Patents by Inventor Dennis E. Hruby

Dennis E. Hruby has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antiviral drugs for treatment or prevention of dengue infection
    Patent number: 9353051
    Abstract: Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by flavivirus is disclosed, i.e., including but not limited to, Dengue virus, West Nile virus, yellow fever virus, Japanese encephalitis virus, and tick-borne encephalitis virus.
    Type: Grant
    Filed: July 22, 2013
    Date of Patent: May 31, 2016
    Assignee: SIGA Technologies, Inc.
    Inventors: Chelsea M. Byrd, Robert Jordan, Dongcheng Dai, Tove Bolken, Dennis E. Hruby
  • Polymorphic forms of ST-246 and methods of preparation
    Patent number: 9339466
    Abstract: Polymorph forms of 4-trifluoromethyl-N-(3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindol-2(1H)-yl)-benzamide are disclosed as well as their methods of synthesis and pharmaceutical compositions.
    Type: Grant
    Filed: March 23, 2011
    Date of Patent: May 17, 2016
    Assignee: SIGA TECHNOLOGIES, INC.
    Inventors: Shanthakumar R. Tyavanagimatt, Melialani A. C. L. Stone, William C. Weimers, Dylan Nelson, Tove′ C. Bolken, Dennis E. Hruby, Michael H. O'Neill, Gary Sweetapple, Kelley A. McCloughan
  • POLYMORPHIC FORMS OF ST-246 AND METHODS OF PREPARATION
    Publication number: 20160107993
    Abstract: Polymorph forms of 4-trifluoromethyl-N-(3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindol-2(1H)-yl)-benzamide are disclosed as well as their methods of synthesis and pharmaceutical compositions.
    Type: Application
    Filed: December 4, 2015
    Publication date: April 21, 2016
    Applicant: Siga Technologies, Inc.
    Inventors: Shanthakumar R. TYAVANAGIMATT, Melialani A.C.L.S. ANDERSON, William C. WEIMERS, Dylan NELSON, Tove' C. BOLKEN, Dennis E. HRUBY, Michael H. O'NEILL, Gary SWEETAPPLE, Kelley A. McCLOUGHAN
  • Thienopyridine derivatives for the treatment and prevention of dengue virus infections
    Patent number: 9301949
    Abstract: Methods and pharmaceutical compositions for treating viral infections, by administering certain thienopyridine derivative compounds in therapeutically effective amounts are disclosed. Methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by flavivirus is disclosed, i.e., including but not limited to, Dengue virus, West Nile virus, yellow fever virus, Japanese encephalitis virus, and tick-borne encephalitis virus.
    Type: Grant
    Filed: February 24, 2010
    Date of Patent: April 5, 2016
    Assignee: Siga Technologies, Inc.
    Inventors: Chelsea M. Byrd, Dongcheng Dai, Robert Jordan, Dennis E. Hruby
  • ST-246 LIQUID FORMULATIONS AND METHODS
    Publication number: 20160082128
    Abstract: The present invention provides for a novel liquid formulation for solubilizing poorly soluble ST-246 in cyclodextrins and a novel process of making the formulation.
    Type: Application
    Filed: December 1, 2015
    Publication date: March 24, 2016
    Applicant: Siga Technologies, Inc.
    Inventors: Shanthakumar R. TYAVANAGIMATT, Melialani A.C.L.S. ANDERSON, William WEIMERS, Gopi Krishna KASI, N K Peter SAMUEL, Tove' C. Bolken, Dennis E. HRUBY
  • INHIBITORS AND METHODS OF INHIBITING BACTERIAL AND VIRAL PATHOGENS
    Publication number: 20160081950
    Abstract: Compounds, pharmaceutical compositions and methods for treating viral and bacterial infections, by administering certain thiourea compounds, specifically acylthiourea, carboximidoylthiourea and S-alkyl isothiourea derivatives and analogs, in therapeutically effective amounts are disclosed.
    Type: Application
    Filed: December 1, 2015
    Publication date: March 24, 2016
    Applicant: SIGA TECHNOLOGIES, INC.
    Inventors: Robert D. ALLEN, III, Sean M. AMBERG, Dongcheng DAI, James R. BURGESON, Dennis E. HRUBY
  • ST-246 liquid formulations
    Patent number: 9233097
    Abstract: The present invention provides for a novel liquid formulation for solubilizing poorly soluble ST-246 in cyclodextrins and a novel process of making the formulation.
    Type: Grant
    Filed: August 2, 2011
    Date of Patent: January 12, 2016
    Assignee: SIGA TECHNOLOGIES, INC.
    Inventors: Shanthakumar R. Tyavanagimatt, Melialani A. C. L. Stone, William C. Weimers, Gopi Krishna Kasi, Peter N. K. Samuel, Tove Bolken, Dennis E. Hruby
  • Inhibitors and methods of inhibiting bacterial and viral pathogens
    Patent number: 9233087
    Abstract: Compounds, pharmaceutical compositions and methods for treating viral and bacterial infections, by administering certain thiourea compounds, specifically acylthiourea, carboximidoylthiourea and S-alkyl isothiourea derivatives and analogs, in therapeutically effective amounts are disclosed.
    Type: Grant
    Filed: February 18, 2011
    Date of Patent: January 12, 2016
    Assignee: SIGA TECHNOLOGIES, INC
    Inventors: Robert D. Allen, Sean M. Amberg, Dongcheng Dai, James R. Burgeson, Dennis E. Hruby
  • Antiviral drugs for treatment of arenavirus infection
    Patent number: 9199920
    Abstract: Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain novel compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by hemorrhagic fever viruses is disclosed, i.e., including but not limited to, Arenaviridae (Junin, Machupo, Guanarito, Sabia, Lassa, Tacaribe, and Pichinde), Filoviridae (Ebola and Marburg viruses), Flaviviridae (yellow fever, Omsk hemorrhagic fever and Kyasanur Forest disease viruses), and Bunyaviridae (Rift Valley fever).
    Type: Grant
    Filed: February 22, 2012
    Date of Patent: December 1, 2015
    Assignee: Kineta Four, LLC
    Inventors: Dennis E. Hruby, Tove C. Bolken, Sean M. Amberg, Dongcheng Dai
  • Sulfonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with Arenaviruses
    Patent number: 9115065
    Abstract: Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain novel semicarbazides, sulfonyl carbazides, ureas and related compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by hemorrhagic fever viruses is disclosed, i.e., including but not limited to Arenaviridae (Junin, Machupo, Guanavito, Sabia and Lassa), Filoviridae (ebola and Marburg viruses), Flaviviridae (yellow fever, omsk hemorrhagic fever and Kyasanur Forest disease viruses), and Bunyaviridae (Rift Valley fever).
    Type: Grant
    Filed: February 26, 2013
    Date of Patent: August 25, 2015
    Assignee: Kineta, Inc.
    Inventors: Dongcheng Dai, Tove Bolken, Sean M. Amberg, Dennis E. Hruby, Thomas R. Bailey
  • Antiviral drugs for treatment of Arenavirus infection
    Patent number: 9096597
    Abstract: Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by the Arenavirus family such as Lassa fever, Argentine hemorrhagic fever, Bolivian hemorrhagic fever, and Venezuelan hemorrhagic fever.
    Type: Grant
    Filed: May 7, 2014
    Date of Patent: August 4, 2015
    Assignee: Kineta Four, LLC
    Inventors: Dongcheng Dai, Dennis E. Hruby, Tove C. Bolken, Sean M. Amberg, Ryan A. Larson
  • SMALL MOLECULE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DENGUE VIRUS INFECTION
    Publication number: 20150202195
    Abstract: Methods and pharmaceutical compositions for treating viral infections, by administering certain compounds in therapeutically effective amounts are disclosed. Methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by flavivinis is disclosed, i.e., including but not limited to, Dengue virus, West Nile virus, yellow fever virus, Japanese encephalitis virus, and tick-borne encephalitis virus.
    Type: Application
    Filed: March 30, 2015
    Publication date: July 23, 2015
    Inventors: Chelsea M. Byrd, Robert Jordan, Dongcheng Dai, Dennis E. Hruby
  • TREATMENT AND PREVENTION OF DENGUE VIRUS INFECTIONS
    Publication number: 20150150852
    Abstract: Methods and pharmaceutical compositions for treating viral infections, by administering certain 2-aryl-benzothiazole or 2-heteroaryl-benzothiazole derivative compounds in therapeutically effective amounts are disclosed. Methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by flavivirus is disclosed, i.e., including but not limited to, Dengue virus, West Nile virus, yellow fever virus, Japanese encephalitis virus, and tick-borne encephalitis virus.
    Type: Application
    Filed: February 6, 2015
    Publication date: June 4, 2015
    Applicant: SIGA TECHNOLOGIES, INC.
    Inventors: Chelsea M. BYRD, Dongcheng DAI, Robert JORDAN, Dennis E. HRUBY
  • Small molecule inhibitors for the treatment or prevention of dengue virus infection
    Patent number: 9029376
    Abstract: Methods and pharmaceutical compositions for treating viral infections, by administering certain compounds in therapeutically effective amounts are disclosed. Methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by flavivirus is disclosed, i.e., including but not limited to, Dengue virus, West Nile virus, yellow fever virus, Japanese encephalitis virus, and tick-borne encephalitis virus.
    Type: Grant
    Filed: June 2, 2009
    Date of Patent: May 12, 2015
    Assignee: Siga Technologies, Inc.
    Inventors: Chelsea M. Byrd, Robert Jordan, Dongcheng Dai, Dennis E. Hruby
  • Treatment and prevention of dengue virus infections
    Patent number: 8993604
    Abstract: Methods and pharmaceutical compositions for treating viral infections, by administering certain 2-aryl-benzothiazole or 2-heteroaryl-benzothiazole derivative compounds in therapeutically effective amounts are disclosed. Methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by flavivirus is disclosed, i.e., including but not limited to, Dengue virus, West Nile virus, yellow fever virus, Japanese encephalitis virus, and tick-borne encephalitis virus.
    Type: Grant
    Filed: June 22, 2010
    Date of Patent: March 31, 2015
    Assignee: Siga Technologies, Inc.
    Inventors: Chelsea M. Byrd, Dongcheng Dai, Robert Jordan, Dennis E. Hruby
  • ANTIVIRAL DRUGS FOR TREATMENT OF ARENAVIRUS INFECTION
    Publication number: 20150023916
    Abstract: Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by the Arenavirus family such as Lassa fever, Argentine hemorrhagic fever, Bolivian hemorrhagic fever, and Venezuelan hemorrhagic fever.
    Type: Application
    Filed: February 14, 2013
    Publication date: January 22, 2015
    Applicant: SIGA TECHNOLOGIES INC.
    Inventors: Dongcheng Dai, James R. Burgeson, Sean M. Amberg, Dennis E. Hruby
  • SULFONYL SEMICARBAZIDES, SEMICARBAZIDES AND UREAS,PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS FOR TREATING HEMORRHAGIC FEVER VIRUSES, INCLUDING INFECTIONS ASSOCIATED WITH ARENAVIRUSES
    Publication number: 20140378681
    Abstract: Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain novel semicarbazides, sulfonyl carbazides, ureas and related compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by hemorrhagic fever viruses is disclosed, i.e., including but not limited to Arenaviridae (Junin, Machupo, Guanavito, Sabia and Lassa), Filoviridae (ebola and Marburg viruses), Flaviviridae (yellow fever, omsk hemorrhagic fever and Kyasanur Forest disease viruses), and Bunyaviridae (Rift Valley fever).
    Type: Application
    Filed: February 26, 2013
    Publication date: December 25, 2014
    Applicant: Siga Technologies Inc.
    Inventors: Dongcheng Dai, Tove Bolken, Sean M. Amberg, Dennis E. Hruby, Thomas R. Bailey, Jack H. Nunberg, Celestine Johnson Thomas
  • Antiviral drugs for treatment of arenavirus infection
    Patent number: 8871746
    Abstract: Methods, compounds, and pharmaceutical compositions for treating arenavirus infections are disclosed. Methods for preparing the compounds and pharmaceutical compositions are also disclosed. The novel compounds and compositions are used for treatment of arenavirus infections, which include but are not limited to the following viruses: Junin, Machupo, Guanarito, Sabia, Lassa, Tacaribe, Pichinde, and LCMV.
    Type: Grant
    Filed: November 10, 2011
    Date of Patent: October 28, 2014
    Assignee: Kineta Four, LLC
    Inventors: Dongcheng Dai, Sean M. Amberg, Tove Bolken, Dennis E. Hruby
  • ANTI-ARENAVIRAL COMPOUNDS
    Publication number: 20140301979
    Abstract: Described herein are 4-methyl-piperazine-1-carbothioic acid amide derivatives and analogs, as well as compositions containing the same, for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by hemorrhagic fever viruses, such as Arenaviruses.
    Type: Application
    Filed: June 25, 2014
    Publication date: October 9, 2014
    Applicant: SIGA TECHNOLOGIES, INC.,
    Inventors: Sean M. AMBERG, Dongcheng DAI, Tove C. BOLKEN, Dennis E. HRUBY
  • ANTIVIRAL DRUGS FOR TREATMENT OF ARENAVIRUS INFECTION
    Publication number: 20140243367
    Abstract: Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by the Arenavirus family such as Lassa fever, Argentine hemorrhagic fever, Bolivian hemorrhagic fever, and Venezuelan hemorrhagic fever.
    Type: Application
    Filed: May 7, 2014
    Publication date: August 28, 2014
    Applicant: SIGA TECHNOLOGIES, INC.
    Inventors: Dongcheng DAI, Dennis E. HRUBY, Tove C. BOLKEN, Sean M. AMBERG, Ryan A. LARSON