Abstract: The application identifies novel fragments of alpha-synuclein in patients with Lewy Body Disease (LBD) and transgenic animal models thereof. These diseases are characterized by aggregations of alpha-synuclein. The fragments have a truncated C-terminus relative to full-length alpha-synuclein. Some fragments are characterized by a molecular weight of about 12 kDa as determined by SDS gel electrophoresis in tricine buffer and a truncation of at least ten contiguous amino acids from the C-terminus of natural alpha-synuclein. The site of cleavage preferably occurs after residue 117 and before residue 126 of natural alpha-synuclein. The identification of these novel fragments of alpha-synuclein has a number of application in for example, drug discovery, diagnostics, therapeutics, and transgenic animals.

Abstract: Numerous structural/patient positioning features are provided for use with a dental x-ray machine. At least the following features are included: an inverted motor arrangement to actuate an outer support column with respect to an inner support column; wiper elements disposed between the inner and outer support columns to provide enhanced electrical grounding therebetween; adjustable roller subassemblies disposed between the inner and outer columns; a flexible electrical cable disposed inside the inner column; a self-aligning base for use with the inner column, the base having symmetric halves; an adaptable handgrip handrail extending from the outer column at compound oblique angles; a drive system for film transport; and a side projection system for patient head positioning, including multiple horizontal light beams.

Abstract: The application identifies novel fragments of alpha-synuclein in patients with Lewy Body Disease (LBD) and transgenic animal models thereof. These diseases are characterized by aggregations of alpha-synuclein. The fragments have a truncated C-terminus relative to full-length alpha-synuclein. Some fragments are characterized by a molecular weight of about 12 kDa as determined by SDS gel electrophoresis in tricine buffer and a truncation of at least ten contiguous amino acids from the C-terminus of natural alpha-synuclein. The site of cleavage preferably occurs after residue 117 and before residue 126 of natural alpha-synuclein. The identification of these novel fragments of alpha-synuclein has a number of application in for example, drug discovery, diagnostics, therapeutics, and transgenic animals.

Abstract: The application identifies novel fragments of alpha-synuclein in patients with Lewy Body Disease (LBD) and transgenic animal models thereof. These diseases are characterized by aggregations of alpha-synuclein. The fragments have a truncated C-terminus relative to full-length alpha-synuclein. Some fragments are characterized by a molecular weight of about 12 kDa as determined by SDS gel electrophoresis in tricine buffer and a truncation of at least ten contiguous amino acids from the C-terminus of natural alpha-synuclein. The site of cleavage preferably occurs after residue 117 and before residue 126 of natural alpha-synuclein. The identification of these novel fragments of alpha-synuclein has a number of application in for example, drug discovery, diagnostics, therapeutics, and transgenic animals.

Abstract: Numerous structural/patient positioning features are provided for use with a dental x-ray machine. At least the following features are included: an inverted motor arrangement to actuate an outer support column with respect to an inner support column; wiper elements disposed between the inner and outer support columns to provide enhanced electrical grounding therebetween; adjustable roller subassemblies disposed between the inner and outer columns; a flexible electrical cable disposed inside the inner column; a self-aligning base for use with the inner column, the base having symmetric halves; an adaptable handgrip handrail extending from the outer column at compound oblique angles; a drive system for film transport; and a side projection system for patient head positioning, including multiple horizontal light beams.

Abstract: A bite piece is provided for use with a dental x-ray system. A substantially straight first portion extends to a curved second portion. An end of the second portion opposite the first portion has a region of reduced cross section adjacent the end of the second portion. The region is received between a patient's opposed upper and lower anterior teeth to secure the patient's head position during operation of the dental x-ray system. The region and the second portion substantially lack transitional edges, improving each of the quality of a radiograph produced during operation of the dental x-ray system, a patient's level of comfort and stability of the patient's head position.

Abstract: A container to secure an x-ray source is provided. The container includes a base and a cover each having an inside surface. The base and cover are assembled together forming a fluid tight chamber defined by the inside surfaces of the base and cover to secure x-ray source components to positions along the inside surface of the base. A plurality of these positions are machinable to provide a precision arrangement of at least a portion of the x-ray source components and at least one fluid tight seal between x-ray source components and the base. During fabrication of the base, each position of the inside surface required to provide a precise arrangement of at least a portion of the x-ray source components and at least one fluid tight seal between the x-ray source components and the base being accessible from exterior of the base by a substantially straight tool.

Abstract: The present invention relates to a process for preparing tetrasubstituted imidazole derivatives of the general formula (I) wherein R1, R2, R3 and R4 are as defined in the specification below. The present invention further relates to a process for preparing the compound of formula (II) and novel crystalline structures of the compound of formula (II).

Abstract: A tri-mode co-boresighted seeker including a primary collecting mirror assembly having a parabolic surface and a forwardly located dielectric secondary mirror assembly including a dielectric mirror coating which reflects infrared (IR) energy to an IR detector assembly located on a central longitudinal axis on one side of the secondary mirror while providing substantially unobstructed propagation of millimeter wave RF energy and laser energy in a joint or common signal path therethrough to means located on the other side of the secondary mirror for extracting and diverting laser energy away from the common RF-optical signal path to a laser sensor assembly while causing little or no disturbance to the RF signal as it propagates to a co-located bifurcated waveguide assembly which couples the RF energy to an RF sensor means located behind the primary mirror.

Abstract: A system and method for automatically transcribing a conversation of a plurality of persons comprises a plurality of speech recognition engines each dedicated to a particular person involved in the conversation for converting the speech of the particular person into text. A transcription service provides a transcript associated with the conversation based on the texts of the plurality of persons.

Abstract: In thermal printing the guide (29) positionable toward the platen (3) on a pivoted arm (50) during lift-off correction allows a bond for correction to set before the ribbon (22) is pulled away. The ribbon (22) has an outer layer which adheres to printed characters at somewhat elevated temperatures but is non-tacky at room temperatures. Thermal printing is conducted by setting the switch (44) for heating to temperatures higher than the lift-off temperature.

Abstract: A ribbon feed failure in a printer can cause serious problems, particularly for a printer that uses heat to cause selective ink transfers. Localized heat buildup may injure the printhead and, if allowed to continue, might injure other printer instrumentalities.According to the invention, it is recognized that for ribbons having a degree of electrical conductivity, a mechanical ribbon failure will almost always result in a detectable change of electrical properties. By monitoring the characteristics of an electrical circuit passing through a section of the ribbon around the print point and, preferably, also the printhead-ribbon interface, abnormal electrical parameter values that indicate ribbon failure may be detected to trigger a cessation of printer operation.

Abstract: A multi-track magnetic recording head is used to record data in human readable form on a magnetic track on a record medium. A viewer, having a viewing window containing microencapsulated ferromagnetic particles, is used to read the data. When the viewing window is placed in operative proximity with the magnetic track, an image corresponding to the data on the track is formed on the viewing window to enable a user of the record medium to read the data thereon. The image on the viewing window is erased after reading by providing relative movement between the viewing window and a magnetic field.

Abstract: Pre-cast concrete beams for supporting a filterbed have deep downwardly extending flanges for providing an underchannel lengthwise of the beam. The beams generally extend across a flume. For backwashing with an air-water mixture, air should be supplied at substantially the same rate to all of the channels. Cross passages between the channels are an aid to this even distribution. Heretofore, special molding procedures for providing the passages or limbers through the beam flanges have increased manufacturing costs. According to the present invention, such passages are provided without extra molding steps and without extra cost by following a delightfully simple concept of merely omitting the end portions of the flanges where beam strength is not required. The end portion projecting beyond the flanges may have a leg across its end to ensure support and aid sealing.

Abstract: The downcomer through which air is supplied to a header for liberation of air deep in an aeration tank is of straight-line nature to minimize constant waste of power due to air flow friction. The downcomer nevertheless folds when the header is to be raised for inspection or servicing. The folding axis is external of the downcomer, which breaks open as the folding action starts. In one form the header is straight while initially raised, hanging from a first hoist cable, and then as the lower section is raised further by a second cable the upper section is allowed to fold over. In another form, the folding progresses as the structure is raised, the upper section being hinged to the air supply fitting.

Abstract: Diffusers on the bottom of a submerged header each include coarse bubble orifices which discharge a stream of air to form a bubble or film on the underside of a horizontal spreader at the edges of which the bubble is sheared by flowing water into multitudinous tiny bubblets rising in the surrounding liquid as a cloud. A second horizontal spreader, slightly above the first, has a similar action, shearing into fine bubblets any larger bubbles which escape from the first spreader to the second. Edges are staggered to supply air to different parts of the water flow. The rising bubblets set up a conventional rolling action in the body of liquid. It is this rolling action which produces the flow of water past the spreaders to shear the bubbles at their edges. A snap-in screw-tightened band secures each diffuser to the header.