Abstract: A surgical instrument, has an end effector that includes an ultrasonic blade, and a clamp arm that moves relative to the ultrasonic blade from an opened position toward an intermediate position and a closed position. The clamp arm is offset from the ultrasonic blade to define a predetermined gap in the intermediate position between the opened position and the closed position. A clamp arm actuator connects to the clamp arm and moves from an opened configuration to a closed configuration to direct the clamp arm from the opened position toward the intermediate position and the closed position. A spacer connects with the clamp arm to inhibit movement of the clamp arm from the intermediate position toward the closed position for maintaining the predetermined gap between the clamp arm and the ultrasonic blade.

Abstract: A method for operating a drive train (1) of a vehicle includes, in order to check the plausibility of an adapted charge pressure value, changing an actuating pressure of a starting component (7) corresponding to an adapted charge pressure value by an offset and ascertaining a resultant change in a torque of an electric machine (3). When the change in the torque of the electric machine (3) and the offset of the actuating pressure correspond to each other within defined limits, a plausible adapted charge pressure value is inferred. When the change in the torque of the electric machine (3) and the offset of the actuating pressure do not correspond to each other within the defined limits, an implausible adapted charge pressure value is inferred.

Abstract: An aircraft wing is disclosed herein having a fixed-location trip device placed along the span of the wing to transition airflow from laminar flow to turbulent flow so that potential load increases are limited and flight performance uncertainties associated with laminar flow wings are reduced. Wings designed for extended laminar flow offer the potential to significantly reduce airplane drag and fuel consumption. A collateral impact of a laminar flow wing is the generation of elevated wing loads at critical load conditions. This impact is mitigated by controlling the downstream limit of transition at these critical load conditions.

Abstract: Peptide-immuno-oncology agent complexes (“peptide-I/O complexes”) that can home, target, migrate to, are directed to, are retained by, accumulate in, penetrate, or bind to the tumor microenvironment, tumor tissues, or cells or compartments or cytosol of cells thereof, or any combination thereof, are disclosed. Additionally disclosed are peptide-I/O complexes that can cross the blood-brain barrier. Pharmaceutical compositions and uses for peptide-I/O complexes comprising such peptides are also disclosed. Such compositions can be formulated for targeted delivery of an immuno-oncology agent (“I/O”) to the tumor microenvironment. Targeted compositions of the disclosure can deliver peptide-I/O complexes to target regions, tissues, structures or cells targeted by the peptide.

Abstract: Compositions and formulations comprising peptide conjugate compounds are provided, including native and modified variants of chlorotoxin peptide conjugated to detectable agents or active agents. Methods of detecting and treating vascular lesions, vascular malformations, and vascular abnormalities including cerebral cavernous malformation (CCM) with peptide conjugate compounds are also provided, including methods of imaging and resecting vascular lesions tissues and cells.

Abstract: Disclosed herein are methods of vascular and structural imaging using imaging systems and methods described, the methods comprising producing an image of the vasculature or structure by imaging fluorescence using an imaging system, the system comprising: i) one or more detectors configured to form a fluorescence image of the sample and form a visible image of the sample; ii) a light source configured to emit an excitation light to induce fluorescence from the sample; and iii) a plurality of optics arranged to: direct the excitation light toward the sample; and direct a fluorescent light and a visible light from the sample to the detector; wherein the excitation light and the fluorescence light are directed substantially coaxially.

Abstract: A concrete building block for masonry block walls is formed with first, second and third spaced parallel rectangular face shells, where the second face shell is intermediate the first and third face shells. First and second vertical end cross webs connect the first and second face shells and first and second spaced intermediate vertical cross webs connect the second and third face shells. Insulating inserts include end protrusions extending outwardly at the top edge thereof to fit into notches of the cross webs and include cutouts to accommodate mortar crumbs. The inserts further include longitudinal notches along the entire bottom edges and longitudinal notches along the entire top edges wherein said longitudinal notches along a bottom edge are dimensioned to mate with longitudinal notches along a top edge of neighboring ones of the insulating inserts creating an overlap that serves to (i) insulate against temperature transfer and (ii) provide a sound barrier.

Abstract: A concrete building block for masonry block walls is formed with first, second and third spaced parallel rectangular face shells, where the second face shell is intermediate the first and third face shells. First and second vertical end cross webs connect the first and second face shells and first and second spaced intermediate vertical cross webs connect the second and third face shells. Insulating inserts include end protrusions extending outwardly at the top edge thereof to fit into notches of the cross webs and include cutouts to accommodate mortar crumbs. The inserts further include longitudinal notches along the entire bottom edges and longitudinal notches along the entire top edges wherein said longitudinal notches along a bottom edge are dimensioned to mate with longitudinal notches along a top edge of neighboring ones of the insulating inserts creating an overlap that serves to (i) insulate against temperature transfer and (ii) provide a sound barrier.

Abstract: A concrete building block for masonry block walls is formed with first, second and third spaced rectangular face shells, where the second face shell is intermediate the first and third face shells. First and second cross webs connect the first and second face shells and a third cross web connects the second and third face shells. Insulating cores include end protrusions extending outwardly at the top edge thereof to fit into notches of the cross webs and include cutouts to accommodate mortar crumbs. The insulating cores further mate, creating an overlap that serves to (i) insulate against temperature transfer and (ii) provide a sound barrier. A unique block permits a combination of insulating inserts and solid grouting as well as a symmetric arrangement.

Abstract: A system and method of treating vaginal prolapse and incontinence comprises a kit. The kit includes a mesh graft configured for attachment to the anterior and posterior vaginal walls to thereby treat the vaginal prolapse. A graft delivery device is also provided for introducing and placing the mesh graft to a location deep within the peritoneal cavity and for attaching the graft thereto. A leg assembly is provided and coupled to an end of the mesh graft and cooperates with the graft delivery device to anchor and affix the mesh graft to the desired anatomical structures. The method according to the present invention contemplates a laparoscopic graft placement utilizing the components of the kit.

Abstract: Peptide-immuno-oncology agent complexes (“peptide-I/O complexes”) that can home, target, migrate to, are directed to, are retained by, accumulate in, penetrate, or bind to the tumor microenvironment, tumor tissues, or cells or compartments or cytosol of cells thereof, or any combination thereof, are disclosed. Additionally disclosed are peptide-I/O complexes that can cross the blood-brain barrier. Pharmaceutical compositions and uses for peptide-I/O complexes comprising such peptides are also disclosed. Such compositions can be formulated for targeted delivery of an immuno-oncology agent (“I/O”) to the tumor microenvironment. Targeted compositions of the disclosure can deliver peptide-I/O complexes to target regions, tissues, structures or cells targeted by the peptide.

Abstract: An aircraft wing is disclosed herein having a fixed-location trip device placed along the span of the wing to transition airflow from laminar flow to turbulent flow so that potential load increases are limited and flight performance uncertainties associated with laminar flow wings are reduced. Wings designed for extended laminar flow offer the potential to significantly reduce airplane drag and fuel consumption. A collateral impact of a laminar flow wing is the generation of elevated wing loads at critical load conditions. This impact is mitigated by controlling the downstream limit of transition at these critical load conditions.

Abstract: The present invention related to CNT filled polymer composite system possessing a high thermal conductivity and high temperature stability so that it is a highly thermally conductive for use in 3D and 4D integration for joining device sub-laminate layers. The CNT/polymer composite also has a CTE close to that of Si, enabling a reduced wafer structural warping during high temperature processing cycling. The composition is tailored to be suitable for coating, curing and patterning by means conventionally known in the art.

Abstract: The present invention relates to CNT filled polymer composite system possessing a high thermal conductivity and high temperature stability so that it is a highly thermally conductive for use in 3D and 4D integration for joining device sub-laminate layers. The CNT/polymer composite also has a CTE close to that of Si, enabling a reduced wafer structural warping during high temperature processing cycling. The composition is tailored to be suitable for coating, curing and patterning by means conventionally known in the art.

Abstract: The present invention related to CNT filled polymer composite system possessing a high thermal conductivity and high temperature stability so that it is a highly thermally conductive for use in 3D and 4D integration for joining device sub-laminate layers. The CNT/polymer composite also has a CTE close to that of Si, enabling a reduced wafer structural warping during high temperature processing cycling. The composition is tailored to be suitable for coating, curing and patterning by means conventionally known in the art.

Abstract: A system and method of treating vaginal prolapse and incontinence comprises a kit. The kit includes a mesh graft configured for attachment to the anterior and posterior vaginal walls to thereby treat the vaginal prolapse. A graft delivery device is also provided for introducing and placing the mesh graft to a location deep within the peritoneal cavity and for attaching the graft thereto. A leg assembly is provided and coupled to an end of the mesh graft and cooperates with the graft delivery device to anchor and affix the mesh graft to the desired anatomical structures. The method according to the present invention contemplates a laparoscopic graft placement utilizing the components of the kit.

Abstract: A system and method of treating vaginal prolapse and incontinence comprises a kit. The kit includes a mesh graft configured for attachment to the anterior and posterior vaginal walls to thereby treat the vaginal prolapse. A graft delivery device is also provided for introducing and placing the mesh graft to a location deep within the peritoneal cavity and for attaching the graft thereto. A leg assembly is provided and coupled to an end of the mesh graft and cooperates with the graft delivery device to anchor and affix the mesh graft to the desired anatomical structures. The method according to the present invention contemplates a laparoscopic graft placement utilizing the components of the kit.

Abstract: The present invention relates to CNT filled polymer composite system possessing a high thermal conductivity and high temperature stability so that it is a highly thermally conductive for use in 3D and 4D integration for joining device sub-laminate layers. The CNT/polymer composite also has a CTE close to that of Si, enabling a reduced wafer structural warping during high temperature processing cycling. The composition is tailored to be suitable for coating, curing and patterning by means conventionally known in the art.

Abstract: A medical device includes a first end portion, a second end portion, and medial portion disposed between the first end portion and the second end portion. The first end portion defines a first axis. The second end portion defines a second axis. The first axis is disposed at an angle with respect to the second axis.

Abstract: The present invention relates to CNT filled polymer composite system possessing a high thermal conductivity and high temperature stability so that it is a highly thermally conductive for use in 3D and 4D integration for joining device sub-laminate layers. The CNT/polymer composite also has a CTE close to that of Si, enabling a reduced wafer structural warping during high temperature processing cycling. The composition is tailored to be suitable for coating, curing and patterning by means conventionally known in the art.