Abstract: A safety system for laser treatment, comprising a first sensor configured to monitor a parameter at a source and to generate first parameter data, a second sensor configured to monitor the parameter at a treatment head and to generate second parameter data, a control system configured to receive the first parameter data and the second parameter data and to determine whether the first parameter data or the second parameter data exceed a predetermined value and the control system further configured to modify an operational parameter of the source in response to a determination that the first parameter data or the second parameter data exceed the predetermined value.

Abstract: A safety system for laser treatment, comprising a first sensor configured to monitor a parameter at a source and to generate first parameter data, a second sensor configured to monitor the parameter at a treatment head and to generate second parameter data, a control system configured to receive the first parameter data and the second parameter data and to determine whether the first parameter data or the second parameter data exceed a predetermined value and the control system further configured to modify an operational parameter of the source in response to a determination that the first parameter data or the second parameter data exceed the predetermined value.

Abstract: A safety system for laser treatment, comprising a robotic controller configured to monitor a distance between a treatment device and a treatment area, the robotic controller configured to detect a manual movement of the treatment device and to generate a counterbalancing force in response to the manual movement and wherein the robotic controller is configured to increase the counterbalancing force if the distance between the treatment device and the treatment area is less than a predetermined distance.

Abstract: A system for performing a treatment procedure, comprising a robotic movement controller coupled to a treatment device, the robotic movement controller configured to control movement of the treatment device in three dimensions. A manual override system configured to interrupt the robotic movement controller to allow a user to manually control movement of the treatment device. The robotic movement controller is configured to resume operations when the user has completed manual movement of the treatment device.

Abstract: A system for controlling a laser treatment, comprising a three dimensional image generator configured to receive three dimensional surface data and to generate a user display of the three dimensional surface data, a user control configured to allow a user to select one or more sections from the user display of the three dimensional surface data and to assign a laser wavelength to the selected section and a robotic treatment device configured to receive the assigned laser wavelength and the selected section and to control a laser device to deliver a laser treatment to the selected section at the assigned laser wavelength.

Abstract: A laser treatment system comprising a plurality of laser devices disposed on a cart, a combiner coupled to the plurality of laser devices, the combiner configured to combine a plurality of laser signals from the plurality of laser devices into a single conducting medium and a treatment head coupled to the conducting medium, the treatment head configured to deliver the plurality of laser signals to a predetermined location.

Abstract: A safety system for laser treatment, comprising a robotic controller configured to monitor a distance between a treatment device and a treatment area, the robotic controller configured to detect a manual movement of the treatment device and to generate a counterbalancing force in response to the manual movement and wherein the robotic controller is configured to increase the counterbalancing force if the distance between the treatment device and the treatment area is less than a predetermined distance.

Abstract: An optoacoustic system and method for providing enhanced laser safety includes a laser light source, a control and processing system, a laser override, and an array of optoacoustic transducers. The laser light source is capable of generating a laser light pulse upon receiving a laser light source trigger. The control and processing system is configured to generate a laser light source trigger, to receive and process ultrasound data, and to control operation of the optoacoustic system. The control and processing system determines whether received ultrasound data reflects acoustic coupling between the transducer array and the volume. The laser override is configured to automatically prevent the generation of a laser light pulse if received ultrasound data does not reflect acoustic coupling between the optoacoustic transducer array and the volume.

Abstract: An optoacoustic system and method for providing enhanced laser safety includes a laser light source, a control and processing system, a laser override, and an array of optoacoustic transducers. The laser light source is capable of generating a laser light pulse upon receiving a laser light source trigger. The control and processing system is configured to generate a laser light source trigger, to receive and process ultrasound data, and to control operation of the optoacoustic system. The control and processing system determines whether received ultrasound data reflects acoustic coupling between the transducer array and the volume. The laser override is configured to automatically prevent the generation of a laser light pulse if received ultrasound data does not reflect acoustic coupling between the optoacoustic transducer array and the volume.

Abstract: In an embodiment, an opto-acoustic probe includes an acoustic receiver, an optical energy path, and an exterior surface with a combined optical and acoustic port. The probe includes an acoustically transmissive optical distribution element having a distal surface and a proximal surface. The distal surface is adapted to be coupled to a volume of a biological tissue to deliver optical energy to the volume and to exchange acoustic energy with the volume and the proximal surface permits acoustic energy originating within the volume due to delivered optical energy to be detected by the acoustic receiver after the acoustic energy passes through the optical distribution element. The optical energy path of the probe is adapted to pass optical energy to one or more optical energy inputs of the optical distribution element.

Abstract: An optoacoustic probe including an ultrasound transducer array, an acoustic lens and a light path separated from the transducer array by an isolator to mitigate light energy from the light path from reaching the transducer array. The isolator being formed from a mixture including a flexible carrier, a coloring and between 10% and 80% by volume micro-bubbles. The isolator mixture being adapted to both absorb light energy and the optoacoustic response to light energy. In an embodiment, an optoacoustic probe also comprises an optical window and/or a diffuser, and the isolator also separating the transducer array from these components.

Abstract: A real-time imaging system that provides ultrasonic imaging and optoacoustic imaging coregistered through application of the same hand-held probe to generate and detect ultrasonic and optoacoustic signals. These signals are digitized, processed and used to reconstruct anatomical maps superimposed with maps of two functional parameters of blood hemoglobin index and blood oxygenation index. The blood hemoglobin index represents blood hemoglobin concentration changes in the areas of diagnostic interest relative to the background blood concentration. The blood oxygenation index represents blood oxygenation changes in the areas of diagnostic interest relative to the background level of blood oxygenation. These coregistered maps can be used to noninvasively differentiate malignant tumors from benign lumps and cysts.

Abstract: An optoacoustic imaging system includes a handheld probe and first and second pulsed light sources having a common output. The first and second light sources generate pulses of light at first and second predominant wavelengths, respectively. The handheld probe includes an ultrasound transducer array having an active end located at the distal end of the handheld probe for receiving an optoacoustic return signal. A sensor measures a portion of the light transmitted along the light path. A data acquisition samples the ultrasound transducer array during a predetermined period of time after a pulse of light from the first light source and during a predetermined period of time after a pulse of light from the second light source. The sampled data is stored.

Abstract: A testing apparatus for an optoacoustic device includes a light pulse sensor operatively connected to a light output port of the optoacoustic device, the light pulse sensor being adapted to sense a pulse of light capable of generating an optoacoustic response in a subject and to distinguish between the light pulse and the at least one other light pulse on the basis of the predominant wavelength. The light pulse sensor outputs a trigger signal associated with the distinguished light pulse when such light pulse is sensed. A transducer signal simulator outputs a first plurality of electrical signals simulating those produced by a transducer array and reflective of an optoacoustic response in a subject to a light pulse at a first wavelength in response to a trigger signal from the light pulse sensor associated with a light pulse having a first wavelength.

Abstract: An optoacoustic imaging system includes a hand-held imaging probe having a light emitting portion and an array of ultrasonic transducers. The probe includes an acoustic lens having an optically reflective material that operates to avoid image artifacts associated with light interactions with the acoustic lens. The optically reflective material may be a thin, highly optically reflective metallic layer. The acoustic lens may be formed from a material such as silicone rubber filled with titanium dioxide or barium sulfate that allows it to reflect and scatter light from illumination components with substantially no absorption of such light, and yet be optically opaque. The probe may include a housing that provides hypo-echoic encapsulation of the probe. An assembly of the array of ultrasonic transducers may include a hypo-echoic material. The probe may include optical windows, each comprising one or more anti-reflection coated plates with acoustic impedance matching that of tissues to be imaged.

Abstract: An optoacoustic imaging system includes a handheld probe and first and second pulsed light sources having a common output. The first and second light sources generate pulses of light at first and second predominant wavelengths, respectively. The handheld probe includes an ultrasound transducer array having an active end located at the distal end of the handheld probe for receiving an optoacoustic return signal. A sensor measures a portion of the light transmitted along the light path. A data acquisition samples the ultrasound transducer array during a predetermined period of time after a pulse of light from the first light source and during a predetermined period of time after a pulse of light from the second light source. The sampled data is stored.

Abstract: Systems and methods for relaying electrical signals representing acoustic response of a volume of tissue to light and ultrasound stimulation. In an embodiment, a plurality of ultrasound transducers receive acoustic energy from the volume and generate electrical energy, which is transmitted via an electrical path to a relay system. The ultrasound transducers are operated at a wide band frequency of at least 1 MHz to 5 MHz to receive acoustic energy from the volume of tissue responsive to light stimulation and at a narrower band frequency to receive acoustic energy from the volume of tissue responsive to acoustic stimulation. The relay system relays the electrical signals to an optoacoustic system or an ultrasound instrument for further processing depending on whether the electrical signals resulted from ultrasound or light stimulation. In an embodiment, optoacoustic, ultrasound, or other images are generated from the electrical signals and may be coregistered, overlayed, or displayed.

Abstract: Disclosed is an optoacoustic probe with a coated transducer assembly. The probe includes a transducer assembly with a multi-layer coating on the active end thereof. The multi-layer coating includes a layer of parylene and at least two layers of metal. In an embodiment, the multi-layer coating includes a layer of nickel, at least one layer of parylene, and a layer of gold.

Abstract: An optoacoustic system and method for providing enhanced laser safety includes a laser light source, a control and processing system, a laser override, and an array of optoacoustic transducers. The laser light source is capable of generating a laser light pulse upon receiving a laser light source trigger. The control and processing system is configured to generate a laser light source trigger, to receive and process ultrasound data, and to control operation of the optoacoustic system. The control and processing system determines whether received ultrasound data reflects acoustic coupling between the transducer array and the volume. The laser override is configured to automatically prevent the generation of a laser light pulse if received ultrasound data does not reflect acoustic coupling between the optoacoustic transducer array and the volume.

Abstract: Systems and methods for relaying electrical signals representing acoustic response of a volume of tissue to light and ultrasound stimulation. In an embodiment, a plurality of ultrasound transducers receive acoustic energy from the volume and generate electrical energy, which is transmitted via an electrical path to a relay system. The ultrasound transducers are operated at a wide band frequency of at least 1 MHz to 5 MHz to receive acoustic energy from the volume of tissue responsive to light stimulation and at a narrower band frequency to receive acoustic energy from the volume of tissue responsive to acoustic stimulation. The relay system relays the electrical signals to an optoacoustic system or an ultrasound instrument for further processing depending on whether the electrical signals resulted from ultrasound or light stimulation. In an embodiment, optoacoustic, ultrasound, or other images are generated from the electrical signals and may be coregistered, overlayed, or displayed.