Abstract: The present invention relates to a combination for the treatment of osteoporosis and/or the prophylaxis and treatment of bone fractures, said combination comprising collagen, an additional peptide, a calcium-containing substance and a wetting agent with a terminally functionalized oligolactone. The invention also relates to artificial bones and implants produced by the combination and to the use of said combination for fixing implants and treating osteoporosis and/or the prophylaxis and treatment of bone fractures. The invention further relates to a method for producing artificial bones and implants.

Abstract: An electrode arrangement for sensing electrical activity in target tissue is described. A support electrode has an elongate electrode body with a base end and a penetrating end for insertion into the target tissue. A fixation electrode has an elongate electrode body with a base end and a penetrating end at an angle to the electrode body. The electrodes are joined together with their electrode bodies in parallel so that the penetrating end of the fixation electrode penetrates a fixed distance into the target tissue so that at least one of the electrodes senses electrical activity in the target tissue.

Abstract: The invention relates to a stapedius muscle electrode array for detecting the action elements generated when a human stapedius muscle is contracted. Said array comprises an electrode (2, 2?, 2?) that is adapted for bipolar discharge and is to be attached to a human stapedius muscle. The electrode has two flexible, elastic, electrically conducting elongate elements (2a, 2b), each of which has a distal (4a, 4b) and a proximal end (17a, 17b) and is helically preshaped along at least some of the length thereof to the distal end (4a, 4b) thereof in such a way that the distal end (4a, 4b) and a section of the respective elongate element (2a, 2b) which adjoins the distal end (4a, 4b) can be placed at least in part around the tendon (7) extending between the stapedius muscle and the stapes while the helical part can be guided along the tendon (7), can be moved in the direction of the stapedius muscle, and can be at least partly twisted into and/or slid onto the region of the muscle belly (6) adjoining the tendon (7).

Abstract: The present invention relates to an ocular implant, particularly a glaucoma stent. It is the object of the present invention to devise an ocular implant which allows the ocular eye pressure to be regulated, i.e., to be maintained at a desired level, while preventing the flow resistance from increasing over time, for example due to fibrosis. In order to achieve this object, the ocular implant according to the invention comprises a small tube (5), the wall surface (3) of which encloses a hollow duct that is open on both sides in the longitudinal direction of the hollow duct, wherein a first opening (1) allowing ocular humor to flow in and a second opening (2) allowing the ocular humor to be discharged is provided, and wherein the wall surface (3) is formed by a liquid-tight material, and wherein at least one pressure-controlled valve (4) is disposed in the area of the wall surface (3).

Abstract: Absorbable stents and absorbable stent coatings have been developed with improved properties. These devices preferably comprise biocompatible copolymers or homopolymers of 4-hydroxybutyrate, and optionally poly-L-lactic acid and other absorbable polymers and additives. Compositions of these materials can be used to make absorbable stents that provide advantageous radial strengths, resistance to recoil and creep, can be plastically expanded on a balloon catheter, and can be deployed rapidly in vivo. Stent coatings derived from these materials provide biocompatible, uniform coatings that are ductile, and can be expanded without the coating cracking and/or delaminating and can be used as a coating matrix for drug incorporation.

Abstract: An implant for implantation in a human or animal body having a structure comprising a) an implant base body; b) a primer layer which is partially or completely applied to the surface of the implant; c) an active ingredient layer consisting of one, two, three or more active ingredients applied entirely or partially to the surface of the primer layer; and d) a diffusion-controlling layer which is applied partially or entirely to the active ingredient layer, and optionally to the primer layer, wherein diffusion of the active ingredients of the active ingredient layer is controlled. Also disclosed is a manufacturing method for an implant.

Abstract: Absorbable stents and absorbable stent coatings have been developed with improved properties. These devices preferably comprise biocompatible copolymers or homopolymers of 4-hydroxybutyrate, and optionally polylactic acid and other absorbable polymers and additives. Compositions of these materials can be used to make absorbable stents that provide advantageous radial strengths, resistance to recoil and creep, can be plastically expanded on a balloon catheter, and can be deployed rapidly in vivo. Stent coatings derived from these materials provide biocompatible, uniform coatings that are ductile, and can be expanded without the coating cracking and/or delaminating and can be used as a coating matrix for drug incorporation.

Abstract: An isoelastic endodontic pin for the long-term endodontic restoration of teeth is based on a single-piece, fibre-reinforced plastic base body having deformation zones and at least one zone designed in such a way that it possesses reduced flexural and torsional strength; displacement elements, preferably channels, for a fastening material are located outside these zones.

Abstract: Absorbable stents and absorbable stent coatings have been developed with improved properties. These devices preferably comprise biocompatible copolymers or homopolymers of 4-hydroxybutyrate, and optionally poly-L-lactic acid and other absorbable polymers and additives. Compositions of these materials can be used to make absorbable stents that provide advantageous radial strengths, resistance to recoil and creep, can be plastically expanded on a balloon catheter, and can be deployed rapidly in vivo. Stent coatings derived from these materials provide biocompatible, uniform coatings that are ductile, and can be expanded without the coating cracking and/or delaminating and can be used as a coating matrix for drug incorporation.

Abstract: A stent made of a biocorrodible metallic material and having a coating or cavity filling which contains genistein.

Abstract: Absorbable stents and absorbable stent coatings have been developed with improved properties. These devices preferably comprise biocompatible copolymers or homopolymers of 4-hydroxybutyrate, and optionally poly-L-lactic acid and other absorbable polymers and additives. Compositions of these materials can be used to make absorbable stents that provide advantageous radial strengths, resistance to recoil and creep, can be plastically expanded on a balloon catheter, and can be deployed rapidly in vivo. Stent coatings derived from these materials provide biocompatible, uniform coatings that are ductile, and can be expanded without the coating cracking and/or delaminating and can be used as a coating matrix for drug incorporation.

Abstract: A method of applying a marker element (6; 6?; 6?; 25; 25?; 26; 28) to an implant (1; 1?; 1?; 1??; 20; 20?), in particular a stent, intended for implantation in the human or animal body, comprising a main body and an opening (3; 3?; 3?; 3??; 21; 21?) provided in said main body (2; 2?; 2?; 2??; 22; 22?) for receiving the marker element (6; 6?; 6?; 25; 25?; 26; 28), wherein to form at least a part of the marker element (6; 6?; 6?; 25; 25?; 26; 28) a hardenable material or material mix is introduced into the opening and hardened therein.

Abstract: The invention concerns a method and a device for crimping a stent onto a balloon of a balloon catheter. The stent is arranged on the balloon so that an outside surface of the balloon and an inside surface of the stent contact each other to form a combination of balloon and stent. The combination is compressed to crimp the stent onto the balloon. The invention is distinguished in that the combination is compressed to varying degrees along the longitudinal axis of the combination.

Abstract: A method of applying a marker element (6; 6′; 6″; 25; 25′; 26; 28) to an implant (1; 1′; 1″; 1′″; 20; 20′), in particular a stent, intended for implantation in the human or animal body, comprising a main body and an opening (3; 3′; 3″; 3′″; 21; 21′) provided in said main body (2; 2′; 2″; 2′″; 22; 22′) for receiving the marker element (6; 6′; 6″; 25; 25′; 26; 28), wherein to form at least a part of the marker element (6; 6′; 6″; 25; 25′; 26; 28) a hardenable material or material mix is introduced into the opening and hardened therein.

Abstract: The invention concerns a method and a device for crimping a stent onto a balloon of a balloon catheter. The stent is arranged on the balloon so that an outside surface of the balloon and an inside surface of the stent contact each other to form a combination of balloon and stent. The combination is compressed to crimp the stent onto the balloon. The invention is distinguished in that the combination is compressed to varying degrees along the longitudinal axis of the combination.

Abstract: A method for the manufacture of intravascular stents of bioresorbable material comprises the following steps:preparing a viscous solution of poly-.beta.-hydroxybutanoic acid as a bioresorbable polymeric material in a solvent,successively coating a male mold core with layers of the polymer solution in several steps by precipitation of the polymeric material by the solvent being evaporated and by the layer previously precipitated being dissolved at least partially for a homogeneous stent blank to build up,drawing the stent blank off the male mold core, andsubsequently treating the stent blank to finish the shaping of the stent.