Patents by Inventor Denis Danvy

Denis Danvy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Amino acids derivatives, the process for their preparation and their applications to therapy
    Patent number: 5846956
    Abstract: Amino acid derivatives of formula (Ia) and (Ib) and pro-drugs thereof containing a group responsible for chelating the zinc atom of enkephalinase and angiotensin convertase enzymes are disclosed as inhibitors of these enzymes.
    Type: Grant
    Filed: July 7, 1997
    Date of Patent: December 8, 1998
    Assignee: Societe Civile Bioprojet
    Inventors: Jean-Christophe Plaquevent, Denis Danvy, Thierry Monteil
  • Process for the synthesis of .alpha.-substituted acrylic acids and their application
    Patent number: 5786494
    Abstract: Process for the synthesis of a-substituted acrylic acids and their application.Process for the synthesis of a-substituted acrylic acids of general formula (I) and their application to the synthesis of N- (mercaptoacyl) aminoacid derivatives of formula (II).
    Type: Grant
    Filed: March 1, 1996
    Date of Patent: July 28, 1998
    Assignee: Societe Civile Bioprojet
    Inventors: Pierre Duhamel, Lucette Duhamel, Denis Danvy, Thierry Monteil, Jeanne-Marie Lecomte, Jean-Charles Schwartz
  • Amino acid derivatives, the process for their preparation and their applications to therapy
    Patent number: 5670531
    Abstract: Amino acid derivatives having both enkephalinase and ACE inhibiting properties corresponding to the formula: ##STR1##
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: September 23, 1997
    Assignee: Societe Civile Bioprojet
    Inventors: Jean-Christophe Plaquevent, Denis Danvy, Thierry Monteil, Helene Greciet, Lucette Duhamel, Pierre Duhamel, Claude Gros, Jean-Charles Schwartz, Jeanne-Marie Lecomte
  • Amino acid derivatives, processes for their preparation and their therapeutic application
    Patent number: 5646313
    Abstract: New amino acid derivatives, processes for their preparation, and their therapeutic application are described.These amino acid derivatives correspond to the general formulae ##STR1## These derivatives may be used as medicaments which exhibit an enkephalinase-inhibitory activity.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: July 8, 1997
    Assignee: Societe Civile Bioprojet
    Inventors: Denis Danvy, Thierry Monteil, Christophe Lusson, Jean-Charles Schwartz, Claude Gros, Nadine Noel, Jeanne-Marie LeComte, Pierre Duhamel, Lucette Duhamel
  • Amino acid, derivatives, processes for their preparation and their therapeutic application
    Patent number: 5612371
    Abstract: New amino acid derivatives, processes for their preparation and their therapeutic application.Amino acid derivatives corresponding to the general formulae ##STR1## These derivatives may be used as medicaments which exhibit an enkephalinase-inhibitory activity.
    Type: Grant
    Filed: July 18, 1994
    Date of Patent: March 18, 1997
    Assignee: Societe Civile Bioproject
    Inventors: Denis Danvy, Thierry Monteil, Christophe Lusson, Jean-Charles Schwartz, Claude Gros, Nadine Noel, Jeanne-Marie Lecomte, Pierre Duhamel, Lucette Duhamel
  • Amino acid derivatives, the process for their preparation and their applications to therapy
    Patent number: 5599951
    Abstract: Amino acid derivatives of formula (Ia) and (Ib) and prodrugs thereof containing a group responsible for chelating the zinc atom of enkephalinase and angiotensin convertase enzymes are disclosed as inhibitors of these enzymes.
    Type: Grant
    Filed: April 14, 1995
    Date of Patent: February 4, 1997
    Assignee: Societe Civile Bioprojet
    Inventors: Jean-Christophe Plaquevent, Denis Danvy, Thierry Monteil, Claude Gros, Jean-Charles Schwartz, Jeanne-Marie LeComte, Helene Greciet, Lucette Duhamel, Pierre Duhamel
  • Thioester enantiomeric compounds and their therapeutic uses
    Patent number: 5331008
    Abstract: The (R) or (S) isomer of acetorphan or N-/(acetylthiomethyl)-2-oxo-1-phenyl-3-propyl/(S) alanine methyl ester is prepared by splitting of racemic acetylthio-3-benzyl-2-propanoic acid by reaction with ephedrin, separation of the enantiomeric salt obtained, then freeing of the acid and coupling with the corresponding amino acid ester. The obtained preparations possess remarkable therapeutic activities and can notably be used as drugs.
    Type: Grant
    Filed: February 1, 1993
    Date of Patent: July 19, 1994
    Assignee: Societe Civile Bioprojet
    Inventors: Pierre Duhamel, Lucette Duhamel, Denis Danvy, Jean-Christophe Plaquevent, Bruno Giros, Claude Gros, Jean-Charles Schwartz, Jeanne-Marie Lecomte
  • Thioester enantiomeric compounds and their therapeutic uses
    Patent number: 5296509
    Abstract: The (R) or (S) isomer of acetorphan or N-/(acetylthiomethyl)-2-oxo-1-phenyl-3-propyl/(S) alanine methyl ester is prepared by splitting of racemic acetylthio-3-benzyl-2-propanoic acid by reaction with ephedrin, separation of the enantiomeric salt obtained, then freeing of the acid and coupling with the corresponding amino acid ester. The obtained preparations possess remarkable therapeutic activities and can notably be used as drugs.
    Type: Grant
    Filed: February 1, 1993
    Date of Patent: March 22, 1994
    Assignee: Societe Civile Bioprojet
    Inventors: Pierre Duhamel, Lucette Duhamel, Denis Danvy, Jean-Christophe Plaquevent, Bruno Giros, Claude Gros, Jean-Charles Schwartz, Jeanne-Marie Lecomte
  • Thioester enantiomeric compounds and their therapeutic uses
    Patent number: 5208255
    Abstract: The (R) or (S) isomer of acetorphan or N-/2-acetylthiomethyl)-1-oxo-3-phenylpropyl/(S) alanine methyl ester is prepared by splitting of racemic acetylthio-2-benzylpropanoic acid by reaction with ephedrin, separation of the enantiomeric salt obtained, then freeing of the acid and coupling with the corresponding amino acid ester. The obtained preparations possess remarkable therapeutic activities and can notably be used as drugs.
    Type: Grant
    Filed: November 22, 1988
    Date of Patent: May 4, 1993
    Assignee: Societe Civile Bioprojet
    Inventors: Pierre Duhamel, Lucette Duhamel, Denis Danvy, Jean-Christophe Plaquevent, Bruno Giros, Claude Gros, Jean-Charles Schwartz, Jeanne-Marie Lecomte
  • Process for the preparation of amino acid-derived enatiomeric compounds
    Patent number: 5136076
    Abstract: The (R) or (S) isomer of acetorphan or N-12-acetylthiomethyl-1-oxo-3-phenyl propyl/(S) alanine methyl ester is prepared by splitting of racemic 3-acetylthio-2-benzyl propanoic acid by reaction with ephedrin, separation of the enantiomeric salt obtained, then freeing of the acid and coupling with the corresponding amino acid ester. The obtained preparations possess remarkable therapeutic activities and can notably be used as drugs.
    Type: Grant
    Filed: June 19, 1990
    Date of Patent: August 4, 1992
    Assignee: Societe Civile Bioprojet
    Inventors: Pierre Duhamel, Lucette Duhamel, Denis Danvy, Jean-Christophe Plaquevent, Bruno Giros, Claude Gros, Jean-Charles Schwartz, Jeanne-Marie Lecomte