Patents by Inventor DIMITRIOS MANTZILAS

DIMITRIOS MANTZILAS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Purification method
    Patent number: 8969580
    Abstract: A diagnostic imaging agent useful for positron emission tomography (PET) imaging as well as to improved hardware for producing such imaging agents is described. Flutemetamol (18F) Injection for the imaging of b amyloid plaques in the brain and methods and devices for preparing same are described including the automated synthesis and purification of [18F]flutemetamol by means of solid phase extraction (SPE).
    Type: Grant
    Filed: October 8, 2010
    Date of Patent: March 3, 2015
    Assignee: GE Healthcare Limited
    Inventors: Eric Horn, Steven Fairway, Dimitrios Mantzilas, Nigel Powell
  • SOLID PHASE EXTRACTION METHOD
    Publication number: 20130261315
    Abstract: The present invention provides a method to prepare an 18F-labelled tricyclic indole compound comprising a solid-phase extraction (SPE) purification step. This method is particularly suitable for carrying out the radiofluorination method on an automated synthesiser. In addition to the radiofluorination method, the present invention provides a cassette designed to carry out the method on an automated synthesiser.
    Type: Application
    Filed: December 14, 2011
    Publication date: October 3, 2013
    Applicant: GE HEALTHCARE LIMITED
    Inventors: Dimitrios Mantzilas, Gry Helene Olaussen, Torild Wickstrom, Eric Horn, Imtiaz Khan
  • Active enantiomer
    Patent number: 8501153
    Abstract: The present invention provides a PET tracer that has improved properties for imaging the peripheral benzodiazepine receptor (PBR) as compared with known such PET tracers. The present invention also provides a precursor compound useful in the preparation of the PET tracer of the invention and methods for the preparation of said precursor compound and said PET tracer. Also provided by the present invention is a radiopharmaceutical composition comprising the PET tracer of the invention. Methods for using the PET tracer and the radiopharmaceutical composition are also provided.
    Type: Grant
    Filed: September 13, 2010
    Date of Patent: August 6, 2013
    Assignee: GE Healthcare Limited
    Inventors: Radha Achanath, Srinath Balaji, Afsal M. Kadavilpparampu Mohamed, Umamaheshwar Mokkapati, Steven Fairway, Dimitrios Mantzilas, Dennis O'Shea, William John Trigg, Harry John Wadsworth, Joanna Marie Passmore, Bo Shan
  • PURIFICATION METHOD
    Publication number: 20130012718
    Abstract: A diagnostic imaging agent useful for positron emission tomography (PET) imaging as well as to improved hardware for producing such imaging agents is described. Flutemetamol (18F) Injection for the imaging of b amyloid plaques in the brain and methods and devices for preparing same are described including the automated synthesis and purification of [18F]flutemetamol by means of solid phase extraction (SPE).
    Type: Application
    Filed: October 8, 2010
    Publication date: January 10, 2013
    Applicant: GE HEALTHCARE LIMITED
    Inventors: Eric Horn, Steven Fairway, Dimitrios Mantzilas, Nigel Powell
  • ACTIVE ENANTIOMER
    Publication number: 20110070161
    Abstract: The present invention provides a PET tracer that has improved properties for imaging the peripheral benzodiazepine receptor (PBR) as compared with known such PET tracers. The present invention also provides a precursor compound useful in the preparation of the PET tracer of the invention and methods for the preparation of said precursor compound and said PET tracer. Also provided by the present invention is a radiopharmaceutical composition comprising the PET tracer of the invention. Methods for using the PET tracer and the radiopharmaceutical composition are also provided.
    Type: Application
    Filed: September 13, 2010
    Publication date: March 24, 2011
    Applicant: GE HEALTHCARE LIMITED
    Inventors: RADHA ACHANATH, SRINATH BALAJI, STEVEN FAIRWAY, AFSAL M. KADAVILPPARAMPU MOHAMED, DIMITRIOS MANTZILAS, UMAMAHESHWAR MOKKAPATI, DENNIS O'SHEA, JOANNA MARIE PASSMORE, BO SHAN, WILLIAM JOHN TRIGG, HARRY JOHN WADSWORTH