Patents by Inventor Debabrata Mukhopadhyay

Debabrata Mukhopadhyay has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210213137
    Abstract: This document relates to materials and methods for administering (e.g., topically administering) one or more vascular endothelial growth factor (VEGF) inhibitors to reduce and/or treat ultraviolet (UV)-induced skin injury. For example, compositions including one or more VEGF inhibitors that can be administered (e.g., topically administered) to a mammal to reduce and/or treat UV-induced skin injury following UV exposure are provided.
    Type: Application
    Filed: January 20, 2021
    Publication date: July 15, 2021
    Inventors: Stephen C. Ekker, Debabrata Mukhopadhyay, Priyabrata Mukherjee, Victoria M. Bedell, Luke H. Hoeppner, Stella P. Hartono
  • Publication number: 20210171538
    Abstract: The present invention relates to nimbolide analogs useful as anti-cancer agents and preparation thereof. Particularly the present invention relates to nimbolide analogs of general formula I. wherein, ring M is any ring selected from the group consisting of substituted or unsubstituted aryl, heteroaryl, cycloalkyl and heterocyclic; A and B are selected from the group consisting of C, O, N, S and H; R1, R2, R3, R4, R5 and R6 are selected from the group consisting of C1-C6 alkyl, aryl, heteroaryl, C1-C7 cycloalkyl, heteroalkyl, hydrogen, hydroxy, alkoxy, nitro, halogen, amino, alkylamino, aryl amino and cyano; wherein each of these groups may be further substituted with one or more substituents selected from the group consisting of hydrogen, hydroxy, halogen, cyano, alkyl amino, aryl amino, alkoxy, amino, nitro, aldehyde, carboxylic acid and ester.
    Type: Application
    Filed: February 9, 2021
    Publication date: June 10, 2021
    Applicant: Council of Scientific & Industrial Research
    Inventors: Srivari Chandrasekhar, Prathama Satyendra Mainkar, Karre Nagaraju, Togapur Pavan Kumar, Ummanni Ramesh, Kanchanapally Tejaswini, Jerald Mahesh Kumar, Katragadda Suresh Babu, Boggavarapu Subrahmanya Sastry, Debabrata Mukhopadhyay
  • Patent number: 10947249
    Abstract: The present invention relates to nimbolide analogs useful as anti-cancer agents and preparation thereof. Particularly the present invention relates to nimbolide analogs of general formula I. wherein, ring M is any ring selected from the group consisting of substituted or unsubstituted aryl, heteroaryl, cycloalkyl and heterocyclic; A and B are selected from the group consisting of C, O, N, S and H; R1, R2, R3, R4, R5 and R6 are selected from the group consisting of C1-C6 alkyl, aryl, heteroaryl, C1-C7 cycloalkyl, heteroalkyl, hydrogen, hydroxy, alkoxy, nitro, halogen, amino, alkylamino, aryl amino and cyano; wherein each of these groups may be further substituted with one or more substituents selected from the group consisting of hydrogen, hydroxy, halogen, cyano, alkyl amino, aryl amino, alkoxy, amino, nitro, aldehyde, carboxylic acid and ester.
    Type: Grant
    Filed: October 26, 2018
    Date of Patent: March 16, 2021
    Inventors: Srivari Chandrasekhar, Prathama Satyendra Mainkar, Karre Nagaraju, Togapur Pavan Kumar, Ummanni Ramesh, Kanchanapally Tejaswini, Jerald Mahesh Kumar, Katragadda Suresh Babu, Boggavarapu Subrahmanya Sastry, Debabrata Mukhopadhyay
  • Patent number: 10919119
    Abstract: A method for repairing a component is disclosed. The method includes removing a portion originally including a plurality of cooling holes, of the component to form a cavity, forming by additive manufacturing a replacement portion including a plurality of cooling holes, and varying a surface roughness and a diameter of at least one cooling hole of the plurality of cooling holes during the forming by additive manufacturing the replacement portion. The replacement portion replaces the portion of the component.
    Type: Grant
    Filed: July 23, 2018
    Date of Patent: February 16, 2021
    Assignee: General Electric Company
    Inventors: Dheepa Srinivasan, Joydeep Pal, Debabrata Mukhopadhyay
  • Patent number: 10907545
    Abstract: A cooling system for a turbine engine is provided. The turbine engine includes a compressor, a compressor discharge chamber (CDC), a combustor assembly, and a turbine coupled in a serial flow relationship such that a first portion of air from the CDC is channeled to the combustor assembly. The turbine is coupled to the compressor via a rotor. The cooling system includes an air duct configured to channel a second portion of air from the CDC to a mid-rotor region of the rotor, and a fluid supply system coupled to the air duct at a coupling. The fluid supply system is configured to channel a flow of fluid to the coupling. The coupling is configured to cool the second portion of CDC air via absorption of heat by the fluid from the second portion of CDC air.
    Type: Grant
    Filed: May 22, 2018
    Date of Patent: February 2, 2021
    Assignee: General Electric Company
    Inventors: Rajesh Mavuri, Debabrata Mukhopadhyay
  • Patent number: 10641174
    Abstract: A gas turbine casing with an internal heat exchange system. The gas turbine extends between an inlet section and an exhaust section and defines a downstream direction from the inlet section to the exhaust section. The casing includes a forward end, an aft end downstream of the forward end, a first exterior surface facing radially outward, a second exterior surface facing radially inward, and an internal body at least partially defined between the first exterior surface and the second exterior surface. The heat exchange system includes an inlet and an outlet formed in an exterior surface of the casing proximate the aft end, a supply bore extending upstream from the inlet through the interior body of the casing, and a return bore extending downstream to the outlet through the interior body of the casing.
    Type: Grant
    Filed: January 18, 2017
    Date of Patent: May 5, 2020
    Assignee: General Electric Company
    Inventors: Debabrata Mukhopadhyay, Sanjeev Kumar Jain, Sendilkumaran Soundiramourty, Rajesh Mavuri, Jagdish Prasad Tyagi
  • Patent number: 10611796
    Abstract: The present invention discloses a Plectin-1 receptor targeting novel cationic KTLLPTPK(SEQ ID NO: 1)-lipopeptide. The present invention further discloses a liposomal formulation comprising the cationic KTLLPTPK(SEQ ID NO: 1)-lipopeptide, at least two co-lipids, a therapeutic agent, and a pharmaceutically acceptable carrier. The present invention also provides a method for regressing established pancreatic tumors comprising administering a therapeutically effective amount of the liposomal formulation with the therapeutic agents in combination with targeted genetic immunization (DNA vaccination) i.e. by immunizing mice with electrostatic complexes (direct in-vivo DC-targeting cationic liposomes) of DNA vaccines encoding mesothelin (p-CMV-MSLN).
    Type: Grant
    Filed: March 16, 2017
    Date of Patent: April 7, 2020
    Assignees: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH, MAYO CLINIC
    Inventors: Vijay Sagar Madamsetty, Arabinda Chaudhuri, Debabrata Mukhopadhyay
  • Patent number: 10543231
    Abstract: This document provides methods and materials involved in treating cancer. For example, methods and materials involved in making and using particles (e.g., gold nanoparticles) containing a KTLLPTPYC amino acid sequence (SEQ ID NO:1) or a KTLLPTPYCC amino acid sequence (SEQ ID NO:2) to treat cancer (e.g., pancreatic cancer) are provided.
    Type: Grant
    Filed: May 16, 2018
    Date of Patent: January 28, 2020
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Santanu Bhattacharya, Debabrata Mukhopadhyay, Krishnendu Pal
  • Publication number: 20190336613
    Abstract: This document relates to materials and methods for administering (e.g., topically administering) one or more vascular endothelial growth factor (VEGF) inhibitors to reduce and/or treat ultraviolet (UV)-induced skin injury. For example, compositions including one or more VEGF inhibitors that can be administered (e.g., topically administered) to a mammal to reduce and/or treat UV-induced skin injury following UV exposure are provided.
    Type: Application
    Filed: September 21, 2017
    Publication date: November 7, 2019
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Stephen C. Ekker, Debabrata Mukhopadhyay, Priyabrata Mukherjee, Victoria M. Bedell, Luke H. Hoeppner, Stella P. Hartono
  • Publication number: 20190211027
    Abstract: The present invention relates to nimbolide analogs useful as anti-cancer agents and preparation thereof. Particularly the present invention relates to nimbolide analogs of general formula I. wherein, ring M is any ring selected from the group consisting of substituted or unsubstituted aryl, heteroaryl, cycloalkyl and heterocyclic; A and B are selected from the group consisting of C, O, N, S and H; R1, R2, R3, R4, R5 and R6 are selected from the group consisting of C1-C6 alkyl, aryl, heteroaryl, C1-C7 cycloalkyl, heteroalkyl, hydrogen, hydroxy, alkoxy, nitro, halogen, amino, alkylamino, aryl amino and cyano; wherein each of these groups may be further substituted with one or more substituents selected from the group consisting of hydrogen, hydroxy, halogen, cyano, alkyl amino, aryl amino, alkoxy, amino, nitro, aldehyde, carboxylic acid and ester.
    Type: Application
    Filed: October 26, 2018
    Publication date: July 11, 2019
    Applicant: Council of Scientific & Industrial Research
    Inventors: Srivari Chandrasekhar, Prathama Satyendra Mainkar, Karre Nagaraju, Togapur Pavan Kumar, Ummanni Ramesh, Kanchanapally Tejaswini, Jerald Mahesh Kumar, Katragadda Suresh Babu, Boggavarapu Subrahmanya Sastry, Debabrata Mukhopadhyay
  • Publication number: 20190022803
    Abstract: A method for repairing a component is disclosed. The method includes removing a portion originally including a plurality of cooling holes, of the component to form a cavity, forming by additive manufacturing a replacement portion including a plurality of cooling holes, and varying a surface roughness and a diameter of at least one cooling hole of the plurality of cooling holes during the forming by additive manufacturing the replacement portion. The replacement portion replaces the portion of the component.
    Type: Application
    Filed: July 23, 2018
    Publication date: January 24, 2019
    Inventors: Dheepa SRINIVASAN, Joydeep PAL, Debabrata MUKHOPADHYAY
  • Publication number: 20190010821
    Abstract: This disclosure provides systems and methods for controlling gas turbine airfoil clearance using virtual clearance measurement. The disclosure includes a gas turbine system having a stage of airfoils and a casing adjacent the stage of airfoils that define a clearance distance between them. A clearance control mechanism controllably adjusts the clearance distance based upon a clearance control signal. The clearance control signal to the clearance control mechanism is based on a virtual clearance function that generates a clearance value from at least one system measurement of the gas turbine system.
    Type: Application
    Filed: June 6, 2018
    Publication date: January 10, 2019
    Inventors: Debabrata MUKHOPADHYAY, James ADAICKALASAMY, Muralikrishna RANGHARAJHAN
  • Publication number: 20180371999
    Abstract: A cooling system for a turbine engine is provided. The turbine engine includes a compressor, a compressor discharge chamber (CDC), a combustor assembly, and a turbine coupled in a serial flow relationship such that a first portion of air from the CDC is channeled to the combustor assembly. The turbine is coupled to the compressor via a rotor. The cooling system includes an air duct configured to channel a second portion of air from the CDC to a mid-rotor region of the rotor, and a fluid supply system coupled to the air duct at a coupling. The fluid supply system is configured to channel a flow of fluid to the coupling. The coupling is configured to cool the second portion of CDC air via absorption of heat by the fluid from the second portion of CDC air.
    Type: Application
    Filed: May 22, 2018
    Publication date: December 27, 2018
    Inventors: Rajesh MAVURI, Debabrata MUKHOPADHYAY
  • Publication number: 20180333432
    Abstract: This document provides methods and materials involved in treating cancer. For example, methods and materials involved in making and using particles (e.g., gold nanoparticles) containing a KTLLPTPYC amino acid sequence (SEQ ID NO:1) or a KTLLPTPYCC amino acid sequence (SEQ ID NO:2) to treat cancer (e.g., pancreatic cancer) are provided.
    Type: Application
    Filed: May 16, 2018
    Publication date: November 22, 2018
    Inventors: Santanu Bhattacharya, Debabrata Mukhopadhyay, Krishnendu Pal
  • Patent number: 10119471
    Abstract: A turbine engine assembly is provided. The assembly includes a compressor, and an air duct coupled in flow communication with the compressor. The air duct is configured to channel a flow of bleed air from the compressor therethrough. The assembly also includes a fluid supply system coupled in flow communication with the air duct, wherein the fluid supply system is configured to channel a flow of fluid towards the air duct to modify a temperature of the bleed air based on an operating condition of the turbine engine assembly.
    Type: Grant
    Filed: October 9, 2015
    Date of Patent: November 6, 2018
    Assignee: General Electric Company
    Inventors: Debabrata Mukhopadhyay, Pugalenthi Nandagopal, James Adaickalasamy
  • Publication number: 20180202360
    Abstract: A gas turbine casing with an internal heat exchange system. The gas turbine extends between an inlet section and an exhaust section and defines a downstream direction from the inlet section to the exhaust section. The casing includes a forward end, an aft end downstream of the forward end, a first exterior surface facing radially outward, a second exterior surface facing radially inward, and an internal body at least partially defined between the first exterior surface and the second exterior surface. The heat exchange system includes an inlet and an outlet formed in an exterior surface of the casing proximate the aft end, a supply bore extending upstream from the inlet through the interior body of the casing, and a return bore extending downstream to the outlet through the interior body of the casing.
    Type: Application
    Filed: January 18, 2017
    Publication date: July 19, 2018
    Inventors: Debabrata Mukhopadhyay, Sanjeev Kumar Jain, Sendilkumaran Soundiramourty, Rajesh Mavuri, Jagdish Prasad Tyagi
  • Publication number: 20180149085
    Abstract: This application provides exhaust frame cooling systems for use with gas turbine engines. Example systems may include an exhaust system for use with a gas turbine engine. The exhaust system may include a strut positioned between an inner barrel and an outer barrel. The strut may include an inner body and an outer body. The exhaust system may include at least one strut hole formed in the inner body, where the at least one strut hole forms a first cooling path for cooling flow in a first direction, a cavity between the inner body and the outer body, where the cavity forms a second cooling path for the cooling flow in a second direction, and a purge outlet to purge the cooling flow at the inner barrel.
    Type: Application
    Filed: November 28, 2016
    Publication date: May 31, 2018
    Inventors: Veerraju Chennoju, Debabrata Mukhopadhyay, Rohit Pruthi
  • Publication number: 20180027190
    Abstract: A system and method for thermal inspection of a component having at least one cooling hole is disclosed, that uses an evaporative membrane for direct evaporative cooling of an exhausted working fluid. A working fluid is supplied to at least one internal passage of a component that is configured to exhaust the working fluid from the internal passage sequentially through the cooling holes and the wetted evaporative membrane disposed in direct air-tight contact with the component. An imager captures a time series of images corresponding to a transient evaporative response of the exhausted working fluid to determine a plurality of temperature values for the exhausted working fluid after passage through the evaporative membrane. A processor circuit is configured to evaluate the transient evaporative response of the exhausted working fluid.
    Type: Application
    Filed: July 21, 2016
    Publication date: January 25, 2018
    Inventors: Dheepa Srinivasan, Joel John Bosco, Debabrata Mukhopadhyay, Paul Stephen DiMascio
  • Patent number: 9861653
    Abstract: The present invention provides an anti-cancer lipid-based composition that kills very aggressive pancreatic cancer cells and breast cancer stem cell (CSC)-like cells. This composition is a concoction of an anti-cancer agent, ESC8 and a glucocorticoid receptor (GR)-targeting cationic lipid delivery system, DX which is further complexed with plasmid DNA. This composition shows anti-cancer effect and initiates killing of cancer cells and CSC-like cells within 3 h. When anti-cancer gene encoded plasmid is used, residual cancer cells were also significantly eradicated after 2 days of exposure. The formulation-free naked ESC8 requires at least ten-fold more concentration and 3 days of continuous treatment to get a similar level of killing. The composition could also inhibit the tumor growth in mice orthotopically implanted with very aggressive mouse breast cancer cell, ANV-1. This cell is known to produce breast CSC-like cells that show phenotype of advanced cancer relapsing.
    Type: Grant
    Filed: September 12, 2013
    Date of Patent: January 9, 2018
    Assignee: Council of Scientific and Industrial Research
    Inventors: Rajkumar Banerjee, Debabrata Mukhopadhyay
  • Publication number: 20170267719
    Abstract: The present invention discloses a Plectin-1 receptor targeting novel cationic KTLLPTPK-lipopeptide. The present invention further discloses a liposomal formulation comprising the cationic KTLLPTPK-lipopeptide, at least two co-lipids, therapeutic agents and a pharmaceutically acceptable carrier. The present invention also provides a method for regressing established pancreatic tumors comprising administering therapeutically effective amount of the liposomal formulation with the therapeutic agents in combination with targeted genetic immunization (DNA vaccination) i.e. by immunizing mice with electrostatic complexes (direct in-vivo DC-targeting cationic liposomes) of DNA vaccines encoding mesothelin (p-CMV-MSLN).
    Type: Application
    Filed: March 16, 2017
    Publication date: September 21, 2017
    Inventors: Vijay Sagar Madamsetty, Arabinda Chaudhuri, Debabrata Mukhopadhyay