Abstract: A system is provided for component separation. In an embodiment, a light source or other source of electromagnetic energy delivers energy to a volume of tissue. A transducer array or other sensor receives a resulting acoustic signal, and a processing subsystem processes the acoustic signal to separate a direct acoustic return component from a secondary acoustic return component of the acoustic signal. An output and/or storage device presents and/or stores information about the direct acoustic return component, the secondary acoustic return component, or both. Other embodiments include a coded probe, a probe having an isolator that produces a wavefront, a sensor for measuring intensity of an acoustic wave produced by absorbed photons, and a system that receives acoustic signals from surface targets to determine an optical parameter of the volume.

Abstract: An optoacoustic system includes first and second light sources capable of generating pulse of light at first and second wavelengths, optical output control, first and second light sync detectors, and a combiner. A power meter that is calibrated to determine power at the first and second predominant wavelength measures power at the first wavelength after the first light sync is detected and measures power at the second wavelength after the second light sync is detected. The system includes a calibration mode wherein it reduces optical output of the first light source when the power measured by the power meter at the first wavelength after the first light sync is detected is above a first level, and reduces optical output of the second light source when the power measured by the power meter at the second wavelength after the second light sync is detected is above a second level.

Abstract: An optoacoustic probe including an ultrasound transducer array, an acoustic lens and a light path separated from the transducer array by an isolator to mitigate light energy from the light path from reaching the transducer array. The isolator can be formed from a mixture including a carrier material and between 10% and 80% by volume micro-bubbles. The isolator can be adapted to absorb, reflect or scatter light energy and absorb the optoacoustic response to light energy. In an embodiment, an optoacoustic probe also comprises an optical window and/or a diffuser, the isolator also separating the transducer array from these components.

Abstract: Systems and methods for relaying electrical signals representing acoustic response of a volume of tissue to light and ultrasound stimulation. In an embodiment, a plurality of ultrasound transducers receive acoustic energy from the volume and generate electrical energy, which is transmitted via an electrical path to a relay system. The ultrasound transducers are operated at a wide band frequency of at least 1 MHz to 5 MHz to receive acoustic energy from the volume of tissue responsive to light stimulation and at a narrower band frequency to receive acoustic energy from the volume of tissue responsive to acoustic stimulation. The relay system relays the electrical signals to an optoacoustic system or an ultrasound instrument for further processing depending on whether the electrical signals resulted from ultrasound or light stimulation. In an embodiment, optoacoustic, ultrasound, or other images are generated from the electrical signals and may be coregistered, overlayed, or displayed.

Abstract: An optoacoustic probe including an ultrasound transducer array, an acoustic lens and a light path separated from the transducer array by an isolator to mitigate light energy from the light path from reaching the transducer array. The isolator being formed from a mixture including a flexible carrier, a coloring and between 10% and 80% by volume micro-bubbles. The isolator mixture being adapted to both absorb light energy and the optoacoustic response to light energy. In an embodiment, an optoacoustic probe also comprises an optical window and/or a diffuser, and the isolator also separating the transducer array from these components.

Abstract: Disclosed is an optoacoustic probe with a coated transducer assembly. The probe includes a transducer assembly with a multi-layer coating on the active end thereof. The multi-layer coating includes a layer of parylene and at least two layers of metal. In an embodiment, the multi-layer coating includes a layer of nickel, at least one layer of parylene, and a layer of gold.

Abstract: The quality of a parametric map is improved based upon information contained in optoacoustic images. Frames are acquired by a multi-wavelength optoacoustic imaging system. A first sub-set including uncorrelated frames from a first wavelength is generated. A first interframe artifact estimate is generated. The first artifact estimate is applied to a frame from a first wavelength to mitigate the interframe persistent artifact in the frame, creating a first processed frame. A second sub-set including uncorrelated frames from a second wavelength is generated. A second interframe artifact estimate is generated. The second artifact estimate is applied to a frame from the second wavelength to mitigate the artifact in the frame from the second wavelength, creating a second processed frame. A parametric map is generated from information in the first processed frame and information in the second processed frame.

Abstract: An optoacoustic imaging system includes a hand-held imaging probe having a light emitting portion and an array of ultrasonic transducers. The probe includes an acoustic lens having an optically reflective material that operates to avoid image artifacts associated with light interactions with the acoustic lens. The optically reflective material may be a thin, highly optically reflective metallic layer. The acoustic lens may be formed from a material such as silicon rubber filled with titanium dioxide or barium sulfate that allows it to reflect and scatter light from illumination components with substantially no absorption of such light, and yet be optically opaque. The probe may include a housing that provides hypo-echoic encapsulation of the probe. An assembly of the array of ultrasonic transducers may include a hypo-echoic material. The probe may include optical windows, each comprising one or more anti-reflection-coated plates with acoustic impedance matching that of tissues to be imaged.

Abstract: A real-time imaging method that provides ultrasonic imaging and optoacoustic imaging coregistered through application of the same hand-held probe to generate and detect ultrasonic and optoacoustic signals. These signals are digitized, processed and used to reconstruct anatomical maps superimposed with maps of two functional parameters of blood hemoglobin index and blood oxygenation index. The blood hemoglobin index represents blood hemoglobin concentration changes in the areas of diagnostic interest relative to the background blood concentration. The blood oxygenation index represents blood oxygenation changes in the areas of diagnostic interest relative to the background level of blood oxygenation. These coregistered maps can be used to noninvasively differentiate malignant tumors from benign lumps and cysts.

Abstract: An optoacoustic probe includes an optical window, a light path, an acoustic lens and an ultrasound transducer array. The light path operatively connects a light source to the probe, and is adapted to transmit light through the optical window at an angle of light transmission. The ultrasound transducer array includes ultrasound transducer elements, and has the inner surface of the acoustic lens at its active end. The probe is enabled to vary the angle of light transmission responsive to at least one command. In an embodiment, the light source generates a light pulse at at least one predominant wavelength. The light path may comprise at least first plurality of optical fibers. A control and processing system may be provided that is capable of pulsing the light source, causing the probe to transmit ultrasound, receiving and processing optoacoustic and ultrasound data, and controlling the operation of the system.

Abstract: A holder for an optoacoustic probe includes a probe-end enclosing portion formed from material that is substantially opaque to light emanating from an optical window of a probe. The probe-end enclosing portion is sized to enclose the active end of the probe and have a snug fit therewith when the optoacoustic probe is inserted therein, and has minimal or no contact with the optical window and acoustic lens of the probe. The probe holder further includes a cutaway adapted to support the probe's strain relief under the downward force of gravity, thereby supporting the probe at an angle that provides for easy manual grasping and removal. The probe support also blocks an in-holder probe from sliding away from the probe-enclosing end. A cable guide is spaced from the probe support to accept a connecting cable exiting from the proximal end of the probe, and thus reduce pressure on the strain relief and soften the angle of curvature of the connecting cable.

Abstract: A testing apparatus for an optoacoustic device includes a light pulse sensor operatively connected to a light output port of the optoacoustic device, the light pulse sensor being adapted to sense a pulse of light capable of generating an optoacoustic response in a subject and to distinguish between the light pulse and the at least one other light pulse on the basis of the predominant wavelength. The light pulse sensor outputs a trigger signal associated with the distinguished light pulse when such light pulse is sensed. A transducer signal simulator outputs a first plurality of electrical signals simulating those produced by a transducer array and reflective of an optoacoustic response in a subject to a light pulse at a first wavelength in response to a trigger signal from the light pulse sensor associated with a light pulse having a first wavelength.

Abstract: A real-time imaging system that provides ultrasonic imaging and optoacoustic imaging coregistered through application of the same hand-held probe to generate and detect ultrasonic and optoacoustic signals. These signals are digitized, processed and used to reconstruct anatomical maps superimposed with maps of two functional parameters of blood hemoglobin index and blood oxygenation index. The blood hemoglobin index represents blood hemoglobin concentration changes in the areas of diagnostic interest relative to the background blood concentration. The blood oxygenation index represents blood oxygenation changes in the areas of diagnostic interest relative to the background level of blood oxygenation. These coregistered maps can be used to noninvasively differentiate malignant tumors from benign lumps and cysts.

Abstract: An optoacoustic system includes first and second light sources capable of generating pulse of light at first and second wavelengths, first and second electrically controlled optical attenuators, first and second light sync detectors, and a combiner. A power meter that is calibrated to determine power at the first and second predominant wavelength measures power at the first wavelength after the first light sync is detected and measures power at the second wavelength after the second light sync is detected. The system includes a calibration mode wherein it electrically attenuates the first optical attenuator when the power measured by the power meter at the first wavelength after the first light sync is detected is above a first level, and electrically attenuated the second optical attenuator when the power measured by the power meter at the second wavelength after the second light sync is detected is above a second level.

Abstract: A fiber optic cable and connector includes a bundle of optical fibers and a ferrule associated with the bundle. The ferrule has an insertable portion and an external portion, the insertable portion retaining the respective proximal ends of the optical fibers on substantially the same plane with one another, the plane being substantially perpendicular to the longitudinal access of the ferrule. A collar around the external portion of the ferrule has a positioning means with a slot, a recess, a hole, a tongue, a pin, a shaft, a bar, a notch, a flat, a detent, a bump, a ridge or a groove. The positioning means engages with at least one positioning element, and provides a repeatable rotational alignment of the fibers with respect to a receiver when engaged with the positioning element.

Abstract: A handheld optoacoustic probe includes an ultrasound transducer array and optical fibers with a first end formed into a fiber bundle providing an input and a second, distal end providing an output. A light bar guide retains the distal end of the optical fibers on the same plane. One or more optical windows may be associated with, and spaced from the light bar guide so as to prevent contact between a coupling agent and the distal ends of the optical fibers, thus mitigating a potential acoustic effect of the coupling agent in response to light emitting from the fibers. A silicon rubber acoustic lens doped with TiO2 may be provided, with a reflective metal surrounding the outer surface of the acoustic lens. A handheld probe shell houses the light bar guide, the ultrasound transducer array, and the acoustic lens.

Abstract: A tape has a format of the type wherein digital video information is recorded with each frame or field disposed on a set of multiple tracks and with at least one track being intended for replay during scene search modes of operation, only the most significant bits of pixels are recorded on the search tracks.

Abstract: In a VTR of the type having information recorded in adjacent tracks disposed angularly across the direction of tape travel, a search mode playback arrangement is incorporated having a pair of transducer gaps which are alternately enabled to continuously pickup coherent information while the playback arrangement scans across adjacent tracks during a search mode.

Abstract: A flat field laser recorder includes means to direct a beam from a laser through an acousto-optic light modulator, an acousto-optic light deflector/modulator, and a beam scanner, to scan-lines on a linearly-moving light-sensitive film. The acousto-optic light modulator is operated by electrical oscillations which are amplitude modulated by a video information signal. The acousto-optic light deflector/modulator is operated by electrical oscillations which are amplitude modulated to provide an automatic brightness control of the beam, and are frequency modulated to provide an automatic scan-line spacing control. In addition, a plurality of simultaneous oscillation frequencies are selectively applied to the deflector/modulator to provide beam spot elongation control in the direction perpendicular to the scan-lines.

Abstract: A scanner for reading binary digit spots on a transparent film includes a laser light beam which is directed through a beam splitter and through the film to a mirror, from which it is reflected back through the film to illuminate a small area on the film. Light which is not blocked by a recorded spot on the film continues back to the beam splitter, from which the beam is directed to a photodetector. The photodetector is positioned to receive light from solely a portion of the illuminated area of the film, to provide high definition scanning not adversely affected by distortion of the illuminating light beam by imperfections in the film and mirror.