Abstract: Disclosed herein is a polynucleotide construct comprising one or more nuclease recognition sequences upstream and downstream of a Gene editing multi-site that comprises a plurality of nuclease recognition sequences. The plurality of nuclease recognition sequences facilitate insertion of one or more exogenous donor genes into the host cell.

Abstract: Disclosed are a type of tridentate linkers and use thereof. The tridentate linkers can be used to prepare an antibody drug conjugates as represented by formula I, L-(T-A-D)n??I wherein, L is an antibody, antibody fragment or protein; T is a tridentate linker part; A is a cleavable linker group or a noncleavable linker part; D is a drug part; n is an integer of 0-8. The structure of the tridentate linker part is as represented by formula II, wherein, W is substituted aryl, heteroaryl, linear alkyl, cycloalkyl, heterocycloalkyl, or any combination thereof.

Abstract: A display panel and a display device are provided. The display panel includes: a plurality of pixel circuits arranged in a matrix; a data line extending in a first direction and being electrically connected to the plurality of pixel circuits; a power signal line extending in the first direction and being electrically connected to the plurality of pixel circuits; an inorganic passivation layer located on surfaces, facing toward a light-emitting surface of the display panel, of the data line and the power signal line; and an anti-crosstalk structure. An orthographic projection of at least partial region of the anti-crosstalk structure on a plane of the display panel is located between an orthographic projection of the data line and an orthographic projection of the power signal line on the plane of the display panel.

Abstract: An isolated resonant converter has an analog comparator with hysteresis for generating a first ON/OFF signal, a digital isolator for outputting a second ON/OFF signal, an oscillator for providing a clock pulse signal with a frequency, and a primary pulse width modulator coupled to receive the clock pulse signal and the second ON/OFF signal. An output voltage of the isolated resonant converter is controlled by the analog comparator within a predefined range. The second ON/OFF signal is electrically isolated from the first ON/OFF signal. The primary pulse width modulator controls the switching of the isolated resonant converter in response to the clock pulse signal during the logic high state of the second ON/OFF signal and stops the switching of the isolated resonant converter during the logic low state of the second ON/OFF signal.

Abstract: Provided are an electronic device for a network control terminal and a network node, and a method for the electronic device. The electronic device for a network control terminal comprises processing circuitry configured to set a first condition concerning a beam-forming capacity of a network node for determining the network node capable of serving as a relay node, and to generate control signaling of indication information comprising the first condition for indicating the network node served by the network control terminal.

Abstract: A salt of a quinazoline derivative (N-[4-(3-chlorine-4-fluoroanilino)]-7-(3-morpholinepropanol)-6-(2-fluoroacrylamide)-quinazoline, the structure thereof is as represented by formula I). Compared with a known quinazoline derivative, the salt of the quinazoline derivative has one or more improved properties and at least has better water solubility, wherein a citrate, a benzene sulfonate, and an ethanedisulphonate thereof further have better crystallinity and are not easy to absorb moisture.

Abstract: This invention relates to certain novel pyrazine derivatives (Formula I) as SHP2 inhibitors which is shown as formula I, their synthesis and their use for treating a SHP2 mediated disorder. More particularly, this invention is directed to fused heterocyclic group derivatives useful as inhibitors of SHP2, methods for producing such compounds and methods for treating a SHP2-mediated disorder.

Abstract: Provided are a touch screen, a method of manufacturing the touch screen, and a terminal device. The touch screen includes a flexible display screen, a supporting layer and a transparent supporting member. The supporting layer includes a first surface, a second surface opposite to the first surface, and a light transmitting hole communicating the first surface and the second surface. The first surface is connected with a back surface of the flexible display screen. At least a part of the supporting member is disposed in the light transmitting hole, the at least a part of the supporting member includes an end the supporting member, and at least a part of the end of the supporting member in the light transmitting hole is flush with the first surface.

Abstract: Provided are an electronic device for a network control terminal and a network node, and a method for the electronic device. The electronic device for a network control terminal comprises processing circuitry configured to set a first condition concerning a beam-forming capacity of a network node for determining the network node capable of serving as a relay node, and to generate control signaling of indication information comprising the first condition for indicating the network node served by the network control terminal.

Abstract: Disclosed herein is a polynucleotide construct comprising one or more nuclease recognition sequences upstream and downstream of a Gene editing multi-site that comprises a plurality of nuclease recognition sequences. The plurality of nuclease recognition sequences facilitate insertion of one or more exogenous donor genes into the host cell.

Abstract: This disclosure provides a heat dissipation device configured to be in thermal contact with a heat source of a circuit board and including a main body part and an engagement assembly. The main body part includes a thermally conductive component and at least one fin assembly. The thermally conductive component is configured to be in thermal contact with the heat source, and the at least one fin assembly is thermally coupled to the thermally conductive component. The engagement assembly includes at least one first cover and at least one fastener. The at least one first cover presses against a side of the at least one fin assembly that is located away from the heat source. The at least one fastener is disposed through the at least one first cover and the at least one fin assembly and is configured to be fixed to the circuit board.

Abstract: Provided is a liquid crystal composition, comprising: one or more compounds of general formula I accounting for 1-30% of the total weight of the liquid crystal composition; one or more compounds of general formula II accounting for 1-30% of the total weight of the liquid crystal composition; one or more compounds of general formula III accounting for 1-20% of the total weight of the liquid crystal composition; and one or more compounds of general formula IV accounting for 30-80% of the total weight of the liquid crystal composition. The liquid crystal composition has at least one of the following properties: a large specific resistance, a high voltage holding ratio, a suitable optical anisotropy, a large dielectric anisotropy, a small viscosity, a low threshold voltage, etc., and is also green and environmentally friendly.

Abstract: A display panel and a display device are provided. The display panel includes: a plurality of pixel circuits arranged in a matrix; a data line extending in a first direction and being electrically connected to the plurality of pixel circuits; a power signal line extending in the first direction and being electrically connected to the plurality of pixel circuits; an inorganic passivation layer located on surfaces, facing toward a light-emitting surface of the display panel, of the data line and the power signal line; and an anti-crosstalk structure. An orthographic projection of at least partial region of the anti-crosstalk structure on a plane of the display panel is located between an orthographic projection of the data line and an orthographic projection of the power signal line on the plane of the display panel.

Abstract: The present invention provides a liquid crystal composition, comprising, 14-30% of one or more compounds of general Formula I, 8-30% of one or more compounds of general Formula II, 13-58% of one or more compounds of general Formula III, and 20-65% of one or more compounds of general Formula IV, on the basis of the total weight of the liquid crystal composition. The liquid crystal composition of the present invention has a higher retardation, a higher transmittance, a larger optical anisotropy, a proper clearing point, a lower rotational viscosity and a good low-temperature storage stability, and is applicable to liquid crystal display devices to meet the rapid response required by a liquid crystal display, and ensure good display of the liquid crystal display in a harsh environment.

Abstract: Disclosed herein is a polynucleotide construct comprising one or more nuclease recognition sequences upstream and downstream of a Gene editing multi-site that comprises a plurality of nuclease recognition sequences. The plurality of nuclease recognition sequences facilitate insertion of one or more exogenous donor genes into the host cell.

Abstract: Disclosed herein is a polynucleotide construct comprising one or more primary endonuclease recognition sequences upstream and downstream of a multiple gene editing site that comprises a plurality of secondary endonuclease recognition sequences. The primary endonuclease recognition sequences facilitate insertion of the multiple gene editing site into a host cell genome. The secondary endonuclease recognition sequences facilitate insertion of one or more exogenous donor genes into the host cell.

Abstract: Provided is a liquid crystal composition, comprising: 1-30% of one or more compounds of general formula I; 1-50% of one or more compounds of general formula II; 1-20% of one or more compounds of general formula III; 20-70% of one or more compounds of general formula IV; and 1-30% of one or more compounds of general formula V. The liquid crystal composition has properties such as a large maximum absolute transmittance, a high voltage holding ratio, better anti-UV properties, and high temperature reliability, and has a suitable optical anisotropy, a suitable dielectric anisotropy, and a relatively high clearing point, and is environmentally friendly.

Abstract: Systems and methods are disclosed to control the power grid frequency by capturing the frequency change using an extended Kalman filter method with the distributed smart outlet devices at the low-voltage distribution level; and locally control the relay that provides power to the appliance by comparing the captured frequency with the threshold sent from the cloud control center.

Abstract: The present disclosure discloses a subject matter message notification method performed at a terminal and to be disseminated to one or more target users. The method includes: displaying a subject matter editing interface, the subject matter editing interface including an editing item used for editing subject matter content, an editing item used for adding a target user, and an editing item used for adding a file; generating a subject matter message in accordance with user-provided subject matter content through the editing item used for editing subject matter content, one or more user-selected target users through the editing item used for adding a target user, and one or more user-selected files through the editing item used for adding a file; and sending the subject matter message to a server, wherein the server is configured to send the subject matter message to the one or more user-selected target users.

Abstract: A liquid crystal composition comprises a compound of general formula I serving as a first component; a compound of general formula II-1 and/or general formula II-2 serving as a second component; a compound of general formula III serving as a third component; a compound of general formula IV serving as a fourth component; a compound of general formula V serving as a fifth component; and a compound of general formula VI serving as a sixth component. The liquid crystal composition has at least one characteristic among the characteristics of a large dielectric anisotropy, a large optical anisotropy, a high voltage holding ratio and a low threshold voltage and the like, and is suitable to be used in a liquid crystal display device. Additionally, a liquid crystal display device comprising the liquid crystal composition is also provided.