Abstract: The disclosure provides methods for treating a subject in need thereof comprising administering to the subject a therapeutically-effective dose of psilocybin. The methods described herein may be used to treat a variety of diseases, disorders, and conditions. For example, the methods may be used to treat neurocognitive disorders (e.g., Alzheimer's disease, Parkinson's disease), ADHD, Epilepsy, Autism, Sleep-wake disorders, Chronic pain, Inflammatory Disorders, IBD, Stroke, ALS, and/or Multiple Sclerosis.

Abstract: The present disclosure relates to systems, non-transitory computer-readable media, and methods for determining different routes along which provider vehicles and rental vehicles can transport a requestor to a destination. For instance, in some cases, a multi-modal-transportation system receives a transportation request that includes a pickup location and a destination location. The multi-modal-transportation system analyzes the transportation request to generate (i) a provider transportation route by which a provider vehicle transports the requestor to the destination location and (ii) a rental route by which one or more intermediate vehicles and a rental vehicle transport the requestor along rental-route segments to the destination location. The multi-modal-transportation system further transmits data for both routes to a requestor device to display within a multi-modal graphical user interface.

Abstract: Fire protection systems and methods having piping interconnections for connecting a fire protection device to a fluid source. The piping interconnections include a branch connector connected to a pipe header. The branch connector includes a tubular member and an internal annular seal member housed in an internal gasket chamber of the tubular member. The tubular member includes an internal stepless surface between a terminal end of the tubular member and the internal gasket chamber.

Abstract: Fire protection systems and methods having piping interconnections for connecting a fire protection device to a fluid source. The piping interconnections include a branch connector connected to a pipe header. The branch connector includes a tubular member and an internal annular seal member housed in an internal gasket chamber of the tubular member. The tubular member includes an internal stepless surface between a terminal end of the tubular member and the internal gasket chamber.

Abstract: This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin.

Abstract: This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin.

Abstract: A method at a server for container location verification within a container yard, the method including requesting image data from at least one image sensor apparatus affixed to a container within the container yard; receiving the image data; and processing the image data to identify a location of a target container.

Abstract: Fire protection systems and methods having piping interconnections for connecting a fire protection device to a fluid source. The piping interconnections include a branch connector connected to a pipe header. The branch connector includes a tubular member and an internal annular seal member housed in an internal gasket chamber of the tubular member. The tubular member includes an internal stepless surface between a terminal end of the tubular member and the internal gasket chamber.

Abstract: The present invention is directed to a tread and a tire having a tread, wherein over most of a circumferential length i) a maximum axial width in a top portion of a tread groove is at least 5% smaller than an axial width of the tread groove in its bottom portion, ii) the axial width of the tread groove in the bottom portion is at least 5% smaller than the maximum axial width of the tread groove in a radial intermediate portion of the tread groove, and iii) a maximum axial width of the tread groove in the intermediate portion is within a range of 15% to 50% of the total radial height of the tread groove.

Abstract: An implantable medical device is disclosed. The implantable medical device includes a housing forming an internal compartment. The housing includes a frame disposed within the internal compartment forming a first partition and a second partition within the internal compartment. The first partition is hermetically sealed from the second partition. At least one electronic component and a power source are disposed within the first partition. The medical device includes a fluidics circuit including a manifold operably coupled to at least one fluidics component. The fluidics circuit is operably coupled to the at least one electronic component across the frame.

Abstract: A tire comprising a tire tread having a tread region comprising a first and second rib, wherein the first and second ribs are separated by a groove; at least one tie-bar element disposed within the groove, and the tie-bar block element having opposed sidewalls separated by a radially extending groove, wherein the radially extending groove tapers from a first width to a second width, wherein the second width is wider than the first width.

Abstract: This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin.

Abstract: The invention provides a novel synthetic route for the preparation of the Chk-1 inhibitor compound: as well as novel process intermediates per se.

Abstract: The disclosure provides methods for treating a subject in need thereof comprising administering to the subject a therapeutically-effective dose of psilocybin. The methods described herein may be used to treat a variety of diseases, disorders, and conditions. For example, the methods may be used to treat anxiety disorders, eating disorders, and headache disorders.

Abstract: A breather used for vacuum bag compaction of a composite laminate part is semi-permanently installed on a compaction tool. The breather is a channel member having an internal passageway that routes air and volatiles from the vacuum bag to a vacuum port in the tool.

Abstract: A medical device includes a first housing section with a first cavity and including a ceramic material, a second housing section coupled to the first housing section and including a second cavity, a first circuit board section positioned within the first cavity, a second circuit board section positioned within the second cavity, and an antenna coupled to the first circuit board section.

Abstract: This invention relates to the large-scale production of psilocybin for use in medicine. More particularly, it relates to a method of obtaining high purity crystalline psilocybin, particularly, in the form of Polymorph A. It further relates to a method for the manufacture of psilocybin and intermediates in the production thereof and formulations containing psilocybin.