Patents by Inventor Dennis Hurley

Dennis Hurley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Quinazolines useful as modulators of ion channels
    Patent number: 7928107
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Grant
    Filed: March 3, 2006
    Date of Patent: April 19, 2011
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Dean Wilson, Andreas Termin, Jesus Gonzalez, Lev Fanning, Timothy Neubert, Paul Krenitsky, Pramod Joshi, Dennis Hurley, Urvi Sheth
  • Modulators of muscarinic receptors
    Patent number: 7820817
    Abstract: The present invention relates to substituted piperazine compounds that are useful modulators of muscarinic receptors. The present invention also provides compositions comprising such compounds, and methods for treating muscarinic receptor mediated diseases.
    Type: Grant
    Filed: May 31, 2005
    Date of Patent: October 26, 2010
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Lewis Makings, Dennis Hurley, Miguel Gracia-Guzman Blanco, Daniele Bergeron, Akiko Nakatani
  • Modulators of ATP-Binding Cassette Transporters
    Publication number: 20100184739
    Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
    Type: Application
    Filed: December 11, 2009
    Publication date: July 22, 2010
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Urvi Sheth, Lev T.D. Fanning, Mehdi Michael Djamel Numa, Hayley Binch, Dennis Hurley, Jinglan Zhou, Sara S. Hadida Ruah, Anna Hazlewood, Alina Silina, Rajendran Vairagoundar, Fredrick van Goor, Peter D.J. Grootenhuis, Martyn Botfield
  • MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR
    Publication number: 20100168094
    Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating diseases using such CFTR modulators.
    Type: Application
    Filed: December 21, 2009
    Publication date: July 1, 2010
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Hayley Binch, Dennis Hurley, Lev T.D. Fanning, Peter D.J. Grootenhuis, Martyn Botfield, Fredrick Van Goor
  • Modulators of Cystic Fibrosis Transmembrane Conductance Regulator
    Publication number: 20100113508
    Abstract: The present invention relates to modulators of cystic fibrosis transmembrane conductance regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating diseases using modulators of CFTR.
    Type: Application
    Filed: October 23, 2009
    Publication date: May 6, 2010
    Applicant: Vertex Pharmaceuticals, Incorporated
    Inventors: Hayley Binch, Lev T.D. Fanning, Dennis Hurley, Urvi Sheth, Alina Silina, Xiaoqing Yang, Martyn Botfield, Peter D.J. Grootenhuis, Fredrick Van Goor, Mehdi Michel Djamel Numa
  • Modulators of Muscarinic Receptors
    Publication number: 20100105693
    Abstract: The present invention relates to substituted piperazine compounds that are useful modulators of muscarinic receptors. The present invention also provides compositions comprising such compounds, and methods for treating muscarinic receptor mediated diseases.
    Type: Application
    Filed: January 5, 2010
    Publication date: April 29, 2010
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Lewis Makings, Dennis Hurley, Miguel Gracia-Guzman Blanco, Daniele Bergeron, Akiko Nakatani
  • Quinazolines useful as modulators of ion channels
    Publication number: 20090312342
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Application
    Filed: March 3, 2006
    Publication date: December 17, 2009
    Inventors: Dean Wilson, Andreas Termin, Jesus Gonzalez, Lev Fanning, Timothy Neubert, Paul Krenitsky, Pramod Joshi, Dennis Hurley, Urvi Sheth
  • Phenyl-piperazine derivatives as modulators of muscarinic receptors
    Publication number: 20090239873
    Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
    Type: Application
    Filed: December 31, 2008
    Publication date: September 24, 2009
    Inventors: Miguel Garcia-Guzman Blanco, Daniele Bergeron, Peter D. J. Grootenhuis, Dennis Hurley, Akiko Nakatani, Lewis R. Makings, Daniel DiSepio, Gabriel Raffai
  • Phenyl-piperazine derivatives as modulators of muscarinic receptors
    Patent number: 7563795
    Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
    Type: Grant
    Filed: September 27, 2004
    Date of Patent: July 21, 2009
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Miguel Garcia-Guzman Blanco, Daniele Bergeron, Peter D. J. Grootenhuis, Dennis Hurley, Akiko Nakatani, Lewis R. Makings, Daniel DiSepio, Gabriel Raffai
  • Modulators of muscarinic receptors
    Publication number: 20080015179
    Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
    Type: Application
    Filed: December 22, 2006
    Publication date: January 17, 2008
    Inventors: Lewis Makings, Miguel Blanco, Dennis Hurley, Ioana Drutu, Gabriel Raffai, Daniele Bergeron, Akiko Nakatani, Andreas Termin, Alina Silina
  • System, program product, and methods for attenuation correction of emission data on PET/CT and SPECT/CT
    Publication number: 20070081704
    Abstract: Embodiments of the present invention provide the use of average CT (ACT) to match the temporal resolution of CT and PET to enhance PET imaging and evaluated tumor quantification with HCT and ACT. For example, an embodiment of a method of enhanced PET imaging on a PET/CT scanner includes generating an average CT scan responsive to 4D CT emission image data to thereby correct attenuation in PET emission image data. Another embodiment of a method of attenuation correction in a PET/CT scan includes averaging a plurality of consecutive low dose CT images of approximately one breathing cycle to thereby obtain an average CT.
    Type: Application
    Filed: March 17, 2006
    Publication date: April 12, 2007
    Inventors: Tinsu Pan, Osama Mawlawi, Dershan Luo, Steven Kohlmyer, Dennis Hurley
  • Modulators of muscarinic receptors
    Publication number: 20070043023
    Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
    Type: Application
    Filed: February 22, 2006
    Publication date: February 22, 2007
    Inventors: Lewis Makings, Miguel Blanco, Dennis Hurley, Ioana Drutu, Gabriel Raffai, Daniele Bergeron, Akiko Nakatani, Andreas Termin, Alina Silina
  • System, method, and apparatus for improved packaging of data tape cartridges
    Patent number: 7165685
    Abstract: A plastic cartridge holder for restraining and protecting data tape cartridges during shipping has individual cartridge slots with corrugated padding between adjacent slots and on the sides of the slots to decouple the cartridges from virtually any shock event. The cartridges do not separate or fall apart from each other when the external bundling material or shrink-wrapping is removed. The corrugations and slots hold the cartridges in place with a retention force that is firm yet comfortable for the user to overcome. The slots on the beveled corners allow individual cartridge actuation of access doors for inspection of the tape leader pins before the cartridges are removed. The opposite side of the holder has a full, cartridge-length access to the individual slots. The holder also has an access slot to allow the user to manually push all of the cartridges out of the holder simultaneously.
    Type: Grant
    Filed: July 11, 2003
    Date of Patent: January 23, 2007
    Assignee: International Business Machines Corporation
    Inventors: Dennis Hurley Byrne, David Michael Davis, James Mitchell Karp
  • Modulators of muscarinic receptors
    Publication number: 20060287303
    Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
    Type: Application
    Filed: November 29, 2005
    Publication date: December 21, 2006
    Inventors: Dennis Hurley, Daniele Bergeron, Ioana Drutu, Miguel Blanco, Lewis Makings, Akiko Nakatani, Gabriel Raffai, Alina Silina
  • Modulators of muscarinic receptors
    Publication number: 20060270653
    Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
    Type: Application
    Filed: November 29, 2005
    Publication date: November 30, 2006
    Inventors: Ioana Drutu, Dennis Hurley, Upul Bandarage, Daniele Bergeron, Paul Charifson, Robert Davies, Miguel Blanco, Lewis Makings, Akiko Nakatani, Gabriel Raffai
  • Quinazolines useful as modulators of ion channels
    Publication number: 20060173018
    Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Application
    Filed: August 31, 2005
    Publication date: August 3, 2006
    Inventors: Dean Wilson, Andreas Termin, Jesus Gonzalez, Lev Fanning, Timothy Neubert, Paul Krenitsky, Pramod Joshi, Dennis Hurley, Urvi Sheth
  • Releasable, repeatable electrical connection employing compression
    Patent number: 7076333
    Abstract: An electrical connection of a transfer station releasably, repeatably electrically couples with respect to a matching connection of a portable cartridge. A substrate in the portable cartridge has electrical contacts on a facing surface. In the transfer station, a matching circuitized flexible substrate has electrical contacts on a facing surface thereof, which are arranged to match the portable cartridge electrical contacts when in a face-to-face relationship. An elastomeric compression element, at the rear of the matching substrate, has individual protruding compression members contacting the rear surface and registered with corresponding individual electrical contacts. Elongated electrical contacts are registered with two adjacent individual compression members.
    Type: Grant
    Filed: September 24, 2004
    Date of Patent: July 11, 2006
    Assignee: Quantum Corporation
    Inventors: William Louis Brodsky, Dennis Hurley Byrne, Alex Chliwnyj, David Michael Davis, James Mitchell Karp, George G. Zamora
  • Modulators of muscarinic receptors
    Publication number: 20060079505
    Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
    Type: Application
    Filed: August 19, 2005
    Publication date: April 13, 2006
    Applicant: VERTEX PHARMACEUTICALS, INCORPORATED
    Inventors: Lewis Makings, Miguel Blanco, Dennis Hurley, Ioana Drutu, Gabriel Raffai, Daniele Bergeron, Akiko Nakatani, Andreas Termin, Alina Silina
  • Modulators of muscarinic receptors
    Publication number: 20060019962
    Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
    Type: Application
    Filed: May 31, 2005
    Publication date: January 26, 2006
    Inventors: Lewis Makings, Dennis Hurley, Miguel Blanco, Daniele Bergeron, Akiko Nakatani
  • Phenyl-piperazine derivatives as modulators of muscarinic receptors
    Publication number: 20050137211
    Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
    Type: Application
    Filed: September 27, 2004
    Publication date: June 23, 2005
    Inventors: Miguel Blanco, Daniele Bergeron, Peter Grootenhuis, Dennis Hurley, Akiko Nakatani, Lewis Makings, Daniel DiSepio, Gabriel Raffai