Abstract: The present invention relates to nimbolide analogs useful as anti-cancer agents and preparation thereof. Particularly the present invention relates to nimbolide analogs of general formula I. wherein, ring M is any ring selected from the group consisting of substituted or unsubstituted aryl, heteroaryl, cycloalkyl and heterocyclic; A and B are selected from the group consisting of C, O, N, S and H; R1, R2, R3, R4, R5 and R6 are selected from the group consisting of C1-C6 alkyl, aryl, heteroaryl, C1-C7 cycloalkyl, heteroalkyl, hydrogen, hydroxy, alkoxy, nitro, halogen, amino, alkylamino, aryl amino and cyano; wherein each of these groups may be further substituted with one or more substituents selected from the group consisting of hydrogen, hydroxy, halogen, cyano, alkyl amino, aryl amino, alkoxy, amino, nitro, aldehyde, carboxylic acid and ester.

Abstract: The present application provides liposomal compositions containing anti-cancer agents and tumor-targeting lipopeptides. The present application also provides nanodiamond complexes and particles as carriers for anti-cancer agents.

Abstract: This document relates to materials and methods for administering (e.g., topically administering) one or more vascular endothelial growth factor (VEGF) inhibitors to reduce and/or treat ultraviolet (UV)-induced skin injury. For example, compositions including one or more VEGF inhibitors that can be administered (e.g., topically administered) to a mammal to reduce and/or treat UV-induced skin injury following UV exposure are provided.

Abstract: The present invention relates to nimbolide analogs useful as anti-cancer agents and preparation thereof. Particularly the present invention relates to nimbolide analogs of general formula I. wherein, ring M is any ring selected from the group consisting of substituted or unsubstituted aryl, heteroaryl, cycloalkyl and heterocyclic; A and B are selected from the group consisting of C, O, N, S and H; R1, R2, R3, R4, R5 and R6 are selected from the group consisting of C1-C6 alkyl, aryl, heteroaryl, C1-C7 cycloalkyl, heteroalkyl, hydrogen, hydroxy, alkoxy, nitro, halogen, amino, alkylamino, aryl amino and cyano; wherein each of these groups may be further substituted with one or more substituents selected from the group consisting of hydrogen, hydroxy, halogen, cyano, alkyl amino, aryl amino, alkoxy, amino, nitro, aldehyde, carboxylic acid and ester.

Abstract: The present invention relates to nimbolide analogs useful as anti-cancer agents and preparation thereof. Particularly the present invention relates to nimbolide analogs of general formula I. wherein, ring M is any ring selected from the group consisting of substituted or unsubstituted aryl, heteroaryl, cycloalkyl and heterocyclic; A and B are selected from the group consisting of C, O, N, S and H; R1, R2, R3, R4, R5 and R6 are selected from the group consisting of C1-C6 alkyl, aryl, heteroaryl, C1-C7 cycloalkyl, heteroalkyl, hydrogen, hydroxy, alkoxy, nitro, halogen, amino, alkylamino, aryl amino and cyano; wherein each of these groups may be further substituted with one or more substituents selected from the group consisting of hydrogen, hydroxy, halogen, cyano, alkyl amino, aryl amino, alkoxy, amino, nitro, aldehyde, carboxylic acid and ester.

Abstract: A method for repairing a component is disclosed. The method includes removing a portion originally including a plurality of cooling holes, of the component to form a cavity, forming by additive manufacturing a replacement portion including a plurality of cooling holes, and varying a surface roughness and a diameter of at least one cooling hole of the plurality of cooling holes during the forming by additive manufacturing the replacement portion. The replacement portion replaces the portion of the component.

Abstract: A cooling system for a turbine engine is provided. The turbine engine includes a compressor, a compressor discharge chamber (CDC), a combustor assembly, and a turbine coupled in a serial flow relationship such that a first portion of air from the CDC is channeled to the combustor assembly. The turbine is coupled to the compressor via a rotor. The cooling system includes an air duct configured to channel a second portion of air from the CDC to a mid-rotor region of the rotor, and a fluid supply system coupled to the air duct at a coupling. The fluid supply system is configured to channel a flow of fluid to the coupling. The coupling is configured to cool the second portion of CDC air via absorption of heat by the fluid from the second portion of CDC air.

Abstract: A gas turbine casing with an internal heat exchange system. The gas turbine extends between an inlet section and an exhaust section and defines a downstream direction from the inlet section to the exhaust section. The casing includes a forward end, an aft end downstream of the forward end, a first exterior surface facing radially outward, a second exterior surface facing radially inward, and an internal body at least partially defined between the first exterior surface and the second exterior surface. The heat exchange system includes an inlet and an outlet formed in an exterior surface of the casing proximate the aft end, a supply bore extending upstream from the inlet through the interior body of the casing, and a return bore extending downstream to the outlet through the interior body of the casing.

Abstract: The present invention discloses a Plectin-1 receptor targeting novel cationic KTLLPTPK(SEQ ID NO: 1)-lipopeptide. The present invention further discloses a liposomal formulation comprising the cationic KTLLPTPK(SEQ ID NO: 1)-lipopeptide, at least two co-lipids, a therapeutic agent, and a pharmaceutically acceptable carrier. The present invention also provides a method for regressing established pancreatic tumors comprising administering a therapeutically effective amount of the liposomal formulation with the therapeutic agents in combination with targeted genetic immunization (DNA vaccination) i.e. by immunizing mice with electrostatic complexes (direct in-vivo DC-targeting cationic liposomes) of DNA vaccines encoding mesothelin (p-CMV-MSLN).

Abstract: This document provides methods and materials involved in treating cancer. For example, methods and materials involved in making and using particles (e.g., gold nanoparticles) containing a KTLLPTPYC amino acid sequence (SEQ ID NO:1) or a KTLLPTPYCC amino acid sequence (SEQ ID NO:2) to treat cancer (e.g., pancreatic cancer) are provided.

Abstract: This document relates to materials and methods for administering (e.g., topically administering) one or more vascular endothelial growth factor (VEGF) inhibitors to reduce and/or treat ultraviolet (UV)-induced skin injury. For example, compositions including one or more VEGF inhibitors that can be administered (e.g., topically administered) to a mammal to reduce and/or treat UV-induced skin injury following UV exposure are provided.

Abstract: The present invention relates to nimbolide analogs useful as anti-cancer agents and preparation thereof. Particularly the present invention relates to nimbolide analogs of general formula I. wherein, ring M is any ring selected from the group consisting of substituted or unsubstituted aryl, heteroaryl, cycloalkyl and heterocyclic; A and B are selected from the group consisting of C, O, N, S and H; R1, R2, R3, R4, R5 and R6 are selected from the group consisting of C1-C6 alkyl, aryl, heteroaryl, C1-C7 cycloalkyl, heteroalkyl, hydrogen, hydroxy, alkoxy, nitro, halogen, amino, alkylamino, aryl amino and cyano; wherein each of these groups may be further substituted with one or more substituents selected from the group consisting of hydrogen, hydroxy, halogen, cyano, alkyl amino, aryl amino, alkoxy, amino, nitro, aldehyde, carboxylic acid and ester.

Abstract: A method for repairing a component is disclosed. The method includes removing a portion originally including a plurality of cooling holes, of the component to form a cavity, forming by additive manufacturing a replacement portion including a plurality of cooling holes, and varying a surface roughness and a diameter of at least one cooling hole of the plurality of cooling holes during the forming by additive manufacturing the replacement portion. The replacement portion replaces the portion of the component.

Abstract: This disclosure provides systems and methods for controlling gas turbine airfoil clearance using virtual clearance measurement. The disclosure includes a gas turbine system having a stage of airfoils and a casing adjacent the stage of airfoils that define a clearance distance between them. A clearance control mechanism controllably adjusts the clearance distance based upon a clearance control signal. The clearance control signal to the clearance control mechanism is based on a virtual clearance function that generates a clearance value from at least one system measurement of the gas turbine system.

Abstract: A cooling system for a turbine engine is provided. The turbine engine includes a compressor, a compressor discharge chamber (CDC), a combustor assembly, and a turbine coupled in a serial flow relationship such that a first portion of air from the CDC is channeled to the combustor assembly. The turbine is coupled to the compressor via a rotor. The cooling system includes an air duct configured to channel a second portion of air from the CDC to a mid-rotor region of the rotor, and a fluid supply system coupled to the air duct at a coupling. The fluid supply system is configured to channel a flow of fluid to the coupling. The coupling is configured to cool the second portion of CDC air via absorption of heat by the fluid from the second portion of CDC air.

Abstract: This document provides methods and materials involved in treating cancer. For example, methods and materials involved in making and using particles (e.g., gold nanoparticles) containing a KTLLPTPYC amino acid sequence (SEQ ID NO:1) or a KTLLPTPYCC amino acid sequence (SEQ ID NO:2) to treat cancer (e.g., pancreatic cancer) are provided.

Abstract: A turbine engine assembly is provided. The assembly includes a compressor, and an air duct coupled in flow communication with the compressor. The air duct is configured to channel a flow of bleed air from the compressor therethrough. The assembly also includes a fluid supply system coupled in flow communication with the air duct, wherein the fluid supply system is configured to channel a flow of fluid towards the air duct to modify a temperature of the bleed air based on an operating condition of the turbine engine assembly.

Abstract: A gas turbine casing with an internal heat exchange system. The gas turbine extends between an inlet section and an exhaust section and defines a downstream direction from the inlet section to the exhaust section. The casing includes a forward end, an aft end downstream of the forward end, a first exterior surface facing radially outward, a second exterior surface facing radially inward, and an internal body at least partially defined between the first exterior surface and the second exterior surface. The heat exchange system includes an inlet and an outlet formed in an exterior surface of the casing proximate the aft end, a supply bore extending upstream from the inlet through the interior body of the casing, and a return bore extending downstream to the outlet through the interior body of the casing.

Abstract: This application provides exhaust frame cooling systems for use with gas turbine engines. Example systems may include an exhaust system for use with a gas turbine engine. The exhaust system may include a strut positioned between an inner barrel and an outer barrel. The strut may include an inner body and an outer body. The exhaust system may include at least one strut hole formed in the inner body, where the at least one strut hole forms a first cooling path for cooling flow in a first direction, a cavity between the inner body and the outer body, where the cavity forms a second cooling path for the cooling flow in a second direction, and a purge outlet to purge the cooling flow at the inner barrel.

Abstract: A system and method for thermal inspection of a component having at least one cooling hole is disclosed, that uses an evaporative membrane for direct evaporative cooling of an exhausted working fluid. A working fluid is supplied to at least one internal passage of a component that is configured to exhaust the working fluid from the internal passage sequentially through the cooling holes and the wetted evaporative membrane disposed in direct air-tight contact with the component. An imager captures a time series of images corresponding to a transient evaporative response of the exhausted working fluid to determine a plurality of temperature values for the exhausted working fluid after passage through the evaporative membrane. A processor circuit is configured to evaluate the transient evaporative response of the exhausted working fluid.