Patents by Inventor Dhruti Vasudev Dalal

Dhruti Vasudev Dalal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Exonuclease deficient polymerases
    Patent number: 11718836
    Abstract: Described herein are polymerase variants that are exonuclease deficient. Some variants retain the strand displacement capability comparable to the wild-type or parental polymerase. Some variants have a strand displacement capability that is improved relative to the wild-type or parental polymerase. The variants may have an extension rate that is greater than the wild-type or parental polymerase. The variants may have a waiting time that is less than the wild-type or parental polymerase.
    Type: Grant
    Filed: February 5, 2021
    Date of Patent: August 8, 2023
    Assignee: Roche Sequencing Solutions, Inc.
    Inventors: Aruna Ayer, Arkadiusz Bibillo, Preethi Sarvabhowman, Dhruti Vasudev Dalal, Ilya Lederman, Eileen Thai
  • EXONUCLEASE DEFICIENT POLYMERASES
    Publication number: 20210163904
    Abstract: Described herein are polymerase variants that are exonuclease deficient. Some variants retain the strand displacement capability comparable to the wild-type or parental polymerase. Some variants have a strand displacement capability that is improved relative to the wild-type or parental polymerase. The variants may have an extension rate that is greater than the wild-type or parental polymerase. The variants may have a waiting time that is less than the wild-type or parental polymerase.
    Type: Application
    Filed: February 5, 2021
    Publication date: June 3, 2021
    Inventors: Aruna Ayer, Arkadiusz Bibillo, Preethi Sarvabhowman, Dhruti Vasudev Dalal, Ilya Lederman, Eileen Thai
  • Exonuclease deficient polymerases
    Patent number: 10947516
    Abstract: Described herein are polymerase variants that are exonuclease deficient. Some variants retain the strand displacement capability comparable to the wild-type or parental polymerase. Some variants have a strand displacement capability that is improved relative to the wild-type or parental polymerase. The variants may have an extension rate that is greater than the wild-type or parental polymerase. The variants may have a waiting time that is less than the wild-type or parental polymerase.
    Type: Grant
    Filed: February 20, 2019
    Date of Patent: March 16, 2021
    Assignee: Roche Sequencing Solutions, Inc.
    Inventors: Aruna Ayer, Arkadiusz Bibillo, Preethi Sarvabhowman, Dhruti Vasudev Dalal, Ilya Lederman, Eileen Thai
  • POLYMERASE VARIANTS
    Publication number: 20200190572
    Abstract: The present disclosure provides variant Pol6 polymerase polypeptides, compositions comprising the Pol6 variant polypeptides, and methods for using the variant Pol6 polypeptides for determining the sequencing of nucleic acids, for example, by nanopore sequencing. The variant Pol6 polymerases possess decreased rates of dissociation of template from the polymerase-template complex, which result in increased processivity relative to the parental Pol6 polypeptides from which they are derived.
    Type: Application
    Filed: February 26, 2020
    Publication date: June 18, 2020
    Inventors: Aruna Ayer, Preethi Sarvabhowman, Dhruti Vasudev Dalal
  • Polymerase variants
    Patent number: 10590480
    Abstract: The present of disclosure provides variant Pol6 polymerase polypeptide, compositions comprising the Pol6 variant polypeptides, and methods for using the variant Pol6 polypeptides for determining the sequencing of nucleic acids, for example, by nanopore sequencing. The variant Pol6 polymerases possess decreased rates of dissociation of template from the polymerase-template complex, which result in increased processivity relative to the parental Pol6 polypeptides from which they are derived.
    Type: Grant
    Filed: February 27, 2017
    Date of Patent: March 17, 2020
    Assignee: Roche Sequencing Solutions, Inc.
    Inventors: Aruna Ayer, Preethi Sarvabhowman, Dhruti Vasudev Dalal
  • EXONUCLEASE DEFICIENT POLYMERASES
    Publication number: 20190177706
    Abstract: Described herein are polymerase variants that are exonuclease deficient. Some variants retain the strand displacement capability comparable to the wild-type or parental polymerase. Some variants have a strand displacement capability that is improved relative to the wild-type or parental polymerase. The variants may have an extension rate that is greater than the wild-type or parental polymerase. The variants may have a waiting time that is less than the wild-type or parental polymerase.
    Type: Application
    Filed: February 20, 2019
    Publication date: June 13, 2019
    Inventors: Aruna Ayer, Arkadiusz Bibillo, Preethi Sarvabhowman, Dhruti Vasudev Dalal, Ilya Lederman, Eileen Thai
  • Exonuclease deficient polymerases
    Patent number: 10266813
    Abstract: Described herein are polymerase variants that are exonuclease deficient. Some variants retain the strand displacement capability comparable to the wild-type or parental polymerase. Some variants have a strand displacement capability that is improved relative to the wild-type or parental polymerase. The variants may have an extension rate that is greater than the wild-type or parental polymerase. The variants may have a waiting time that is less than the wild-type or parental polymerase.
    Type: Grant
    Filed: February 27, 2017
    Date of Patent: April 23, 2019
    Assignee: Genia Technologies, Inc.
    Inventors: Aruna Ayer, Arkadiusz Bibillo, Preethi Sarvabhowman, Dhruti Vasudev Dalal, Ilya Lederman, Eileen Thai
  • POLYMERASE VARIANTS
    Publication number: 20180245147
    Abstract: The present of disclosure provides variant Pol6 polymerase polypeptide, compositions comprising the Pol6 variant polypeptides, and methods for using the variant Pol6 polypeptides for determining the sequencing of nucleic acids, for example, by nanopore sequencing. The variant Pol6 polymerases possess decreased rates of dissociation of template from the polymerase-template complex, which result n increased processivity relative to the parental Pol6 polypeptides from which they are derived.
    Type: Application
    Filed: February 27, 2017
    Publication date: August 30, 2018
    Inventors: Aruna Ayer, Preethi Sarvabhowman, Dhruti Vasudev Dalal
  • Exonuclease Deficient Polymerases
    Publication number: 20170267983
    Abstract: Described herein are polymerase variants that are exonuclease deficient. Some variants retain the strand displacement capability comparable to the wild-type or parental polymerase. Some variants have a strand displacement capability that is improved relative to the wild-type or parental polymerase. The variants may have an extension rate that is greater than the wild-type or parental polymerase. The variants may have a waiting time that is less than the wild-type or parental polymerase.
    Type: Application
    Filed: February 27, 2017
    Publication date: September 21, 2017
    Inventors: Aruna Ayer, Arkadiusz Bibillo, Preethi Sarvabhowman, Dhruti Vasudev Dalal, Ilya Lederman, Eileen Thai