Abstract: An in vitro culture system of human embryonic stem (hES) derived cells is used as a synthetic lethality screening platform for cells undergoing alternative lengthening of telomeres (ALT).

Abstract: A method for determining a signal propagation time mismatch in a modulator comprises generating a predetermined signal shape of a amplitude component of a radio frequency signal generating one or more predetermined conditions in a frequency component of the radio frequency signal at a first time interval relative to the predetermined signal shape and detecting the one or more predetermined conditions in the frequency component at a second time interval. The method further includes determining the amplitude component at the second time interval and calculating a signal propagation time mismatch value based on the signal shape of the amplitude component, on the first time interval and the second time interval.

Abstract: A method for determining a signal propagation time mismatch in a modulator comprises generating a predetermined signal shape of a amplitude component of a radio frequency signal generating one or more predetermined conditions in a frequency component of the radio frequency signal at a first time interval relative to the predetermined signal shape and detecting the one or more predetermined conditions in the frequency component at a second time interval. The method further includes determining the amplitude component at the second time interval and calculating a signal propagation time mismatch value based on the signal shape of the amplitude component, on the first time interval and the second time interval.

Abstract: Modulation circuitry is configured to generate a phase modulated signal having an output frequency that corresponds to a local oscillator (LO) signal divided by N.5. A phase locked loop (PLL) is configured to generate an LO signal having a frequency that is N.5 times the output frequency. Pulse circuitry configured to generate, based at least on a value of N, an edge signal including a pulse aligned with a positive edge of the LO signal and a pulse aligned with a negative edge of the LO signal. The edge signal is used to generate the phase modulated signal.

Abstract: Examples provide an adaptation circuit and apparatus, method and computer programs for adapting, fabricating and operating, a radio transceiver, a mobile transceiver, a base station transceiver and storage for computer programs or instructions. The adaptation circuit (10) is configured to adapt a local oscillator signal in a radio transceiver (30). The radio transceiver (30) comprises a transmission branch (14) and a reception branch (16), which are subject to cross-talk. The reception branch (16) comprises a local oscillator (18) configured to generate the local oscillator signal. The adaptation circuit (10) comprises a control module (12) configured to determine crosstalk level information between the transmission branch (14) and the reception branch (16), and to adapt the local oscillator signal based on the crosstalk level information.

Abstract: A transmitter for generating an analog radio frequency transmit signal is provided. The transmitter includes a digital-to-analog converter configured to receive an oscillation signal and a first digital data signal to generate an analog radio frequency transmit signal. Further, the transmitter includes an oscillation signal generator configured to generate the oscillation signal with an oscillation frequency based on a second digital data signal. The transmitter additionally includes a controller configured to change a first sample frequency of the first digital data signal from a first frequency to a value different than the oscillation frequency, wherein the first frequency is at least the oscillation frequency.

Abstract: Modulation circuitry is configured to generate a phase modulated signal having an output frequency that corresponds to a local oscillator (LO) signal divided by N.5. A phase locked loop (PLL) is configured to generate an LO signal having a frequency that is N.5 times the output frequency. Pulse circuitry configured to generate, based at least on a value of N, an edge signal including a pulse aligned with a positive edge of the LO signal and a pulse aligned with a negative edge of the LO signal. The edge signal is used to generate the phase modulated signal.

Abstract: Examples provide an adaptation circuit and apparatus, method and computer programs for adapting, fabricating and operating, a radio transceiver, a mobile transceiver, a base station transceiver and storage for computer programs or instructions. The adaptation circuit (10) is configured to adapt a local oscillator signal in a radio transceiver (30). The radio transceiver (30) comprises a transmission branch (14) and a reception branch (16), which are subject to cross-talk. The reception branch (16) comprises a local oscillator (18) configured to generate the local oscillator signal. The adaptation circuit (10) comprises a control module (12) configured to determine crosstalk level information between the transmission branch (14) and the reception branch (16), and to adapt the local oscillator signal based on the crosstalk level information.

Abstract: A transmitter for generating an analog radio frequency transmit signal is provided. The transmitter includes a digital-to-analog converter configured to receive an oscillation signal and a first digital data signal to generate an analog radio frequency transmit signal. Further, the transmitter includes an oscillation signal generator configured to generate the oscillation signal with an oscillation frequency based on a second digital data signal. The transmitter additionally includes a controller configured to change a first sample frequency of the first digital data signal from a first frequency to a value different than the oscillation frequency, wherein the first frequency is at least the oscillation frequency.

Abstract: One embodiment relates to a feedback receiver (FBR). The FBR includes a FBR signal input configured to receive a radio frequency (RF) signal, a first local oscillator (LO) signal input configured to receive a first LO signal having an LO frequency, and a second LO signal input configured to receive a second LO signal having the LO frequency. The second LO signal is phase shifted by approximately 90° relative to the first LO signal. FBR also includes a divider that induces a time-varying phase shift in the first and second LO signals while concurrently retaining a 90° phase shift between the first and second LO signals.

Abstract: A signal processing circuit for providing a modulated analog transmit signal on the basis of a digital transmit data signal is disclosed. The signal processing circuit includes one or more digital circuit components and one or more analog circuit components, and is configured to vary a bias voltage or a supply voltage of at least one of the one or more digital circuit components or at least one of the one or more analog circuit components in dependence on a detected or predefined parameter when providing the modulated analog transmit signal. The detected or predefined parameter includes a parametric or environmental condition associated with the signal processing circuit.

Abstract: A signal processing circuit for providing a modulated analog transmit signal on the basis of a digital transmit data signal is disclosed. The signal processing circuit includes one or more digital circuit components and one or more analog circuit components, and is configured to vary a bias voltage or a supply voltage of at least one of the one or more digital circuit components or at least one of the one or more analog circuit components in dependence on a detected or predefined parameter when providing the modulated analog transmit signal. The detected or predefined parameter includes a parametric or environmental condition associated with the signal processing circuit.

Abstract: A signal processing circuit for providing a modulated analog transmit signal on the basis of a digital transmit data signal is configured to vary a resolution in dependence on a detected or predefined parameter when providing the modulated analog transmit signal.

Abstract: One embodiment relates to a feedback receiver (FBR). The FBR includes a FBR signal input configured to receive a radio frequency (RF) signal, a first local oscillator (LO) signal input configured to receive a first LO signal having an LO frequency, and a second LO signal input configured to receive a second LO signal having the LO frequency. The second LO signal is phase shifted by approximately 90° relative to the first LO signal. FBR also includes a divider that induces a time-varying phase shift in the first and second LO signals while concurrently retaining a 90° phase shift between the first and second LO signals.

Abstract: A localization device display method and apparatus for recording positional parameters associated with a tool being navigated with the localization device. The localization device monitors the position of a tool and automatically records positional parameters associated with the tool when the positional parameters conform to an area of interest and the tool is stable.

Abstract: A signal processing circuit for providing a modulated analog transmit signal on the basis of a digital transmit data signal is configured to vary a resolution in dependence on a detected or predefined parameter when providing the modulated analog transmit signal.

Abstract: A system and method for creating a cavity to receive an acetabulum in a pelvic bone with the aid of a navigated tool are provided. A tear-drop point on a pelvic bone is located by means of a scanning instrument. A tear-drop plane is determined from position data of the tear-drop point and the plane of the pelvic inlet. The tear-drop plane lies perpendicular to the plane of the pelvic inlet, extends parallel to a line connecting the two anterior superior iliac spines, and runs through the tear-drop point. A reference point is determined which is at a defined height above the tear-drop plane, in a defined position in an anterior-posterior direction, and at a defined spacing from an outer surface of the pelvic bone in a lateral-medial direction. A tool is worked into the pelvic bone in a desired direction relative to the reference point.

Abstract: A method and apparatus for cross checking points palpated with a localization device. Points corresponding to the palpated points are obtained from a preoperative image of an object such as an X-Ray of a tibia bone. During a surgical procedure, the accuracy of palpated points are determined based on the palpated points and corresponding points obtained from the preoperative image. If a palpated point is inaccurate, an indicator is generated to indicate the inaccuracy of the palpated point.

Abstract: To facilitate assistance of the operating surgeon when determining the disposition of a receiving cavity in the case of a method and a navigation system for creating a cavity to receive an acetabulum in a navigated pelvic bone with the aid of a navigated tool, it is proposed that the tear-drop point on the pelvic bone is located by means of a navigated scanning instrument, from the position data and the plane of the pelvic inlet of said pelvic bone there is determined a tear-drop plane, which lies perpendicular to said plane of the pelvic inlet and extends parallel to a line connecting the two anterior superior iliac spines and through the scanned tear-drop point, that a reference point is determined at a defined height above the tear-drop plane and in a defined position in the anterior-posterior direction and at a defined spacing from the outer surface of the pelvic bone in the lateral-medial direction, and that the tool is worked into the pelvic bone in a desired direction relative to the reference point un

Abstract: To be able to determine the insertion position of the parts of an artificial knee joint without changing the original knee joint, a method is proposed for determining the position of the tibial part and/or the femoral part of a knee-joint endoprosthesis in relation to the proximal tibial head or to the distal femur in which the position of the femur and of the tibia are monitored by means of a navigation system, in which the distal femur and the proximal tibial head are laterally and medially displaced with a defined force into a spread position by means of a distraction appliance when the knee is straightened and bent, and the relative positions of the femur and the tibia, and consequently the size of the gap between the femur and the tibia, are thereby respectively determined, in which various virtual relative positions of the femur and the tibia are calculated according to geometrical data of the knee-joint endoprosthesis and to different assumed positions of the tibial part on the tibia and/or of the femo