Patents by Inventor Donald R. Owen
Donald R. Owen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230210745Abstract: A low-urea retinoate containing less than 5% of urea or a urea-containing compound produced by a reaction of (a) retinoic acid and (b) glyceryl oleate, wherein the low-urea retinoate is a pourable, homogenous solution at room temperature.Type: ApplicationFiled: March 3, 2023Publication date: July 6, 2023Applicant: Owen Biosciences, Inc.Inventor: Donald R. Owen
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Publication number: 20230201096Abstract: A low-urea retinoate containing less than 5% of urea or a urea-containing compound produced by a reaction of (a) retinoic acid and (b) glyceryl oleate, wherein the low-urea retinoate is a pourable, homogenous solution at room temperature.Type: ApplicationFiled: March 3, 2023Publication date: June 29, 2023Applicant: Owen Biosciences, Inc.Inventor: Donald R. Owen
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Patent number: 11617710Abstract: A self-emulsifying bioactive concentrate produced by a process comprising the steps of (a) creating a lysophospholipid concentrate comprised of a de-oiled lecithin source and 0.1% to 10% of an enzyme with having phospholipase A activity, wherein the lysophospholipid concentrate contains greater than 20% lysophosphatidyl-choline; and (b) combining the lysophospholipid concentrate from step (a) with a retinyl ester formed by the reaction of retinol and one or a mixture of unsaturated fatty acid(s).Type: GrantFiled: October 12, 2021Date of Patent: April 4, 2023Assignee: Owen Biosciences, Inc.Inventor: Donald R. Owen
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Publication number: 20220062140Abstract: A self-emulsifying bioactive concentrate produced by a process comprising the steps of (a) creating a lysophospholipid concentrate comprised of a de-oiled lecithin source and 0.1% to 10% of an enzyme with having phospholipase A activity, wherein the lysophospholipid concentrate contains greater than 20% lysophosphatidyl-choline; and (b) combining the lysophospholipid concentrate from step (a) with a retinyl ester formed by the reaction of retinol and one or a mixture of unsaturated fatty acid(s).Type: ApplicationFiled: October 12, 2021Publication date: March 3, 2022Inventor: Donald R. Owen
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Patent number: 11173103Abstract: A novel lysophospholipid concentrate produced by a process comprising the steps of combining (i) a de-oiled lecithin and (ii) from about 0.5 to about 2% of an enzyme with PLA2 activity. The lysophospholipid concentrate is a pourable, homogenous mixture/solution at or about room temperature with has no significant visible precipitate that (a) has an HLB of greater than 12, (b) contains greater than about 20% lysophosphatidylcholine, and (c) contains greater than about 10% lysophosphatidic acid or an LPA-mimetic. Novel low-urea retinoate compounds produced by the reaction of (a) retinoic acid and (b) one or both of glycerine and/or a monoacylglyceride in the presence of a carbodiimide coupling agent, and preferably in the presence of p-toluene sulfonic acid. The low-urea retinoate is a pourable, homogenous mixture/solution at or about room temperature with no significant visible precipitate.Type: GrantFiled: August 1, 2018Date of Patent: November 16, 2021Assignee: Owen Biosciences, Inc.Inventor: Donald R. Owen
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Publication number: 20160042084Abstract: Methods of monitoring, maintaining, and/or restoring viability of at least one organ in a perfusion apparatus are disclosed. The methods include monitoring data comprising information relating to events occurring while at least one organ is present in a perfusion apparatus to form a data record. And they further include connecting the perfusion apparatus to a network through wiring or wirelessly, and continuously uploading the data record to a database at a location away from the perfusion apparatus in such a manner that a database computer that obtains the data record from the database can at least one of manage, track, monitor, and diagnose the at least one organ in the perfusion apparatus in real-time based upon the information in the data record.Type: ApplicationFiled: October 21, 2015Publication date: February 11, 2016Inventors: Donald R. OWEN, David C. KRAVITZ, John BRASSIL, Kelvin G.M. BROCKBANK, Andrew BURROUGHS, Douglas SCHEIN, Stanley HARRIS, Dennis J. STEIBEL, Richard FRASER, Christopher G. CURTIS
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Patent number: 8962303Abstract: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate.Type: GrantFiled: August 10, 2011Date of Patent: February 24, 2015Assignee: Lifeline Scientific, Inc.Inventors: Donald R. Owen, David C. Kravitz, John Brassil, Kelvin G. M. Brockbank, Andrew Burroughs, Dickon Isaacs, Douglas Schein
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Patent number: 8609400Abstract: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program.Type: GrantFiled: May 12, 2010Date of Patent: December 17, 2013Assignee: Lifeline Scientific, Inc.Inventors: Donald R. Owen, David C. Kravitz, John Brassil, Kelvin G. M. Brockbank, Andrew Burroughs, Dickon Isaacs, Douglas Schein
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Patent number: 8445260Abstract: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate.Type: GrantFiled: August 10, 2011Date of Patent: May 21, 2013Assignee: Lifeline Scientific, Inc.Inventors: Donald R. Owen, David C. Kravitz, John Brassil, Kelvin G. M. Brockbank, Andrew Burroughs, Douglas Schein, Stanley Harris, Dennis Steibel, Richard Fraser, Dickon Isaacs
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Patent number: 8431385Abstract: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures.Type: GrantFiled: January 21, 2011Date of Patent: April 30, 2013Assignee: Lifeline Scientific, Inc.Inventors: Donald R. Owen, David C. Kravitz, John Brassil, Kelvin G. M. Brockbank, Andrew Burroughs, Dickon Isaacs, Douglas Schein
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Patent number: 8431523Abstract: Oligomeric acylated biosurfactants (“OABs”) having low critical micelle concentrations of from about 1.0 ppm to about 200 ppm, preferably less than about 50 ppm, in an aqueous solution of Minimal Essential Media that can lower the surface tension in the aqueous MEM environment to less than about 50 dynes/cm2 and have the ability to increase metabolic soluble proteins and/or increase synthesis of extracellular skin matrix proteins and/or increase rates of cell turnover while at the same time exhibiting comparatively low toxicity—preferably, an LD50 of greater 200 ppm in 37 year-old female fibroblast cells. Another aspect of the present invention is directed to the use of OABs in formulations that are topically-applied, by which is meant the formulation is placed in direct contact with the skin, hair and nails as well as mucosa of the eyes, ears, nose, mouth, anus and vagina.Type: GrantFiled: May 29, 2009Date of Patent: April 30, 2013Inventors: Donald R. Owen, Lili Fan
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Patent number: 8420381Abstract: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures.Type: GrantFiled: November 5, 2010Date of Patent: April 16, 2013Assignee: Lifeline Scientific, Inc.Inventors: Donald R. Owen, David C. Kravitz, John Brassil, Kelvin G. M. Brockbank, Andrew Burroughs, Dickon Isaacs, Dennis J. Steibel, Richard Fraser, Stanley Harris, Douglas Schein
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Patent number: 8349551Abstract: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program.Type: GrantFiled: November 5, 2010Date of Patent: January 8, 2013Assignee: Lifeline Scientific, Inc.Inventors: Donald R. Owen, David C. Kravitz, John Brassil, Kelvin G. M. Brockbank, Andrew Burroughs, Dickon Isaacs, Dennis J. Steibel, Richard Fraser, Stanley Harris, Douglas Schein
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Patent number: 8318415Abstract: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures.Type: GrantFiled: October 22, 2010Date of Patent: November 27, 2012Assignee: Lifeline Scientific, Inc.Inventors: Donald R. Owen, David C. Kravitz, John Brassil, Kelvin G. M. Brockbank, Andrew Burroughs, Dickon Isaacs, Dennis J Steibel, Richard Fraser, Stanley Harris, Douglas Schein, Christopher G. Curtis
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Patent number: 8268612Abstract: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures.Type: GrantFiled: August 10, 2011Date of Patent: September 18, 2012Assignee: Lifeline Scientific, Inc.Inventors: Donald R. Owen, David C. Kravitz, John Brassil, Kelvin G. M. Brockbank, Andrew Burroughs, Douglas Schein, Dickon Isaacs
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Patent number: 8268547Abstract: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off.Type: GrantFiled: October 25, 2005Date of Patent: September 18, 2012Assignee: Lifeline Scientific, Inc.Inventors: Donald R. Owen, David C. Kravitz
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Publication number: 20110300615Abstract: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures.Type: ApplicationFiled: August 10, 2011Publication date: December 8, 2011Applicant: LIFELINE SCIENCETIFIC, INC.Inventors: Donald R. Owen, David C. Kravitz, John Brassil, Kelvin G.M. Brockbank, Andrew Burroughs, Dickon Isaacs, Dennis J. Steibel, Richard Fraser, Stanley Harris, Douglas Schein
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Publication number: 20110300614Abstract: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures.Type: ApplicationFiled: August 10, 2011Publication date: December 8, 2011Applicant: LIFELINE SCIENTIFIC, INC.Inventors: Donald R. Owen, David C. Kravitz, John Brassil, Kelvin G.M. Brockbank, Andrew Burroughs, Dickon Isaacs, Dennis J. Steibel, Richard Fraser, Stanley Harris, Douglas Schein
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Publication number: 20110300613Abstract: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures.Type: ApplicationFiled: August 10, 2011Publication date: December 8, 2011Applicant: LIFELINE SCIENTIFIC, INC.Inventors: Donald R. Owen, David C. Kravitz, John Brassil, Kelvin G.M. Brockbank, Andrew Burroughs, Dickon Isaacs, Dennis J. Steibel, Richard Fraser, Santley Harris, Douglas Schein
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Publication number: 20110300611Abstract: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures.Type: ApplicationFiled: August 10, 2011Publication date: December 8, 2011Applicant: LIFELINE SCIENTIFIC, INC.Inventors: Donald R. Owen, David C. Kravitz, John Brassil, Kelvin G.M. Brockbank, Andrew Burroughs, Dickon Isaacs, Dennis J. Steibel, Richard Fraser, Stanley Harris, Douglas Schein