Abstract: Novel inhibitors of polyamine transport having inhibition constants two orders of magnitude lower than those of known compounds are disclosed. These polyamine analogues are useful pharmaceutical agents for treating diseases where it is desired to inhibit polyamine transport or other polyamine binding proteins, for example cancer and post-angioplasty injury. Novel chemical synthetic methods to obtain polyamine analogues are disclosed, including the production of a combinational polyamine library. These approaches yield analogues with desirable activities both for diagnostic and research assays and therapy. The assays of the invention are useful for high throughput screening of targets in the discovery of drugs that interact with the polyamine system.

Abstract: Oligonucleotides having at least ten nucleosides, at least two of which are selected from the group consisting of A, T, C and G, and at least one nucleoside being a universal nucleoside of the formula: ##STR1## wherein: each R.sub.n is H, OH, F or OCH.sub.3 ;Z is a member of the group consisting of O, S and CH.sub.2 ; andB is a five-membered, heterocyclic base having at least two double bonds, and further having an electron withdrawing group bonded thereto, said base with electron withdrawing group being represented by the formula: ##STR2## wherein: said base with electron withdrawing group is bonded at X.sub.4 to the sugar portion of the nucleoside;X.sub.1, X.sub.3 and X.sub.5 are each members of the group consisting of N, O, C, S and Se;X.sub.2 and X.sub.4 are each members of the group consisting of N and C; andW is a member of the group consisting of F, Cl, Br, I, O, S, OH, SH, NH.sub.2, NO.sub.2, C(O)H, C(O)NHOH, C(S)NHOH, NO, C(NOCH.sub.3)NH.sub.2, OCH.sub.3, SCH.sub.3, SeCH.sub.3, ONH.sub.2, NHOCH.sub.

Abstract: Wire nails are collated by means for conveying the nails in a specified manner and by means comprising a wheel for engaging keyways defining flat surfaces on the shanks of the nails. Each nail is rotated by the wheel, about an axis of the shank of such nail, to such extent as may be then necessary to orient the keyways of such nail and of other nails with such surfaces defining a plane. The wheel fits between end surfaces defined by the keyways so as to cause the keyways that have been engaged by the wheel to define a continuous channel.

Abstract: A method of preparing C-5 substituted nucleotides by reacting a C-5 posit mercurated nucleoside with an alkyl or aryl disulfide in the presence of palladium(II) ion. The resulting new method for attaching linker arms to nucleic acids (DNA,RNA) provides a wide ranging reaction far more useful than those heretofore developed, and allows preparation of modified components with linking reactive functionality that allows usefulness as probes, therapeutics, and for DNA sequencing.

Abstract: C-5 Substituted cytosine nucleosides wherein the C-5 substituent is substituted alkyl, alkenyl or substituted alkenyl; and the pharmaceutically acceptable acid addition salts thereof, are useful as antiviral agents. A novel process for the preparation of the subject compounds is also disclosed.

Abstract: Compounds of the formula ##STR1## wherein R.sub.o is --CH.dbd.CH--CH.sub.3 or --CH.dbd.CH--CF.sub.3 and R is .beta.-D-ribofuranosyl, .beta.-D-2-deoxyribofuranosyl or .beta.-D-arabinofuranosyl are useful as antiviral agents.