conservin nucleic acid molecules and compositions
    Patent number: 5807708
    Abstract: The present invention relates to the discovery of novel conservin genes and polypeptides. Therapeutics, diagnostics and screening assays based on these molecules are also disclosed.
    Type: Grant
    Filed: July 30, 1996
    Date of Patent: September 15, 1998
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Dean A. Falb, Carlos J. Gimeno