Abstract: The automobile display apparatus provides a triangular caution that easily attaches to and detaches from an automobile driven by a new driver. The apparatus, most importantly, attaches without damage to the auto but also insures that detachment is by choice only. The majority of the apparatus is fully flexible, thereby further improving adhesion. The inverted triangle is easily recognized as a cautionary symbol. Part of the reflective indicia is designed to progressively become a recognized symbol for a new driver so that the printed words may be omitted, by choice, in the future. Additionally, the indicia of the young person in the car serve the same purpose as an identifiable symbol to most motorists of a new or young driver. Identifying the driver as new encourages other motorists in the vicinity to be cautious and to also adapt a more courteous posture toward the new driver.

Abstract: The presently disclosed subject matter is directed to methods of aiding diagnosis, prognosis, monitoring and evaluation of a disease or other medical condition in a? subject by detecting a biomarker in microvesicles isolated from a biological, sample from the subject. Moreover, disclosed subject matter is directed to methods of diagnosis, monitoring a disease by determining the concentration of microvesicles within a biological sample; methods of delivering a nucleic acid or protein to a target all by administering microvesicles that contain said nucleic acid or protein; methods for performing a body fluid transfusion by introducing a microvesicle-free or microvesicle enriched fluid fraction into a patient.

Abstract: The present invention provides a double bladed spiral slicer including a first and second blade assemblies on a surface, each assembly having a mechanical output and operable to rotate about a vertical axis. A meat rotation assembly, having a headstock and tailstock, is adapted for rotation of a received meat. A processor and controller in communication with the blade assemblies operate to direct the blade assemblies to form a spiral slice on the surface of the meat. The meat product is engaged to the meat rotation assembly where the upper position of the meat product is determined. The meat product is rotated about a vertical axis and the blade assemblies operate by simultaneously reciprocally engaging the meat product and moving vertically from the central position of the meat product.

Abstract: The presently disclosed subject matter is directed to methods of aiding diagnosis, prognosis, monitoring and evaluation of a disease or other medical condition in a subject by detecting a biomarker in microvesicles isolated from a biological sample from the subject.

Abstract: A portable filter and filter system. The filter has a filter housing defining a liquid channel from an inlet to an outlet. The portable filter includes a liquid filter located in the filter housing, a mouthpiece mechanically associated with the dispensing end of the filter housing, and a liquid receiving means connected to the receiving end of the filter housing. The device can include a pre-filter assembly of which the liquid receiving means is a part. The liquid receiving means can include multiple connection members to receive liquid from a variety of liquid sources. The filter can be combined with a liquid container to form a portable filter system. The container can be a flexible bladder having a strap to connect the filtration device to the bladder.

Abstract: The present invention relates to a novel method of preventing and/or treating respiratory disorders and respiratory-related complications in a subject by inhibiting the release of nitric oxide from basal cells in the respiratory tract.

Abstract: The presently disclosed subject matter is directed to methods of aiding diagnosis, prognosis, monitoring and evaluation of a disease or other medical condition in a subject by detecting a biomarker in microvesicles isolated from a biological sample from the subject.

Abstract: A surgical instrument case which includes a primary case which is substantially rectangular and has a pair of opposite side walls, a pair of opposite end walls and a bottom wall. A secondary case fits within the primary case, and the secondary case has at least one attachment element on an outside surface of the secondary case. The at least one attachment element is configured for connecting to at least one of the side walls and the end walls when the secondary case is mounted on an outside of at least one of the opposite side walls and the opposite end walls.

Abstract: A method for treating a leukemia patient that is resistant to a thymidine kinase inhibitor (TKI) other than imantinib comprising administering a cephalotaxine to said patient until said patient demonstrates a hematological or cytological response to said leukemia.

Abstract: The present disclosure provides oral dosage forms comprising a cephalotaxine and a pharmaceutically acceptable carrier selected from protein, carbohydrate and lipid, an oral dosage form comprising cephalotaxine and a second active agent, as well as methods of treating subjects with such oral formulations.

Abstract: A fuel cell stack antifreeze system that purges a plurality of fuel cell stacks connected in parallel includes a compressor that supplies pressurized cathode gas to each of the plurality of fuel cell stacks. A controller deactivates a first group of one or more of the plurality of fuel cell stacks and maintains operation of a second group of one or more of the plurality of fuel cell stacks. The second group powers the compressor and the compressor purges excess fluid from the first group using the pressurized cathode gas.

Abstract: A payment card comprises an internal virtual account number generator and a user display for online transactions. Offline transactions with merchant card readers are enabled by a magnetic array positioned behind the card's magnetic stripe on the back. The internal virtual account number generator is able to program the magnetic bits encoded in the magnetic stripe to reflect the latest virtual account number. The internal virtual account number generator produces a sequence of virtual numbers that can be predicted and approved by the issuing bank. Once a number is used, it is discarded and put on an exclusion list.

Abstract: A portable filter and filter system. The filter has a filter housing defining a liquid channel from an inlet to an outlet. The portable filter includes a liquid filter located in the filter housing, a mouthpiece mechanically associated with the dispensing end of the filter housing, and a liquid receiving means connected to the receiving end of the filter housing. The device can include a pre-filter assembly of which the liquid receiving means is a part. The liquid receiving means can include multiple connection members to receive liquid from a variety of liquid sources. The filter can be combined with a liquid container to form a portable filter system. The container can be a flexible bladder having a strap to connect the filtration device to the bladder.

Abstract: A method of treatment of a host with a cellular proliferative disease, comprising contacting the host with a naphthalimide and an antiproliferative agent, each in an amount sufficient to modulate said cellular proliferative disease, is described. In some embodiments, the naphthalimide comprises amonafide (5-amino-2-[2-(dimethylamine)ethyl]-1H-benz[de-]isoquinoline-1,3-(2H)-dione). Antiproliferative agents of the invention comprise alkylating agents, intercalating agents, metal coordination complexes, pyrimidine nucleosides, purine nucleosides, inhibitors of nucleic acid associated enzymes and proteins, and agents affecting structural proteins and cytoplasmic enzymes. The invention comprises the described methods as well as compositions and kits comprising a naphthalimide and an antiproliferative agent.

Abstract: Cleavage site for the protease furin is inserted between domains of a membrane glycoprotein. Upon cleavage by furin in the trans-Golgi network, the protein is separated into individual membrane-free domain that retains its native conformation. This protocol can be used to produce virus membrane protein domains for structural analysis and for trials as vaccines.

Abstract: A system for hydration has a back pack that holds a bladder with liquids for consumption by the user. The bladder has an intake port for filling and a discharge port connected to a discharge tube to transmit the fluid to a bite valve. A magnet is attached to the bite valve; and a magnet is attached to a buckle on the straps supporting the back pack. The bite valve has a free position remote from the buckle and a stored position in which the magnet on the bite valve is magnetically attached to a magnet on the buckle. The magnet has sufficient force to draw the bite valve to the buckle when the bite valve is proximate the buckle so that a user need not use a hand to unite the bite valve with the buckle.