Patents by Inventor Donald Karanewsky

Donald Karanewsky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diarylamine-Containing Compounds and Compositions, and their use as Modulators of C-Kit Receptors
    Publication number: 20070149538
    Abstract: Described herein are compounds that include a diarylamine structural feature. Also described herein are methods for making such compounds, methods for using such compounds to modulate the activity of c-kit receptors, and pharmaceutical compositions and medicaments comprising such compounds. Also described herein are methods of using such compounds, pharmaceutical compositions and medicaments to treat and/or prevent and/or inhibit and/or ameliorate the pathology and/or symptomology diseases or conditions associated with the activity of c-kit receptors.
    Type: Application
    Filed: September 26, 2006
    Publication date: June 28, 2007
    Applicants: IRM LLC, Novartis, AG
    Inventors: Valentina Molteni, Xiaolin Li, Donatella Chianelli, Jon Loren, Shuli You, Juliet Nabakka, Xiadong Liu, Shifeng Pan, Yi Liu, Donald Karanewsky, Pascal Furet, Vito Guagnano
  • Tricyclic quinolinone and tricyclic quinoline androgen receptor modulator compounds and methods
    Publication number: 20070072849
    Abstract: Non-steroidal tricyclic quinolinone and tricyclic quinoline compounds and compositions that are agonists, partial agonists and/or antagonists for androgen receptors (AR), their preparation and their uses are described.
    Type: Application
    Filed: November 17, 2006
    Publication date: March 29, 2007
    Inventors: Robert Higuchi, Lin Zhi, Donald Karanewsky, Anthony Thompson, Thomas Caferro, Neelakandha Mani, Jyun-Hung Chen, Marquis Cummings, James Edwards, Mark Adams, Charlotte Deckhut
  • 5-Cycloalkenyl 5H-chromeno[3,4-f]quinoline derivatives as selective progesterone receptor modulator compounds
    Publication number: 20060194827
    Abstract: The present invention relates to methods for modulating processes mediated by progesterone receptor using nonsteroidal compounds and compositions which may be high affinity, high specificity agonists, partial agonists (i.e., partial activators and/or tissue-specific activators) and/or antagonists for progesterone receptors.
    Type: Application
    Filed: April 25, 2006
    Publication date: August 31, 2006
    Inventors: Lin Zhi, Cornelis Van Oeveren, Bijan Pedram, Donald Karanewsky
  • Inhibitors of cathepsin S
    Publication number: 20050130959
    Abstract: The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.
    Type: Application
    Filed: October 20, 2004
    Publication date: June 16, 2005
    Applicant: IRM LLC
    Inventors: Hong Liu, Phillip Alper, Daniel Mutnick, Donald Karanewsky
  • Inhibitors of cathepsin S
    Publication number: 20050113356
    Abstract: The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.
    Type: Application
    Filed: August 18, 2004
    Publication date: May 26, 2005
    Applicant: IRM LLC
    Inventors: Hong Liu, Arnab Chatterjee, David Tully, Phillip Alper, Badry Bursulaya, Jianhua Guo, David Woodmansee, Daniel Mutnick, Donald Karanewsky, Yun He
  • Inhibitors of cathepsin S
    Publication number: 20050107368
    Abstract: The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.
    Type: Application
    Filed: August 18, 2004
    Publication date: May 19, 2005
    Applicant: IRM LLC
    Inventors: Hong Liu, Phillip Alper, Donald Karanewsky
  • C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
    Publication number: 20050020504
    Abstract: This invention is directed to novel oxamyl dipeptide ICE/ced-3 family inhibitor compounds. The invention is also directed to pharmaceutical compositions containing these compounds, as well as to the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that are to undergo a transplantation procedure.
    Type: Application
    Filed: August 25, 2004
    Publication date: January 27, 2005
    Applicant: Idun Pharmaceuticals, Inc.
    Inventors: Donald Karanewsky, Robert Ternansky, Steven Linton, Thang Dinh
  • 5-cycloalkenyl 5H-chromeno[3,4-f]quinoline derivatives as selective progesterone receptor modulator compounds
    Publication number: 20040152718
    Abstract: The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by Progesterone Receptor. Also provided are methods of making such compounds and pharmaceutical compositions.
    Type: Application
    Filed: October 10, 2003
    Publication date: August 5, 2004
    Inventors: Lin Zhi, Cornelis Arjan van Oeveren, Bijan Pedram, Donald Karanewsky