Abstract: The present invention relates to compounds useful as promoters of the SMN2 gene. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of Spinal Muscular Atrophy.

Abstract: An electrical connection releasably, repeatably electrically couples with respect to a matching connection of a portable cartridge. A substrate in the portable cartridge has electrical contacts on a facing surface of a flex cable termination mounted on a backing plate. A matching circuitized flexible substrate has electrical contacts on a facing surface thereof, which are arranged to match the portable cartridge electrical contacts when in a face-to-face relationship, and is mounted on a compression element with protruding compression members. Elongated electrical contacts are registered with two adjacent individual compression members. A loader exerts a normal force to the cartridge to compress the compression element and create non-wiping contact between the facing electrical contacts.

Abstract: The present invention relates to compounds useful as modulators of the vanilloid receptor, and also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

Abstract: An electrical connection releasably, repeatably electrically couples with respect to a matching connection of a portable cartridge. A substrate in the portable cartridge has electrical contacts on a facing surface of a flex cable mounted on a backing plate. A matching circuitized flexible substrate has electrical contacts on a facing surface thereof, which are arranged to match the portable cartridge electrical contacts when in a face-to-face relationship, and is mounted on a compression element with protruding compression members. Elongated electrical contacts are registered with two adjacent individual compression members. A loader exerts a normal force to the cartridge to compress the compression element and create non-wiping contact between the facing electrical contacts.

Abstract: An electrical connection of a transfer station releasably, repeatably electrically couples with respect to a matching connection of a portable cartridge. A substrate in the portable cartridge has electrical contacts on a facing surface. In the transfer station, a matching circuitized flexible substrate has electrical contacts on a facing surface thereof, which are arranged to match the portable cartridge electrical contacts when in a face-to-face relationship. An elastomeric compression element, at the rear of the matching substrate, has individual protruding compression members contacting the rear surface and registered with corresponding individual electrical contacts. Elongated electrical contacts are registered with two adjacent individual compression members.

Abstract: An indicator comprises a rotary device in the form of a right cylinder arranged to be rotatable in a chamber of a portable data storage cartridge, which has an exterior wall opening to the chamber. A peripheral surface of the rotary device has an encoded pattern of at least one cylindrical surface and a plurality of facets interrupting the cylindrical surface(s). The facets are located at various axial positions, and at various angularly spaced rotational positions, such that, at differing rotational positions of the rotary device, at least one or none of the facets is positioned at the exterior opening.

Abstract: An electrical connection of a transfer station releasably, repeatably electrically couples with respect to a matching connection of a portable cartridge. A substrate in the portable cartridge has electrical contacts on a facing surface. In the transfer station, a matching circuitized flexible substrate has electrical contacts on a facing surface thereof, which are arranged to match the portable cartridge electrical contacts when in a face-to-face relationship. An elastomeric compression element, at the rear of the matching substrate, has individual protruding compression members contacting the rear surface and registered with corresponding individual electrical contacts. Elongated electrical contacts are registered with two adjacent individual compression members.

Abstract: An electrical connection of a transfer station releasably, repeatably electrically couples with respect to a matching connection of a portable cartridge. A substrate in the portable cartridge has electrical contacts on a facing surface. In the transfer station, a matching circuitized flexible substrate has electrical contacts on a facing surface thereof, which are arranged to match the portable cartridge electrical contacts when in a face-to-face relationship. An elastomeric compression element, at the rear of the matching substrate, has individual protruding compression members contacting the rear surface and registered with corresponding individual electrical contacts. Elongated electrical contacts are registered with two adjacent individual compression members.

Abstract: An indicator comprises a rotary device in the form of a right cylinder arranged to be rotatable in a chamber of a portable data storage cartridge, which has an exterior wall opening to the chamber. A peripheral surface of the rotary device has an encoded pattern of at least one cylindrical surface and a plurality of facets interrupting the cylindrical surface(s). The facets are located at various axial positions, and at various angularly spaced rotational positions, such that, at differing rotational positions of the rotary device, at least one or none of the facets is positioned at the exterior opening.

Abstract: An electrical connection of a transfer station releasably, repeatably electrically couples with respect to a matching connection of a portable cartridge. A substrate in the portable cartridge has electrical contacts on a facing surface. In the transfer station, a matching circuitized flexible substrate has electrical contacts on a facing surface thereof, which are arranged to match the portable cartridge electrical contacts when in a face-to-face relationship. An elastomeric compression element, at the rear of the matching substrate, has individual protruding compression members contacting the rear surface and registered with corresponding individual electrical contacts. Elongated electrical contacts are registered with two adjacent individual compression members.

Abstract: A tape cartridge which includes an internally disposed rotatable reel, wherein the tape cartridge includes two, three, or a plurality of piloting members disposed adjacent an annular ring to limit the movement of the reel within the tape cartridge. An automated data storage and retrieval system which includes a plurality of Applicants' tape cartridges. A method to prevent damage to a tape medium disposed in a tape cartridge.

Abstract: An electrical connection of a transfer station releasably, repeatably electrically couples with respect to a matching connection of a portable cartridge. A substrate in the portable cartridge has electrical contacts on a facing surface. In the transfer station, a matching circuitized flexible substrate has electrical contacts on a facing surface thereof, which are arranged to match the portable cartridge electrical contacts when in a face-to-face relationship. An elastomeric compression element, at the rear of the matching substrate, has individual protruding compression members contacting the rear surface and registered with corresponding individual electrical contacts. Elongated electrical contacts are registered with two adjacent individual compression members.

Abstract: An electrical connection of a transfer station releasably, repeatably electrically couples with respect to a matching connection of a portable cartridge. A substrate in the portable cartridge has electrical contacts on a facing surface. In the transfer station, a matching circuitized flexible substrate has electrical contacts on a facing surface thereof, which are arranged to match the portable cartridge electrical contacts when in a face-to-face relationship. An elastomeric compression element, at the rear of the matching substrate, has individual protruding compression members contacting the rear surface and registered with corresponding individual electrical contacts. Elongated electrical contacts are registered with two adjacent individual compression members.

Abstract: A tape cartridge which includes an internally disposed rotatable reel, wherein the tape cartridge includes two, three, or a plurality of piloting members disposed adjacent an annular ring to limit the movement of the reel within the tape cartridge. An automated data storage and retrieval system which includes a plurality of Applicants' tape cartridges. A method to prevent damage to a tape medium disposed in a tape cartridge.

Abstract: A principal catch basin defining a certain storage capacity, the catch basis situated below the level of the ground, having an upper level opening for receiving surface water drainage thereunto, and having side walls partially constructed of permeable geotextile fabric for allowing both sub-surface air to flow into the catch basin for providing additional water absorption by the ground, and for allowing water flow and sub-surface air to flow into the catch basin for providing additional water absorption by the ground, and for allowing water flow into the sub-surface water flow through the permeable basin to serve as a collection for sub-surface drainage. The system would include the ability to create a siphon within the system so that as water drains into the principal collection basin, the water may be automatically siphoned to a distant exit point or to an exit cylinder, so that there is a constant movement of water from the principal collection point to the distant exit point.

Abstract: A system for constructing golf course traps which would include the steps of forming a cutout area in the fairway in the desired shape of the trap, the cutout area including a continuous substantially vertical sidewall and a substantially flat floor portion; and forming a plurality of channels for housing the "turf drain" composite drainage line within the channels for undertaking drainage of the traps; prior to the placement of the turf drain lines within the channels, placing a continuous sheet of material such as plastic liner along the floor of the trap and the continuous sheet forming within the plurality of channels; positioning the "turf drain" composite drainage line within the channels so that the plastic liner is positioned between the soil and the turf drainage line; and filling the trap with sufficient sand for allowing the upper most portion space of the sand within the trap to be substantially flush with the surrounding fairway, so that as water drains into the trap, the water would essentially

Abstract: A principal catch basin defining a certain storage capacity, the catch basin situated below the level of the ground, having an upper level opening for receiving surface water drainage thereunto, and having side walls partially constructed of permeable geotextile fabric for allowing both sub-surface air to flow into the catch basin for providing additional water absorption by the ground, and for allowing water flow and sub-surface air to flow into the catch basin for providing additional water absorption by the ground, and for allowing water flow into the sub-surface water flow through the permeable basin to serve as a collection for sub-surface drainage. The system would include the ability to create a siphon within the system so that as water drains into the principle collection basin, the water may be automatically siphoned to a distant exit point or to an exit cylinder, so that there is a constant movement of water from the principle collection point to the distant exit point.

Abstract: A geotextile fabric composite sleeve having three interconnected portions so that two of the portions are slidable over the principal drain line, and define a main sleeve portion and the third portion for accommodating a lateral line for defining an auxiliary sleeve portion in fluid communication with the main sleeve portion, the auxiliary sleeve portion projecting out flexible to any angle from the main sleeve portion, with the main sleeve portion position onto the principle drain line at a point so that the opening of the auxiliary sleeve portion into the main sleeve portion is that the window cut into the main sleeve.