Patents by Inventor Dirk Schübeler

Dirk Schübeler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANALYSIS OF METHYLATED NUCLEIC ACID
    Publication number: 20120288509
    Abstract: The present invention provides a method for analysis methylation patterns in DNA and identifying aberrantly methylated genes in disease tissue. The invention also provides a method of identifying novel targets for therapeutic intervention and disease markers. Novel cancer targets are provided.
    Type: Application
    Filed: May 3, 2012
    Publication date: November 15, 2012
    Inventors: Dirk SCHUEBELER, Michael Philippe Weber
  • ANALYSIS OF METHYLATED NUCLEIC ACID
    Publication number: 20090270482
    Abstract: The present invention provides a method for analysis methylation patterns in DNA and identifying aberrantly methylated genes in disease tissue. The invention also provides a method of identifying novel targets for therapeutic intervention and disease markers. Novel cancer targets are provided.
    Type: Application
    Filed: March 3, 2005
    Publication date: October 29, 2009
    Inventors: Dirk Schuebeler, Michael Philippe Weber
  • Method for marker-free repetitive DNA expression cassette exchange in the genome of cells or parts of cells
    Patent number: 6992235
    Abstract: The invention relates to a method for marker-free DNA expression cassette exchange in the genome of cells or parts of cells by using the FLP recombinase mediated cassette exchange. A first DNA expression cassette carrying a positive-negative selection marker flanked by two FLP recombinase recognition target (FRT) sites is integrated into a chromosomal locus of the genome. Following selection of cell clones surviving the conditions for positive selection, the first DNA cassette is exchanged by an incoming second DNA expression cassette located on a circular vector and carrying a transgene flanked by the same FRT sites as the first DNA cassette by using FLP-recombinase. The cell clones surviving the conditions for negative selection contain specifically inserted the gene of the incoming DNA cassette without inserted unwanted vector sequences or positive selectable markers.
    Type: Grant
    Filed: April 25, 2001
    Date of Patent: January 31, 2006
    Assignee: Gesellschaft fur Biotechnologische Forschung mbH
    Inventors: Jürgen Bode, Jost Seibler, Dirk Schübeler