Patents by Inventor Denis Danvy

Denis Danvy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Benzazole derivatives as histamine H4 receptor ligands
    Patent number: 9029357
    Abstract: The present patent application concerns new ligands of the H4-receptor, their process of preparation and their therapeutic use.
    Type: Grant
    Filed: June 27, 2014
    Date of Patent: May 12, 2015
    Assignee: Bioprojet
    Inventors: Isabelle Berrebi-Bertrand, Xavier Billot, Thierry Calmels, Marc Capet, Denis Danvy, Stéphane Krief, Olivier Labeeuw, Jeanne-Marie Lecomte, Nicolas Levoin, Xavier Ligneau, Philippe Robert, Jean-Charles Schwartz
  • Benzazole Derivatives as Histamine H4 Receptor Ligands
    Publication number: 20150004181
    Abstract: The present patent application concerns new ligands of the H4-receptor, their process of preparation and their therapeutic use.
    Type: Application
    Filed: June 27, 2014
    Publication date: January 1, 2015
    Inventors: Isabelle BERREBI-BERTRAND, Xavier BILLOT, Thierry CALMELS, Marc CAPET, Denis DANVY, Stéphane KRIEF, Olivier LABEEUW, Jeanne-Marie LECOMTE, Nicolas LEVOIN, Xavier LIGNEAU, Philippe ROBERT, Jean-Charles SCHWARTZ
  • Carbonylated (aza) cyclohexanes as dopamine Dreceptor ligands
    Patent number: 8802678
    Abstract: The invention relates to compounds of the general formula (I): to the process for preparing them, and to the use thereof as a therapeutic agent.
    Type: Grant
    Filed: June 21, 2007
    Date of Patent: August 12, 2014
    Assignee: Bioprojet
    Inventors: Marc Capet, Denis Danvy, Nicolas Levoin, Isabelle Berrebi-Bertrand, Thierry Calmels, Philippe Robert, Jeanne-Marie Lecomte, Jean-Charles Schwartz, Xavier Ligneau
  • Benzazole derivatives as histamine H4 receptor ligands
    Patent number: 8802664
    Abstract: The present patent application concerns new ligands of the H4-receptor of formula (I), their process of preparation and their therapeutic use.
    Type: Grant
    Filed: September 27, 2011
    Date of Patent: August 12, 2014
    Assignee: Bioproject
    Inventors: Isabelle Berrebi-Bertrand, Xavier Billot, Thierry Calmels, Marc Capet, Denis Danvy, Stephane Krief, Olivier Labeeuw, Jeanne-Marie Lecomte, Nicolas Levoin, Xavier Ligneau, Philippe Robert, Jean-Charles Schwartz
  • Benzazole Derivatives as Histamine H4 Receptor Ligands
    Publication number: 20130231329
    Abstract: The present patent application concerns new ligands of the H4-receptor of formula (I), their process of preparation and their therapeutic use.
    Type: Application
    Filed: September 27, 2011
    Publication date: September 5, 2013
    Applicant: BIOPROJET
    Inventors: Isabelle Berrebi-Bertrand, Xavier Billot, Thierry Calmels, Marc Capet, Denis Danvy, Stéphane Krief, Olivier Labeeuw, Jeanne-Marie Lecomte, Nicolas Levoin, Xavier Ligneau, Philippe Robert, Jean-Charles Schwartz
  • CARBONYLATED (AZA) CYCLOHEXANES AS DOPAMINE D3 RECEPTOR LIGANDS
    Publication number: 20090286801
    Abstract: The invention relates to compounds of the general formula (I): to the process for preparing them, and to the use thereof as a therapeutic agent.
    Type: Application
    Filed: June 21, 2007
    Publication date: November 19, 2009
    Inventors: Marc Capet, Denis Danvy, Nicolas Levoin, Isabelle Berrebi-Bertrand, Thierry Calmels, Philippe Robert, Jeanne-Marie Lecomte, Jean-Charles Schwartz, Xavier Ligneau
  • Arylpiperaszine derivatives, to the process for the production thereof and to the use thereof as therapeutic agents
    Patent number: 7432269
    Abstract: The invention relates to compounds of the general formula (I): to the process for preparing them, and to the use thereof as a therapeutic agent having the property of being selective ligands for the dopamine D3 receptor. These selective D3 ligands are useful as medicines in neuropsychiatry, in particular in the treatment of psychotic or depressive states, or in the treatment of motor disorders, such as dyskinesia or essential tremor. They are furthermore useful in the treatment of dependency on nicotine, cocaine, alcohol, opioids and for facilitating withdrawal in drug-dependent individuals.
    Type: Grant
    Filed: October 19, 2005
    Date of Patent: October 7, 2008
    Assignee: Bioprojet
    Inventors: Marc Capet, Denis Danvy, Nicolas Levoin, Marcel Morvan, Isabelle Berrebi-Bertrand, Thierry Calmels, Philippe Robert, Jean-Charles Schwartz, Jeanne-Marie Lecomte
  • Arylpiperazine Derivatives and their Use as Selective Dopamine D3 Receptor Ligands
    Publication number: 20080214542
    Abstract: The invention concerns compounds of general formula (I), a method for preparing same, as well as their use as therapeutic agent.
    Type: Application
    Filed: November 29, 2005
    Publication date: September 4, 2008
    Applicant: BIOPROJET
    Inventors: Marc Capet, Denis Danvy, Catherine Dartois, Nicolas Levoin, Marcel Morvan, Isabelle Berrebi-Bertrand, Thierry Calmels, Philippe Robert, Jean-Charles Schwartz, Jeanne-Marie Lecomte
  • NOVEL ARYLPIPERAZINE DERIVATIVES
    Publication number: 20080167320
    Abstract: Compounds of the general formula (I) below: are provided along with a process for preparing them, and these compounds may be used as therapeutic agents, e.g., for prevention and/or treatment of a neuropsychiatric illness or any illness involving the dopamine D3 receptor.
    Type: Application
    Filed: March 7, 2008
    Publication date: July 10, 2008
    Inventors: Marc Capet, Denis Danvy, Nicolas Levoin, Marcel Morvan, Isabelle Berrebi-Bertrand, Thierry Calmels, Philippe Robert, Jean-Charles Schwartz, Jeanne-Marie Lecomte
  • LTAhydrolase inhibitors
    Patent number: 7094773
    Abstract: The invention relates to compounds which constitute a class of medicaments which have an anti-inflammatory activity and which act by inhibiting leukotriene A4 (LTA4), and enzyme which is responsible for the biosynthesis of leukotriene LTB4, a major proinflammatory mediator. The invention also relates to therapeutic anti-inflammatory, applications of these compounds as well as for methods of preparing these compounds.
    Type: Grant
    Filed: July 28, 2004
    Date of Patent: August 22, 2006
    Assignee: Institut National de la Santa et de la rescherche Medicale Bioprojet
    Inventors: Denis Danvy, Thierry Monteil, Jean-Christophe Plaquevent, Pierre Duhamel, Lucette Duhamel, Nadine Noel, Claude Gros, Olivier Chamard, Jean-Charles Schwartz, Jeanne-Marie Lecomte, Serge Piettre
  • Arylpiperaszine derivatives, to the process for the production thereof and to the use thereof as therapeutic agents
    Publication number: 20060089364
    Abstract: The invention relates to compounds of the general formula (I): to the process for preparing them, and to the use thereof as a therapeutic agent.
    Type: Application
    Filed: October 19, 2005
    Publication date: April 27, 2006
    Inventors: Marc Capet, Denis Danvy, Nicolas Levoin, Marcel Morvan, Isabelle Berrebi-Bertrand, Thierry Calmels, Philippe Robert, Jean-Charles Schwartz, Jeanne-Marie Lecomte
  • LTA4 hydrolase inhibitors
    Patent number: 6878723
    Abstract: The invention concerns compounds inhibiting LTA4 hydrolase of formula (I). The invention also concerns their therapeutic, in particular anti-inflammatory, applications.
    Type: Grant
    Filed: April 6, 2000
    Date of Patent: April 12, 2005
    Assignees: Institut National de la Sante et de la rescherche Medicale (INSERM), Bioprojet
    Inventors: Denis Danvy, Thierry Monteil, Jean-Christophe Plaquevent, Pierre Duhamel, Lucette Duhamel, Nadine Noel, Claude Gros, Olivier Chamard, Jean-Charles Schwartz, Jeanne-Marie Lecomte, Serge Piettre
  • LTA4 hydrolase inhibitors
    Publication number: 20050027013
    Abstract: The invention relates to compounds which constitute a class of medicaments which have an anti-inflammatory activity and which act by inhibiting leukotriene A4 (LTA4), and enzyme which is responsible for the biosynthesis of leukotriene LTB4, a major proinflammatory mediator. The invention also relates to therapeutic anti-inflammatory, applications of these compounds as well as for methods of preparing these compounds.
    Type: Application
    Filed: October 19, 2004
    Publication date: February 3, 2005
    Inventors: Denis Danvy, Thierry Monteil, Jean-Christophe Plaquevent, Pierre Duhamel, Lucette Duhamel, Nadine Noel, Claude Gros, Olivier Chamard, Jean-Charles Schwartz, Jeanne-Marie Lecomte, Serge Piettre
  • Process for synthesizing N-(mercaptoacyl) amino acid derivatives from alpha-substituted acrylic acids
    Patent number: 6835851
    Abstract: The instant invention relates to a process for preparing a compound of formula (I): said process comprising a step (B) which consists in performing a Michael addition of a thioacid RS4H on to an &agr;-substituted acrylamide derivative.
    Type: Grant
    Filed: November 9, 2001
    Date of Patent: December 28, 2004
    Assignee: Bioprojet
    Inventors: Thierry Monteil, Denis Danvy, Jean-Christophe Plaquevent, Pierre Duhamel, Lucette Duhamel, Jeanne-Marie Lecomte, Jean-Charles Schwartz, Serge Piettre
  • Polymorphic forms of fasidotril, their methods of preparation and pharmaceutical compositions comprising them
    Patent number: 6767921
    Abstract: The subject of the present invention is the various polymorphic forms I, II, III, IV of benzyl (S,S)-2-(2-acetylsulphanylmethyl-3-benzo[1,3]dioxol-5-ylpropionyl-amino)propionate, hereinafter called Fasidotril, their methods of preparation and novel pharmaceutical compositions containing them.
    Type: Grant
    Filed: March 26, 2003
    Date of Patent: July 27, 2004
    Assignee: Bioproject
    Inventors: Marc Capet, Gérard Coquerel, Denis Danvy, Jeanne-Marie Lecomte, Marie-Noëlle Petit, Jean-Charles Schwartz
  • Polymorphic forms of fasidotril, their methods of preparation and pharmaceutical compositions comprising them
    Publication number: 20030203965
    Abstract: The subject of the present invention is the various polymorphic forms I, II, III, IV of benzyl (S,S)-2-(2-acetylsulphanylmethyl-3-benzo[1,3]dioxol-5-ylpropionyl-amino)propionate, hereinafter called Fasidotril, their methods of preparation and novel pharmaceutical compositions containing them.
    Type: Application
    Filed: March 26, 2003
    Publication date: October 30, 2003
    Inventors: Marc Capet, Gerard Coquerel, Denis Danvy, Jeanne-Marie Lecomte, Marie-Noelle Petit, Jean-Charles Schwartz
  • LTA4 hydrolase inhibitors
    Patent number: 6436973
    Abstract: The invention concerns LTA4 hydrolase inhibiting compositions of formula (1) as set forth below. It also concerns their therapeutic, in particular anti-inflammatory, applications.
    Type: Grant
    Filed: June 11, 2001
    Date of Patent: August 20, 2002
    Assignees: Bioprojet, Institut National de la Sante et de la Recherche Medicale (Inserm)
    Inventors: Denis Danvy, Thierry Monteil, Jean-Christophe Plaquevent, Pierre Duhamel, Lucette Duhamel, Nadine Noel, Claude Gros, Olivier Chamard, Jean-Charles Schwartz, Jeanne-Marie Lecomte
  • Process for synthesizing N-(mercaptoacyl) amino acid derivatives from alpha-substituted acrylic acids
    Publication number: 20020055645
    Abstract: The instant invention relates to a process for preparing a compound of formula (I): 1
    Type: Application
    Filed: November 9, 2001
    Publication date: May 9, 2002
    Inventors: Thierry Monteil, Denis Danvy, Jean-Christophe Plaquevent, Pierre Duhamel, Lucette Duhamel, Jeanne-Marie Lecomte, Jean-Charles Schwartz, Serge Piettre
  • Process for the asymmetric synthesis of S-acyl derivatives of 2-mercaptomethyl -3- phenyl propanoic acid, application to the synthesis of N-(mercaptoacyl) amino acid derivatives
    Patent number: 6013829
    Abstract: Process for the asymmetric synthesis of S-acyl derivatives of 2-mercaptomethyl-3-phenylpropanoic acid of formula (I): characterized in that it comprises the steps consisting in:a) preparing the diol (VI) by reduction of a malonic ester (V) in the presence of a hydride;b) preparing the monoacetates (VII R) or (VII S) respectively;c) subjecting these monoacetates to an oxidation in order to form the acids (IX S) or (IX R);d) saponifying the compounds (IX S) or (IX R) in order to form the hydroxy acids (X S) or (X R);e) thioacylating the hydroxy acids (X S) or (X R) with a mercapto acid R.sub.1 SH (XI), according to a Mitsunobu-type reaction, in order to lead to the desired acids (I R) (I S) respectively and application to the synthesis of N-(mercaptoacyl)amino acid derivatives (II).
    Type: Grant
    Filed: November 26, 1997
    Date of Patent: January 11, 2000
    Assignee: Societe Civile Bioprojet
    Inventors: Denis Danvy, Thierry Monteil, Pierre Duhamel, Lucette Duhamel, Jeanne-Marie Lecomte, Jean-Charles Schwartz, Nadine Noel-Lefebvre, Claude Gros, Jean-Christophe Plaquevent
  • Process for the synthesis of .alpha.-substituted acrylic acids and their application
    Patent number: 5945548
    Abstract: Process for the synthesis of .alpha.-substituted acrylic acids of general formula (I) and their application to the synthesis of N-(mercaptoacyl)aminoacid derivatives of formula (II).
    Type: Grant
    Filed: May 21, 1998
    Date of Patent: August 31, 1999
    Assignee: Societe Civile Bioproject
    Inventors: Pierre Duhamel, Lucette Duhamel, Denis Danvy, Thierry Monteil, Jeanne-Marie Lecomte, Jean-Charles Schwartz