Patents by Inventor Detlef Behrend
Detlef Behrend has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 9592325Abstract: Absorbable stents and absorbable stent coatings have been developed with improved properties. These devices preferably comprise biocompatible copolymers or homopolymers of 4-hydroxybutyrate, and optionally poly-L-lactic acid and other absorbable polymers and additives. Compositions of these materials can be used to make absorbable stents that provide advantageous radial strengths, resistance to recoil and creep, can be plastically expanded on a balloon catheter, and can be deployed rapidly in vivo. Stent coatings derived from these materials provide biocompatible, uniform coatings that are ductile, and can be expanded without the coating cracking and/or delaminating and can be used as a coating matrix for drug incorporation.Type: GrantFiled: August 7, 2008Date of Patent: March 14, 2017Assignee: Tepha, Inc.Inventors: Klaus-Peter Schmitz, Detlef Behrend, Katrin Sternberg, Niels Grabow, David Martin, Simon Williams
-
Patent number: 9162010Abstract: Drug delivery systems and biocompatible coatings for use with implantable stimulation devices such as cochlear implants have been developed. These drug delivery systems and coatings comprise polyhydroxyalkanoate (PHA) polymers and copolymers. The drug delivery systems may be used to deliver pharmacologically active substances, for example, directly from a cochlear implant to the inner ear. The coatings can impart lubricity to cochlear devices for ease of insertion of the electrodes. In the preferred embodiment, the drug delivery system comprises a polyhydroxyalkanoate polymer, and in the most preferred embodiment, the PHA polymer comprises poly(4-hydroxybutyrate) (P(4HB)) or copolymer thereof. A particularly preferred embodiment is where the silicone sheath of the cochlear implant electrodes has been surface modified, and coated with P(4HB), and the P(4HB) either contains a pharmacologically active substance or has been coated with such a substance.Type: GrantFiled: October 28, 2011Date of Patent: October 20, 2015Assignee: Tepha, Inc.Inventors: Thomas Lenarz, Klaus-Peter Schmitz, Detlef Behrend, Katrin Sternberg, Simon Williams, David Martin
-
Patent number: 8979921Abstract: Absorbable stents and absorbable stent coatings have been developed with improved properties. These devices preferably comprise biocompatible copolymers or homopolymers of 4-hydroxybutyrate, and optionally polylactic acid and other absorbable polymers and additives. Compositions of these materials can be used to make absorbable stents that provide advantageous radial strengths, resistance to recoil and creep, can be plastically expanded on a balloon catheter, and can be deployed rapidly in vivo. Stent coatings derived from these materials provide biocompatible, uniform coatings that are ductile, and can be expanded without the coating cracking and/or delaminating and can be used as a coating matrix for drug incorporation.Type: GrantFiled: October 14, 2008Date of Patent: March 17, 2015Assignee: Tepha, Inc.Inventors: Klaus-Peter Schmitz, Detlef Behrend, Katrin Sternberg, Niels Grabow, David P. Martin, Simon F. Williams
-
Patent number: 8961591Abstract: Absorbable stents and absorbable stent coatings have been developed with improved properties. These devices preferably comprise biocompatible copolymers or homopolymers of 4-hydroxybutyrate, and optionally poly-L-lactic acid and other absorbable polymers and additives. Compositions of these materials can be used to make absorbable stents that provide advantageous radial strengths, resistance to recoil and creep, can be plastically expanded on a balloon catheter, and can be deployed rapidly in vivo. Stent coatings derived from these materials provide biocompatible, uniform coatings that are ductile, and can be expanded without the coating cracking and/or delarmnating and can be used as a coating matrix for drug incorporation.Type: GrantFiled: July 17, 2009Date of Patent: February 24, 2015Assignee: Tepha, Inc.Inventors: Klaus-Peter Schmitz, Detlef Behrend, Katrin Sternberg, Niels Grabow, David P. Martin, Simon F. Williams
-
Patent number: 8774892Abstract: An electrode arrangement for sensing electrical activity in target tissue is described. A support electrode has an elongate electrode body with a base end and a penetrating end for insertion into the target tissue. A fixation electrode has an elongate electrode body with a base end and a penetrating end at an angle to the electrode body. The electrodes are joined together with their electrode bodies in parallel so that the penetrating end of the fixation electrode penetrates a fixed distance into the target tissue so that at least one of the electrodes senses electrical activity in the target tissue.Type: GrantFiled: April 20, 2010Date of Patent: July 8, 2014Assignee: MED-EL Elektromedizinische Geraete GmbHInventors: Detlef Behrend, Klaus-Peter Schmitz, Hans Wilhelm Pau, Katrin Sternberg, Wolfram Schmidt
-
Patent number: 8725227Abstract: The invention relates to an electrode arrangement and a measuring device for measuring the action flow and/or the action potential of an electrically active tissue. The aim of the invention is to provide a simple and economically producible electrode for measuring action flows and/or action potentials in electrically active tissues (preferably the stapedius muscle tissue), ensuring that the electrode is fixed securely, but reversibly, in the muscle tissue and that the muscle tissue is disturbed as little as possible. The electrode arrangement according to the invention comprises a first electrode (2) and a fixing element (3), the first electrode (2) being connected to a first, long electrical line (4) and consisting of a long base body (6) comprising a first end (7) and a second end (8). The first electrical line (4) is connected to the base body (6) in the region of the second end (8) thereof, and means are provided for reversibly fixing the fixing element (3) to the first electrode (2).Type: GrantFiled: June 4, 2008Date of Patent: May 13, 2014Assignee: MED-EL Elektromedizinische Geraete GmbHInventors: Detlef Behrend, Klaus-Peter Schmitz, Hans Wilhelm Pau, Katrin Sternberg, Wolfram Schmidt
-
Patent number: 8718741Abstract: An electrode arrangement is described for sensing electrical activity in target tissue. An inner electrode has an elongate electrode body formed as a cylindrical section with an inner penetrating end for insertion into the stapedius muscle target tissue. An outer electrode fits over the inner electrode and an outer penetrating end for insertion into the target tissue. The two electrodes are joined together with their electrode bodies in parallel so that the penetrating ends of the electrodes penetrate in the same direction into the target tissue to sense electrical activity in the target tissue.Type: GrantFiled: June 19, 2013Date of Patent: May 6, 2014Assignee: MED-EL Elektromedizinische Geraete GmbHInventors: Hans Wilhelm Pau, Detlef Behrend, Mareike Warkentin, Wolfram Schmidt, Olaf Specht, Daniel Schaudel, Guido Reetz
-
Publication number: 20140100471Abstract: A device for measuring stapedius tissue activity uses a mechanoelectrical transducer having two ends. A static end is configured for attachment to the bony pyramid in the middle ear, and a dynamic end is configured for attachment to stapedius tissue in the middle ear. The transducer generates a corresponding electrical sensing signal output when the stapedius tissue moves the dynamic end relative to the static end.Type: ApplicationFiled: October 4, 2013Publication date: April 10, 2014Applicant: MED-EL Elektromedizinische Geraete GmbHInventors: Roland Hessler, Anandhan Dhanasingh, Maria del Carmen Fuentes, Hans Wilhelm Pau, Attila Ovari, Detlef Behrend, Mareike Warkentin, Olaf Specht, Wolfram Schmidt
-
Publication number: 20130281812Abstract: An electrode arrangement is described for sensing electrical activity in target tissue. An inner electrode has an elongate electrode body formed as a cylindrical section with an inner penetrating end for insertion into the stapedius muscle target tissue. An outer electrode fits over the inner electrode and an outer penetrating end for insertion into the target tissue. The two electrodes are joined together with their electrode bodies in parallel so that the penetrating ends of the electrodes penetrate in the same direction into the target tissue to sense electrical activity in the target tissue.Type: ApplicationFiled: June 19, 2013Publication date: October 24, 2013Inventors: Hans Wilhelm Pau, Detlef Behrend, Mareike Warkentin, Wolfram Schmidt, Olaf Specht, Daniel Schaudel, Guido Reetz
-
Patent number: 8521250Abstract: An electrode arrangement is described for sensing electrical activity in target tissue. An inner electrode has an elongate electrode body formed as a cylindrical section with an inner penetrating end for insertion into the stapedius muscle target tissue. An outer electrode fits over the inner electrode and an outer penetrating end for insertion into the target tissue. The two electrodes are joined together with their electrode bodies in parallel so that the penetrating ends of the electrodes penetrate in the same direction into the target tissue to sense electrical activity in the target tissue.Type: GrantFiled: December 15, 2011Date of Patent: August 27, 2013Assignee: MED-EL Elektromedizinische Geraete GmbHInventors: Hans Wilhelm Pau, Detlef Behrend, Mareike Warkentin, Wolfram Schmidt, Olaf Specht, Daniel Schaudel, Guido Reetz
-
Patent number: 8496971Abstract: The present invention relates to a combination for the treatment of osteoporosis and/or the prophylaxis and treatment of bone fractures, said combination comprising collagen, an additional peptide, a calcium-containing substance and a wetting agent with a terminally functionalized oligolactone. The invention also relates to artificial bones and implants produced by the combination and to the use of said combination for fixing implants and treating osteoporosis and/or the prophylaxis and treatment of bone fractures. The invention further relates to a method for producing artificial bones and implants.Type: GrantFiled: October 16, 2007Date of Patent: July 30, 2013Assignee: Universitaet RostockInventors: Georg Gradl, Detlef Behrend, Klaus-Peter Schmitz, Katrin Sternberg, Kathleen Schmohl, Sven Kramer
-
Patent number: 8460703Abstract: A composition for the adhesive bonding and/or fixing of biological and/or synthetic tissues includes the components: a) a nitrogen-functionalized polysaccharide; and b) a terminally functionalized oligolactone.Type: GrantFiled: August 1, 2008Date of Patent: June 11, 2013Assignees: Aesculap AG, Universitat RostockInventors: Erich Odermatt, Jürgen Wegmann, Katrin Sternberg, Detlef Behrend
-
Publication number: 20120283666Abstract: Drug delivery systems and biocompatible coatings for use with implantable stimulation devices such as cochlear implants have been developed. These drug delivery systems and coatings comprise polyhydroxyalkanoate (PHA) polymers and copolymers. The drug delivery systems may be used to deliver pharmacologically active substances, for example, directly from a cochlear implant to the inner ear. The coatings can impart lubricity to cochlear devices for ease of insertion of the electrodes. In the preferred embodiment, the drug delivery system comprises a polyhydroxyalkanoate polymer, and in the most preferred embodiment, the PHA polymer comprises poly(4-hydroxybutyrate) (P(4HB)) or copolymer thereof. A particularly preferred embodiment is where the silicone sheath of the cochlear implant electrodes has been surface modified, and coated with P(4HB), and the P(4HB) either contains a pharmacologically active substance or has been coated with such a substance.Type: ApplicationFiled: October 28, 2011Publication date: November 8, 2012Inventors: Thomas Lenarz, Klaus-Peter Schmitz, Detlef Behrend, Katrin Sternberg, Simon Williams, David Martin
-
Patent number: 8280480Abstract: The invention relates to a stapedius muscle electrode array for detecting the action elements generated when a human stapedius muscle is contracted. Said array comprises an electrode (2, 2?, 2?) that is adapted for bipolar discharge and is to be attached to a human stapedius muscle. The electrode has two flexible, elastic, electrically conducting elongate elements (2a, 2b), each of which has a distal (4a, 4b) and a proximal end (17a, 17b) and is helically preshaped along at least some of the length thereof to the distal end (4a, 4b) thereof in such a way that the distal end (4a, 4b) and a section of the respective elongate element (2a, 2b) which adjoins the distal end (4a, 4b) can be placed at least in part around the tendon (7) extending between the stapedius muscle and the stapes while the helical part can be guided along the tendon (7), can be moved in the direction of the stapedius muscle, and can be at least partly twisted into and/or slid onto the region of the muscle belly (6) adjoining the tendon (7).Type: GrantFiled: February 19, 2008Date of Patent: October 2, 2012Assignee: Med-El Elektromedizinische Geraete GmbHInventors: Hans Wilhelm Pau, Detlef Behrend, Wolfram Schmidt, Klaus-Peter Schmitz
-
Patent number: 8257729Abstract: An implant for implantation in a human or animal body having a structure comprising a) an implant base body; b) a primer layer which is partially or completely applied to the surface of the implant; c) an active ingredient layer consisting of one, two, three or more active ingredients applied entirely or partially to the surface of the primer layer; and d) a diffusion-controlling layer which is applied partially or entirely to the active ingredient layer, and optionally to the primer layer, wherein diffusion of the active ingredients of the active ingredient layer is controlled. Also disclosed is a manufacturing method for an implant.Type: GrantFiled: December 10, 2008Date of Patent: September 4, 2012Assignees: Biotronik VI Patent AG, Universitaet Rostock, Universitaet GreifswaldInventors: Klaus-Peter Schmitz, Detlef Behrend, Katrin Sternberg, Niels Grabow, Claus Harder, Bjoern Klocke, Heyo K. Kroemer, Werner Weitschies
-
Patent number: 8206333Abstract: The present invention relates to an ocular implant, particularly a glaucoma stent. It is the object of the present invention to devise an ocular implant which allows the ocular eye pressure to be regulated, i.e., to be maintained at a desired level, while preventing the flow resistance from increasing over time, for example due to fibrosis. In order to achieve this object, the ocular implant according to the invention comprises a small tube (5), the wall surface (3) of which encloses a hollow duct that is open on both sides in the longitudinal direction of the hollow duct, wherein a first opening (1) allowing ocular humor to flow in and a second opening (2) allowing the ocular humor to be discharged is provided, and wherein the wall surface (3) is formed by a liquid-tight material, and wherein at least one pressure-controlled valve (4) is disposed in the area of the wall surface (3).Type: GrantFiled: January 25, 2008Date of Patent: June 26, 2012Assignee: Universitaet RostockInventors: Wolfram Schmidt, Katrin Sternberg, Detlef Behrend, Rudolf Guthoff, Klaus-Peter Schmitz
-
Publication number: 20120157815Abstract: An electrode arrangement is described for sensing electrical activity in target tissue. An inner electrode has an elongate electrode body formed as a cylindrical section with an inner penetrating end for insertion into the stapedius muscle target tissue. An outer electrode fits over the inner electrode and an outer penetrating end for insertion into the target tissue. The two electrodes are joined together with their electrode bodies in parallel so that the penetrating ends of the electrodes penetrate in the same direction into the target tissue to sense electrical activity in the target tissue.Type: ApplicationFiled: December 15, 2011Publication date: June 21, 2012Applicant: MED-EL ELEKTROMEDIZINISCHE GERAETE GMBHInventors: Hans Wilhelm Pau, Detlef Behrend, Mareike Warkentin, Wolfram Schmidt, Olaf Specht, Daniel Schaudel, Guido Reetz
-
Publication number: 20110282177Abstract: The invention relates to an electrode arrangement and a measuring device for measuring the action flow and/or the action potential of an electrically active tissue. The aim of the invention is to provide a simple and economically producible electrode for measuring action flows and/or action potentials in electrically active tissues (preferably the stapedius muscle tissue), ensuring that the electrode is fixed securely, but reversibly, in the muscle tissue and that the muscle tissue is disturbed as little as possible. The electrode arrangement according to the invention comprises a first electrode (2) and a fixing element (3), the first electrode (2) being connected to a first, long electrical line (4) and consisting of a long base body (6) comprising a first end (7) and a second end (8). The first electrical line (4) is connected to the base body (6) in the region of the second end (8) thereof, and means are provided for reversibly fixing the fixing element (3) to the first electrode (2).Type: ApplicationFiled: June 4, 2008Publication date: November 17, 2011Applicant: MED-EL ELEKTROMEDIZINISCHE GERAETE GMBHInventors: Detlef Behrend, Klaus-Peter Schmitz, Hans Wilhelm Pau, Katrin Sternberg, Wolfram Schmidt
-
Publication number: 20110190866Abstract: Absorbable stents and absorbable stent coatings have been developed with improved properties. These devices preferably comprise biocompatible copolymers or homopolymers of 4-hydroxybutyrate, and optionally poly-L-lactic acid and other absorbable polymers and additives. Compositions of these materials can be used to make absorbable stents that provide advantageous radial strengths, resistance to recoil and creep, can be plastically expanded on a balloon catheter, and can be deployed rapidly in vivo. Stent coatings derived from these materials provide biocompatible, uniform coatings that are ductile, and can be expanded without the coating cracking and/or delarmnating and can be used as a coating matrix for drug incorporation.Type: ApplicationFiled: July 17, 2009Publication date: August 4, 2011Inventors: Klaus-Peter Schmitz, Detlef Behrend, Katrin Sternberg, Niels Grabow, David P. Martin, Simon F. Williams
-
Publication number: 20110040323Abstract: The present invention relates to a combination, in particular for the adhesive bonding and/or fixing of biological and/or synthetic tissues, wherein the combination comprises the components a) a nitrogen-functionalized polysaccharide and b) a terminally functionalized oligolactone.Type: ApplicationFiled: August 1, 2008Publication date: February 17, 2011Applicants: AESCULAP AG, UNIVERSITÄT ROSTOCKInventors: Erich Odermatt, Jürgen Wegmann, Katrin Sternberg, Detlef Behrend