Abstract: Novel compounds, compositions, and methods of using and preparing the same, which may be useful for treating alpha-1 antitrypsin deficiency (AATD).

Abstract: A vapor-enhancing apparatus is provided for an electronic vapor smoking article. Such an apparatus includes a filter material and a tubular housing defining a lumen. The lumen has a mouth-engaging end and a longitudinally-opposed component-engaging end, and is configured to receive the filter material therein. The component-engaging end is adapted to operably engage a control body portion associated with the electronic vapor smoking article and to receive a vapor therethrough. A vapor-enhancing element is operably engaged with the filter material and is configured to enhance the vapor drawn through the filter material within the lumen, and through the mouth-engaging end, by application of suction to the mouth-engaging end of the housing. An associated method is also provided.

Abstract: A transport mechanism for engaging a pouch in an erect configuration at a first station of a packaging machine and transferring the pouch to a second station of the packaging machine includes a carriage and a grip assembly. The carriage is moveable between the first station and the second station. The grip assembly is coupled to the carriage and is at least partially moveable relative to the carriage between an engaged position for clamping the pouch in the erect configuration within the grip assembly, and a released position.

Abstract: Pyrrolo[2,3-f]indazole and 2,4,5,10-tetrazatricyclo[7.3.0.

Abstract: A biosensor component is provided that provides enhanced characteristics for use in biosensors, such as blood glucose sensors. The biosensor component comprises a substrate, a conductive layer deposited on the substrate, and a resistive material layer deposited on the conductive layer. The conductive layer includes nickel, chromium, and iron, such that a combined weight percent of the nickel and chromium in the conductive layer is in the range of 25 to less than 95 weight percent, the weight percent of nickel in the conductive layer is at least 4 weight percent, the weight percent of chromium in the conductive layer is at least 10 weight percent, the weight percent of iron in the conductive layer at least 2 weight percent, and such that the conductive layer comprises 0 to 20 weight percent molybdenum.

Abstract: A biosensor component is provided that provides enhanced characteristics for use in biosensors, such as blood glucose sensors. The biosensor component comprises a substrate, a conductive layer deposited on the substrate, and a resistive material layer deposited on the conductive layer. The conductive layer includes nickel, chromium, and iron, such that a combined weight percent of the nickel and chromium in the conductive layer is in the range of 25 to less than 95 weight percent, the weight percent of nickel in the conductive layer is at least 8 weight percent, the weight percent of chromium in the conductive layer is at least 10 weight percent, the weight percent of iron in the conductive layer at least 2 weight percent, and such that the conductive layer comprises 0 to 20 weight percent molybdenum.

Abstract: A mounting system for retrofitting a vibration sensor to a machine component is provided. The mounting system includes an elongate fastener, a washer, and a mounting boss. The elongate fastener includes a fastener head and an elongated body defining a longitudinal top end and a longitudinal bottom end. The longitudinal bottom end defines a fastening end configured to engage with a corresponding fastening receptacle of the machine component. The washer defines an external surface and includes a central cavity for engaging the elongated body of the elongate fastener therein. The mounting boss includes a first portion and a second portion. The first portion includes an internal cavity defining a first cavity section configured to engage with the external surface of the washer, and a second cavity section to engage with the fastener head of the elongate fastener. The second portion defines a receiving port for receiving the vibration sensor.

Abstract: A biosensor component that provides enhanced characteristics for use in biosensors, such as blood glucose sensors. The biosensor component comprises a substrate, and a composite layer deposited on the substrate. The composite layer includes a conductive metal component and a resistive material component, where the conductive metal component comprises one or more non-noble metals, and where the resistive material component in the composite layer is present in an amount greater than 20 atomic percent.

Abstract: The present invention provides a conductive substrate useful for Joule heating, such as in an electronic smoking article. Particularly, the invention provides a resistive heating element formed of a conductive substrate. The conductive substrate comprises an electrically conductive material and a carbonaceous additive, such as a binder material. The conductive substrate is carbonized in that it is subjected to calcining conditions to effectively reduce the carbonaceous additive to its carbon skeleton. It has been found that such carbonized substrate has surprisingly improved resistance properties in relation a substrate of the same formulation that is not carbonized. The carbonized substrate can include an aerosol precursor material. The formed resistive heating element can be included in an electronic smoking article to simultaneously provide resistive heating and aerosol formation with a single, unitary component.

Abstract: An electrochemical electrode for use in a biosensor. The electrode comprises a substrate, a palladium metal layer manufactured on the substrate, and a palladium oxide-containing layer manufactured on the palladium metal layer. The palladium metal layer has a thickness of no more than 90 nm, and the palladium oxide-containing layer has a thickness of no more than 40 nm.

Abstract: The present disclosure relates to aerosol delivery devices. The aerosol delivery devices include mechanisms configured to deliver an aerosol precursor composition from a reservoir to an atomizer including a vaporization heating element to produce a vapor. For example, a bubble jet head may be configured to dispense the aerosol precursor composition to the atomizer. The bubble jet head may be fixedly coupled to the atomizer. The bubble jet head may include a precursor inlet, an ejection heating element, and a precursor nozzle. The atomizer may include a vaporization heating element.

Abstract: The present disclosure relates to an electronic smoking article that provides for improved aerosol delivery. Particularly, the article comprises one or more microheaters. In various embodiments, the microheaters provide for improved control of vaporization of an aerosol precursor composition and provide for reduced power requirements to achieve consistent aerosolization. The present disclosure further relates to methods of forming an aerosol in a smoking article.

Abstract: Aerosol delivery devices including mechanisms configured to deliver an aerosol precursor composition from a reservoir to an atomizer including a vaporization heating element to produce a vapor are disclosed. For example, a bubble jet head may be configured to dispense the aerosol precursor composition to the atomizer. The bubble jet head may be fixedly coupled to the atomizer. The bubble jet head may include a precursor inlet, an ejection heating element, and a precursor nozzle. The atomizer may include a vaporization heating element.

Abstract: A mounting system for retrofitting a vibration sensor to a machine component is provided. The mounting system includes an elongate fastener, a washer, and a mounting boss. The elongate fastener includes a fastener head and an elongated body defining a longitudinal top end and a longitudinal bottom end. The longitudinal bottom end defines a fastening end configured to engage with a corresponding fastening receptacle of the machine component. The washer defines an external surface and includes a central cavity for engaging the elongated body of the elongate fastener therein. The mounting boss includes a first portion and a second portion. The first portion includes an internal cavity defining a first cavity section configured to engage with the external surface of the washer, and a second cavity section to engage with the fastener head of the elongate fastener. The second portion defines a receiving port for receiving the vibration sensor.

Abstract: The present invention provides for an apparatus and a method for automating the dispensing a liquid agent into a toilet.