Abstract: The present invention provides an anti-cancer lipid-based composition that kills very aggressive pancreatic cancer cells and breast cancer stem cell (CSC)-like cells. This composition is a concoction of an anti-cancer agent, ESC8 and a glucocorticoid receptor (GR)-targeting cationic lipid delivery system, DX which is further complexed with plasmid DNA. This composition shows anti-cancer effect and initiates killing of cancer cells and CSC-like cells within 3 h. When anti-cancer gene encoded plasmid is used, residual cancer cells were also significantly eradicated after 2 days of exposure. The formulation-free naked ESC8 requires at least ten-fold more concentration and 3 days of continuous treatment to get a similar level of killing. The composition could also inhibit the tumor growth in mice orthotopically implanted with very aggressive mouse breast cancer cell, ANV-1. This cell is known to produce breast CSC-like cells that show phenotype of advanced cancer relapsing.

Abstract: The present invention discloses a Plectin-1 receptor targeting novel cationic KTLLPTPK-lipopeptide. The present invention further discloses a liposomal formulation comprising the cationic KTLLPTPK-lipopeptide, at least two co-lipids, therapeutic agents and a pharmaceutically acceptable carrier. The present invention also provides a method for regressing established pancreatic tumors comprising administering therapeutically effective amount of the liposomal formulation with the therapeutic agents in combination with targeted genetic immunization (DNA vaccination) i.e. by immunizing mice with electrostatic complexes (direct in-vivo DC-targeting cationic liposomes) of DNA vaccines encoding mesothelin (p-CMV-MSLN).

Abstract: The present application provides a gas turbine engine intended to be used in part in hot ambient conditions. The gas turbine engine may include a compressor, a turbine with a wheel space adjacent to a number of rotor wheels, and a wheel space water cooling system in communication with the wheel space to provide a flow of water thereto.

Abstract: A turbine engine assembly is provided. The assembly includes a compressor, and an air duct coupled in flow communication with the compressor. The air duct is configured to channel a flow of bleed air from the compressor therethrough. The assembly also includes a fluid supply system coupled in flow communication with the air duct, wherein the fluid supply system is configured to channel a flow of fluid towards the air duct to modify a temperature of the bleed air based on an operating condition of the turbine engine assembly.

Abstract: A system is provided including a turbine exhaust section. The turbine exhaust section includes an exhaust flow path. The turbine exhaust section also includes an outer structure having an outer casing and an outer exhaust wall disposed along the exhaust flow path. An inner structure of the turbine exhaust section includes an inner exhaust wall disposed along the exhaust flow path. A strut extends between the outer structure and the inner structure, and the strut is configured to convey a flow of fluid from the inner structure toward the outer structure. The strut includes a plurality of cooling fins to facilitate heat transfer from the strut to the flow of fluid.

Abstract: A seal arrangement between radially-opposed rotating and stationary components in a turbomachine includes a first rotating component, a second stationary component, and a brush seal located radially therebetween. The brush seal has an axially-extending portion secured to the second stationary component, and an inwardly-extending portion extending across a gap between the first and second components. An inner ring portion of the second stationary component is located radially inward of, and in engagement with the axially-extending portion and at least part of the inwardly-extending portion of the brush seal, wherein an end of the axially-extending portion of the brush seal remote from the inwardly-extending portion is sandwiched between a pair of side rails fixed between the inner ring portion and an outer ring portion of the second stationary component.

Abstract: Various embodiments include a steam turbine nozzle and turbomachinery including such a nozzle. In various particular embodiments, a steam turbine nozzle includes: a body having: a first sidewall and a second sidewall opposite the first sidewall; a pressure side and a suction side each extending between the first sidewall and the second sidewall; and a leading edge section at a first junction of the pressure side and the suction side, and a trailing edge section at a second junction of the pressure side and the suction side; and a bypass fluid conduit including: a channel having an opening to at least one of the first sidewall or the second sidewall; and an outlet passageway fluidly connected with the channel between the first sidewall and the second sidewall, the outlet passageway including a first opening on at least one of the pressure side of the body, the suction side of the body or the trailing edge section.

Abstract: A brush seal for a turbine including an annular layer of filaments having a generally L-shape including an axial portion of the filaments and a radial portion of filaments, wherein a first end of the filaments is at an end of the radial portion and faces a rotating component of the turbine and a second end region of the filaments is at an end of the axial portion of the filaments and is fastened to a stationary component of the turbine.

Abstract: The disclosure includes a sealing assembly for a turbine system. In one embodiment, the sealing assembly is for a turbine having a rotor blade and a stator nozzle. The sealing assembly includes a pair of oppositely facing seal teeth including concave surfaces. The pair of oppositely facing seal teeth are positioned on one of the rotor blade and the stator nozzle, and are for sealingly engaging the other of the rotor blade and the stator nozzle during operation of the turbine.

Abstract: A power plant is provided and includes components for generating power from fluids at high and intermediate pressures, a pathway defined between the components along which a heated fluid flows to the one of the components for generating power from fluids at intermediate pressures and a circuit fluidly coupled to the pathway to cool a portion of the heated fluid prior to the portion of the heated fluid reaching the one of the components for generating power from fluids at intermediate pressures.

Abstract: A brush seal for a turbine including an annular layer of filaments having a generally L-shape including an axial portion of the filaments and a radial portion of filaments, wherein a first end of the filaments is at an end of the radial portion and faces a rotating component of the turbine and a second end region of the filaments is at an end of the axial portion of the filaments and is fastened to a stationary component of the turbine.

Abstract: Provided herein are peptides and nanoparticles conjugates thereof useful for the treatment of diseases and disorders mediated by GIPC/synectin, such as cancer.

Abstract: The present invention provides an anti-cancer lipid-based composition that kills very aggressive pancreatic cancer cells and breast cancer stem cell (CSC)-like cells. This composition is a concoction of an anti-cancer agent, ESC8 and a glucocorticoid receptor (GR)-targeting cationic lipid delivery system, DX which is further complexed with plasmid DNA. This composition shows anti-cancer effect and initiates killing of cancer cells and CSC-like cells within 3 h. When anti-cancer gene encoded plasmid is used, residual cancer cells were also significantly eradicated after 2 days of exposure. The formulation-free naked ESC8 requires at least ten-fold more concentration and 3 days of continuous treatment to get a similar level of killing. The composition could also inhibit the tumor growth in mice orthotopically implanted with very aggressive mouse breast cancer cell, ANV-1. This cell is known to produce breast CSC-like cells that show phenotype of advanced cancer relapsing.

Abstract: A seal arrangement between radially-opposed rotating and stationary components in a turbomachine includes a first rotating component, a second stationary component, and a brush seal located radially therebetween. The brush seal has an axially-extending portion secured to the second stationary component, and an inwardly-extending portion extending across a gap between the first and second components. An inner ring portion of the second stationary component is located radially inward of, and in engagement with the axially-extending portion and at least part of the inwardly-extending portion of the brush seal, wherein an end of the axially-extending portion of the brush seal remote from the inwardly-extending portion is sandwiched between a pair of side rails fixed between the inner ring portion and an outer ring portion of the second stationary component.

Abstract: The present application provides a steam turbine system. The steam turbine system may include a high pressure section, an intermediate pressure section, a shaft packing location positioned between the high pressure section and the intermediate pressure section, a source of steam, and a cooling system. The cooling system delivers a cooling steam extraction from the source of steam to the shaft packing location so as to cool the high pressure section and the intermediate pressure section.

Abstract: The present application provides a section cooling system for a steam turbine to limit a leakage flow therethrough. The section cooling system may include a first pressure flow extraction from a first section to a shaft packing location between the first section and a second section and a rotor aperture extending towards the first section. The first pressure flow extraction diverts the leakage flow from the first section into the rotor aperture so as to limit the leakage flow to the second section.

Abstract: Provided herein are peptides and nanoparticles conjugates thereof useful for the treatment of diseases and disorders mediated by GIPC/synectin, such as cancer.

Abstract: The disclosure includes a sealing assembly for a turbine system. In one embodiment, the sealing assembly is for a turbine having a rotor blade and a stator nozzle. The sealing assembly includes a pair of oppositely facing seal teeth including concave surfaces. The pair of oppositely facing seal teeth are positioned on one of the rotor blade and the stator nozzle, and are for sealingly engaging the other of the rotor blade and the stator nozzle during operation of the turbine.

Abstract: Various embodiments include a steam turbine nozzle and turbomachinery including such a nozzle. In various particular embodiments, a steam turbine nozzle includes: a body having: a first sidewall and a second sidewall opposite the first sidewall; a pressure side and a suction side each extending between the first sidewall and the second sidewall; and a leading edge section at a first junction of the pressure side and the suction side, and a trailing edge section at a second junction of the pressure side and the suction side; and a bypass fluid conduit including: a channel having an opening to at least one of the first sidewall or the second sidewall; and an outlet passageway fluidly connected with the channel between the first sidewall and the second sidewall, the outlet passageway including a first opening on at least one of the pressure side of the body, the suction side of the body or the trailing edge section.

Abstract: Provided herein are peptides and nanoparticles conjugates thereof useful for the treatment of diseases and disorders mediated by GIPC/synectin, such as cancer.