Abstract: This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.

Abstract: This invention relates to certain aryl alkyl acid compounds, compositions, and methods for treating or preventing obesity and related diseases.

Abstract: Di-N-substituted piperazine or 1,4 di-substituted piperadine compounds in accordance with formula I (including all isomers, salts, esters, and solvates) wherein R, R1, R2, R3, R4, R21, R27, R28, X, Y, and Z are as defined herein are muscarinic antagonists useful for treating cognitive disorders such as Alzheimer's disease. Pharmaceutical compositions and methods of preparation are also disclosed. Also disclosed are synergistic combinations of compounds of the above formula or other compounds capable of enhancing acetylcholine release with acetylcholinesterase inhibitors.

Abstract: Di-N-substituted piperazine or 1,4 di-substituted piperadine compounds in accordance with formula I (including all isomers, salts, esters, and solvates) 1

Abstract: Di-N-substituted piperazine or 1,4 di-substituted piperadine compounds in accordance with formula I (including all isomers, salts, esters, and solvates) wherein R, R1, R2, R3, R4, R21, R27, R28, X, Y, and Z are as defined herein are muscarinic antagonists useful for treating cognitive disorders such as Alheimer's disease. Pharmaceutical compositions and methods of preparation are also disclosed. Also disclosed are synergistic combinations of compounds of the above formula or other compounds capable of enhancing acetylcholine release with acetylcholinesterase inhibitors.

Abstract: Di-N-substituted piperazine or 1,4 di-substituted piperadine compounds in accordance with formula I (including all isomers, salts, esters, and solvates) ##STR1## wherein R, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.21, R.sup.27, R.sup.28, X, Y, and Z are as defined herein are muscarinic antagonists useful for treating cognitive disorders such as Alzheimer's disease. Pharmaceutical compositions and methods of preparation are also disclosed. Also disclosed are synergistic combinations of compounds of the above formula or other compounds capable of enhancing acetylcholine release with acetylcholinesterase inhibitors.

Abstract: Di-N-substituted piperazine or 1,4 di-substituted piperadine compounds of formula I ##STR1## wherein one of Y and Z is N and the other is N, CH, or C-alkyl;X is --O--, --SO.sub.0-2 --, amino, substituted amino, --CO--, --CH.sub.2 --, mono or di-substituted methylene, --CS--, --CONR.sup.20 --, --NR.sup.20 --SO.sub.2 --, --NR.sup.20 CO--, --SO.sub.2 NR.sup.20 --, --CH.dbd.CH--, --C.tbd.C-- or --NHC(O)NH--;R is optionally substituted phenyl, aryl or cycloalkyl, or other substituents as defined in the specification;R.sup.1 and R.sup.21 are H, CN or optionally substituted alkyl, or other substituents as defined in the specification;R.sup.2 is optionally substituted cycloalkyl or piperidyl, or other substituents as defined in the specification; andR.sup.3, R.sup.4, R.sup.5, R.sup.20, R.sup.27 and R.sup.

Abstract: A dual-circuit brake system including a diagonal division is provided by the invention. The brakes of the driven wheels, on the one hand, through inlet valves are in communication with the brake pressure generator and, on the other hand, through intake valves, are in direct communication with a pressure source. Moreover, communication is established with a reservoir through the outlet valves. For brake slip control purposes, pairs of inlet and outlet valves are actuated, while for traction slip control purposes, pairs of intake and outlet valves are actuated; during a traction slip control, the inlet valves and separator valves in bypass conduits leading to the inlet valves are closed. This circuit configuration involves the advantage that the intake and inlet valves may be provided with different diaphragms that are adjusted to the respective control mode.

Abstract: A connecting arrangement for connecting two hollow components of a hydraulic circuit to one another, especially a pipe or hose to a mating component, includes a guiding formation on one of the components, especially the mating component, and a mounting formation connected to the other component, these formations having correlated cross-sectional shapes such that the guiding formation guides the mounting formation in a predetermined direction, especially the longitudinal direction of the one component, and prevents relative displacement in all other directions. The mounting formation is advantageously constituted by a separate mounting element which is affixed to the other component by a threaded connection, such as by a screw cap. The formations advantageously have complementary dovetail-shaped cross-sectional configurations.

Abstract: In a known dual-circuit braking pressure control valve, a tilting lever arrangement is provided for distribution of the preloading force to the two control pistons, whereby the change-over point of the intact brake circuit is increased upon failure of one brake circuit. The tilting lever arrangement is complicated with respect to its construction and assembly, and its mode of operation is not safe. According to the present invention the tilting lever arrangement is replaced by a carrier bridge at the ends of the two pistons which synchronizes the points of application of the preloading forces by allowing a slight relative movement betweeen the two pistons when both of the brake circuits are operative.

Abstract: A pressure reducer for hydraulic brake systems comprises a stepped piston carrying a sealing ring in a circumferential groove thereof. The sealing section of the sealing ring begins at the groove wall adjacent the outlet chamber and joins a transitional section of smaller diameter adjacent the inlet chamber. The sealing ring fills the groove essentially completely at least in the sealing section. Preferably the sealing ring abuts the bottom of the groove over its entire axial length. This results in a defined position for the sealing section without excessive friction and wear occurring during operation.

Abstract: Dual circuit pressure control valves for brake system are known in which the control pistons are located parallel to each other with each control piston controlling a different one of two brake circuits. Both control pistons are loaded by a common preloading force. The known arrangement is complicated in its construction and has a large overall length. According to the present invention, the construction is simplified and the overall length is reduced by providing a torsion spring which provides the preloading force acting on the control pistons via stationarily supported swivelling levers.

Abstract: Dual-circuit pressure control valves are known in which the control pistons are acted upon by a common control force. A preload distributor constructed as beams of balance to compensate for differences in the control behavior of the two control valves due to manufacturing tolerances have not provided the desired compensation. Therefore, according to the present invention an improved compensation arrangement is provided in the form of a compensating piston which is subjected to the outlet pressures of the two brake circuits.