Abstract: A novel synthetic functionalized backbone polymer is provided which is a polyanionic side-chain functionalized backbone polymer comprising a hydrophilic backbone polymer functionalized with an activated alkene or epoxy group. The functionalized backbone polymer may be combined with a free or protected thiol-containing compound to form a crosslinked hydrogel having biomedical application, and may additionally be combined with a hydrogel matrix to yield a hydrogel system useful for in vivo delivery of cells and other therapeutic agents.

Abstract: The invention provides a molecular classifier and a targeted sequencing assay for use in characterization and treatment of diffuse large B-cell lymphoma.

Abstract: The invention provides compositions and methods useful in characterizing and/or treating classical Hodgkin's Lymphoma and/or primary mediastinal B-cell lymphoma (PMBL). In embodiments, the characterization is carried out using a biological sample comprising circulating tumor DNA (ctDNA) from a subject.

Abstract: There is disclosed an excavation apparatus (5), such as an underwater excavation apparatus, having means for producing, in use, at least one vortex, spiral or turbulent flow in a laminar flow of fluid, e.g. water. The excavation apparatus (5) comprises a rotor (10) having a rotor rotation axis (A), wherein, in use, flow of fluid past or across the rotor (10) is at a first angle (a) from the axis of rotation (A). The excavation apparatus (5) comprises the rotor (5) and means or an arrangement for dampening reactive torque on the apparatus (5) caused by rotation of the rotor (10), in use. The turbulent flow is provided within, such as within a (transverse) cross-section, of the laminar flow.

Abstract: The invention provides an active noise reduction system which may be self-contained within a headset of the system, wherein circuitry within the system applies an active noise reduction profile to a signal to the speakers in the headset, to provide active noise reduction to the user of the headset, the system being arranged to receive power both from a power supply external to the system and from a battery of the system and to automatically modify the active noise reduction applied, in dependence on whether or not the system is connected to an external power supply.

Abstract: There is disclosed an excavation apparatus (5), such as an underwater excavation apparatus, having means for producing, in use, at least one vortex, spiral or turbulent flow in a laminar flow of fluid, e.g. water. The excavation apparatus (5) comprises a rotor (10) having a rotor rotation axis (A), wherein, in use, flow of fluid past or across the rotor (10) is at a first angle (?) from the axis of rotation (A). The excavation apparatus (5) comprises the rotor (5) and means or an arrangement for dampening reactive torque on the apparatus (5) caused by rotation of the rotor (10), in use. The turbulent flow is provided within, such as within a (transverse) cross-section, of the laminar flow.

Abstract: “There is disclosed an excavation apparatus (5), such as an underwater excavation apparatus, having means for producing, in use, at least one vortex, spiral or turbulent flow in a laminar flow of fluid, e.g. water. The excavation apparatus (5) comprises a rotor (10) having a rotor rotation axis (A), wherein, in use, flow of fluid passedpast or across the rotor (10) is at a first angle (?) from the axis of rotation (A). The excavation apparatus (5) comprises the rotor (5) and means or an arrangement for dampening reactive torque on the apparatus (5) caused by rotation of the rotor (10), in use. The turbulent flow is provided within, such as within a (transverse) cross-section, of the laminar flow.

Abstract: There is disclosed an excavation apparatus (5), such as an underwater excavation apparatus, having means for producing, in use, at least one vortex, spiral or turbulent flow in a laminar flow of fluid, e.g. water. The excavation apparatus (5) comprises a rotor (10) having a rotor rotation axis (A), wherein, in use, flow of fluid passed or across the rotor (10) is at a first angle (?) from the axis of rotation (A). The excavation apparatus (5) comprises the rotor (10) and means or an arrangement for dampening reactive torque on the apparatus (5) caused by rotation of the rotor (10), in use. The turbulent flow is provided within, such as within a (transverse) cross-section, of the laminar flow.

Abstract: An excavation apparatus comprises a controlled flow underwater excavation apparatus. A housing thereof comprises at least one inlet and at least one outlet. The at least one inlet is provided on or at a side of the housing. A fluid flow path extends from the/each at least one inlet to the outlet. The fluid flow path comprises a first portion provided at or adjacent the/each at least one inlet. The first portion is included at a non-300 angle, e.g. is substantially perpendicular, to or converges towards a longitudinal axis of the housing and substantially straight. A second portion extends or continues from the first portion. A third portion extends or continues from the second portion. The third portion is substantially straight, contains at least part of a rotor, and is divergent away from the longitudinal axis of the housing in a flow direction from the inlet to the outlet.

Abstract: There is disclosed an excavation apparatus (5), such as an underwater excavation apparatus, having means for producing, in use, at least one vortex, spiral or turbulent flow in a laminar flow of fluid, e.g. water. The excavation apparatus (5) comprises a rotor (10) having a rotor rotation axis (A), wherein, in use, flow of fluid passed or across the rotor (10) is at a first angle (a) from the axis of rotation (A). The excavation apparatus (5) comprises the rotor (10) and means or an arrangement for dampening reactive torque on the apparatus (5) caused by rotation of the rotor (10), in use. The turbulent flow is provided within, such as within a (transverse) cross-section, of the laminar flow.

Abstract: An underwater tool (5; 205; 305) including a grabber arrangement (15; 215; 315) and a cutter arrangement (20; 220; 320) connected together. The grabber arrangement comprises a plurality of grabber elements (30; 230; 330) disposed on first and second sides (35a; 235a; 335a; 35b; 235b; 335b) of the tool. The cutter arrangement includes a cutter slot (75; 275; 375), an anvil (80; 280; 380) movable to close the slot comprises an anvil and a cutter blade (90; 290?; 390). In use, a cable (10; 210; 310) is held by the grabber arrangement, and thereby moved into the slot which is then closed by the anvil so as to entrap the cable within the slot. The cutter blade is then driven against the anvil so as to cut the cable.

Abstract: A portable instrument or apparatus includes a portable device and a rangefinder module. The rangefinder module can be attached to the portable device, which may be any suitable smartphone, tablet or other consumer electronics device having a camera. By suitable alignment of the rangefinder and camera, the device is capable of capturing accurate data over significant ranges, including for example an image of a target together with position information concerning the target. A folded optical arrangement reduces the volume and thickness of the rangefinder module.

Abstract: An improved turbine or motor, such as a fluid or liquid driven turbine or motor or hydraulic turbine or motor including a downhole turbine for the oil/gas and geothermal industries, such as a drilling turbine or downhole drilling turbine. The turbine or motor provides a fluid passage comprising at least one portion or zone arranged to cause a drive fluid to be moved or diverted, such as at least partly radially. The turbine or motor may comprise a rotor having a rotor blade extending within the fluid passage. The turbine or motor may comprise a stator having a stator blade extending within the fluid passage. The stator (30) may comprise or define at least part of the at least one portion or zone configured or arranged to cause the fluid to be moved in or diverted from an at least part axial path to an at least part radial path or radially inward path.

Abstract: A portable instrument or apparatus includes a portable device and a rangefinder module. The rangefinder module can be attached to the portable device, which may be any suitable smartphone, tablet or other consumer electronics device having a camera. By suitable alignment of the rangefinder and camera, the device is capable of capturing accurate data over significant ranges, including for example an image of a target together with position information concerning the target. A folded optical arrangement reduces the volume and thickness of the rangefinder module.

Abstract: A method and apparatus for melting aluminum uses a dense metal salt of Rubidium, Cesium, or Strontium. The salt is melted by a stinger and then superheated by AC applied to electrodes immersed in the salt. Aluminum in contact with the salt melts and floats on the salt. In continuous scrap melting, inflows and outflows of aluminum are comparable and may be shielded by inert gas. The superheated salt may be purified and may be heated in a separate reservoir and pumped to and from another reservoir containing salt and/or metal. The salt may be used to supplement the heating of an existing furnace.

Abstract: The present invention relates to an underwater excavation apparatus and a method of excavation with the same. The apparatus of the invention performs the excavation by both mass flow and jet flow. Mass flow excavation takes place at a pressure that is lower than the jet flow excavation performed by the apparatus, and the volume flow rate of the mass flow excavation is greater than the volume flow rate of the jet flow excavation performed by the apparatus. The outlet for jet flow excavation is provided within the outlet for mass flow excavation of the apparatus.

Abstract: A method and apparatus for melting aluminum uses a dense metal salt of Rubidium, Cesium, or Strontium. The salt is melted by a stinger and then superheated by AC applied to electrodes immersed in the salt. Aluminum in contact with the salt melts and floats on the salt. In continuous scrap melting, inflows and outflows of aluminum are comparable and may be shielded by inert gas. The superheated salt may be purified and may be heated in a separate reservoir and pumped to and from another reservoir containing salt and/or metal. The salt may be used to supplement the heating of an existing furnace.

Abstract: The present invention relates to an underwater excavation apparatus. The apparatus of the invention utilizes mass flow for disturbing or excavating an underwater location and for extracting or sucking excavated material from the underwater location to another location. Restriction of spoil and/or direct spoil is provided for the apparatus and comprises a baffle provided within a cavity of a housing having an open base for the extracting or sucking of excavated material. An outlet for disturbing or excavating and an inlet for extraction or suction are located within the housing while an inlet for disturbing or excavating and an outlet for extraction or suction are located external to the housing.

Abstract: A barrier having an upper elongate support and a lower elongate support, and a two-wire tensioning assembly with two only substantially vertical portions extending between the upper and lower elongate supports, with two wires each attached through a spreader, the spreader having a threaded aperture and a shaft threadably engaging the aperture and being positioned to either directly or indirectly engage a one of the elongate supports, where rotation of the shaft relative to the spreader will effect a change in tensioning of both substantially vertical portions of the wires at the same time.

Abstract: A power generator includes at least one underwater turbine unit providing a housing having a flow channel therethrough and at least one turbine means mounted in the flow channel for rotation in response to water flow through the flow channel. The turbine unit provides a turbine unit part releasably mountable in the turbine unit. The turbine unit part includes at least one of the at least one turbine means and a pump means. The turbine unit part is releasably mountable through an aperture in a side wall of the housing.