Patents by Inventor DiZhong Chen

DiZhong Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Benzimidazole derivatives: preparation and pharmaceutical applications
    Patent number: 10736881
    Abstract: The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to benzimidazole containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with dysregulation of histone deacetylase (HDAC).
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: August 11, 2020
    Assignee: MEI Pharma, Inc.
    Inventors: DiZhong Chen, Hong Yan Song, Eric T. Sun, Niefang Yu, Yong Zou
  • BENZIMIDAZOLE DERIVATIVES: PREPARATION AND PHARMACEUTICAL APPLICATIONS
    Publication number: 20190282547
    Abstract: The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to benzimidazole containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with dysregulation of histone deacetylase (HDAC).
    Type: Application
    Filed: December 14, 2018
    Publication date: September 19, 2019
    Inventors: DiZhong CHEN, Hong Yan SONG, Eric T. SUN, Niefang YU, Yong ZOU
  • Benzimidazole derivatives: preparation and pharmaceutical applications
    Patent number: 10201527
    Abstract: The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to benzimidazole containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with dysregulation of histone deacetylase (HDAC).
    Type: Grant
    Filed: June 2, 2017
    Date of Patent: February 12, 2019
    Assignee: MEI PHARMA, INC.
    Inventors: DiZhong Chen, Hong Yan Song, Eric T. Sun, Niefang Yu, Yong Zou
  • FUSED PYRIMIDINE-BASED HYDROXAMATE DERIVATIVES
    Publication number: 20180265512
    Abstract: The present invention relates to fused pyrimidine-based hydroxamate compounds of formula (I), comprising a hydroxamate group, that are inhibitors of hiStone deacetylase (HDAC) and kinases. More particularly, the present invention relates to hydroxamate substituted purine or 5H-pyrrolo[3,2-d]pyrimidine derivatives, methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of disorders/conditions/diseases involving, relating to or associated with enzymes having histone deacetylase, non-histone deacetylase and kinase activities/functions and/or via unspecified/multi-targeted mechanisms.
    Type: Application
    Filed: March 9, 2018
    Publication date: September 20, 2018
    Inventors: Haishan Wang, Dizhong Chen, Chang Kai Soh
  • Fused pyrimidine-based hydroxamate derivatives
    Patent number: 9957270
    Abstract: The present invention relates to fused pyrimidine-based hydroxamate compounds of formula (I), comprising a hydroxamate group, that are inhibitors of histone deacetylase (HDAC) and kinases. More particularly, the present invention relates to hydroxamate substituted purine or 5H-pyrrolo[3,2-d]pyrimidine derivatives, methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of disorders/conditions/diseases involving, relating to or associated with enzymes having histone deacetylase, non-histone deacetylase and kinase activities/functions and/or via unspecified/multi-targeted mechanisms.
    Type: Grant
    Filed: March 13, 2015
    Date of Patent: May 1, 2018
    Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Haishan Wang, Dizhong Chen, Chang Kai Soh
  • BENZIMIDAZOLE DERIVATIVES: PREPARATION AND PHARMACEUTICAL APPLICATIONS
    Publication number: 20170360757
    Abstract: The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to benzimidazole containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with dysregulation of histone deacetylase (HDAC).
    Type: Application
    Filed: June 2, 2017
    Publication date: December 21, 2017
    Inventors: DiZhong CHEN, Hong Yan SONG, Eric T. Sun, Niefang YU, Yong ZOU
  • Benzimidazole derivatives: preparation and pharmaceutical applications
    Patent number: 9717713
    Abstract: The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to benzimidazole containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with dysregulation of histone deacetylase (HDAC).
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: August 1, 2017
    Assignee: MEI PHARMA, INC.
    Inventors: DiZhong Chen, Hong Yan Song, Eric T. Sun, Niefang Yu, Yong Zou
  • PYRIMIDINE SUBSTITUTED PURINE COMPOUNDS AS KINASE (S) INHIBITORS
    Publication number: 20170121332
    Abstract: The present invention relates to a purine compound useful as a kinase inhibitor.
    Type: Application
    Filed: January 9, 2017
    Publication date: May 4, 2017
    Inventors: DiZhong Chen, Meredith Williams
  • Fused Pyrimidine-Based Hydroxamate Derivatives
    Publication number: 20170044162
    Abstract: The present invention relates to fused R1 pyrimidine-based hydroxamate compounds of formula (I), comprising a hydroxamate group, that are inhibitors of histone deacetylase (HDAC) and kinases. More particularly, the present invention relates to hydroxamate substituted purine or 5H-pyrrolo[3,2-d]pyrimidine derivatives, methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of disorders/conditions/diseases involving, relating to or associated with enzymes having histone deacetylase, non-histone deacetylase and kinase activities/functions and/or via unspecified/multi-targeted mechanisms.
    Type: Application
    Filed: March 13, 2015
    Publication date: February 16, 2017
    Inventors: Haishan WANG, Dizhong CHEN, Chang Kai SOH
  • BENZIMIDAZOLE DERIVATIVES: PREPARATION AND PHARMACEUTICAL APPLICATIONS
    Publication number: 20160279102
    Abstract: The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to benzimidazole containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with dysregulation of histone deacetylase (HDAC).
    Type: Application
    Filed: June 10, 2016
    Publication date: September 29, 2016
    Inventors: DiZhong Chen, Hong Yan Song, Eric T. Sun, Niefang Yu, Yong Zou
  • Benzimidazole derivatives: preparation and pharmaceutical applications
    Patent number: 9402829
    Abstract: The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to benzimidazole containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with dysregulation of histone deacetylase (HDAC).
    Type: Grant
    Filed: February 20, 2015
    Date of Patent: August 2, 2016
    Assignee: MEI PHARMA, INC.
    Inventors: DiZhong Chen, Hong Yan Song, Eric T. Sun, Niefang Yu, Yong Zou
  • PYRIMIDINE SUBSTITUTED PURINE COMPOUNDS AS KINASE (S) INHIBITORS
    Publication number: 20160207927
    Abstract: The present invention relates to a purine compound useful as a kinase inhibitor.
    Type: Application
    Filed: August 18, 2015
    Publication date: July 21, 2016
    Inventors: DiZhong Chen, Meredith Williams
  • Pyrimidine substituted purine compounds as kinase (S) inhibitors
    Patent number: 9138437
    Abstract: The present invention relates to a purine compound useful as a kinase inhibitor. The compound has the structure: or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: May 7, 2014
    Date of Patent: September 22, 2015
    Assignee: Verastem, Inc.
    Inventors: DiZhong Chen, Meredith Williams
  • BENZIMIDAZOLE DERIVATIVES: PREPARATION AND PHARMACEUTICAL APPLICATIONS
    Publication number: 20150157608
    Abstract: The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to benzimidazole containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with dysregulation of histone deacetylase (HDAC).
    Type: Application
    Filed: February 20, 2015
    Publication date: June 11, 2015
    Inventors: DiZhong Chen, Hong Yan Song, Eric T. Sun, Niefang Yu, Yong Zou
  • Benzimidazole derivatives: preparation and pharmaceutical applications
    Patent number: 9024029
    Abstract: The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to benzimidazole containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with dysregulation of histone deacetylase (HDAC).
    Type: Grant
    Filed: September 3, 2013
    Date of Patent: May 5, 2015
    Assignee: MEI Pharma, Inc.
    Inventors: DiZhong Chen, Hong Yan Song, Eric T. Sun, Niefang Yu, Yong Zou
  • PYRIMIDINE SUBSTITUTED PURINE COMPOUNDS AS KINASE (S) INHIBITORS
    Publication number: 20150105382
    Abstract: The present invention relates to a purine compound useful as a kinase inhibitor.
    Type: Application
    Filed: May 7, 2014
    Publication date: April 16, 2015
    Applicant: VERASTEM, INC.
    Inventors: DiZhong Chen, Meredith Williams
  • Pyrimidine substituted purine compounds as kinase (S) inhibitors
    Patent number: 8754080
    Abstract: The present invention relates to a purine compound useful as a kinase inhibitor. The compound has the structure (I) or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: April 3, 2009
    Date of Patent: June 17, 2014
    Assignee: Verastem, Inc.
    Inventors: DiZhong Chen, Meredith Williams
  • BENZIMIDAZOLE DERIVATIVES: PREPARATION AND PHARMACEUTICAL APPLICATIONS
    Publication number: 20140005194
    Abstract: The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to benzimidazole containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with dysregulation of histone deacetylase (HDAC).
    Type: Application
    Filed: September 3, 2013
    Publication date: January 2, 2014
    Applicant: MEI Pharma, Inc.
    Inventors: DiZhong CHEN, Hong Yan SONG, Eric T. SUN, Niefang YU, Yong ZOU
  • Benzimidazole derivatives: preparation and pharmaceutical applications
    Patent number: 8551988
    Abstract: The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to benzimidazole containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with dysregulation of histone deacetylase (HDAC).
    Type: Grant
    Filed: June 14, 2010
    Date of Patent: October 8, 2013
    Assignee: Mei Pharma, Inc.
    Inventors: DiZhong Chen, Hong Yan Song, Eric T. Sun, Niefang Yu, Yong Zou
  • PYRIMIDINE SUBSTITUTED PURINE COMPOUNDS AS KINASE (S) INHIBITORS
    Publication number: 20120142683
    Abstract: The present invention relates to a purine compound useful as a kinase inhibitor.
    Type: Application
    Filed: April 3, 2009
    Publication date: June 7, 2012
    Applicant: S*BIO Pte Ltd.
    Inventors: DiZhong Chen, Meredith Williams