Patents by Inventor Dharmaraj Ramachandra Rao

Dharmaraj Ramachandra Rao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180111915
    Abstract: The present invention relates to a novel polymorph of nilotinib hydrochloride (Form X), to processes for its preparation, to pharmaceutical compositions containing the same and to its use in medicine.
    Type: Application
    Filed: March 21, 2016
    Publication date: April 26, 2018
    Applicant: Cipla Limited
    Inventors: Dharmaraj Ramachandra RAO, Geena MALHOTRA, Srinivas Laxminarayan PATHI, Venugopalarao CHINIMILLI, Manish Gopaldas GANGRADE
  • Patent number: 9938297
    Abstract: The present invention relates to a novel process for the synthesis of everolimus of formula (I): and intermediates thereof.
    Type: Grant
    Filed: August 4, 2015
    Date of Patent: April 10, 2018
    Assignee: Cipia Limited
    Inventors: Dharmaraj Ramachandra Rao, Geena Malhotra, Venkata Srinivas Pullela, Vinod Parameshwaran Acharya
  • Publication number: 20180072690
    Abstract: The present invention relates to a process for preparing serotonin reuptake inhibitors of formula (I) and pharmaceutically acceptable salts thereof, (Formula (I)) wherein, R1, R2, R3, l, m, n and Z are as defined in the specification.
    Type: Application
    Filed: March 23, 2016
    Publication date: March 15, 2018
    Applicant: CIPLA Limited
    Inventors: Dharmaraj Ramachandra Rao, Geena Malhotra, Venkata Srinivas Pullela, Shrikant Suresh Mudgal
  • Patent number: 9877953
    Abstract: Amorphous rifaximin, methods of making it, and pharmaceutical compositions containing it. Also described are methods of converting amorphous rifaximin to crystalline rifaximin and vice versa.
    Type: Grant
    Filed: July 29, 2016
    Date of Patent: January 30, 2018
    Assignee: CIPLA LIMITED
    Inventors: Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan, Manjinder Singh Phull, Maruti Ghagare
  • Publication number: 20170354644
    Abstract: Amorphous methyl((1S)-1-(((2S)-2-(5-(4?-(2-((2S)-1-((2S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1H-imidazol-5-yl)-4-biphenylyl)-1H-imidazol-2-yl)-1-pyrrolidinyl) carbonyl)-2-methylpropyl) carbamate free base, amorphous methyl((1S)-1-(((2S)-2-(5-(4?-(2-((2S)-1-((2S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1H-imidazol-5-yl)-4-biphenylyl)-1H-imidazol-2-yl)-1-pyrrolidinyl) carbonyl)-2-methylpropyl) carbamate dihydrochloride, methods of making them, and pharmaceutical compositions containing them.
    Type: Application
    Filed: December 24, 2015
    Publication date: December 14, 2017
    Inventors: Dharmaraj Ramachandra RAO, Geena MALHOTRA, Manjinder Singh PHULL, Shashirekha KANATHALA, Manish Gopaldas GANGRADE
  • Publication number: 20170267669
    Abstract: The present invention relates to an environmentally friendly process for preparing rivaroxaban. The present invention provides a process for preparing rivaroxaban of formula I, the process comprising: reacting a compound of formula VI with a base in the presence of a solvent to form a compound of formula VII; and condensing the compound of formula VII with a compound of formula VIII or a compound of formula IX in the presence of a solvent to prepare rivaroxaban of formula I, wherein the solvent used in both steps comprises water.
    Type: Application
    Filed: August 24, 2015
    Publication date: September 21, 2017
    Inventors: Dharmaraj Ramachandra RAO, Geena MALHOTRA, Venkata Srinivas PULLELA, Manohar Raghunath SURVE, Hemant Sanjeevan DORLE, Kiran Balasaheb JADHAV
  • Publication number: 20170240561
    Abstract: The present invention discloses a novel process for the preparation of macrocyclic ketone analogs of halichondrin B or pharmaceutically acceptable salts thereof and to novel intermediates which are produced during the course of carrying out the novel process.
    Type: Application
    Filed: September 9, 2015
    Publication date: August 24, 2017
    Inventors: Dharmaraj Ramachandra RAO, Geena MALHOTRA, Venkata Srinivas PULLELA, Vinod Parameshwaran ACHARYA, Nagarjuna Reddy VANTADOU
  • Publication number: 20170217988
    Abstract: The present invention relates to a novel process for the synthesis of everolimus of formula (I): and intermediates thereof.
    Type: Application
    Filed: August 4, 2015
    Publication date: August 3, 2017
    Inventors: Dharmaraj Ramachandra RAO, Geena MALHOTRA, Venkata Srinivas PULLELA, Vinod Parameshwaran ACHARYA
  • Patent number: 9676803
    Abstract: The present invention relates to an efficient process for the separation of diastereomers of 9-[(R)-2-[[(R,S)-[[(S)-1-(Isopropoxycarbonyl)ethyl]amino]-phenoxyphosphinyl]methoxy]propyl]adenine and to a process for preparing 9-[(R)-2-[[(R)-[[(S)-1-(Isopropoxycarbonyl)ethyl]amino]phenoxyphosphinyl]methoxy]propyl]adenine and 9-[(R)-2-[[(S)-[[(S)-1-(Isopropoxycarbonyl)ethyl]amino]phenoxyphosphinyl]methoxy]propyl]adenine.
    Type: Grant
    Filed: June 6, 2014
    Date of Patent: June 13, 2017
    Assignee: Cipla Limited
    Inventors: Dharmaraj Ramachandra Rao, Ashwini Amol Sawant, Nayan Shivalkar, Nitin Thakur
  • Patent number: 9505787
    Abstract: The present invention provides improved processes for the preparation of Bortezomib, tert -butyl[1-({(1S)-3-methyl-1-[(3aS,4S,6S,7aS)-3a,5,5-trimethylhexahydro-4,6-methano-1,3,2-benzodioxaborol-2-yl]butyl}amino)-1-oxo-3-phenylpropan-2-yl]carbamate of formula (IV) and N-{(1S)-3-methyl-1-[(3aS,4S,6S,7aS)-3a,5,5-trimethylhexahydro-4,6-methano-1,3,2-benzodioxaborol-2-yl]butyl} phenylalanine of formula (V). Compound (IV) is prepared by coupling (1R)-3-methyl-1-[(3aS,4S,6S,7aR)-3a,5,5-trimethyl-hexahydro-4,6-methano-1,3,2-benzodioxaborol-2-yl]butan-1-amine of formula (II) or its salt with N-(tert-butoxycarbonyl)-L -phenylalanine of formula (III) in a first solvent in the presence of a first coupling agent and a first base, wherein the coupling process does not comprise solvent exchange. Compound (V) is prepared by deprotecting compound (IV) using an alcoholic solution of an inorganic acid.
    Type: Grant
    Filed: September 11, 2013
    Date of Patent: November 29, 2016
    Assignee: Cipla Limited
    Inventors: Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan, Srinivas Laxminarayan Pathi, Ravikumar Puppala
  • Patent number: 9403844
    Abstract: Amorphous rifaximin, methods of making it, and pharmaceutical compositions containing it. Also described are methods of converting amorphous rifaximin to crystalline rifaximin and vice versa.
    Type: Grant
    Filed: June 8, 2015
    Date of Patent: August 2, 2016
    Assignee: Cipla Ltd.
    Inventors: Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan, Manjinder Singh Phull, Maruti Ghagare
  • Publication number: 20160122373
    Abstract: The present invention relates to an efficient process for the separation of diastereomers of 9-[(R)-2-[[(R,S)-[[(S)-1-(Isopropoxycarbonyl)ethyl]amino]-phenoxyphosphinyl]methoxy]propyl]adenine and to a process for preparing 9-[(R)-2-[[(R)-[[(S)-1-(Isopropoxycarbonyl)ethyl]amino]phenoxyphosphinyl]methoxy]propyl]adenine and 9-[(R)-2-[[(S)-[[(S)-1-(Isopropoxycarbonyl)ethyl]amino]phenoxyphosphinyl]methoxy]propyl]adenine.
    Type: Application
    Filed: June 6, 2014
    Publication date: May 5, 2016
    Inventors: Dharmaraj Ramachandra RAO, Ashwini Amol SAWANT, Nayan SHIVALKAR, Nitin THAKUR
  • Publication number: 20160075736
    Abstract: A novel and improved process for preparation of bortezomib mannitol ester is derived, which process avoids excessive use of solvents, involves convenient, industrially feasible and economical techniques, and provides improvements in purity over processes known in the art.
    Type: Application
    Filed: April 16, 2014
    Publication date: March 17, 2016
    Inventors: Ravikumar PUPPALA, Srinivas Laxminarayan PATHI, Dharmaraj Ramachandra RAO, Rajendra Narayanrao KANKAN
  • Patent number: 9233967
    Abstract: There is provided a process for the preparation of sitagliptin or a pharmaceutically acceptable salt thereof, and a process for the preparation of intermediate compounds useful in the preparation of sitagliptin. In particular, there is provided a process comprising condensing 3-tert-butoxycarbonylamino-4-(2,4,5-trifluorophenyl)butyric acid of formula (II) with 3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine of formula (III) or a salt thereof in presence of a catalyst to obtain (R)-tert-butyl-4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]-triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl-carbamate of formula (IV) or a pharmaceutically acceptable salt thereof. The catalyst is represented by the compound of formula (V). Compound of formula (IV) or its pharmaceutically acceptable salt obtained may be deprotected to obtain a compound of formula (I).
    Type: Grant
    Filed: August 8, 2013
    Date of Patent: January 12, 2016
    Assignee: CIPLA Limited
    Inventors: Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan, Maruti Ghagare, Swati Atul Kadam
  • Patent number: 9227990
    Abstract: The present invention provides a compound of the Formula (I) wherein R is 9-isopropyl-9H-purin-6-amine; 2-amino-9-isopropyl-1H-purin-6(9H)-one; 4-amino-1-isopropyl pyrimidin-2(1H)-one; or 1-isopropyl-5-methylpyrimidine-2,4(1H,3H)-dione, R? is —CH2OC(O)R?, and R? is —C(CH3)3 or —CH(CH3)2 including pharmaceutically acceptable salts thereof. The present invention also provides a process for preparing a compound of formula (Ia) and a compound of formula (I) for use in treating a viral infection.
    Type: Grant
    Filed: October 29, 2013
    Date of Patent: January 5, 2016
    Assignee: CIPLA LIMITED
    Inventors: Manjinder Singh Phull, Rajendra Narayanrao Kankan, Dharmaraj Ramachandra Rao
  • Publication number: 20150359898
    Abstract: A complex comprises pemetrexed and a coformer. A pharmaceutical composition comprises a complex of pemetrexed and a co-former and one or more pharmaceutically acceptable excipients.
    Type: Application
    Filed: February 6, 2014
    Publication date: December 17, 2015
    Applicant: CIPLA LIMITED
    Inventors: Shrinivas Madhukar Purandare, Geena Malhotra, Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan, Srinivas Laxminarayan Pathi, Ravikumar Puppla
  • Publication number: 20150291639
    Abstract: The present invention provides a compound of the Formula (I) wherein R is 9-isopropyl-9H-purin-6-amine; 2-amino-9-isopropyl-1H-purin-6(9H)-one; 4-amino-1-isopropyl pyrimidin-2(1H)-one; or 1-isopropyl-5-methylpyrimidine-2,4(1H,3H)-dione, R? is —CH2OC(O)R?, and R? is —C(CH3)3 or —CH(CH3)2 including pharmaceutically acceptable salts thereof. The present invention also provides a process for preparing a compound of formula (Ia) and a compound of formula (I) for use in treating a viral infection.
    Type: Application
    Filed: October 29, 2013
    Publication date: October 15, 2015
    Applicant: Cipla Limited
    Inventors: Manjinder Singh Phull, Rajendra Narayanrao Kankan, Dharmaraj Ramachandra Rao
  • Patent number: 9150499
    Abstract: The present invention relates to a process for the preparation of substantially pure nateglinide of formula (I), substantially free from the cis-isomer and L-enantiomer and preparation of enantiomerically pure nateglinide form B, directly from the hydrolysis of a (?)-N-(trans-4-isopropylcyclohexyl-1-carbonyl)-D-phenylalanine alkyl ester in a ketonic solvent or water or mixture thereof.
    Type: Grant
    Filed: June 14, 2011
    Date of Patent: October 6, 2015
    Assignee: Cipla Limited
    Inventors: Rajendra Narayanrao Kankan, Dharmaraj Ramachandra Rao, Dilip Ramdas Birari
  • Publication number: 20150266898
    Abstract: Amorphous rifaximin, methods of making it, and pharmaceutical compositions containing it. Also described are methods of converting amorphous rifaximin to crystalline rifaximin and vice versa.
    Type: Application
    Filed: June 8, 2015
    Publication date: September 24, 2015
    Inventors: Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan, Manjinder Singh Phull
  • Publication number: 20150246935
    Abstract: The present invention provides improved processes for the preparation of Bortezomib, tert-butyl[1-({(1S)-3-methyl-1-[(3aS,4S,6S,7aS)-3a,5,5-trimethylhexahydro-4,6-methano-1,3,2-benzodioxaborol-2-yl]butyl}amino)-1-oxo-3-phenylpropan-2-yl]carbamate of formula (IV) and N-{(1S)-3-methyl-1-[(3aS,4S,6S,7aS)-3a,5,5-trimethylhexahydro-4,6-methano-1,3,2-benzodioxaborol-2-yl]butyl} phenylalanine of formula (V). Compound (IV) is prepared by coupling (1R)-3-methyl-1-[(3aS,4S,6S,7aR)-3a,5,5-trimethyl-hexahydro-4,6-methano-1,3,2-benzodioxaborol-2-yl]butan-1-amine of formula (II) or its salt with N-(tert-butoxycarbonyl)-L-phenylalanine of formula (III) in a first solvent in the presence of a first coupling agent and a first base, wherein the coupling process does not comprise solvent exchange. Compound (V) is prepared by deprotecting compound (IV) using an alcoholic solution of an inorganic acid.
    Type: Application
    Filed: September 11, 2013
    Publication date: September 3, 2015
    Inventors: Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan, Srinivas Laxminarayan Pathi, Ravikumar Puppala