Patents by Inventor Dirk Schübeler

Dirk Schübeler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • USE OF A COMBINATION OF AN ORPHAN MOTIF AND CPG DENSITY TO CONTROL EXPRESSION OF A HETEROLOGOUS TRANSGENE
    Publication number: 20240035034
    Abstract: The present invention provides an isolated nucleic acid comprising more than 220 bp, one or more copy of a sequence selected from the group of SEQ ID NO:1, SEQ ID NO:2 and SEQ ID NO:3, and a CpG Observed over Estimated ratio (O/E ratio) larger than 0.
    Type: Application
    Filed: December 2, 2021
    Publication date: February 1, 2024
    Inventors: Ralph GRAND, Marlena LUEBKE, Dirk Schuebeler
  • Expression cassette with a SynP160 promoter
    Patent number: 11883507
    Abstract: The present invention provides an isolated nucleic acid molecule comprising, or consisting of, the nucleic acid sequence of SEQ ID NO:1 or a nucleic acid sequence of at least 300 bp having at least 80% identity to said sequence of SEQ ID NO:1, wherein said isolated nucleic acid molecule specifically leads to the expression in rod photoreceptors of a gene when operatively linked to a nucleic acid sequence coding for said gene.
    Type: Grant
    Filed: April 2, 2021
    Date of Patent: January 30, 2024
    Assignee: Friedrich Miescher Institute for Biomedical Research
    Inventors: Dominik Hartl, Josephine Juettner, Arnaud Krebs, Botond Roska, Dirk Schuebeler
  • SYNP161, a promoter for the expression of genes
    Patent number: 11857642
    Abstract: The present invention provides an isolated nucleic acid molecule comprising, or consisting of, the nucleic acid sequence of SEQ ID NO:1 or a nucleic acid sequence of at least 150 bp having at least 80% identity to said sequence of SEQ ID NO:1, wherein said isolated nucleic acid molecule specifically leads to the expression in rod photoreceptors of a gene when operatively linked to a nucleic acid sequence coding for said gene.
    Type: Grant
    Filed: January 22, 2021
    Date of Patent: January 2, 2024
    Assignee: Friedrich Miescher Institute for Biomedical Research
    Inventors: Dominik Hartl, Josephine Juettner, Arnaud Krebs, Botond Roska, Dirk Schuebeler
  • USE OF AN ORPHAN MOTIF TO INCREASE EXPRESSION OF A HETEROLOGOUS TRANSGENE
    Publication number: 20230220402
    Abstract: The present invention provides an isolated nucleic acid comprising, operably linked to an heterologous transgene, at least two copies of a sequence selected from the group of SEQ ID NO:1, SEQ ID NO:2 and SEQ ID NO:3, said at least two copies being selected independently from one another.
    Type: Application
    Filed: April 15, 2021
    Publication date: July 13, 2023
    Inventors: Dirk SCHUEBELER, Ralph GRAND
  • SYNP162, a promoter for the expression of genes
    Patent number: 11608365
    Abstract: The present invention provides an isolated nucleic acid molecule comprising, or consisting of, the nucleic acid sequence of SEQ ID NO:1 or a nucleic acid sequence of at least 300 bp having at least 80% identity to said sequence of SEQ ID NO:1, wherein said isolated nucleic acid molecule specifically leads to the expression in rod photoreceptors of a gene when operatively linked to a nucleic acid sequence coding for said gene.
    Type: Grant
    Filed: June 8, 2021
    Date of Patent: March 21, 2023
    Assignee: Friedrich Miescher Institute for Biomedical Research
    Inventors: Dominik Hartl, Josephine Juettner, Arnaud Krebs, Botond Roska, Dirk Schuebeler
  • SynP159, a promoter for the expression of genes
    Patent number: 11591618
    Abstract: The present invention provides an isolated nucleic acid molecule comprising, or consisting of, the nucleic acid sequence of SEQ ID NO:1 or a nucleic acid sequence of at least 400 bp having at least 80% identity to said sequence of SEQ ID NO:1, wherein said isolated nucleic acid molecule specifically leads to the expression in rod photoreceptors of a gene when operatively linked to a nucleic acid sequence coding for said gene.
    Type: Grant
    Filed: April 6, 2021
    Date of Patent: February 28, 2023
    Assignee: Friedrich Miescher Institute for BioMedical Research
    Inventors: Dominik Hartl, Josephine Juettner, Arnaud Krebs, Botond Roska, Dirk Schuebeler
  • SynP198, a promoter for the specific expression of genes in direction selective retinal ganglion cells
    Patent number: 11525145
    Abstract: The present invention provides an isolated nucleic acid molecule comprising, or consisting of, the nucleic acid sequence of SEQ ID NO:1 or a nucleic acid sequence of at least 400 bp having at least 80% identity to said sequence of SEQ ID NO:1, wherein said isolated nucleic acid molecule specifically leads to the expression in direction selective retinal ganglion cells of a gene when operatively linked to a nucleic acid sequence coding for said gene.
    Type: Grant
    Filed: November 1, 2017
    Date of Patent: December 13, 2022
    Assignee: Friedrich Miescher Institute for Biomedical Research
    Inventors: Dominik Hartl, Josephine Juettner, Arnaud Krebs, Botond Roska, Dirk Schuebeler
  • SYNP162, A PROMOTER FOR THE EXPRESSION OF GENES
    Publication number: 20210292792
    Abstract: The present invention provides an isolated nucleic acid molecule comprising, or consisting of, the nucleic acid sequence of SEQ ID NO:1 or a nucleic acid sequence of at least 300 bp having at least 80% identity to said sequence of SEQ ID NO:1, wherein said isolated nucleic acid molecule specifically leads to the expression in rod photoreceptors of a gene when operatively linked to a nucleic acid sequence coding for said gene.
    Type: Application
    Filed: June 8, 2021
    Publication date: September 23, 2021
    Inventors: Dominik HARTL, Josephine JUETTNER, Arnaud KREBS, Botond ROSKA, Dirk SCHUEBELER
  • SYNP159, A PROMOTER FOR THE EXPRESSION OF GENES
    Publication number: 20210230634
    Abstract: The present invention provides an isolated nucleic acid molecule comprising, or consisting of, the nucleic acid sequence of SEQ ID NO:1 or a nucleic acid sequence of at least 400 bp having at least 80% identity to said sequence of SEQ ID NO:1, wherein said isolated nucleic acid molecule specifically leads to the expression in rod photoreceptors of a gene when operatively linked to a nucleic acid sequence coding for said gene.
    Type: Application
    Filed: April 6, 2021
    Publication date: July 29, 2021
    Inventors: Dominik HARTL, Josephine JUETTNER, Arnaud KREBS, Botond ROSKA, Dirk SCHUEBELER
  • SYNP160, A PROMOTER FOR THE EXPRESSION OF GENES
    Publication number: 20210220485
    Abstract: The present invention provides an isolated nucleic acid molecule comprising, or consisting of, the nucleic acid sequence of SEQ ID NO:1 or a nucleic acid sequence of at least 300 bp having at least 80% identity to said sequence of SEQ ID NO:1, wherein said isolated nucleic acid molecule specifically leads to the expression in rod photoreceptors of a gene when operatively linked to a nucleic acid sequence coding for said gene.
    Type: Application
    Filed: April 2, 2021
    Publication date: July 22, 2021
    Inventors: Dominik HARTL, Josephine JUETTNER, Arnaud KREBS, Botond ROSKA, Dirk SCHUEBELER
  • SYNP161, A PROMOTER FOR THE SPECIFIC EXPRESSION OF GENES IN ROD PHOTORECEPTORS
    Publication number: 20210213143
    Abstract: The present invention provides an isolated nucleic acid molecule comprising, or consisting of, the nucleic acid sequence of SEQ ID NO:1 or a nucleic acid sequence of at least 150 bp having at least 80% identity to said sequence of SEQ ID NO:1, wherein said isolated nucleic acid molecule specifically leads to the expression in rod photoreceptors of a gene when operatively linked to a nucleic acid sequence coding for said gene.
    Type: Application
    Filed: January 22, 2021
    Publication date: July 15, 2021
    Inventors: Dominik HARTL, Josephine JUETTNER, Arnaud KREBS, Botond ROSKA, Dirk SCHUEBELER
  • SYNP162, a promoter for the specific expression of genes in rod photoreceptors
    Patent number: 11059871
    Abstract: The present invention provides an isolated nucleic acid molecule comprising, or consisting of, the nucleic acid sequence of SEQ ID NO:1 or a nucleic acid sequence of at least 300 bp having at least 80% identity to said sequence of SEQ ID NO:1, wherein said isolated nucleic acid molecule specifically leads to the expression in rod photoreceptors of a gene when operatively linked to a nucleic acid sequence coding for said gene.
    Type: Grant
    Filed: December 1, 2016
    Date of Patent: July 13, 2021
    Assignee: FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH
    Inventors: Dominik Hartl, Josephine Juettner, Arnaud Krebs, Botond Roska, Dirk Schuebeler
  • SYNP159, a promoter for the specific expression of genes in rod photoreceptors
    Patent number: 10995344
    Abstract: The present invention provides an isolated nucleic acid molecule comprising, or consisting of, the nucleic acid sequence of SEQ ID NO:1 or a nucleic acid sequence of at least 400 bp having at least 80% identity to said sequence of SEQ ID NO:1, wherein said isolated nucleic acid molecule specifically leads to the expression in rod photoreceptors of a gene when operatively linked to a nucleic acid sequence coding for said gene.
    Type: Grant
    Filed: December 1, 2016
    Date of Patent: May 4, 2021
    Assignee: Friedrich Miescher Institute for Biomedical Research
    Inventors: Dominik Hartl, Josephine Juettner, Arnaud Krebs, Botond Roska, Dirk Schuebeler
  • SynP160, a promoter for the specific expression of genes in rod photoreceptors
    Patent number: 10994026
    Abstract: The present invention provides an isolated nucleic acid molecule comprising, or consisting of, the nucleic acid sequence of SEQ ID NO:1 or a nucleic acid sequence of at least 300 bp having at least 80% identity to said sequence of SEQ ID NO:1, wherein said isolated nucleic acid molecule specifically leads to the expression in rod photoreceptors of a gene when operatively linked to a nucleic acid sequence coding for said gene.
    Type: Grant
    Filed: December 1, 2016
    Date of Patent: May 4, 2021
    Assignee: Friedrich Miescher Institute for Biomedical Research
    Inventors: Dominik Hartl, Josephine Juettner, Arnaud Krebs, Botond Roska, Dirk Schuebeler
  • SynP161, a promoter for the specific expression of genes in rod photoreceptors
    Patent number: 10898586
    Abstract: The present invention provides an isolated nucleic acid molecule comprising, or consisting of, the nucleic acid sequence of SEQ ID NO:1 or a nucleic acid sequence of at least 150 bp having at least 80% identity to said sequence of SEQ ID NO:1, wherein said isolated nucleic acid molecule specifically leads to the expression in rod photoreceptors of a gene when operatively linked to a nucleic acid sequence coding for said gene.
    Type: Grant
    Filed: December 1, 2016
    Date of Patent: January 26, 2021
    Assignee: FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH
    Inventors: Dominik Hartl, Josephine Juettner, Arnaud Krebs, Botond Roska, Dirk Schuebeler
  • SynP198, a promoter for the specific expression of genes in direction selective retinal ganglion cells
    Publication number: 20190276847
    Abstract: The present invention provides an isolated nucleic acid molecule comprising, or consisting of, the nucleic acid sequence of SEQ ID NO:1 or a nucleic acid sequence of at least 400 bp having at least 80% identity to said sequence of SEQ ID NO:1, wherein said isolated nucleic acid molecule specifically leads to the expression in direction selective retinal ganglion cells of a gene when operatively linked to a nucleic acid sequence coding for said gene.
    Type: Application
    Filed: November 1, 2017
    Publication date: September 12, 2019
    Inventors: Dominik HARTL, Josephine JUETTNER, Arnaud KREBS, Botond ROSKA, Dirk SCHUEBELER
  • SYNP161, A PROMOTER FOR THE SPECIFIC EXPRESSION OF GENES IN ROD PHOTORECEPTORS
    Publication number: 20190054191
    Abstract: The present invention provides an isolated nucleic acid molecule comprising, or consisting of, the nucleic acid sequence of SEQ ID NO:1 or a nucleic acid sequence of at least 150 bp having at least 80% identity to said sequence of SEQ ID NO:1, wherein said isolated nucleic acid molecule specifically leads to the expression in rod photoreceptors of a gene when operatively linked to a nucleic acid sequence coding for said gene.
    Type: Application
    Filed: December 1, 2016
    Publication date: February 21, 2019
    Applicant: Friedrich Miescher Institute for Biomedical Research
    Inventors: Dominik HARTL, Josephine JUETTNER, Arnaud KREBS, Botond ROSKA, Dirk SCHUEBELER
  • SYNP159, A PROMOTER FOR THE SPECIFIC EXPRESSION OF GENES IN ROD PHOTORECEPTORS
    Publication number: 20180355377
    Abstract: The present invention provides an isolated nucleic acid molecule comprising, or consisting of, the nucleic acid sequence of SEQ ID NO:1 or a nucleic acid sequence of at least 400 bp having at least 80% identity to said sequence of SEQ ID NO:1, wherein said isolated nucleic acid molecule specifically leads to the expression in rod photoreceptors of a gene when operatively linked to a nucleic acid sequence coding for said gene.
    Type: Application
    Filed: December 1, 2016
    Publication date: December 13, 2018
    Applicant: Friedrich Miescher Institute for Biomedical Research
    Inventors: Dominik HARTL, Josephine JUETTNER, Arnaud KREBS, Botond ROSKA, Dirk SCHUEBELER
  • SYNP160, A PROMOTER FOR THE SPECIFIC EXPRESSION OF GENES IN ROD PHOTORECEPTORS
    Publication number: 20180353617
    Abstract: The present invention provides an isolated nucleic acid molecule comprising, or consisting of, the nucleic acid sequence of SEQ ID NO:1 or a nucleic acid sequence of at least 300 bp having at least 80% identity to said sequence of SEQ ID NO:1, wherein said isolated nucleic acid molecule specifically leads to the expression in rod photoreceptors of a gene when operatively linked to a nucleic acid sequence coding for said gene.
    Type: Application
    Filed: December 1, 2016
    Publication date: December 13, 2018
    Applicant: Friedrich Miescher Institute for Biomedical Research
    Inventors: Dominik HARTL, Josephine JUETTNER, Arnaud KREBS, Botond ROSKA, Dirk SCHUEBELER
  • SYNP162, A PROMOTER FOR THE SPECIFIC EXPRESSION OF GENES IN ROD PHOTORECEPTORS
    Publication number: 20180346529
    Abstract: The present invention provides an isolated nucleic acid molecule comprising, or consisting of, the nucleic acid sequence of SEQ ID NO:1 or a nucleic acid sequence of at least 300 bp having at least 80% identity to said sequence of SEQ ID NO:1, wherein said isolated nucleic acid molecule specifically leads to the expression in rod photoreceptors of a gene when operatively linked to a nucleic acid sequence coding for said gene.
    Type: Application
    Filed: December 1, 2016
    Publication date: December 6, 2018
    Applicant: Friedrich Miescher Institute for Biomedical Research
    Inventors: Dominik HARTL, Josephine JUETTNER, Arnaud KREBS, Botond ROSKA, Dirk SCHUEBELER