Patents by Inventor Deborah Lynn Greene NGUYEN

Deborah Lynn Greene NGUYEN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of engineered renal tissues in assays
    Patent number: 11982668
    Abstract: Disclosed are methods of assessing the ability of a candidate therapeutic agent to reverse, reduce or prevent renal injury by a potential toxic agent using a three-dimensional, engineered, bioprinted, biological renal tubule model. Also disclosed are methods of assessing the effect of an agent on renal function, the method comprising contacting the agent with a three-dimensional, engineered, bioprinted, biological renal tubule model. Also disclosed are models of renal disorder. In one embodiment, disclosed are models of renal fibrosis, comprising a three-dimensional, engineered, bioprinted, biological renal tubule model. Also disclosed are methods of making the model of renal disorder. In one embodiment disclosed are methods of making the model of renal fibrosis comprising contacting a three-dimensional, engineered, bioprinted, biological renal tubule model with an agent that is capable of inducing interstitial fibrotic tissue formation.
    Type: Grant
    Filed: January 26, 2022
    Date of Patent: May 14, 2024
    Assignee: Organovo, Inc.
    Inventors: Shelby Marie King, Deborah Lynn Greene Nguyen, Sharon C. Presnell
  • Engineered renal tissues, arrays thereof, and methods of making the same
    Patent number: 11867689
    Abstract: Disclosed are renal tissues and arrays thereof that include a layer of renal interstitial tissue, the renal interstitial tissue comprising renal fibroblasts and endothelial cells; and a layer of renal epithelial tissue, the renal epithelial tissue comprising renal tubular epithelial cells, the renal epithelial tissue in contact with the layer of renal interstitial tissue to form a three-dimensional, engineered, biological renal tissue. Also disclosed are methods of fabricating and using the same.
    Type: Grant
    Filed: March 25, 2021
    Date of Patent: January 9, 2024
    Assignee: ORGANOVO, INC.
    Inventors: Deborah Lynn Greene Nguyen, Shelby Marie King, Sharon C. Presnell
  • Engineered three-dimensional breast tissue, adipose tissue, and tumor disease model
    Patent number: 11789011
    Abstract: Described are three-dimensional, engineered, biological breast tissues, adipose tissues, and tumor models, including breast cancer models.
    Type: Grant
    Filed: December 12, 2019
    Date of Patent: October 17, 2023
    Inventors: Shelby Marie King, Deborah Lynn Greene Nguyen, Vivian A. Gorgen, Benjamin R. Shepherd, Sharon C. Presnell, Rosalie Sears, Brittany Allen-Petersen, Ellen Langer
  • Engineered Three-Dimensional Skin Tissues, Arrays Thereof, and Methods of Making the Same
    Publication number: 20230201420
    Abstract: Disclosed are bioprinted, three-dimensional, biological skin tissues comprising: a dermal layer comprising dermal fibroblasts; and an epidermal layer comprising keratinocytes, the epidermal layer in contact with the dermal layer to form the three-dimensional, engineered, biological skin tissue. Also disclosed are arrays of engineered skin tissues and methods of making engineered skin tissues.
    Type: Application
    Filed: December 19, 2022
    Publication date: June 29, 2023
    Inventors: Kelsey Nicole RETTING, Colin M. O'NEILL, Deborah Lynn Greene NGUYEN, Sharon C. PRESNELL, Jessica LANGER, Guive BALOOCH, Elizabeth WU, Julien DEMAUDE
  • Engineered intestinal tissue and uses thereof
    Patent number: 11655456
    Abstract: Disclosed are methods of assessing the ability of a candidate therapeutic agent to reverse, reduce or prevent intestinal injury by a potential toxic agent using a three-dimensional, engineered, bioprinted, biological intestinal tissue model. Also disclosed are methods of assessing the effect of an agent on intestinal function, the method comprising contacting the agent with a three-dimensional, engineered, bioprinted, biological intestinal tissue model.
    Type: Grant
    Filed: November 10, 2017
    Date of Patent: May 23, 2023
    Assignee: Organovo, Inc.
    Inventors: Kelsey Nicole Retting, Deborah Lynn Greene Nguyen, Lauran Madden
  • Engineered three-dimensional skin tissues, arrays thereof, and methods of making the same
    Patent number: 11529436
    Abstract: Disclosed are bioprinted, three-dimensional, biological skin tissues comprising: a dermal layer comprising dermal fibroblasts; and an epidermal layer comprising keratinocytes, the epidermal layer in contact with the dermal layer to form the three-dimensional, engineered, biological skin tissue. Also disclosed are arrays of engineered skin tissues and methods of making engineered skin tissues.
    Type: Grant
    Filed: November 5, 2015
    Date of Patent: December 20, 2022
    Assignees: Organovo, Inc., L'Oreal
    Inventors: Kelsey Nicole Retting, Colin M. O'Neill, Deborah Lynn Greene Nguyen, Sharon C. Presnell, Jessica Langer, Guive Balooch, Elizabeth Wu, Julien Demaude
  • Use of Engineered Renal Tissues in Assays
    Publication number: 20220229045
    Abstract: Disclosed are methods of assessing the ability of a candidate therapeutic agent to reverse, reduce or prevent renal injury by a potential toxic agent using a three-dimensional, engineered, bioprinted, biological renal tubule model. Also disclosed are methods of assessing the effect of an agent on renal function, the method comprising contacting the agent with a three-dimensional, engineered, bioprinted, biological renal tubule model. Also disclosed are models of renal disorder. In one embodiment, disclosed are models of renal fibrosis, comprising a three-dimensional, engineered, bioprinted, biological renal tubule model. Also disclosed are methods of making the model of renal disorder. In one embodiment disclosed are methods of making the model of renal fibrosis comprising contacting a three-dimensional, engineered, bioprinted, biological renal tubule model with an agent that is capable of inducing interstitial fibrotic tissue formation.
    Type: Application
    Filed: January 26, 2022
    Publication date: July 21, 2022
    Applicant: Organovo, Inc.
    Inventors: Shelby Marie KING, Deborah Lynn Greene NGUYEN, Sharon C. PRESNELL
  • Engineered Intestinal Tissue and Uses Thereof
    Publication number: 20220204941
    Abstract: Disclosed are methods of assessing the ability of a candidate therapeutic agent to reverse, reduce or prevent intestinal injury by a potential toxic agent using a three-dimensional, engineered, bioprinted, biological intestinal tissue model. Also disclosed are methods of assessing the effect of an agent on intestinal function, the method comprising contacting the agent with a three-dimensional, engineered, bioprinted, biological intestinal tissue model.
    Type: Application
    Filed: March 15, 2022
    Publication date: June 30, 2022
    Inventors: Kelsey Nicole RETTING, Deborah Lynn Greene NGUYEN, Lauran MADDEN
  • Engineered Intestinal Tissue and Uses Thereof
    Publication number: 20220204942
    Abstract: Disclosed are methods of assessing the ability of a candidate therapeutic agent to reverse, reduce or prevent intestinal injury by a potential toxic agent using a three-dimensional, engineered, bioprinted, biological intestinal tissue model. Also disclosed are methods of assessing the effect of an agent on intestinal function, the method comprising contacting the agent with a three-dimensional, engineered, bioprinted, biological intestinal tissue model.
    Type: Application
    Filed: March 15, 2022
    Publication date: June 30, 2022
    Inventors: Kelsey Nicole RETTING, Deborah Lynn Greene NGUYEN, Lauran MADDEN
  • METHODS FOR TISSUE FABRICATION
    Publication number: 20220195380
    Abstract: Disclosed herein are improved methods for fabricating bioprinted, three-dimensional, biological tissues. The methods relate to exposures to low temperatures, incubations at low temperatures of various durations, and fabrication in environments without structural cross-linking treatments.
    Type: Application
    Filed: October 1, 2021
    Publication date: June 23, 2022
    Inventors: Kelsey Nicole RETTING, Deborah Lynn Greene NGUYEN, Sharon C. PRESNELL, Shelby Marie KING
  • Use of engineered renal tissues in assays
    Patent number: 11268950
    Abstract: Disclosed are methods of assessing the ability of a candidate therapeutic agent to reverse, reduce or prevent renal injury by a potential toxic agent using a three-dimensional, engineered, bioprinted, biological renal tubule model. Also disclosed are methods of assessing the effect of an agent on renal function, the method comprising contacting the agent with a three-dimensional, engineered, bioprinted, biological renal tubule model. Also disclosed are models of renal disorder. In one embodiment, disclosed are models of renal fibrosis, comprising a three-dimensional, engineered, bioprinted, biological renal tubule model. Also disclosed are methods of making the model of renal disorder. In one embodiment disclosed are methods of making the model of renal fibrosis comprising contacting a three-dimensional, engineered, bioprinted, biological renal tubule model with an agent that is capable of inducing interstitial fibrotic tissue formation.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: March 8, 2022
    Assignee: Organovo, Inc.
    Inventors: Shelby Marie King, Deborah Lynn Greene Nguyen, Sharon C. Presnell
  • Engineered Intestinal Tissue and Uses Thereof
    Publication number: 20210284967
    Abstract: Disclosed are methods of assessing the ability of a candidate therapeutic agent to reverse, reduce or prevent intestinal injury by a potential toxic agent using a three-dimensional, engineered, bioprinted, biological intestinal tissue model. Also disclosed are methods of assessing the effect of an agent on intestinal function, the method comprising contacting the agent with a three-dimensional, engineered, bioprinted, biological intestinal tissue model.
    Type: Application
    Filed: November 10, 2017
    Publication date: September 16, 2021
    Inventors: Kelsey Nicole RETTING, Deborah Lynn Greene NGUYEN, Lauran MADDEN
  • Engineered Renal Tissues, Arrays Thereof, and Methods of Making the Same
    Publication number: 20210208132
    Abstract: Disclosed are renal tissues and arrays thereof that include a layer of renal interstitial tissue, the renal interstitial tissue comprising renal fibroblasts and endothelial cells; and a layer of renal epithelial tissue, the renal epithelial tissue comprising renal tubular epithelial cells, the renal epithelial tissue in contact with the layer of renal interstitial tissue to form a three-dimensional, engineered, biological renal tissue. Also disclosed are methods of fabricating and using the same.
    Type: Application
    Filed: March 25, 2021
    Publication date: July 8, 2021
    Inventors: Deborah Lynn Greene NGUYEN, Shelby Marie KING, Sharon C. PRESNELL
  • Engineered renal tissues, arrays thereof, and methods of making the same
    Patent number: 10962526
    Abstract: Disclosed are renal tissues and arrays thereof that include a layer of renal interstitial tissue, the renal interstitial tissue comprising renal fibroblasts and endothelial cells; and a layer of renal epithelial tissue, the renal epithelial tissue comprising renal tubular epithelial cells, the renal epithelial tissue in contact with the layer of renal interstitial tissue to form a three-dimensional, engineered, biological renal tissue. Also disclosed are methods of fabricating and using the same.
    Type: Grant
    Filed: October 8, 2018
    Date of Patent: March 30, 2021
    Assignee: Organovo, Inc.
    Inventors: Deborah Lynn Greene Nguyen, Shelby Marie King, Sharon C. Presnell
  • Engineered Three-Dimensional Breast Tissue, Adipose Tissue, and Tumor Disease Model
    Publication number: 20200116702
    Abstract: Described are three-dimensional, engineered, biological breast tissues, adipose tissues, and tumor models, including breast cancer models.
    Type: Application
    Filed: December 12, 2019
    Publication date: April 16, 2020
    Inventors: Shelby Marie KING, Deborah Lynn Greene NGUYEN, Vivian A. GORGEN, Benjamin R. SHEPHERD, Sharon C. PRESNELL, Rosalie SEARS, Brittany ALLEN-PETERSEN, Ellen LANGER
  • Use of Engineered Liver Tissue Constructs for Modeling Liver Disorders
    Publication number: 20200115682
    Abstract: The invention is directed to three-dimensional, engineered, bioprinted biological tissue constructs exhibiting a liver disorder, methods of making the constructs, and use of the constructs in assays, such as drug testing and molecular diagnostic testing, including methods of assessing the ability of a candidate therapeutic agent to reverse, reduce, or prevent a liver disorder, and methods for biomarker discovery.
    Type: Application
    Filed: April 3, 2018
    Publication date: April 16, 2020
    Inventors: Deborah Lynn GREENE NGUYEN, Dwayne E. CARTER, Rhiannon HARDWICK, Alice Chen WALTERS, Sharon C. PRESNELL, Chirag B. KHATIWALA, Rami NASRALLAH
  • Use of Engineered Renal Tissues in Assays
    Publication number: 20200018747
    Abstract: Disclosed are methods of assessing the ability of a candidate therapeutic agent to reverse, reduce or prevent renal injury by a potential toxic agent using a three-dimensional, engineered, bioprinted, biological renal tubule model. Also disclosed are methods of assessing the effect of an agent on renal function, the method comprising contacting the agent with a three-dimensional, engineered, bioprinted, biological renal tubule model. Also disclosed are models of renal disorder. In one embodiment, disclosed are models of renal fibrosis, comprising a three-dimensional, engineered, bioprinted, biological renal tubule model. Also disclosed are methods of making the model of renal disorder. In one embodiment disclosed are methods of making the model of renal fibrosis comprising contacting a three-dimensional, engineered, bioprinted, biological renal tubule model with an agent that is capable of inducing interstitial fibrotic tissue formation.
    Type: Application
    Filed: September 28, 2017
    Publication date: January 16, 2020
    Applicant: Organovo, Inc.
    Inventors: Shelby Marie KING, Deborah Lynn Greene NGUYEN, Sharon C. PRESNELL
  • Three Dimensional Bioprinted Tumor Models for Drug Testing
    Publication number: 20190309264
    Abstract: Described are three-dimensional, engineered, biological cancer models, methods of producing the same, and methods of identifying a therapeutic agent for cancer in an individual utilizing the three-dimensional, engineered, biological cancer models.
    Type: Application
    Filed: August 15, 2017
    Publication date: October 10, 2019
    Inventors: Sharon C. PRESNELL, Shelby Marie KING, Deborah Lynn Greene NGUYEN, Minji JO, Rosalie Sears PELZ, Brittany ALLEN-PETERSEN, Ellen LANGER
  • Engineered Renal Tissues, Arrays Thereof, and Methods of Making the Same
    Publication number: 20190041381
    Abstract: Disclosed are renal tissues and arrays thereof that include a layer of renal interstitial tissue, the renal interstitial tissue comprising renal fibroblasts and endothelial cells; and a layer of renal epithelial tissue, the renal epithelial tissue comprising renal tubular epithelial cells, the renal epithelial tissue in contact with the layer of renal interstitial tissue to form a three-dimensional, engineered, biological renal tissue. Also disclosed are methods of fabricating and using the same.
    Type: Application
    Filed: October 8, 2018
    Publication date: February 7, 2019
    Inventors: Deborah Lynn Greene NGUYEN, Shelby Marie KING, Sharon C. PRESNELL
  • Engineered renal tissues, arrays thereof, and methods of making the same
    Patent number: 10094821
    Abstract: Disclosed are renal tissues and arrays thereof that include a layer of renal interstitial tissue, the renal interstitial tissue comprising renal fibroblasts and endothelial cells; and a layer of renal epithelial tissue, the renal epithelial tissue comprising renal tubular epithelial cells, the renal epithelial tissue in contact with the layer of renal interstitial tissue to form a three-dimensional, engineered, biological renal tissue. Also disclosed are methods of fabricating and using the same.
    Type: Grant
    Filed: September 8, 2016
    Date of Patent: October 9, 2018
    Assignee: Organovo, Inc.
    Inventors: Deborah Lynn Greene Nguyen, Shelby Marie King, Sharon C. Presnell