Abstract: A method in a trail aircraft for monitoring the separation distance between the trail aircraft and a lead aircraft during a flight deck interval management paired approach (FIM-PA) procedure is provided. The method includes: receiving an assigned spacing goal (ASG); receiving traffic information regarding the lead aircraft that indicates the position, heading and ground velocity of the lead aircraft; retrieving a predetermined tolerance limit and traffic information regarding the trail aircraft that indicates the position, heading and ground velocity of the trail aircraft; setting a range limit that is at least as great as the absolute limit indicated by the ASG plus the tolerance limit; monitoring the range and ground speed differential between the lead aircraft and the trail aircraft; and generating a caution alert indicator when a monitored condition detected from monitoring the range and ground speed differential indicates a potential problem.

Abstract: A luminaire has a light emitting portion extending between first second end caps to define a length between the first end cap and the second end cap. The first end cap comprises a receptacle and the second end cap comprises a post both of which extend in an insertion direction. The receptacles are configured to closely receive the posts and the insertion direction is disposed transversely to the length. A method of assembling a luminaire assembly includes positioning a first end cap of a first luminaire over a second end cap of a second luminaire; moving the first end cap relative to the second end cap in the insertion direction; and inserting the post into the receptacle. An electrical connector on the first end cap may connect with a mating electrical connector on the second end cap to complete an electrical connection between the first luminaire and the second luminaire.

Abstract: The invention relates to a novel process for preparing ?-carboxamide pyrrolidine derivatives, in particular (2S, 5R)-5-(4-((2-fluorobenzyl)oxy)phenyl)pyrrolidine-2-carboxamide, and to novel intermediates for use in said process along with processes for preparing said intermediates.

Abstract: A lighting fixture includes an LED light source that outputs light for general illumination in response to a drive signal, and a driver module configured to provide the drive signal in response to an intelligent lighting module (ILM) instruction. An ILM that is separate from the driver module is provided and has a first plurality of sensors, a first communication interface, a second communication interface, and first control circuitry. The control circuitry of the ILM is configured to communicate with at least one remote entity via the first communication interface as well as generate the ILM instruction for the driver module based on sensor data gathered from the first plurality of sensors, remote entities, or a combination thereof. The ILM instruction is provided to the driver module via the second communication interface and used by the driver module to control the drive signal for the LED array.

Abstract: A light fixture includes a LED assembly and a housing. A lens assembly comprises a lens and a first end cap and a second end cap. The end caps are releasably connected to the housing such that the lens and the end caps are releasably mounted to the housing as a unit. The end caps may be releasably mounted to the housing by a deformable, resilient first engagement member that releasably engages a second engagement when the lens assembly is moved relative to the housing in a first direction. A force is created between the first engagement member and the second engagement member sufficient to hold the lens assembly in the housing and low enough that the lens assembly is removable from the housing by pulling the lens assembly in a second direction opposite to the first direction.

Abstract: The application identifies novel fragments of alpha-synuclein in patients with Lewy Body Disease (LBD) and transgenic animal models thereof. These diseases are characterized by aggregations of alpha-synuclein. The fragments have a truncated C-terminus relative to full-length alpha-synuclein. Some fragments are characterized by a molecular weight of about 12 kDa as determined by SDS gel electrophoresis in tricine buffer and a truncation of at least ten contiguous amino acids from the C-terminus of natural alpha-synuclein. The site of cleavage preferably occurs after residue 117 and before residue 126 of natural alpha-synuclein. The identification of these novel fragments of alpha-synuclein has a number of application in for example, drug discovery, diagnostics, therapeutics, and transgenic animals.

Abstract: A lighting fixture includes an LED light source that outputs light for general illumination in response to a drive signal, and a driver module configured to provide the drive signal in response to an intelligent lighting module (ILM) instruction. An ILM that is separate from the driver module is provided and has a first plurality of sensors, a first communication interface, a second communication interface, and first control circuitry. The control circuitry of the ILM is configured to communicate with at least one remote entity via the first communication interface as well as generate the ILM instruction for the driver module based on sensor data gathered from the first plurality of sensors, remote entities, or a combination thereof. The ILM instruction is provided to the driver module via the second communication interface and used by the driver module to control the drive signal for the LED array.

Abstract: In one aspect, optic assemblies and waveguide fixtures comprising the same are described herein. In an exemplary embodiment, an optic assembly includes an optic housing, an optical insert positioned in the optic housing, and a waveguide optic positioned in the optical insert. The waveguide optic includes a light extraction face and at least two sets of light extraction elements provided on the light extraction face. The at least two sets of light extraction elements are disposed on opposing sides of an axis of symmetry for extracting a symmetric lighting distribution.

Abstract: A light fixture includes a LED assembly and a housing. A lens assembly comprises a lens and a first end cap and a second end cap. The end caps are releasably connected to the housing such that the lens and the end caps are releasably mounted to the housing as a unit. The end caps may be releasably mounted to the housing by a deformable, resilient first engagement member that releasably engages a second engagement when the lens assembly is moved relative to the housing in a first direction. A force is created between the first engagement member and the second engagement member sufficient to hold the lens assembly in the housing and low enough that the lens assembly is removable from the housing by pulling the lens assembly in a second direction opposite to the first direction.

Abstract: A luminaire has a light emitting portion extending between first second end caps to define a length between the first end cap and the second end cap. The first end cap comprises a receptacle and the second end cap comprises a post both of which extend in an insertion direction. The receptacles are configured to closely receive the posts and the insertion direction is disposed transversely to the length. A method of assembling a luminaire assembly includes positioning a first end cap of a first luminaire over a second end cap of a second luminaire; moving the first end cap relative to the second end cap in the insertion direction; and inserting the post into the receptacle. An electrical connector on the first end cap may connect with a mating electrical connector on the second end cap to complete an electrical connection between the first luminaire and the second luminaire.

Abstract: In one aspect, optic assemblies and waveguide fixtures comprising the same are described herein. In an exemplary embodiment, an optic assembly includes an optic housing, an optical insert positioned in the optic housing, and a waveguide optic positioned in the optical insert. The waveguide optic includes a light extraction face and at least two sets of light extraction elements provided on the light extraction face. The at least two sets of light extraction elements are disposed on opposing sides of an axis of symmetry for extracting a symmetric lighting distribution.

Abstract: A lighting fixture includes an LED light source that outputs light for general illumination in response to a drive signal, and a driver module configured to provide the drive signal in response to an intelligent lighting module (ILM) instruction. An ILM that is separate from the driver module is provided and has a first plurality of sensors, a first communication interface, a second communication interface, and first control circuitry. The control circuitry of the ILM is configured to communicate with at least one remote entity via the first communication interface as well as generate the ILM instruction for the driver module based on sensor data gathered from the first plurality of sensors, remote entities, or a combination thereof. The ILM instruction is provided to the driver module via the second communication interface and used by the driver module to control the drive signal for the LED array.

Abstract: The application identifies novel fragments of alpha-synuclein in patients with Lewy Body Disease (LBD) and transgenic animal models thereof. These diseases are characterized by aggregations of alpha-synuclein. The fragments have a truncated C-terminus relative to full-length alpha-synuclein. Some fragments are characterized by a molecular weight of about 12 kDa as determined by SDS gel electrophoresis in tricine buffer and a truncation of at least ten contiguous amino acids from the C-terminus of natural alpha-synuclein. The site of cleavage preferably occurs after residue 117 and before residue 126 of natural alpha-synuclein. The identification of these novel fragments of alpha-synuclein has a number of application in for example, drug discovery, diagnostics, therapeutics, and transgenic animals.

Abstract: The invention relates to a novel process for preparing ?-carboxamide pyrrolidine derivatives, in particular (2S, 5R)-5-(4-((2-fluorobenzyl)oxy)phenyl)pyrrolidine-2-carboxamide, and to novel intermediates for use in said process along with processes for preparing said intermediates.

Abstract: The application identifies novel fragments of alpha-synuclein in patients with Lewy Body Disease (LBD) and transgenic animal models thereof. These diseases are characterized by aggregations of alpha-synuclein. The fragments have a truncated C-terminus relative to full-length alpha-synuclein. Some fragments are characterized by a molecular weight of about 12 kDa as determined by SDS gel electrophoresis in tricine buffer and a truncation of at least ten contiguous amino acids from the C-terminus of natural alpha-synuclein. The site of cleavage preferably occurs after residue 117 and before residue 126 of natural alpha-synuclein. The identification of these novel fragments of alpha-synuclein has a number of application in for example, drug discovery, diagnostics, therapeutics, and transgenic animals.

Abstract: Exemplary systems and methods for interaction with water usage information are provided. In various embodiments, a method comprises receiving water usage data from a meter device, receiving an identifier from a user associated with the meter device, providing an interactive interface to the user, the interactive interface conveying at least some water usage information based on the water usage data, receiving a first characterization of a first water activity from the user, generating a visualization based on the water usage information and the first characterization of the first water activity, and displaying the visualization.

Abstract: An optical device comprising a sealed waterproof housing comprising at least one LED disposed within the housing; a transparent window to allow light from the LED to be emitted from the housing; a non-imaging light element for coupling light from the LED into a plurality of side emitting optical fibers connected to the housing; and a fixing portion for securing the plurality of side-emitting optical fibers into a coupling position adjacent to the window to allow light to pass between the housing and the plurality of optical fibers, via the transparent window. The fixing portion is adapted to allow connection and/or disconnection of the plurality of optical fibers without opening or breaking a seal of the sealed waterproof housing.

Abstract: A communications system comprising at least one light source, a side-emitting fiber light rope into which light emitted from the light source is coupled, and means for sending at least one data carrying optical signal along the light rope.