Patents by Inventor DIMITRIOS MANTZILAS

DIMITRIOS MANTZILAS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200237921
    Abstract: A method for removing or controlling or quantifying the presence of aldehydes, in particular acetaldehyde, is described. Such a method is useful in prolonging the shelf life of a pharmaceutical product.
    Type: Application
    Filed: April 15, 2020
    Publication date: July 30, 2020
    Inventors: Torgrim Engell, Julian Grigg, Dimitrios Mantzilas, Dag M. Evje
  • Patent number: 10702613
    Abstract: The present invention provides a method for the purification of 227Th from a mixture comprising 227Th and 223Ra, said method comprising: i) preparing a first solution comprising a mixture of 227Th and 223Ra ions dissolved in an aqueous solution of first mineral acid; ii) loading said first solution onto a strong base anion exchange resin; iii) eluting 223Ra from said strong base anion exchange resin using a second mineral acid in an aqueous solution; iv) optionally rinsing said strong base anion exchange resin using a first aqueous medium; v) eluting 227Th from said strong base anion exchange resin using a third mineral acid in an aqueous solution whereby to generate a second solution comprising 227Th. The invention further provides a purified 227Th solution, a corresponding pharmaceutical formulation and methods of treatment of neoplastic disease.
    Type: Grant
    Filed: December 29, 2016
    Date of Patent: July 7, 2020
    Assignee: BAYER AS
    Inventors: Dimitrios Mantzilas, Jan Roger Karlson, Judit Tjelmeland Østby, Janne Olsen Frenvik
  • Patent number: 10660966
    Abstract: A method for removing or controlling or quantifying the presence of aldehydes, in particular acetaldehyde, is described. Such a method is useful in prolonging the shelf life of a pharmaceutical product.
    Type: Grant
    Filed: December 4, 2015
    Date of Patent: May 26, 2020
    Assignee: GE HEALTHCARE LIMITED
    Inventors: Torgrim Engell, Julian Grigg, Dimitrios Mantzilas, Dag M. Evje
  • Publication number: 20190015530
    Abstract: The present invention provides a method for the purification of 227Th from a mixture comprising 227Th and 223Ra, said method comprising: i) preparing a first solution comprising a mixture of 227Th and 223Ra ions dissolved in an aqueous solution of first mineral acid; ii) loading said first solution onto a strong base anion exchange resin; iii) eluting 223Ra from said strong base anion exchange resin using a second mineral acid in an aqueous solution; iv) optionally rinsing said strong base anion exchange resin using a first aqueous medium; v) eluting 227Th from said strong base anion exchange resin using a third mineral acid in an aqueous solution whereby to generate a second solution comprising 227Th. The invention further provides a purified 227Th solution, a corresponding pharmaceutical formulation and methods of treatment of neoplastic disease.
    Type: Application
    Filed: December 29, 2016
    Publication date: January 17, 2019
    Applicant: BAYER AS
    Inventors: Dimitrios MANTZILAS, Jan Roger KARLSON, Judit Tjemeland ØSTBY, Janne Olsen FRENVIK
  • Publication number: 20190009265
    Abstract: The present invention comprises a method for the generation of 227Th of pharmaceutically tolerable purity comprising i) preparing a generator mixture comprising 227Ac, 227Th and 223Ra; ii) loading said generator mixture onto a strong base anion exchange resin; iii) eluting a mixture of said 223Ra and 227Ac from said strong base anion exchange resin using a first mineral acid in an aqueous solution; iv) eluting 227Th from said strong base anion exchange resin using a second mineral acid in an aqueous solution whereby to generate a first 227Th solution containing contaminant 223Ra and 227Ac; v) loading the first 227Th solution onto a strong acid cation exchange resin; vi) eluting at least a part of the contaminant 223Ra and 227Ac from said strong acid cation exchange resin using a third mineral acid in aqueous solution; and vii) eluting the 227Th from said strong acid cation exchange resin using a first aqueous buffer solution to provide a second 227Th solution.
    Type: Application
    Filed: December 29, 2016
    Publication date: January 10, 2019
    Inventors: Dimitrios MANTZILAS, Jan Roger KARLSON, Judit Tjelmeland ØSTBY
  • Patent number: 9987382
    Abstract: The present invention relates to improved radiotracer imaging agent compositions, which comprises 18F-labelled biological targeting moieties, wherein impurities which affect imaging in vivo are identified and suppressed. Also provided are radiopharmaceuticals comprising said improved compositions, together with radiofluorinated aldehyde compositions useful in preparing said radiotracer compositions. The invention also includes methods of imaging and/or diagnosis using the radiopharmaceutical compositions described.
    Type: Grant
    Filed: October 7, 2015
    Date of Patent: June 5, 2018
    Assignee: GE HEALTHCARE LIMITED
    Inventors: Torgrim Engell, Julian Grigg, Dimitrios Mantzilas
  • Publication number: 20170360943
    Abstract: A method for removing or controlling or quantifying the presence of aldehydes, in particular acetaldehyde, is described. Such a method is useful in prolonging the shelf life of a pharmaceutical product.
    Type: Application
    Filed: December 4, 2015
    Publication date: December 21, 2017
    Applicant: GE Healthcare Limited
    Inventors: Torgrim Engell, Julian Grigg, Dimitrios Mantzilas, Dag M. Evje
  • Patent number: 9815785
    Abstract: A method for the purification of cyclic indole compounds that provides advantages over previously-known methods. Using the method of the present invention allows for the facile preparation of a good quality solid form of these compounds.
    Type: Grant
    Filed: July 17, 2014
    Date of Patent: November 14, 2017
    Assignee: GE Healthcare Limited
    Inventors: Sondre Nilsen, Dimitrios Mantzilas
  • Publication number: 20160168091
    Abstract: A method for the purification of cyclic indole compounds that provides advantages over previously-known methods. Using the method of the present invention allows for the facile preparation of a good quality solid form of these compounds.
    Type: Application
    Filed: July 17, 2014
    Publication date: June 16, 2016
    Inventors: Sondre NILSEN, Dimitrios MANTZILAS
  • Patent number: 9346771
    Abstract: A diagnostic imaging agent useful for positron emission tomography (PET) imaging as well as to improved hardware for producing such imaging agents is described. Flutemetamol (18F) Injection for the imaging of ?-amyloid plaques in the brain and methods and devices for preparing same are described including the automated synthesis and purification of [18F]flutemetamol by means of solid phase extraction (SPE).
    Type: Grant
    Filed: February 11, 2015
    Date of Patent: May 24, 2016
    Assignee: GE HEALTHCARE LIMITED
    Inventors: Eric Horn, Steven Fairway, Dimitrios Mantzilas, Nigel Powell
  • Publication number: 20160022847
    Abstract: The present invention relates to improved radiotracer imaging agent compositions, which comprises 18F-labelled biological targeting moieties, wherein impurities which affect imaging in vivo are identified and suppressed. Also provided are radiopharmaceuticals comprising said improved compositions, together with radiofluorinated aldehyde compositions useful in preparing said radiotracer compositions. The invention also includes methods of imaging and/or diagnosis using the radiopharmaceutical compositions described.
    Type: Application
    Filed: October 7, 2015
    Publication date: January 28, 2016
    Applicant: GE HEALTHCARE LIMITED
    Inventors: Torgrim Engell, Julian Grigg, Dimitrios Mantzilas
  • Patent number: 9180213
    Abstract: The present invention relates to improved radiotracer imaging agent compositions, which comprises 18F-labelled biological targeting moieties, wherein impurities which affect imaging in vivo are identified and suppressed. Also provided are radiopharmaceuticals comprising said improved compositions, together with radiofluorinated aldehyde compositions useful in preparing said radiotracer compositions. The invention also includes methods of imaging and/or diagnosis using the radiopharmaceutical compositions described.
    Type: Grant
    Filed: December 9, 2011
    Date of Patent: November 10, 2015
    Assignee: GE Healthcare Limited
    Inventors: Torgrim Engell, Julian Grigg, Dimitrios Mantzilas
  • Publication number: 20150259307
    Abstract: A diagnostic imaging agent useful for positron emission tomography (PET) imaging as well as to improved hardware for producing such imaging agents is described. Flutemetamol (18F) Injection for the imaging of ?-amyloid plaques in the brain and methods and devices for preparing same are described including the automated synthesis and purification of [18F]flutemetamol by means of solid phase extraction (SPE).
    Type: Application
    Filed: February 11, 2015
    Publication date: September 17, 2015
    Inventors: Eric Horn, Steven Fairway, Dimitrios Mantzilas, Nigel Powell
  • Patent number: 9061996
    Abstract: The present invention provides a method to prepare an 18F-labelled tricyclic indole compound comprising a solid-phase extraction (SPE) purification step. This method is particularly suitable for carrying out the radiofluorination method on an automated synthesizer. In addition to the radiofluorination method, the present invention provides a cassette designed to carry out the method on an automated synthesizer.
    Type: Grant
    Filed: December 14, 2011
    Date of Patent: June 23, 2015
    Assignee: GE Healthcare Limited
    Inventors: Dimitrios Mantzilas, Gry Helene Olaussen, Torild Wickstrom, Eric Horn, Imtiaz Khan
  • Publication number: 20150139902
    Abstract: The present invention relates to a method of purification of [18F]-fluciclatide via solid phase extraction (SPE). The method is amenable to automation, and is suitable for use in conjunction with automated synthesizer apparatus—especially cassette-based synthesizers. Also provided are cassettes for carrying out the purification method.
    Type: Application
    Filed: May 23, 2013
    Publication date: May 21, 2015
    Applicant: GE HEALTHCARE LIMITED
    Inventors: Torgrim Engell, Dimitrios Mantzilas, Julian Grigg
  • Patent number: 8969580
    Abstract: A diagnostic imaging agent useful for positron emission tomography (PET) imaging as well as to improved hardware for producing such imaging agents is described. Flutemetamol (18F) Injection for the imaging of b amyloid plaques in the brain and methods and devices for preparing same are described including the automated synthesis and purification of [18F]flutemetamol by means of solid phase extraction (SPE).
    Type: Grant
    Filed: October 8, 2010
    Date of Patent: March 3, 2015
    Assignee: GE Healthcare Limited
    Inventors: Eric Horn, Steven Fairway, Dimitrios Mantzilas, Nigel Powell
  • Publication number: 20130261315
    Abstract: The present invention provides a method to prepare an 18F-labelled tricyclic indole compound comprising a solid-phase extraction (SPE) purification step. This method is particularly suitable for carrying out the radiofluorination method on an automated synthesiser. In addition to the radiofluorination method, the present invention provides a cassette designed to carry out the method on an automated synthesiser.
    Type: Application
    Filed: December 14, 2011
    Publication date: October 3, 2013
    Applicant: GE HEALTHCARE LIMITED
    Inventors: Dimitrios Mantzilas, Gry Helene Olaussen, Torild Wickstrom, Eric Horn, Imtiaz Khan
  • Patent number: 8501153
    Abstract: The present invention provides a PET tracer that has improved properties for imaging the peripheral benzodiazepine receptor (PBR) as compared with known such PET tracers. The present invention also provides a precursor compound useful in the preparation of the PET tracer of the invention and methods for the preparation of said precursor compound and said PET tracer. Also provided by the present invention is a radiopharmaceutical composition comprising the PET tracer of the invention. Methods for using the PET tracer and the radiopharmaceutical composition are also provided.
    Type: Grant
    Filed: September 13, 2010
    Date of Patent: August 6, 2013
    Assignee: GE Healthcare Limited
    Inventors: Radha Achanath, Srinath Balaji, Afsal M. Kadavilpparampu Mohamed, Umamaheshwar Mokkapati, Steven Fairway, Dimitrios Mantzilas, Dennis O'Shea, William John Trigg, Harry John Wadsworth, Joanna Marie Passmore, Bo Shan
  • Publication number: 20130012718
    Abstract: A diagnostic imaging agent useful for positron emission tomography (PET) imaging as well as to improved hardware for producing such imaging agents is described. Flutemetamol (18F) Injection for the imaging of b amyloid plaques in the brain and methods and devices for preparing same are described including the automated synthesis and purification of [18F]flutemetamol by means of solid phase extraction (SPE).
    Type: Application
    Filed: October 8, 2010
    Publication date: January 10, 2013
    Applicant: GE HEALTHCARE LIMITED
    Inventors: Eric Horn, Steven Fairway, Dimitrios Mantzilas, Nigel Powell
  • Publication number: 20110070161
    Abstract: The present invention provides a PET tracer that has improved properties for imaging the peripheral benzodiazepine receptor (PBR) as compared with known such PET tracers. The present invention also provides a precursor compound useful in the preparation of the PET tracer of the invention and methods for the preparation of said precursor compound and said PET tracer. Also provided by the present invention is a radiopharmaceutical composition comprising the PET tracer of the invention. Methods for using the PET tracer and the radiopharmaceutical composition are also provided.
    Type: Application
    Filed: September 13, 2010
    Publication date: March 24, 2011
    Applicant: GE HEALTHCARE LIMITED
    Inventors: RADHA ACHANATH, SRINATH BALAJI, STEVEN FAIRWAY, AFSAL M. KADAVILPPARAMPU MOHAMED, DIMITRIOS MANTZILAS, UMAMAHESHWAR MOKKAPATI, DENNIS O'SHEA, JOANNA MARIE PASSMORE, BO SHAN, WILLIAM JOHN TRIGG, HARRY JOHN WADSWORTH