Abstract: A manually operated vertically reciprocated pump dispenser has a simplified construction with two separate pumps that pump two separate liquids from a container and keep the two separate liquids separated from each other as they are pumped through the dispenser, mixing the liquids for the first time in a discharge passage of the dispenser just prior to the mixed liquids being discharged from the dispenser. The dispenser has a rotatable sleeve that covers the two pumps and is rotated to lock and unlock a dispenser head that operates the two pumps.

Abstract: Novel receptor polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides comprise an extracellular domain of a cell-surface receptor that is expressed in testis cells. The polypeptides may be used within methods for detecting ligands that promote the proliferation and/or differentiation of testis cells, and may also be used in the development of male-specific contraceptives and infertility treatments.

Abstract: A manually operated liquid foaming dispenser is attached to the top of a container of liquid and is manually reciprocated to dispense the liquid from the container as a foam. The dispenser includes a liquid pump chamber and an air pump chamber that respectively pump liquid and air under pressure to a discharge passage of the pump where the liquid and air are mixed, generating the foam dispensed from the dispenser. The air pump chamber has a tube valve controlling the discharge of air from the air pump to the discharge passage, and the air pump chamber is charged with air by opening the air pump chamber to the exterior environment of the dispenser.

Abstract: A venting system of a manually operated trigger sprayer vents the interior of a liquid container connected to the trigger sprayer. The trigger sprayer is provided with a vent chamber that surrounds the pump chamber, and a vent piston that surrounds the pump piston. The vent piston is received in the vent chamber for reciprocating movements between a vent closed and vent opened position in the vent chamber, and the vent chamber having two different interior diameter sections with a larger interior diameter section reducing drag on the vent piston when the vent piston is moved to the vent opened position.

Abstract: Methods for treating cancer by co-administering a therapeutic monoclonal antibody with IL-21 are described. Exemplary monoclonal antibodies that can be used are rituximab, trastuzumab and anti-CTLA-4 antibodies. The enhanced antitumor of the combination therapy is particularly useful for patient populations that are recalcitrant to monoclonal therapy, relapse after treatment with monoclonal antibodies or where the enhanced IL-21 antitumor effect reduces toxicities associated with treatment using the monoclonal antibodies.

Abstract: In accordance with the present invention, there is provided a semiconductor package which includes a generally planar die paddle defining multiple peripheral edge segments and including at least two slots formed therein and extending along respective ones of a pair of the peripheral edge segments thereof. The semiconductor package further comprises a plurality of first leads which are segregated into at least two sets disposed within respective ones of the slots included in the die paddle. In addition to the first leads, the semiconductor package includes a plurality of second leads which are also segregated into at least two sets extending along respective ones of at least two peripheral edge segments of the die paddle in spaced relation thereto. Electrically connected to the top surface of the die paddle is at least one semiconductor die which is electrically connected to at least some of each of the first and second leads.

Abstract: Novel receptor polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides comprise an extracellular domain of a cell-surface receptor that is expressed in testis cells. The polypeptides may be used within methods for detecting ligands that promote the proliferation and/or differentiation of testis cells, and may also be used in the development of male-specific contraceptives and infertility treatments.

Abstract: A hand operated liquid dispenser has a simplified, in-line construction that reduces the number of component parts of the dispenser and thereby reduces the dispenser's manufacturing costs. The in-line construction of the liquid dispenser coaxially aligns a liquid discharge orifice, a liquid discharge passage, and a pump chamber of the dispenser. The construction provides a compact liquid dispenser that can be easily held in one hand by a user and manipulated by the fingers of the user's hand to pump liquid from a bottle attached to the liquid dispenser and dispense the liquid in a variety of different discharge patterns.

Abstract: The present invention provides isolated DNA molecules comprising a DNA segment encoding novel human Kunitz-type inhibitors. Also provided are DNA constructs comprising a first DNA segment encoding a novel human Kunitz-type inhibitor wherein said first DNA segment is operably linked to additional DNA segments required for the expression for the first DNA segment, as well as host cells containing such DNA constructs and methods for producing proteins from the host cells.

Abstract: Novel receptor polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides comprise an extracellular domain of a cell-surface receptor that is expressed in testis cells. The polypeptides may be used within methods for detecting ligands that promote the proliferation and/or differentiation of testis cells, and may also be used in the development of male-specific contraceptives and infertility treatments.

Abstract: A soluble receptor to IL-20 having two polypeptide subunits, IL-20RA (formerly called ZcytoR7) and IL-20RB (formerly called DIRS1). The two subunits are preferably linked together. In one embodiment one subunit is fused to the constant region of the light chain of an immunoglobulin, and the other subunit is fused to the constant region of the heavy chain of the immunoglobulin. The light chain and the heavy chain are connected via a disulfide bond.

Abstract: A lithium ion secondary electrochemical cell includes an anode comprising both a material capable of reversibly incorporating an alkali metal, and a copper current collector, a cathode capable of reversibly incorporating an alkali metal, and an electrolyte which includes a solution of an alkali metal salt dissolved in a polar organic solvent. A method of preventing the electrochemical dissolution of the copper current collector in the lithium ion battery electrolyte includes charging the lithium ion cell immediately after its assembly. By immediately charging the freshly assembled lithium ion cell, lithium will be intercalated into carbon. The copper current collector, therefore, will be at the lithium-carbon potential and thus will be cathodically protected, and will not electrochemically dissolve in the lithium ion battery electrolyte.

Abstract: A method and apparatus for indirectly measuring the percentage of dissolved gas in a process liquid by injecting bubbles of the same kind of gas of predetermined diameter into the liquid to be measured and then measuring gas bubble life or survival time. Bubble lifetime is directly related to dissolved gas percentage. A relatively long gas bubble lifetime would be indicative of a highly saturated or poorly degassed process liquid, whereas a relatively short bubble lifetime would be indicative of a low degree of saturation or a well degassed process liquid. In one embodiment, dissolved gas percentage is determined by placing a small quantity of the process liquid into a container, injecting a burst of gas bubbles, of predetermined size, into this quantity of liquid, and then measuring gas bubble lifetime. In another embodiment, a portion of the liquid being measured is continuously routed through a tube at a known constant flow rate.

Abstract: Improved electrostatically assisted coating apparatus for placing an electrostatic dipole-type charge, of a predetermined magnitude, on material to be coated before and/or remote from the location where the coating is actually applied to said material by a coating applicator.

Abstract: A decorative candle molded from candle material wherein the surface of the candle has a plurality of randomly distributed pores adjacent the surface thereof only and said pores are less than 4 millimeters diameter in size and form an attractive random pattern. There are at least 5 said pores per said centimeter of the surface of said candle and the central portion of the candle is substantially pore-free.The candle is made by melting candle material and then cooling the liquid candle material to a temperature and for a time such that a thin film is formed on the surface of the liquid candle material, then mixing the liquid and film phases until the mixture is bubbly and thereafter pouring the candle material into a candle mold from a height at least 50% greater than the height of the mold, cooling and removing the candle from the mold.

Abstract: A transmission for a pedal-propelled vehicle has a drive shaft rotated by a crankset and disposed radially with respect to the driving wheel of the vehicle. A friction wheel is slidably connected to the shaft by a one-way clutch and is in engagement with a friction member connected to the driving wheel to rotate therewith. The friction wheel includes a tubular shaft through which the drive shaft extends. A shifting unit is connected to the friction wheel by means of the tubular shaft to slide along the drive shaft therewith but is held against turning. The shifting unit includes a gear train having a pinion in mesh with a fixed rack parallel to the drive shaft. First and second normally inoperative connections between the tubular shaft and the gear train are provided, the first to drive the gear train to rotate the pinion to shift the unit and the friction wheel towards the axis of the friction member and the second to drive the gear train to shift the unit and friction wheel towards the periphery thereof.

Abstract: A light weight, thermal battery having a cathode, an anode and a solid complex of SO2 and lithium tetrachloroaluminate as the solid electrolyte therein. The solid complex of SO2 and lithium tetrachloroaluminate is represented by the formula LiAlCl4·xSO2, wherein 1.0<x<4. The thermal battery is activated by heating the battery to temperatures of approximately between 35° C. to 90° C. A method of making the thermal battery is taught.