Patents by Inventor Dennis E. Hruby

Dennis E. Hruby has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Amorphous Tecovirimat preparation
    Patent number: 10045963
    Abstract: Disclosed are methods for the preparation of amorphous N-[(3aR,4R,4aR,5aS,6S,6aS)-3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindol-2(1H)-yl]-4-(trifluoromethyl)-benzamide for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the orthopoxvirus. Also disclosed are methods for the preparation of amorphous solid dispersion of N-[(3aR,4R,4aR,5aS,6S,6aS)-3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindol-2(1H)-yl]-4-(trifluoromethyl)-benzamide.
    Type: Grant
    Filed: January 2, 2018
    Date of Patent: August 14, 2018
    Assignee: SIGA TECHNOLOGIES, INC.
    Inventors: Shanthakumar R. Tyavanagimatt, N K Peter Samuel, Joseph Paz, Ying Tan, Dennis E. Hruby
  • POLYMORPHIC FORMS OF ST-246 AND METHODS OF PREPARATION
    Publication number: 20180193308
    Abstract: Polymorph forms of 4-trifluoromethyl-N-(3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindol-2(1H)-yl)-benzamide are disclosed as well as their methods of synthesis and pharmaceutical compositions.
    Type: Application
    Filed: July 27, 2017
    Publication date: July 12, 2018
    Applicant: Siga Technologies, Inc.
    Inventors: Shanthakumar R. TYAVANAGIMATT, Melialani A.C.L.S. ANDERSON, William C. WEIMERS, Dylan NELSON, Tove' C. BOLKEN, Dennis E. HRUBY, Michael H. O'NEILL, Gary SWEETAPPLE, Kelley A. McCLOUGHAN
  • ST-246 LIQUID FORMULATIONS AND METHODS
    Publication number: 20180185514
    Abstract: The present invention provides for a novel liquid formulation for solubilizing poorly soluble ST-246 in cyclodextrins and a novel process of making the formulation.
    Type: Application
    Filed: January 16, 2018
    Publication date: July 5, 2018
    Applicant: SIGA TECHNOLOGIES, INC.
    Inventors: Shanthakumar R. TYAVANAGIMATT, Melialani A.C.L.S. ANDERSON, William WEIMERS, Gopi Krishna KASI, N K Peter SAMUEL, Tove C. Bolken, Dennis E. HRUBY
  • Antiviral drugs for treatment of arenavirus infection
    Patent number: 10000486
    Abstract: Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by the Arenavirus family such as Lassa fever, Argentine hemorrhagic fever, Bolivian hemorrhagic fever, and Venezuelan hemorrhagic fever.
    Type: Grant
    Filed: November 16, 2016
    Date of Patent: June 19, 2018
    Assignee: Kineta Viral Hemorrhagic Fever, LLC
    Inventors: Dongcheng Dai, James R. Burgeson, Sean M. Amberg, Dennis E. Hruby
  • Inhibitors and methods of inhibiting bacterial and viral pathogens
    Patent number: 9968571
    Abstract: Compounds, pharmaceutical compositions and methods for treating viral and bacterial infections, by administering certain thiourea compounds, specifically acylthiourea, carboximidoylthiourea and S-alkyl isothiourea derivatives and analogs, in therapeutically effective amounts are disclosed.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: May 15, 2018
    Assignee: SIGA TECHNOLOGIES, INC.
    Inventors: Robert D. Allen, III, Sean M. Amberg, Dongcheng Dai, James R. Burgeson, Dennis E. Hruby
  • AMORPHOUS TECOVIRIMAT PREPARATION
    Publication number: 20180125819
    Abstract: Disclosed are methods for the preparation of amorphous N-[(3aR,4R,4aR,5aS,6S,6aS)-3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindol-2(1H)-yl]-4-(trifluoromethyl)-benzamide for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the orthopoxvirus. Also disclosed are methods for the preparation of amorphous solid dispersion of N-[(3aR,4R,4aR,5aS,6S,6aS)-3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindol-2(1H)-yl]-4-(trifluoromethyl)-benzamide.
    Type: Application
    Filed: January 2, 2018
    Publication date: May 10, 2018
    Applicant: SIGA TECHNOLOGIES, INC.
    Inventors: Shanthakumar R. TYAVANAGIMATT, N K Peter SAMUEL, Joseph PAZ, Ying TAN, Dennis E. HRUBY
  • ST-246 liquid formulations and methods
    Patent number: 9907859
    Abstract: The present invention provides for a novel liquid formulation for solubilizing poorly soluble ST-246 in cyclodextrins and a novel process of making the formulation.
    Type: Grant
    Filed: December 1, 2015
    Date of Patent: March 6, 2018
    Assignee: Siga Technologies, Inc.
    Inventors: Shanthakumar R. Tyavanagimatt, Melialani A. C. L. S. Anderson, William Weimers, Gopi Krishna Kasi, N K Peter Samuel, Tove′ C. Bolken, Dennis E. Hruby
  • Amorphous tecovirimat preparation
    Patent number: 9889119
    Abstract: Disclosed are methods for the preparation of amorphous N-[(3aR,4R,4aR,5aS,6S,6aS)-3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindo1-2(1H)-yl]-4-(trifluoromethyl)-benzamide for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the orthopoxvirus. Also disclosed are methods for the preparation of amorphous solid dispersion of N-[(3aR,4R,4aR,5aS,6S,6aS)-3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindo1-2(1H)-yl]-4-(trifluoromethyl)-benzamide.
    Type: Grant
    Filed: April 27, 2017
    Date of Patent: February 13, 2018
    Assignee: SIGA TECHNOLOGIES, INC.
    Inventors: Shanthakumar R. Tyavanagimatt, N K Peter Samuel, Joseph Paz, Ying Tan, Dennis E. Hruby
  • Polymorphic forms of ST-246 and methods of preparation
    Patent number: 9744154
    Abstract: Polymorph forms of 4-trifluoromethyl-N-(3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindol-2(1H)-yl)-benzamide are disclosed as well as their methods of synthesis and pharmaceutical compositions.
    Type: Grant
    Filed: December 4, 2015
    Date of Patent: August 29, 2017
    Assignee: SIGA TECHNOLOGIES, INC.
    Inventors: Shanthakumar R. Tyavanagimatt, Melialani A.C.L.S. Anderson, William C. Weimers, Dylan Nelson, Tove′ C. Bolken, Dennis E. Hruby, Michael H. O'Neill, Gary Sweetapple, Kelley A. McCloughan
  • AMORPHOUS TECOVIRIMAT PREPARATION
    Publication number: 20170224661
    Abstract: Disclosed are methods for the preparation of amorphous N-[(3aR,4R,4aR,5aS,6S,6aS)-3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindo1-2(1H)-yl]-4-(trifluoromethyl)-benzamide for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the orthopoxvirus. Also disclosed are methods for the preparation of amorphous solid dispersion of N-[(3aR,4R,4aR,5aS,6S,6aS)-3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindo1-2(1H)-yl]-4-(trifluoromethyl)-benzamide.
    Type: Application
    Filed: April 27, 2017
    Publication date: August 10, 2017
    Applicant: SIGA TECHNOLOGIES, INC.
    Inventors: Shanthakumar R. TYAVANAGIMATT, N K Peter SAMUEL, Joseph PAZ, Ying TAN, Dennis E. HRUBY
  • Amorphous tecovirimat preparation
    Patent number: 9670158
    Abstract: Disclosed are methods for the preparation of amorphous N-[(3aR,4R,4aR,5aS,6S,6aS)-3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindol-2(1H)-yl]-4-(trifluoromethyl)-benzamide for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the orthopoxvirus. Also disclosed are methods for the preparation of amorphous solid dispersion of N-[(3aR,4R,4aR,5aS,6S,6aS)-3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindol-2(1H)-yl]-4-(trifluoromethyl)-benzamide.
    Type: Grant
    Filed: July 11, 2014
    Date of Patent: June 6, 2017
    Assignee: SIGA TECHNOLOGIES, INC.
    Inventors: Shanthakumar R. Tyavanagimatt, N K Peter Samuel, Joseph Paz, Ying Tan, Dennis E. Hruby
  • ANTIVIRAL DRUGS FOR TREATMENT OF ARENAVIRUS INFECTION
    Publication number: 20170137422
    Abstract: Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by the Arenavirus family such as Lassa fever, Argentine hemorrhagic fever, Bolivian hemorrhagic fever, and Venezuelan hemorrhagic fever.
    Type: Application
    Filed: November 16, 2016
    Publication date: May 18, 2017
    Applicant: Kineta Four, LLC
    Inventors: Dongcheng Dai, James R. Burgeson, Sean M. Amberg, Dennis E. Hruby
  • INHIBITORS AND METHODS OF INHIBITING BACTERIAL AND VIRAL PATHOGENS
    Publication number: 20170128393
    Abstract: Compounds, pharmaceutical compositions and methods for treating viral and bacterial infections, by administering certain thiourea compounds, specifically acylthiourea, carboximidoylthiourea and S-alkyl isothiourea derivatives and analogs, in therapeutically effective amounts are disclosed.
    Type: Application
    Filed: December 22, 2016
    Publication date: May 11, 2017
    Applicant: SIGA TECHNOLOGIES, INC.
    Inventors: Robert D. ALLEN III, Sean M. AMBERG, Dongcheng DAI, James R. BURGESON, Dennis E. HRUBY
  • THIENOPYRIDINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DENGUE VIRUS INFECTIONS
    Publication number: 20170121344
    Abstract: Methods and pharmaceutical compositions for treating viral infections, by administering certain thienopyridine derivative compounds in therapeutically effective amounts are disclosed. Methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment of viral infections such as caused by flavivirus is disclosed, i.e., including but not limited to, Dengue virus, West Nile virus, yellow fever virus, Japanese encephalitis virus, and tick-borne encephalitis virus.
    Type: Application
    Filed: January 9, 2017
    Publication date: May 4, 2017
    Applicant: Siga Technologies, Inc.
    Inventors: Dongcheng DAI, James R. BURGESON, Shanthankumar R. TYAVANAGIMATT, Chelsea OLSEN, Dennis E. HRUBY
  • Inhibitors and methods of inhibiting bacterial and viral pathogens
    Patent number: 9566254
    Abstract: Compounds, pharmaceutical compositions and methods for treating viral and bacterial infections, by administering certain thiourea compounds, specifically acylthiourea, carboximidoylthiourea and S-alkyl isothiourea derivatives and analogs, in therapeutically effective amounts are disclosed.
    Type: Grant
    Filed: December 1, 2015
    Date of Patent: February 14, 2017
    Assignee: SIGA TECHNOLOGIES, INC.
    Inventors: Robert D. Allen, III, Sean M. Amberg, Dongcheng Dai, James R. Burgeson, Dennis E. Hruby
  • Antiviral drugs for treatment of arenavirus infection
    Patent number: 9498470
    Abstract: Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by the Arenavirus family such as Lassa fever, Argentine hemorrhagic fever, Bolivian hemorrhagic fever, and Venezuelan hemorrhagic fever.
    Type: Grant
    Filed: February 14, 2013
    Date of Patent: November 22, 2016
    Assignee: Kineta Four, LLC
    Inventors: Dongcheng Dai, James R. Burgeson, Sean M. Amberg, Dennis E. Hruby
  • ANTIVIRAL DRUGS FOR TREATMENT OR PREVENTION OF DENGUE INFECTION
    Publication number: 20160250233
    Abstract: Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by flavivirus is disclosed, i.e., including but not limited to, Dengue virus, West Nile virus, yellow fever virus, Japanese encephalitis virus, and tick-borne encephalitis virus.
    Type: Application
    Filed: May 6, 2016
    Publication date: September 1, 2016
    Applicant: Siga Technologies, Inc.
    Inventors: Chelsea OLSEN, Robert JORDAN, Dongcheng DAI, Tove BOLKEN, Dennis E. HRUBY
  • REHYDRATION OF MICRONIZED TECOVIRMIMAT MONOHYDRATE
    Publication number: 20160235676
    Abstract: Disclosed are methods for hydration of ST-246 particles comprising exposing said particles to moisture by conveying volumes of air containing moisture.
    Type: Application
    Filed: November 14, 2014
    Publication date: August 18, 2016
    Applicant: SIGA TECHNOLOGIES, INC.
    Inventors: Shanthakumar R. TYAVANAGIMATT, Matthew Reeves, N K Peter SAMUEL, Steven PRIEBE, Ying TAN, Dennis E. HRUBY
  • AMORPHOUS TECOVIRIMAT PREPARATION
    Publication number: 20160152565
    Abstract: Disclosed are methods for the preparation of amorphous N-[(aR,4R,4aR,5aS,6S,6aS)-3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindol-2(1H)-yl]-4-(trifluoromethyl)-benzamide for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the orthopoxvirus. Also disclosed are methods for the preparation of amorphous solid dispersion of N-[(aR,4R,4aR,5aS,6S,6aS)-3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindol-2(1 H)-yl]-4-(trifluoromethyl)-benzamide.
    Type: Application
    Filed: July 11, 2014
    Publication date: June 2, 2016
    Applicant: SIGA TECHNOLOGIES, INC.
    Inventors: Shanthakumar TYAVANAGIMATT, N K Peter SAMUEL, Joseph PAZ, Ying TAN, Dennis E. HRUBY
  • THIENOPYRIDINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DENGUE VIRUS INFECTIONS
    Publication number: 20160152635
    Abstract: Methods and pharmaceutical compositions for treating viral infections, by administering certain thienopyridine derivative compounds in therapeutically effective amounts are disclosed. Methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by flavivirus is disclosed, i.e., including but not limited to, Dengue virus, West Nile virus, yellow fever virus, Japanese encephalitis virus, and tick-borne encephalitis virus.
    Type: Application
    Filed: February 8, 2016
    Publication date: June 2, 2016
    Applicant: Siga Technologies, Inc.
    Inventors: Chelsea OLSEN, Dongcheng DAI, Robert JORDAN, Dennis E. HRUBY