Abstract: The present invention is related to a compound comprising a cyclic peptide of formula (I) and an N-terminal modification group A attached to Xaa1, wherein Xaa1, Xaa2, Xaa3, Xaa4, Xaa5 and Xaa6 are each residues of an amino acid, Xaa7 is a residue of an amino thiol or an amino acid of formula, Yc is a cyclization element which is either present or absent, and the N-terminal modification group A is either a blocking group Abl or an amino acid Aaa.

Abstract: The present invention relates to a sensor configuration (1) for non-invasive measurement of parameters of a body tissue with a sensor unit (10) and a sensor mat (12) for detachable placement of the sensor configuration (1) on a body surface (20). Furthermore the sensor unit (10) of the sensor configuration (1) is connectible to a contact head (16), which is designed for electrical contacting of the sensor unit (10) and for supply of light from a light source to the sensor unit (10), the sensor unit (10) being designed as a flexible printed circuit board with optical components, at least comprising a light detector device (2), in order to detect light that is emitted into the body tissue and has passed through the latter, a first contact means (30) and conducting tracks (5) for operative connection of the sensor unit (10) to the contact head (16).

Abstract: The invention relates to a backing plate (1) for a disc brake of a motor vehicle, comprising a front side (2) for holding a friction lining. The backing plate (1) has a back side (3), on which a holding device (4) is arranged. The holding device is designed to hold a spring element (5), which consists of a spring base (6) and two spring legs (7, 8) arranged at the ends of the spring base (6). The holding device (4) is integrally bonded to the backing plate (1). The invention further relates to a method for producing a backing plate (1).

Abstract: A method for configuring and parameterizing field bus subscribers interconnected via a field bus, wherein a first field bus subscriber provides and/or receives process data and a second field bus subscriber allows a user program to run, where a topology is determined by a configuration tool with configuration parameters of the field bus subscribers in a configuration file, the first field bus subscriber is parameterized for subsequent communication via the field bus with a configuration data set including a first part of the configuration file, from the configuration file and further code portions from a program library, an object-orientated class is generated with elements and functions for communication between the first and second field bus subscribers, and the class is instanced in the user program of the second field bus subscriber, the functions being used for communication during execution of the user program to permit access to the process data.

Abstract: Interface module and method for configuring and parameterizing a field bus user, wherein to facilitate a configuration and parameterization of a field bus user logical addresses on the side of an engineering system are transformed with a transformation device into virtual addresses, where whether virtual addresses are present in a received virtual configuration file is recognized in an interface module via a recognition device, a signal is triggered when addresses are present in the received virtual configuration file to ensure the virtual configuration file is adopted and stored in a non-volatile manner in a configuration store within the interface module, and where the virtual addresses are transformed in the interface module via a reverse transformation device back into physically present addresses, whereby for a data exchange of the process data of the module slot, on request by further field bus users, the process data in the module slot is addressed.

Abstract: A method for horizontally splitting rolled-up web material in the sample thickness. A carbon fiber nonwoven is moved in relation to a knife structure in order to split off a layer or successively several layers from a roll web. The one layer or several layers are continuously removed in the form of a roll from the carbon fiber nonwoven after the splitting process.

Abstract: Interface module and method for configuring and parameterizing a field bus user, wherein to facilitate a configuration and parameterization of a field bus user logical addresses on the side of an engineering system are transformed with a transformation device into virtual addresses, where whether virtual addresses are present in a received virtual configuration file is recognized in an interface module via a recognition device, a signal is triggered when addresses are present in the received virtual configuration file to ensure the virtual configuration file is adopted and stored in a non-volatile manner in a configuration store within the interface module, and where the virtual addresses are transformed in the interface module via a reverse transformation device back into physically present addresses, whereby for a data exchange of the process data of the module slot, on request by further field bus users, the process data in the module slot is addressed.

Abstract: An automation system includes a first/second control devices having first/second field bus terminals, a field bus, a peripheral assembly having at least one input/output peripheral module for connection to sensors and/or actuators, where the peripheral assembly includes an interface module having a third field bus terminal for communication to and/or from the control devices, and where the interface module includes at least one input/output module storing interconnect information that creates an association between inputs/outputs of the at least one input/output peripheral module and the control devices, and where the interface module additionally includes a virtual data set module in which a data set receiving module is associated with the first control device to which a data set is writable by the first control device, and includes a data set transmitting module associated with the second controller from which the data set is retrievable by the second control device.

Abstract: An automation system includes a first control facility with a first fieldbus connection, a second control facility with a second fieldbus connection, a fieldbus, a peripheral board with at least one I/O peripheral module, wherein the peripheral board has an interface module with a third fieldbus connection, where the interface module has at least one I/O module which stores interconnection information featuring an assignment of input/outputs of the I/O peripheral module(s) to the control facilities, where the interface module additionally has a virtual I/O module, in which an output region is assigned to the first control facility, and furthermore an input region is assigned to the second controller, and where the virtual I/O module is configured such that the output data is copied from the output region of the first control facility into the input region as input data for the second control facility.

Abstract: A device for jointly delivering plastic particles and a liquid to a cleaning device to remove impurities from the plastic particles comprises a delivery funnel comprising an inlet and an outlet, wherein the inlet is configured to connect to a supply for the plastic particles, and the outlet is configured to connect to the cleaning device. At least one delivery nozzle is positioned on the delivery funnel and is configure to connect to a liquid supply. The at least one delivery nozzle is configured to discharge at least one liquid jet into the delivery funnel, wherein a position of the at least one delivery nozzle promotes mixing of the supplied plastic particles and the liquid in the delivery funnel.

Abstract: The present invention relates to substituted N-(phenyl-heteroaryl)-3-acetylamino-benzamides and N-[3-(acetylamino)phenyl]-phenyl-heteroaryl-carboxamides of general formula (I) as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease such as cancer, wherein i.a.: LA represents an optionally substituted methylene or ethylene group; LB represents —N(H)—C(?O)— or —C(?O)—N(H)—; R1 represents an optionally substituted 5- to 8-membered heterocycloalkyl, 4- to 10-membered heterocycloalkenyl, aryl, heteroaryl or —N(R7)(Ci-C6-alkyl) group; R2 represents an optionally substituted 5- or 6-membered heteroaryl group; R3 represents an optionally substituted phenyl group.

Abstract: An automation system includes a first/second control devices having first/second field bus terminals, a field bus, a peripheral assembly having at least one input/output peripheral module for connection to sensors and/or actuators, where the peripheral assembly includes an interface module having a third field bus terminal for communication to and/or from the control devices, and where the interface module includes at least one input/output module storing interconnect information that creates an association between inputs/outputs of the at least one input/output peripheral module and the control devices, and where the interface module additionally includes a virtual data set module in which a data set receiving module is associated with the first control device to which a data set is writable by the first control device, and includes a data set transmitting module associated with the second controller from which the data set is retrievable by the second control device.

Abstract: A method for horizontally splitting rolled-up web material in the sample thickness. A carbon fiber nonwoven is moved in relation to a knife structure in order to split off a layer or successively several layers from a roll web. The one layer or several layers are continuously removed in the form of a roll from the carbon fiber nonwoven after the splitting process.

Abstract: The present invention relates to inhibitors of the Wnt signalling pathways of general formula (I) as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative disorder, as a sole agent or in combination with other active ingredients.

Abstract: The present invention relates to inhibitors of the Wnt signalling pathways of general formula (I) wherein LA represents *CH2** or *?**; wherein indicates the point of attachment to the carbonyl group, and ** indicates the point of attachment to R1; LB represents *N(H)—C(?O)** or *C(?O)—N(H)**; wherein * indicates the point of attachment to R2, and ** indicates the point of attachment to the phenyl group; R1 represents a group selected from: (AA); wherein * indicates the point of attachment to LA, R2 represents: (BB) wherein * indicates the point of attachment to R3, and ** indicates the point of attachment to LB R3 represents a group selected from: (CC); wherein * indicates the point of attachment to R2; R4 and R5 represent a hydrogen atom; and R6 represents a halogen atom or group selected from: —CH3, —O—CH3, —O—CHF2, —O—CF3, and —O-cyclopropyl; to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing

Abstract: The present invention relates to inhibitors of the Wnt signalling pathways of general formula (I) as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative disorder, as a sole agent or in combination with other active ingredients, in which: R1 represents a group selected from: C1-C3-alkoxy-C2-C3-alkyl-, (A), (B), (C), (D), (E), (F), (G) or (H); wherein * indicates the point of attachment to the rest of the molecule; R2 represents a group selected from: (I), (J) or (K); wherein * indicates the point of attachment to the rest of the molecule.

Abstract: An automation system includes a first control facility with a first fieldbus connection, a second control facility with a second fieldbus connection, a fieldbus, a peripheral board with at least one I/O peripheral module, wherein the peripheral board has an interface module with a third fieldbus connection, where the interface module has at least one I/O module which stores interconnection information featuring an assignment of input/outputs of the I/O peripheral module(s) to the control facilities, where the interface module additionally has a virtual I/O module, in which an output region is assigned to the first control facility, and furthermore an input region is assigned to the second controller, and where the virtual I/O module is configured such that the output data is copied from the output region of the first control facility into the input region as input data for the second control facility.

Abstract: The present invention relates to inhibitors of the Wnt signalling pathways of general formula (I) as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative disorder, as a sole agent or in combination with other active ingredients.

Abstract: The present invention relates to inhibitors of the Wnt signalling pathways of general formula (I) as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative disorder, as a sole agent or in combination with other active ingredients.

Abstract: The present application relates to novel aryl- and hetaryl-substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of cardiovascular disorders.