Abstract: This invention relates in general to certain substituted substituted 1,1,4-1l6-trioxo[1,2]thiazepan-4-ylamides of formula I as defined herein which are protease inhibitors.

Abstract: This invention relates to 7-substituted 3,6-dioxo-octahydroprrolo[1,2-?]azepine protease inhibitors of formula 1 as defined herein, particularly of cysteine and serine proteases.

Abstract: This invention relates to certain substituted substituted amides of formula I as defined herein which are protease inhibitors.

Abstract: Solid phase combinatorial synthesis is carried out in a multi-reactor synthesizer comprising an array of separate reactor cells containing a solid reaction support medium. Subsets of reactor cells are interconnected with one another in a desired pattern, and, in a first reaction step, reagents are circulated through the subsets. After the first reaction step is completed, the reactor cells are rearranged into a new configuration of subsets, and the same, or other, reagents are circulated through the new subsets. The process can be repeated to produce large numbers of compounds differing from one another.