Patents by Inventor Donald J. Kyle

Donald J. Kyle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Systems and Methods for Treating an Opioid-Induced Adverse Pharmacodynamic Response
    Publication number: 20180193331
    Abstract: Disclosed in certain embodiments is a method of treating or preventing an opioid induced adverse pharmacodynamic response comprising administering to a patient in need thereof an effective amount of buprenorphine.
    Type: Application
    Filed: December 8, 2017
    Publication date: July 12, 2018
    Inventors: Michele Hummel, Donald J. Kyle, Garth Whiteside
  • Systems and Methods for Treating an Opioid-Induced Adverse Pharmacodynamic Response
    Publication number: 20180104237
    Abstract: Disclosed in certain embodiments is a method of treating or preventing an opioid-induced adverse pharmacodynamic response comprising administering to a patient in need thereof an effective amount of buprenorphine.
    Type: Application
    Filed: December 18, 2017
    Publication date: April 19, 2018
    Inventors: Michele Hummel, Donald J. Kyle, Garth Whiteside
  • ANALOGS OF SODIUM CHANNEL PEPTIDE TOXIN
    Publication number: 20180105561
    Abstract: The present invention also relates to pharmaceutical compositions useful for treating or preventing a disorder responsive to the blockade of sodium ion channels, especially Nav1.7 sodium ion channels. The present invention further provides methods of treating a disorder responsive to the blockade of sodium channels, and particularly Nav1.7 sodium channels, in a mammal suffering from excess activity of said channels, compositions and methods for providing analgesia by administering a peptide of the invention.
    Type: Application
    Filed: September 20, 2017
    Publication date: April 19, 2018
    Inventors: Jae Hyun Park, Donald J. Kyle
  • Systems and methods for treating an opioid-induced adverse pharmacodynamic response
    Patent number: 9931337
    Abstract: Disclosed in certain embodiments is a method of treating or preventing an opioid-induced adverse pharmacodynamic response comprising administering to a patient in need thereof an effective amount of buprenorphine.
    Type: Grant
    Filed: December 5, 2014
    Date of Patent: April 3, 2018
    Assignee: Purdue Pharma L.P.
    Inventors: Michelle Hummel, Donald J. Kyle, Garth Whiteside
  • Systems and methods for treating an opioid-induced adverse pharmacodynamic response
    Patent number: 9884059
    Abstract: Disclosed in certain embodiments is a method of treating or preventing an opioid-induced adverse pharmacodynamic response comprising administering to a patient in need thereof an effective amount of buprenorphine.
    Type: Grant
    Filed: March 26, 2015
    Date of Patent: February 6, 2018
    Assignee: Purdue Pharma L.P.
    Inventors: Michele Hummel, Donald J. Kyle, Garth Whiteside
  • ARYL SUBSTITUTED INDOLES AND THE USE THEREOF
    Publication number: 20180022699
    Abstract: The invention relates to aryl and heteroaryl substituted compounds of Formula (I), and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein G, R1, and Z1-Z5 are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of sodium channels. Compounds of the present invention are especially useful for treating pain.
    Type: Application
    Filed: August 4, 2017
    Publication date: January 25, 2018
    Inventors: Donald J. Kyle, Chiyou Ni, Laykea Tafesse, Jiangchao Yao
  • Systems and methods for treating an opioid-induced adverse pharmacodynamic response
    Patent number: 9872856
    Abstract: Disclosed in certain embodiments is a method of treating or preventing an opioid-induced adverse pharmacodynamic response comprising administering to a patient in need thereof an effective amount of buprenorphine.
    Type: Grant
    Filed: February 3, 2015
    Date of Patent: January 23, 2018
    Assignee: Purdue Pharma L.P.
    Inventors: Michele Hummel, Donald J. Kyle, Garth Whiteside
  • Systems and methods for treating an opioid-induced adverse pharmacodynamic response
    Patent number: 9867817
    Abstract: Disclosed in certain embodiments is a method of treating or preventing an opioid-induced adverse pharmacodynamic response comprising administering to a patient in need thereof an effective amount of buprenorphine.
    Type: Grant
    Filed: March 26, 2015
    Date of Patent: January 16, 2018
    Assignee: Purdue Pharma L.P.
    Inventors: Michele Hummel, Donald J. Kyle, Garth Whiteside
  • Systems and methods for treating an opioid-induced adverse pharmacodynamic response
    Patent number: 9855262
    Abstract: Disclosed in certain embodiments is a method of treating or preventing an opioid-induced adverse pharmacodynamic response comprising administering to a patient in need thereof an effective amount of buprenorphine.
    Type: Grant
    Filed: March 26, 2015
    Date of Patent: January 2, 2018
    Assignee: Purdue Pharma L.P.
    Inventors: Michele Hummel, Donald J. Kyle, Garth Whiteside
  • Systems and methods for treating an opioid-induced adverse pharmacodynamic response
    Patent number: 9849124
    Abstract: Disclosed in certain embodiments is a method of treating or preventing an opioid induced adverse pharmacodynamic response comprising administering to a patient in need thereof an effective amount of buprenorphine.
    Type: Grant
    Filed: October 16, 2015
    Date of Patent: December 26, 2017
    Assignee: Purdue Pharma L.P.
    Inventors: Michele Hummel, Donald J. Kyle, Garth Whiteside
  • Methods and Compositions for Decreasing Gastric Emptying
    Publication number: 20170340646
    Abstract: Disclosed in certain embodiments is a method of decreasing gastric emptying comprising administering to a subject an effective amount of a sodium-channel blocker to decrease gastric emptying.
    Type: Application
    Filed: August 18, 2017
    Publication date: November 30, 2017
    Inventors: Michele Hummel, Donald J. Kyle, Garth Whiteside, Nathan Lautermilch
  • MHC-I Restricted Epitopes Containing Non-Natural Amino Acid Residues
    Publication number: 20170319670
    Abstract: The invention provides for the synthesis of more effective generators of a T-cell immune response by providing peptide derivatives that are MHC class I-restricted antigens. The peptide derivatives of the present invention are prepared or derived from a parent peptide of 8 to 11 amino acid residues in length, wherein the peptide derivative contains a non-natural amino acid substituted in place of a naturally-occurring amino acid residue at one or more primary anchor positions in the parent peptide or at position 6, position 7, or the C-terminus.
    Type: Application
    Filed: January 23, 2017
    Publication date: November 9, 2017
    Applicant: Purdue Pharma L.P.
    Inventors: Donald J. KYLE, Daniel A. Soltis, Lynda G. Tussey
  • Methods and compositions for decreasing gastric emptying
    Patent number: 9763955
    Abstract: Disclosed in certain embodiments is a method of decreasing gastric emptying comprising administering to a subject an effective amount of a sodium-channel blocker to decrease gastric emptying.
    Type: Grant
    Filed: February 19, 2016
    Date of Patent: September 19, 2017
    Assignee: Purdue Pharma L.P.
    Inventors: Michele Hummel, Donald J. Kyle, Garth Whiteside, Nathan Lautermilch
  • Systems for treating an opioid-induced adverse pharmacodynamic response
    Patent number: 9662326
    Abstract: Disclosed in certain embodiments is a method of treating or preventing an opioid-induced adverse pharmacodynamic response comprising administering to a patient in need thereof an effective amount of buprenorphine.
    Type: Grant
    Filed: February 26, 2015
    Date of Patent: May 30, 2017
    Assignee: Purdue Pharma L.P.
    Inventors: Michele Hummel, Donald J. Kyle, Garth Whiteside
  • MHC-I restricted epitopes containing non-natural amino acid residues
    Patent number: 9549972
    Abstract: The invention provides for the synthesis of more effective generators of a T-cell immune response by providing peptide derivatives that are MHC class I-restricted antigens. The peptide derivatives of the present invention are prepared or derived from a parent peptide of 8 to 11 amino acid residues in length, wherein the peptide derivative contains a non-natural amino acid substituted in place of a naturally-occurring amino acid residue at one or more primary anchor positions in the parent peptide or at position 6, position 7, or the C-terminus.
    Type: Grant
    Filed: August 6, 2015
    Date of Patent: January 24, 2017
    Assignee: Purdue Pharma L.P.
    Inventors: Donald J. Kyle, Daniel A. Soltis, Lynda G. Tussey
  • 7-BETA ANALOGS OF ORVINOLS
    Publication number: 20160333020
    Abstract: The application is directed to compounds of Formula I (I) and pharmaceutically acceptable salts and solvates thereof, wherein R1, R1a, R1b, X, Y, Z, G, Q, W1 and W2 are defined as set forth in the specification. The invention is also directed to use of the compounds of Formula I and the pharmaceutically acceptable salts and solvates thereof to treat disorders responsive to the modulation of one or more opioid receptors, or as synthetic intermediates. Certain compounds of the present invention are especially useful for treating pain.
    Type: Application
    Filed: December 17, 2014
    Publication date: November 17, 2016
    Inventors: Donald J. Kyle, Laykea Tafesse
  • ARYL SUBSTITUTED INDOLES AND THE USE THEREOF
    Publication number: 20160326111
    Abstract: The invention relates to aryl and heteroaryl substituted compounds of Formula (I), and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein G, R1, and Z1-Z5 are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of sodium channels. Compounds of the present invention are especially useful for treating pain.
    Type: Application
    Filed: December 14, 2015
    Publication date: November 10, 2016
    Inventors: Donald J. Kyle, Chiyou Ni, Laykea Tafesse, Jiangchao Yao
  • Methods and Compositions for Decreasing Gastric Emptying
    Publication number: 20160243129
    Abstract: Disclosed in certain embodiments is a method of decreasing gastric emptying comprising administering to a subject an effective amount of a sodium-channel blocker to decrease gastric emptying.
    Type: Application
    Filed: February 19, 2016
    Publication date: August 25, 2016
    Inventors: Michele Hummel, Donald J. Kyle, Garth Whiteside, Nathan Lautermilch
  • ANALOGS OF SODIUM CHANNEL PEPTIDE TOXIN
    Publication number: 20160222071
    Abstract: The present invention relates to a peptide and analogs thereof that selectively inhibit the Nav1.7 sodium channel. The present invention also relates to pharmaceutical compositions useful for treating or preventing a disorder responsive to the blockade of sodium ion channels, especially Nav1.7 sodium ion channels. The present invention further provides methods of treating a disorder responsive to the blockade of sodium channels, and particularly Nav1.7 sodium channels, in a mammal suffering from excess activity of said channels, compositions and methods for providing analgesia by administering a peptide of the invention.
    Type: Application
    Filed: January 27, 2016
    Publication date: August 4, 2016
    Inventors: Jae Hyun Park, Donald J. Kyle
  • Systems and Methods for Treating an Opioid-Induced Adverse Pharmacodynamic Response
    Publication number: 20160106735
    Abstract: Disclosed in certain embodiments is a method of treating or preventing an opioid induced adverse pharmacodynamic response comprising administering to a patient in need thereof an effective amount of buprenorphine.
    Type: Application
    Filed: October 16, 2015
    Publication date: April 21, 2016
    Inventors: Michele Hummel, Donald J. Kyle, Garth Whiteside